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  1. Article: [Multi-Voiced Narrative of Home-Based Palliative Care:Report of One Case].

    Zhang, Xiao-Tian / Wang, Zi-Dan / Wang, Ming-Hui / Wu, Ling-Ling / Yue, Peng

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2024  Volume 46, Issue 1, Page(s) 68–71

    Abstract: Terminally ill patients face multiple difficulties in home care.Home-based palliative care adhering to the concept of whole-person,whole-family,whole-team,and whole-course care is able to meet the needs of terminally ill patients and their families.In ... ...

    Abstract Terminally ill patients face multiple difficulties in home care.Home-based palliative care adhering to the concept of whole-person,whole-family,whole-team,and whole-course care is able to meet the needs of terminally ill patients and their families.In this paper,we reported the care history and home-based palliative care process of a patient with end-stage breast tumor and summarized the experience,aiming to provide reference for the future work of home-based palliative care.
    MeSH term(s) Humans ; Palliative Care
    Language Chinese
    Publishing date 2024-03-04
    Publishing country China
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.15905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of C. elegans.

    Luo, Hui / Zhao, Xue / Wang, Zi-Dan / Wu, Gang / Xia, Yu / Dong, Meng-Qiu / Ma, Yan

    Journal of lipid research

    2024  , Page(s) 100553

    Abstract: Multiple isozymes are encoded in the C. elegans genome for the various sphingolipid biosynthesis reactions, but the contributions of individual isozymes are characterized only in part. We developed a simple but effective reversed-phase liquid ... ...

    Abstract Multiple isozymes are encoded in the C. elegans genome for the various sphingolipid biosynthesis reactions, but the contributions of individual isozymes are characterized only in part. We developed a simple but effective reversed-phase liquid chromatography-tandem mass spectrometry (RPLC-MS/MS) method that enables simultaneous identification and quantification of ceramides (Cer), glucosylceramides (GlcCer), and sphingomyelins (SM), three important classes of sphingolipids from the same MS run. Validating this sphingolipid profiling method, we show that nearly all 47 quantifiable sphingolipid species found in young adult worms were reduced upon RNA interference (RNAi) of sptl-1 or elo-5, which are required for synthesis of the id17:1 sphingoid base. We also confirm that HYL-1 and HYL-2, but not LAGR-1, constitute the major ceramide synthase activity with different preference for fatty acid substrates, and that CGT-3, but not CGT-1 and CGT-2, plays a major role in producing glucosylceramides. Deletion of sms-5 hardly affects SM levels. RNAi of sms-1, -2, and -3 all lower the abundance of sphingomyelins with an odd number of carbon atoms (mostly C21 and C23, with or without hydroxylation) in the N-acyl chain, and only sms-1 RNAi does not elevate sphingomyelins containing even-numbered N-acyl chains. This suggests that sphingolipids containing even-numbered N-acyl chains could be regulated separately, sometimes in opposite directions, with those containing odd-numbered N-acyls, presumably monomethyl branched chain fatty acyls. We also find that ceramide levels are kept in balance with those of glucosylceramides and sphingomyelins.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2024.100553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Surface-anchored microbial enzyme-responsive solid lipid nanoparticles enabling colonic budesonide release for ulcerative colitis treatment.

    Zhang, Yipeng / Wang, Liying / Wang, Zi-Dan / Zhou, Quan / Zhou, Xuefei / Zhou, Tianhua / Guan, Yi-Xin / Liu, Xiangrui

    Journal of nanobiotechnology

    2023  Volume 21, Issue 1, Page(s) 145

    Abstract: Colon-targeted oral drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC), which is a disease with high relapse and remission rates associated with immune system inflammation and dysregulation localized within the ... ...

    Abstract Colon-targeted oral drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC), which is a disease with high relapse and remission rates associated with immune system inflammation and dysregulation localized within the lining of the large bowel. However, the success of current available approaches used for colon-targeted therapy is limited. Budesonide (BUD) is a corticosteroid drug, and its rectal and oral formulations are used to treat UC, but the inconvenience of rectal administration and the systemic toxicity of oral administration restrict its long-term use. In this study, we designed and prepared colon-targeted solid lipid nanoparticles (SLNs) encapsulating BUD to treat UC by oral administration. A negatively charged surfactant (NaCS-C12) was synthesized to anchor cellulase-responsive layers consisting of polyelectrolyte complexes (PECs) formed by negatively charged NaCS and cationic chitosan onto the SLNs. The release rate and colon-specific release behavior of BUD could be easily modified by regulating the number of coated layers. We found that the two-layer BUD-loaded SLNs (SLN-BUD-2L) with a nanoscale particle size and negative zeta potential showed the designed colon-specific drug release profile in response to localized high cellulase activity. In addition, SLN-BUD-2L exhibited excellent anti-inflammatory activity in a dextran sulfate sodium (DSS)-induced colitis mouse model, suggesting its potential anti-UC applications.
    MeSH term(s) Animals ; Mice ; Colitis, Ulcerative/drug therapy ; Budesonide ; Colon ; Nanoparticles ; Colitis/chemically induced ; Cellulases/therapeutic use ; Disease Models, Animal
    Chemical Substances Budesonide (51333-22-3) ; Lipid Nanoparticles ; Cellulases (EC 3.2.1.-)
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-023-01889-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Development of metformin hydrochloride loaded dissolving tablets with novel carboxymethylcellulose/poly-l-lysine/TPP complex.

    Wu, Qing-Xi / Wang, Zi-Dan / Zheng, Meng-Fei / Su, Ting / Wang, Xiao-Hui / Guan, Yi-Xin / Chen, Yan

    International journal of biological macromolecules

    2020  Volume 155, Page(s) 411–420

    Abstract: Natural polymers like polysaccharides, polypeptides and their derivatives are broadly applied in drug delivery due to excellent biocompatibility and biodegradability. In this study, the dissolving tablets, formed with carboxymethylcellulose/poly-l-lysine/ ...

    Abstract Natural polymers like polysaccharides, polypeptides and their derivatives are broadly applied in drug delivery due to excellent biocompatibility and biodegradability. In this study, the dissolving tablets, formed with carboxymethylcellulose/poly-l-lysine/tripolyphosphate (CMC/PLL/TPP) complex, were prepared using metformin hydrochloride (MetHCl) as model drug. Confocal laser scanning microscopy observation manifested that FITC-labeled PLL interacted with CMC and formed a uniform interior microstructure. Scanning electron microscope images showed the drug-loaded tablets had well-formed shapes with smooth surfaces. MetHCl embedded interior the microstructures of the tablets and represented in a crystal form. Thermo-gravimetric analysis and differential scanning calorimetry indicated that the drug-loaded tablets had stable thermal properties with less moisture content (3.52%). Fourier transform infrared spectrometer confirmed that the CMC/PLL/TPP complex was fabricated via the electrostatic interactions between -NH
    MeSH term(s) Carboxymethylcellulose Sodium/chemistry ; Delayed-Action Preparations ; Drug Liberation ; Humans ; Hypoglycemic Agents/chemistry ; Hypoglycemic Agents/metabolism ; Metformin/chemistry ; Metformin/metabolism ; Polylysine/chemistry ; Polymers/chemistry ; Polyphosphates/chemistry ; Solubility ; Tablets/chemistry
    Chemical Substances Delayed-Action Preparations ; Hypoglycemic Agents ; Polymers ; Polyphosphates ; Tablets ; Polylysine (25104-18-1) ; Metformin (9100L32L2N) ; Carboxymethylcellulose Sodium (K679OBS311) ; triphosphoric acid (NU43IAG5BC)
    Language English
    Publishing date 2020-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.03.191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Development of metformin hydrochloride loaded dissolving tablets with novel carboxymethylcellulose/poly-l-lysine/TPP complex

    Wu, Qing-Xi / Wang, Zi-Dan / Zheng, Meng-Fei / Su, Ting / Wang, Xiao-Hui / Guan, Yi-Xin / Chen, Yan

    International journal of biological macromolecules. 2020 July 15, v. 155

    2020  

    Abstract: Natural polymers like polysaccharides, polypeptides and their derivatives are broadly applied in drug delivery due to excellent biocompatibility and biodegradability. In this study, the dissolving tablets, formed with carboxymethylcellulose/poly-l-lysine/ ...

    Abstract Natural polymers like polysaccharides, polypeptides and their derivatives are broadly applied in drug delivery due to excellent biocompatibility and biodegradability. In this study, the dissolving tablets, formed with carboxymethylcellulose/poly-l-lysine/tripolyphosphate (CMC/PLL/TPP) complex, were prepared using metformin hydrochloride (MetHCl) as model drug. Confocal laser scanning microscopy observation manifested that FITC-labeled PLL interacted with CMC and formed a uniform interior microstructure. Scanning electron microscope images showed the drug-loaded tablets had well-formed shapes with smooth surfaces. MetHCl embedded interior the microstructures of the tablets and represented in a crystal form. Thermo-gravimetric analysis and differential scanning calorimetry indicated that the drug-loaded tablets had stable thermal properties with less moisture content (3.52%). Fourier transform infrared spectrometer confirmed that the CMC/PLL/TPP complex was fabricated via the electrostatic interactions between -NH3+, -COO− and -[P2O54-]− groups. The drug-loaded tablets had a high drug loading efficiency of 85.76% and drug encapsulation efficiency of 81.47%, and a shorter wetting time of 2.16 min in SSF (pH 6.8) and lower swelling ratio of 233.34%. The drug loaded in the samples could be released completely within 10 min in simulated saliva fluid (SSF pH 6.8), indicating a rapid drug release and dissolving profile in the environment, which could be developed for dissolving tablets.
    Keywords Fourier transform infrared spectroscopy ; biocompatibility ; biodegradability ; biopolymers ; carboxymethylcellulose ; confocal laser scanning microscopy ; differential scanning calorimetry ; electrostatic interactions ; encapsulation ; metformin ; microstructure ; models ; pH ; polypeptides ; saliva ; scanning electron microscopes ; thermal properties ; thermogravimetry ; tripolyphosphates ; water content
    Language English
    Dates of publication 2020-0715
    Size p. 411-420.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2020.03.191
    Database NAL-Catalogue (AGRICOLA)

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