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  1. Article ; Online: Reply to G. Yu et al.

    Wu, Hao-Xiang / Pan, Yi-Qian / Wang, Zi-Xian / Wang, Feng

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 15, Page(s) 2864–2865

    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.00358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  2. Article ; Online: Immunotherapy in gastrointestinal cancers: advances, challenges, and countermeasures.

    Wang, Zi-Xian / Pan, Yi-Qian / Li, Xuexin / Tsubata, Takeshi / Xu, Rui-Hua

    Science bulletin

    2023  Volume 68, Issue 8, Page(s) 763–766

    MeSH term(s) Humans ; Immunotherapy ; Gastrointestinal Neoplasms/therapy
    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.03.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Role of Maintenance Therapy in Metastatic Colorectal Cancer.

    Wang, Zi-Xian / Liang, Fei / Xu, Rui-Hua

    JAMA oncology

    2020  Volume 6, Issue 6, Page(s) 937

    MeSH term(s) Bevacizumab ; Capecitabine ; Colorectal Neoplasms/drug therapy ; Humans ; Network Meta-Analysis ; Randomized Controlled Trials as Topic
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Capecitabine (6804DJ8Z9U)
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2020.0580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of prior chemotherapy with two different fluoropyrimidines on the efficacy of capecitabine plus irinotecan or FOLFIRI with or without bevacizumab in metastatic colorectal cancer: a post hoc analysis of the AXEPT study.

    Iwasa, Satoru / Wang, Zi-Xian / Muro, Kei / Morita, Satoshi / Park, Young Suk / Zhang, Dongsheng / Yamada, Yasuhide / Sakamoto, Junichi / Kim, Tae Won

    Cancer communications (London, England)

    2023  Volume 43, Issue 4, Page(s) 519–522

    MeSH term(s) Humans ; Bevacizumab/therapeutic use ; Capecitabine/therapeutic use ; Irinotecan/therapeutic use ; Colorectal Neoplasms/pathology
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Capecitabine (6804DJ8Z9U) ; Irinotecan (7673326042)
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sinapic Acid Attenuates Chronic DSS-Induced Intestinal Fibrosis in C57BL/6J Mice by Modulating NLRP3 Inflammasome Activation and the Autophagy Pathway.

    Li, Wan-Ying / Liu, Jun-Yang / Wang, Zi-Xian / Wang, Ke-Ying / Huang, Chun-Xiang / He, Wen / Song, Jia-Le

    ACS omega

    2023  Volume 9, Issue 1, Page(s) 1230–1241

    Abstract: Ulcerative colitis (UC) is a chronic gastrointestinal disease that results from repeated inflammation and serious complications. Sinapic acid (SA) is a hydroxycinnamic acid present in a variety of plants that has antioxidant, anti-inflammatory, ... ...

    Abstract Ulcerative colitis (UC) is a chronic gastrointestinal disease that results from repeated inflammation and serious complications. Sinapic acid (SA) is a hydroxycinnamic acid present in a variety of plants that has antioxidant, anti-inflammatory, anticancer, and other protective effects. This study investigated the antifibrotic effect of SA on chronic colitis induced by dextran sulfate sodium salt (DSS) in mice. We observed that SA could significantly reduce clinical symptoms (such as improved body weight loss, increased colon length, and decreased disease activity index score) and pathological changes in mice with chronic colitis. SA supplementation has been demonstrated to repair intestinal mucosal barrier function and maintain epithelial homeostasis by inhibiting activation of the NLRP3 inflammasome and decreasing the expression of IL-6, TNF-α, IL-17A, IL-18, and IL-1β. Furthermore, SA could induce the expression of antioxidant enzymes (
    Language English
    Publishing date 2023-12-26
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Modulator of TMB-associated immune infiltration (MOTIF) predicts immunotherapy response and guides combination therapy.

    Qian, Zheng-Yu / Pan, Yi-Qian / Li, Xue-Xin / Chen, Yan-Xing / Wu, Hao-Xiang / Liu, Ze-Xian / Kosar, Martin / Bartek, Jiri / Wang, Zi-Xian / Xu, Rui-Hua

    Science bulletin

    2024  Volume 69, Issue 6, Page(s) 803–822

    Abstract: Patients with high tumor mutational burden (TMB) levels do not consistently respond to immune checkpoint inhibitors (ICIs), possibly because a high TMB level does not necessarily result in adequate infiltration of ... ...

    Abstract Patients with high tumor mutational burden (TMB) levels do not consistently respond to immune checkpoint inhibitors (ICIs), possibly because a high TMB level does not necessarily result in adequate infiltration of CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Mutation ; Neoplasms/drug therapy ; Combined Modality Therapy ; Immunotherapy
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2024.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Sinapic acid modulates oxidative stress and metabolic disturbances to attenuate ovarian fibrosis in letrozole-induced polycystic ovary syndrome SD rats.

    Lan, Huan / Dong, Zhe-Wen / Zhang, Ming-Yu / Li, Wan-Ying / Chong, Chao-Jie / Wu, Ya-Qi / Wang, Zi-Xian / Liu, Jun-Yang / Liu, Zhi-Qiang / Qin, Xiao-Hui / Jiang, Tie-Min / Song, Jia-Le

    Food science & nutrition

    2024  Volume 12, Issue 4, Page(s) 2917–2931

    Abstract: Sinapic acid (SA) is renowned for its many pharmacological activities as a polyphenolic compound. The cause of polycystic ovary syndrome (PCOS), a commonly encountered array of metabolic and hormonal abnormalities in females, has yet to be determined. ... ...

    Abstract Sinapic acid (SA) is renowned for its many pharmacological activities as a polyphenolic compound. The cause of polycystic ovary syndrome (PCOS), a commonly encountered array of metabolic and hormonal abnormalities in females, has yet to be determined. The present experiment was performed to evaluate the antifibrotic properties of SA in rats with letrozole-induced PCOS-related ovarian fibrosis. SA treatment successfully mitigated the changes induced by letrozole in body weight (BW) (
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3973
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  8. Article ; Online: A phase Ib/II study of fruquintinib in combination with paclitaxel as the second-line therapy for advanced gastric cancer.

    Zhang, Yang / Wang, Zi-Xian / Shen, Lin / Li, Jin / Huang, Jing / Su, Wei-Guo / Zhang, Dong-Sheng / Xu, Rui-Hua

    Cancer communications (London, England)

    2022  Volume 43, Issue 1, Page(s) 150–153

    MeSH term(s) Humans ; Benzofurans/therapeutic use ; Paclitaxel/therapeutic use ; Quinazolines/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Benzofurans ; HMPL-013 (49DXG3M5ZW) ; Paclitaxel (P88XT4IS4D) ; Quinazolines
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12379
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article: Maximum Somatic Allele Frequency in Combination With Blood-Based Tumor Mutational Burden to Predict the Efficacy of Atezolizumab in Advanced Non-small Cell Lung Cancer: A Pooled Analysis of the Randomized POPLAR and OAK Studies.

    Chen, Yu-Tong / Seeruttun, Sharvesh Raj / Wu, Xiang-Yuan / Wang, Zi-Xian

    Frontiers in oncology

    2019  Volume 9, Page(s) 1432

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2019.01432
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comprehensive genomic characterization of sporadic synchronous colorectal cancer: Implications for treatment optimization and clinical outcome.

    Yang, Lu-Ping / Jiang, Teng-Jia / He, Ming-Ming / Ling, Yi-Hong / Wang, Zi-Xian / Wu, Hao-Xiang / Zhang, Zhen / Xu, Rui-Hua / Wang, Feng / Yuan, Shu-Qiang / Zhao, Qi

    Cell reports. Medicine

    2023  Volume 4, Issue 10, Page(s) 101222

    Abstract: Sporadic synchronous colorectal cancer (SCRC) refers to multiple primary CRC tumors detected simultaneously in an individual without predisposing hereditary conditions, which accounts for the majority of multiple CRCs while lacking a profound ... ...

    Abstract Sporadic synchronous colorectal cancer (SCRC) refers to multiple primary CRC tumors detected simultaneously in an individual without predisposing hereditary conditions, which accounts for the majority of multiple CRCs while lacking a profound understanding of the genomic landscape and evolutionary dynamics to optimize its treatment. In this study, 103 primary tumor samples from 51 patients with SCRC undergo whole-exome sequencing. The germline and somatic mutations and evolutionary and clinical features are comprehensively investigated. Somatic genetic events are largely inconsistent between paired tumors. Compared with solitary CRC, SCRCs have higher prevalence of tumor mutation burden high (TMB-H; 33.3%) and microsatellite-instability high (MSI-H; 29.4%) and different mutation frequencies in oncogenic signaling pathways. Moreover, neutrally evolving SCRC tumors are associated with higher intratumoral heterogeneity and better prognosis. These findings unveil special molecular features, carcinogenesis, and prognosis of sporadic SCRC. Strategies for targeted therapy and immunotherapy should be optimized accordingly.
    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Microsatellite Instability ; Prognosis ; Biomarkers, Tumor/genetics ; Genomics
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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