LIVIVO - Search results -

Search results

Result 1 - 10 of total 69

Search options

Book ; Online: The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation, Development, Disease and Repair After Injury

Wang, Zhouguang / Li, Xiaokun / Lin, Li / Bellusci, Saverio / Zhang, Jin-San

2020

Keywords	Science: general issues ; Pharmacology ; FGF (fibroblast growth factor) ; regeneration ; development ; metabolic regulation ; ischema-reperfusion injury
Size	1 electronic resource (203 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021230888
ISBN	9782889661282 ; 2889661288
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Capacitive-Coupling-Responsive Hydrogel Scaffolds Offering Wireless In Situ Electrical Stimulation Promotes Nerve Regeneration.

Wu, Ping / Xu, Chao / Zou, Xianghui / Yang, Kun / Xu, Yanping / Li, Xueyao / Li, Xiaokun / Wang, Zhouguang / Luo, Zhiqiang

Advanced materials (Deerfield Beach, Fla.)

2024 Volume 36, Issue 14, Page(s) e2310483

Abstract: Electrical stimulation (ES) has shown beneficial effects in repairing injured tissues. However, current ES techniques that use tissue-traversing leads and bulky external power suppliers have significant limitations in translational medicine. Hence, ... ...

Abstract	Electrical stimulation (ES) has shown beneficial effects in repairing injured tissues. However, current ES techniques that use tissue-traversing leads and bulky external power suppliers have significant limitations in translational medicine. Hence, exploring noninvasive in vivo ES to provide controllable electrical cues in tissue engineering is an imminent necessity. Herein, a conductive hydrogel with in situ electrical generation capability as a biodegradable regeneration scaffold and wireless ES platform for spinal cord injury (SCI) repair is demonstrated. When a soft insulated metal plate is placed on top of the injury site as a wireless power transmitter, the conductive hydrogel implanted at the injury site can serve as a wireless power receiver, and the capacitive coupling between the receiver and transmitter can generate an alternating current in the hydrogel scaffold owing to electrostatic induction effect. In a complete transection model of SCI rats, the implanted conductive hydrogels with capacitive-coupling in situ ES enhance functional recovery and neural tissue repair by promoting remyelination, accelerating axon regeneration, and facilitating endogenous neural stem cell differentiation. This facile wireless-powered electroactive-hydrogel strategy thus offers on-demand in vivo ES with an adjustable timeline, duration, and strength and holds great promise in translational medicine.
MeSH term(s)	Rats ; Animals ; Nerve Regeneration ; Axons ; Hydrogels/pharmacology ; Spinal Cord Injuries/therapy ; Electric Stimulation ; Tissue Scaffolds
Chemical Substances	Hydrogels
Language	English
Publishing date	2024-01-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202310483
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: GnRH pulse frequency and irregularity play a role in male aging.

Wang, Zhouguang / Wu, Wenhe / Kim, Min Soo / Cai, Dongsheng

Nature aging

2021 Volume 1, Issue 10, Page(s) 904–918

Abstract: Gonadotropin-releasing hormone (GnRH) has a role in hypothalamic control of aging, but the underlying patterns and relationship with downstream reproductive hormones are still unclear. Here we report that hypothalamic GnRH pulse frequency and ... ...

Abstract	Gonadotropin-releasing hormone (GnRH) has a role in hypothalamic control of aging, but the underlying patterns and relationship with downstream reproductive hormones are still unclear. Here we report that hypothalamic GnRH pulse frequency and irregularity increase before GnRH pulse amplitude slowly decreases during aging. GnRH is inhibited by nuclear factor (NF)-κB, and GnRH pulses were controlled by oscillations in the transcriptional activity of NF-κB. Exposure to testosterone under pro-inflammatory conditions stimulated both NF-κB oscillations and GnRH pulses. While castration of middle-aged mice induced short-term anti-aging effects, preventing elevation of luteinizing hormone (LH) levels after castration led to long-term anti-aging effects and lifespan extension, indicating that high-frequency GnRH pulses and high-magnitude LH levels coordinately mediate aging. Reprogramming the endogenous GnRH pulses of middle-aged male mice via an optogenetic approach revealed that increasing GnRH pulses frequency causes LH excess and aging acceleration, while lowering the frequency of and stabilizing GnRH pulses can slow down aging. In conclusion, GnRH pulses are important for aging in male mice.
MeSH term(s)	Male ; Mice ; Animals ; Gonadotropin-Releasing Hormone/pharmacology ; Luteinizing Hormone ; Follicle Stimulating Hormone ; NF-kappa B ; Aging ; Orchiectomy
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0) ; NF-kappa B
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-021-00116-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Author Correction: GnRH pulse frequency and irregularity play a role in male aging.

Wang, Zhouguang / Wu, Wenhe / Kim, Min Soo / Cai, Dongsheng

Nature aging

2021 Volume 1, Issue 11, Page(s) 1068

Language	English
Publishing date	2021-10-11
Publishing country	United States
Document type	Published Erratum
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-021-00137-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: In Situ Nanofiber Patch Boosts Postoperative Hepatocellular Carcinoma Immune Activation by Trimodal Combination Therapy.

Zhao, Yanan / Liu, Yiming / Liu, Zaoqu / Ren, Kewei / Jiao, Dechao / Ren, Jianzhuang / Wu, Ping / Li, Xiaokun / Wang, Zhouguang / Han, Xinwei

ACS nano

2023 Volume 18, Issue 1, Page(s) 245–263

Abstract: Poor clinical efficacy associated with postoperative hepatocellular carcinoma (HCC) often results from recurrence and metastasis. Hence, research has focused on establishing an effective multimodal therapy. However, complex combinations of active ... ...

Abstract	Poor clinical efficacy associated with postoperative hepatocellular carcinoma (HCC) often results from recurrence and metastasis. Hence, research has focused on establishing an effective multimodal therapy. However, complex combinations of active ingredients require multiple functions in therapeutic systems. Herein, a portable nanofiber patch composing germanium phosphorus (GeP) and anlotinib (AL) was designed to form a versatile platform for molecularly targeted photothermal-immune checkpoint blockade (ICB) trimodal combination therapy. The patches possess hydrophilic, satisfactory mechanical, and excellent photothermal conversion properties. Moreover, they achieve a penetrating and sustained drug release. The near-infrared light-assisted GeP-induced temperature increase regulates AL release, downregulating the expression of vascular-related factor receptors, triggering immunogenic cell death of tumor cells, and inducing dendritic cell maturation. Simultaneously, ICB therapy (programmed cell death ligand 1, PD-L1) was introduced to improve treatment outcomes. Notably, this trimodal combination therapy significantly inhibits vascular hypergrowth, enhances effector T-cell infiltration, and sensitizes the PD-L1 antibody response, boosting immunotherapy to suppress residual HCC recurrence and metastasis. Further validation of the genome sequencing results revealed cell pathways related primarily to regulatory immune effects. This study demonstrates the use of an effective and practical nanofiber patch to improve multimodal therapy of postoperative HCC, with high clinical translation value.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/drug therapy ; B7-H1 Antigen ; Nanofibers/therapeutic use ; Combined Modality Therapy ; Immunotherapy/methods ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c05829
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Multifunctional Biodegradable Conductive Hydrogel Regulating Microenvironment for Stem Cell Therapy Enhances the Nerve Tissue Repair.

Xu, Chao / Wu, Ping / Yang, Kun / Mu, Congpu / Li, Binbin / Li, Xiaokun / Wang, Zhouguang / Liu, Zhongyuan / Wang, Xinyu / Luo, Zhiqiang

Small (Weinheim an der Bergstrasse, Germany)

2023 , Page(s) e2309793

Abstract: The nerve guidance conduits incorporated with stem cells, which can differentiate into the Schwann cells (SCs) to facilitate myelination, shows great promise for repairing the severe peripheral nerve injury. The innovation of advanced hydrogel materials ... ...

Abstract	The nerve guidance conduits incorporated with stem cells, which can differentiate into the Schwann cells (SCs) to facilitate myelination, shows great promise for repairing the severe peripheral nerve injury. The innovation of advanced hydrogel materials encapsulating stem cells, is highly demanded for generating supportive scaffolds and adaptive microenvironment for nerve regeneration. Herein, this work demonstrates a novel strategy in regulating regenerative microenvironment for peripheral nerve repair with a biodegradable conductive hydrogel scaffold, which can offer multifunctional capabilities in immune regulation, enhancing angiogenesis, driving SCs differentiation, and promoting axon regrowth. The biodegradable conductive hydrogel is constructed by incorporation of polydopamine-modified silicon phosphorus (SiP@PDA) nanosheets into a mixture of methacryloyl gelatin and decellularized extracellular matrix (GelMA/ECM). The biomimetic electrical microenvironment performs an efficacious strategy to facilitate macrophage polarization toward a pro-healing phenotype (M2), meanwhile the conductive hydrogel supports vascularization in regenerated tissue through sustained Si element release. Furthermore, the MSCs 3D-cultured in GelMA/ECM-SiP@PDA conductive hydrogel exhibits significantly increased expression of genes associated with SC-like cell differentiation, thus facilitating the myelination and axonal regeneration. Collectively, both the in vitro and in vivo studies demonstrates that the rationally designed biodegradable multifunctional hydrogel significantly enhances nerve tissues repair.
Language	English
Publishing date	2023-12-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202309793
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action.

Wang, Zhouguang / Khor, Sinan / Cai, Dongsheng

Molecular metabolism

2019 Volume 32, Page(s) 56–68

Abstract: Objective: The glycoprotein hormone erythropoietin (EPO) is required for erythropoiesis, and the kidney is the primary site of adult EPO synthesis. Limited evidence has suggested that EPO could be detectable in the brain under certain conditions, but it ...

Abstract	Objective: The glycoprotein hormone erythropoietin (EPO) is required for erythropoiesis, and the kidney is the primary site of adult EPO synthesis. Limited evidence has suggested that EPO could be detectable in the brain under certain conditions, but it remains unknown if the brain might have its own EPO system for biological functions that are independent of peripheral EPO production and action. We performed this study to address this question using mice under normal conditions versus pathophysiological conditions including aging and dietary obesity. Methods: EPO expression was measured in different brain regions as well as in the cerebrospinal fluid. Hypothalamic ventricular EPO was administered to physiologically examine possible therapeutic effects on the conditions of aging and dietary obesity. Body weight, body composition, insulin tolerance, and glucose tolerance were measured to assess the central effects of EPO on metabolic physiology, and muscle strength and histology were analyzed to assess the central effects of EPO on muscle function. In addition, β2-adrenergic receptor knockout bone marrow transplant was employed to determine the potential role of bone marrow in linking the brain to some of these peripheral functions. Results: This study revealed that EPO is expressed in the ventromedial hypothalamus in addition to a few other brain regions and is present in the cerebrospinal fluid. Unlike blood EPO concentration, which increased with aging and dietary obesity, hypothalamic EPO decreased in these disease conditions. Therapeutically, aged mice were chronically treated with EPO in the hypothalamic ventricle, showing an increase in lean mass, while body weight and fat mass decreased as a result of a moderate reduction of food intake. Both muscle and metabolic functions were improved by this central treatment, and mechanistically, adrenergic signals to the bone marrow played a role in conveying hypothalamic EPO to these peripheral actions. Dietary obesity was also studied, showing that hypothalamic EPO treatment caused a reduction in food intake and obesity, leading to improved metabolic functions related to decreased fat as well as increased lean mass. Conclusions: Hypothalamic EPO plays a role in the central regulation of muscle and metabolic physiology, while its decline contributes to aging and obesity physiology in a manner that is independent of peripheral EPO.
MeSH term(s)	Animals ; Diet, High-Fat/adverse effects ; Erythropoietin/administration & dosage ; Erythropoietin/metabolism ; Glucose Tolerance Test ; Hypothalamus/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Muscles/metabolism ; Obesity/chemically induced ; Obesity/metabolism
Chemical Substances	Erythropoietin (11096-26-7)
Language	English
Publishing date	2019-12-06
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2019.12.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Age-dependent decline of hypothalamic HIF2α in response to insulin and its contribution to advanced age-associated metabolic disorders in mice.

Wang, Zhouguang / Khor, Sinan / Cai, Dongsheng

The Journal of biological chemistry

2019 Volume 294, Issue 13, Page(s) 4946–4955

Abstract: Hypoxia-inducible factor-2α (HIF2α) is a nuclear transcription factor that plays a critical role in cell survival including metabolic adaptation under hypoxia as well as normoxia, but whether HIF2α contributes to the control of whole-body metabolic ... ...

Abstract	Hypoxia-inducible factor-2α (HIF2α) is a nuclear transcription factor that plays a critical role in cell survival including metabolic adaptation under hypoxia as well as normoxia, but whether HIF2α contributes to the control of whole-body metabolic balance is unclear. In this study, we found that the hypothalamic HIF2α protein level rapidly increases in young mice that are centrally stimulated with insulin. However, this insulin-induced HIF2α up-regulation is substantially attenuated in mice of advanced age. This attenuation is comparable with the effect of high-calorie feeding in young mice. Of note, unlike high-calorie feeding conditions, age-dependent HIF2α attenuation occurs without impaired activation of the hypothalamic IR/IRS-2/AKT/FOXO1 pathway in response to insulin. Molecular and physiological analyses revealed that hypothalamic HIF2α contributes to the action of central insulin in regulation of proopiomelanocortin (
MeSH term(s)	Aging/genetics ; Aging/metabolism ; Aging/pathology ; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Gene Expression Regulation ; Glucose Intolerance/genetics ; Glucose Intolerance/metabolism ; Glucose Intolerance/pathology ; Hypothalamus/metabolism ; Hypothalamus/pathology ; Insulin/genetics ; Insulin/metabolism ; Mice ; Mice, Transgenic ; Pro-Opiomelanocortin/biosynthesis ; Pro-Opiomelanocortin/genetics ; Signal Transduction
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Insulin ; endothelial PAS domain-containing protein 1 (1B37H0967P) ; Pro-Opiomelanocortin (66796-54-1)
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA118.005429
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges.

Ding, Jia-Yi / Chen, Min-Jiang / Wu, Ling-Feng / Shu, Gao-Feng / Fang, Shi-Ji / Li, Zhao-Yu / Chu, Xu-Ran / Li, Xiao-Kun / Wang, Zhou-Guang / Ji, Jian-Song

Military Medical Research

2023 Volume 10, Issue 1, Page(s) 36

Abstract: Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or contusions. As such injuries are common to all human groups, they may at times represent a serious socioeconomic burden. Currently, increasing numbers of studies have ... ...

Abstract	Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or contusions. As such injuries are common to all human groups, they may at times represent a serious socioeconomic burden. Currently, increasing numbers of studies have focused on the role of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in skin wound repair. As a cell-free therapy, MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell therapy. Treatment based on MSC-derived EVs can significantly promote the repair of damaged substructures, including the regeneration of vessels, nerves, and hair follicles. In addition, MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization, wound angiogenesis, cell proliferation, and cell migration, and by inhibiting excessive extracellular matrix production. Additionally, these structures can serve as a scaffold for components used in wound repair, and they can be developed into bioengineered EVs to support trauma repair. Through the formulation of standardized culture, isolation, purification, and drug delivery strategies, exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound repair. In conclusion, MSC-derived EVs-based therapies have important application prospects in wound repair. Here we provide a comprehensive overview of their current status, application potential, and associated drawbacks.
MeSH term(s)	Humans ; Skin ; Soft Tissue Injuries ; Extracellular Vesicles ; Mesenchymal Stem Cells ; Wound Healing
Language	English
Publishing date	2023-08-17
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2768940-2
ISSN	2054-9369 ; 2054-9369
ISSN (online)	2054-9369
ISSN	2054-9369
DOI	10.1186/s40779-023-00472-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Editorial: The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation, Development, Disease, and Repair After Injury.

Wang, Zhouguang / Lin, Li / Zhang, Jin-San / Zhong, Xingxing / Bellusci, Saverio / Li, Xiaokun

Frontiers in pharmacology

2020 Volume 11, Page(s) 586654

Language	English
Publishing date	2020-09-08
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.586654
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito