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Article ; Online: Quantitative MR imaging biomarkers for distinguishing inflammatory pancreatic mass and pancreatic cancer-a systematic review and meta-analysis.

Wang, Zi-He / Zhu, Liang / Xue, Hua-Dan / Jin, Zheng-Yu

2024

Abstract: Objectives: To evaluate the diagnostic performance of quantitative magnetic resonance (MR) imaging biomarkers in distinguishing between inflammatory pancreatic masses (IPM) and pancreatic cancer (PC).: Methods: A literature search was conducted using ...

Abstract	Objectives: To evaluate the diagnostic performance of quantitative magnetic resonance (MR) imaging biomarkers in distinguishing between inflammatory pancreatic masses (IPM) and pancreatic cancer (PC). Methods: A literature search was conducted using PubMed, Embase, the Cochrane Library, and Web of Science through August 2023. Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was used to evaluate the risk of bias and applicability of the studies. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were calculated using the DerSimonian-Laird method. Univariate meta-regression analysis was used to identify the potential factors of heterogeneity. Results: Twenty-four studies were included in this meta-analysis. The two main types of IPM, mass-forming pancreatitis (MFP) and autoimmune pancreatitis (AIP), differ in their apparent diffusion coefficient (ADC) values. Compared with PC, the ADC value was higher in MFP but lower in AIP. The pooled sensitivity/specificity of ADC were 0.80/0.85 for distinguishing MFP from PC and 0.82/0.84 for distinguishing AIP from PC. The pooled sensitivity/specificity for the maximal diameter of the upstream main pancreatic duct (dMPD) was 0.86/0.74, with a cutoff of dMPD ≤ 4 mm, and 0.97/0.52, with a cutoff of dMPD ≤ 5 mm. The pooled sensitivity/specificity for perfusion fraction (f) was 0.82/0.68, and 0.82/0.77 for mass stiffness values. Conclusions: Quantitative MR imaging biomarkers are useful in distinguishing between IPM and PC. ADC values differ between MFP and AIP, and they should be separated for consideration in future studies. Clinical relevance statement: Quantitative MR parameters could serve as non-invasive imaging biomarkers for differentiating malignant pancreatic neoplasms from inflammatory masses of the pancreas, and hence help to avoid unnecessary surgery. Key points: • Several quantitative MR imaging biomarkers performed well in differential diagnosis between inflammatory pancreatic mass and pancreatic cancer. • The ADC value could discern pancreatic cancer from mass-forming pancreatitis or autoimmune pancreatitis, if the two inflammatory mass types are not combined. • The diameter of main pancreatic duct had the highest specificity for differentiating autoimmune pancreatitis from pancreatic cancer.
Language	English
Publishing date	2024-04-19
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-024-10720-9
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Book ; Online: Multiplayer General Lotto game

Ni, Bonan / Liu, Yan / Shen, Weiran / Wang, Zihe

2024

Abstract: In this paper, we explore the multiplayer General Lotto Blotto game over a single battlefield, a notable variant of the Colonel Blotto game. In this version, each player employs a probability distribution for resource allocation, ensuring that the ... ...

Abstract	In this paper, we explore the multiplayer General Lotto Blotto game over a single battlefield, a notable variant of the Colonel Blotto game. In this version, each player employs a probability distribution for resource allocation, ensuring that the expected expenditure does not surpass their budget. We first establish the existence of a Nash equilibrium for a modified version of this game, in which there is a common threshold that no player's bid can exceed. We next extend our findings to demonstrate the existence of a Nash equilibrium in the original game, which does not incorporate this threshold. Moreover, we provide detailed characterizations of the Nash equilibrium for both the original game and its modified version. In the Nash equilibrium of the unmodified game, we observe that the upper endpoints of the supports of players' equilibrium strategies coincide, and the minimum value of a player's support above zero inversely correlates with their budget. Specifically, we present closed-form solutions for the Nash equilibrium with threshold for two players.
Keywords	Computer Science - Computer Science and Game Theory
Subject code	629
Publishing date	2024-01-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Functional mechanism of baicalein in alleviating severe acute pancreatitis-acute lung injury by blocking the TLR4/MyD88/TRIF signaling pathway.

Yang, Qingjing / Yue, Chao / Huang, Xing / Wang, Zihe / Li, Zhenlu / Hu, Weiming / Lu, Huimin

Histology and histopathology

2024 , Page(s) 18733

Abstract: Severe acute pancreatitis-acute lung injury (SAP-ALI) is a disease with high mortality. This study aims to explore the mechanism of baicalein on SAP-ALI in rats by blocking toll-like receptor-4 (TLR4)/myeloid differentiation primary response gene 88 ( ... ...

Abstract	Severe acute pancreatitis-acute lung injury (SAP-ALI) is a disease with high mortality. This study aims to explore the mechanism of baicalein on SAP-ALI in rats by blocking toll-like receptor-4 (TLR4)/myeloid differentiation primary response gene 88 (MyD88)/TIR-domain-containing adapter-inducing interferon-β (TRIF) signal pathway. The SAP-ALI rat model was established by intraperitoneal injection of 3% pentobarbital sodium (30 mg/kg), with pancreas and intestines turned over, injected with 3.5% sodium taurocholate backward into the bile-pancreatic duct at 0.1 mL/100 g for 12h, and treated with baicalein, lipopolysaccharide (LPS), miR-182 agomir, or miR-182 antagomir. The TLR4/MyD88/TRIF pathway was activated using LPS in SAP-ALI rats after baicalein treatment. Baicalein attenuated inflammatory cell infiltration, alveolar wall edema, decreased W/D ratio and levels of TLR4, MyD88, and TRIF in the lung tissues, reduced levels of inflammatory factors in pancreatic and lung tissues and BALF, diminished ROS, and elevated GSH, SOD and CAT in pancreatic and lung tissues of SAP-ALI rats. Activation of the TLR4/MyD88/TRIF pathway partly abrogated baicalein-mediated improvements in inflammation and oxidative stress in SAP-ALI rats. miR-182 targeted TLR4. miR-182 suppressed inflammation and oxidative stress in SAP-ALI rats by targeting TLR4. Inhibition of miR-182 partly nullified baicalein-mediated attenuation on inflammation and oxidative stress in SAP-ALI rats. In conclusion, baicalein can inhibit the TLR4/MyD88/TRIF pathway and alleviate inflammatory response and oxidative stress in SAP-ALI rats by upregulating miR-182 and suppressing TLR4, thus ameliorating SAP-ALI.
Language	English
Publishing date	2024-03-11
Publishing country	Spain
Document type	Journal Article
ZDB-ID	83911-5
ISSN	1699-5848 ; 0213-3911
ISSN (online)	1699-5848
ISSN	0213-3911
DOI	10.14670/HH-18-733
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Article ; Online: Minimally invasive versus open total pancreatectomy: a systematic review and meta-analysis.

Chen, Lang / Xia, Ning / Wang, Zihe / Junjie, Xiong / Tian, Bole

International journal of surgery (London, England)

2023 Volume 109, Issue 7, Page(s) 2058–2069

Abstract: Objective: The aim of this study was to perform a systematic review and meta-analysis on the safety and effectiveness regarding outcomes of minimally invasive total pancreatectomy (MITP) versus open total pancreatectomy (OTP).: Background: Total ... ...

Abstract	Objective: The aim of this study was to perform a systematic review and meta-analysis on the safety and effectiveness regarding outcomes of minimally invasive total pancreatectomy (MITP) versus open total pancreatectomy (OTP). Background: Total pancreatectomy is a complicated operation in abdominal surgery. The flexibility of minimally invasive surgery offers a new surgical approach to this technology. At present, there is little research on MITP, and its advantages over OTP remain uncertain. Methods: A systematic literature review and meta-analysis was conducted basing on comparative studies between MITP and OTP from January 1943 to November 2022. Intraoperative outcomes and postoperative outcomes were assessed. Pooled odds ratios (ORs) and mean differences with a 95% CI were calculated using fixed-effect or random-effect models under heterogeneity. Results: Seven studies with a total of 4275 patients were included. The major morbidity in the MITP group was significant lower (OR 0.50, 95% CI: 0.30-0.84, P=0.008, I²= 0%) than OTP group. At the same time, comparing with OTP, the MITP group had lower estimated blood loss (MD -362.50, 95% CI -641.34 to -83.66, P=0.01, I²=96%) and lower intraoperative transfusion rate (OR 0.36, 95% CI 0.16-0.84, P=0.02, I²=0%). There were no significant differences between the MITP and OTP groups for other outcomes. Conclusions: The results suggested that MITP was associated with lower major morbidity, estimated blood loss, and intraoperative transfusion rate comparing with OTP. However, the further evidence with a better design is required.
MeSH term(s)	Humans ; Pancreatectomy/adverse effects ; Pancreatectomy/methods ; Blood Loss, Surgical ; Minimally Invasive Surgical Procedures/adverse effects ; Minimally Invasive Surgical Procedures/methods ; Length of Stay ; Blood Transfusion ; Postoperative Complications/etiology
Language	English
Publishing date	2023-07-01
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000000392
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Article: Decreased phase information transfer from the mPFC to the BLA: During exploratory behavior in CUMS rats.

Cao, Qingying / Wang, Zihe / Bai, Wenwen / Liu, Tiaotiao / Zheng, Xuyuan

Frontiers in neuroscience

2023 Volume 17, Page(s) 1145721

Abstract: Introduction: Depression is a mental disorder characterized by aberrant exploratory behavior. Environmental factors, such as chronic stress, are commonly used to induce depression-like behavior in rodent models. The medial prefrontal cortex (mPFC) and ... ...

Abstract	Introduction: Depression is a mental disorder characterized by aberrant exploratory behavior. Environmental factors, such as chronic stress, are commonly used to induce depression-like behavior in rodent models. The medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) are crucial sites in subjects with chronic stress-induced depression. The transmission of amplitude information from the mPFC to the BLA was abated during exploratory behavior in depressive rats; however, the nature of the phase interaction between these two sites remains unknown. Methods: We used chronic unpredictable mild stress (CUMS) to model depression in rats and acquired local field potentials (LFPs) via multiple electrodes implanted in the mPFC and the BLA while rats (both the control and CUMS groups, respectively) were allowed to explore freely in an open field. The weighted phase lag index (WPLI) within the mPFC and the BLA and phase transfer entropy (PTE) from the mPFC to BLA were computed for two groups of rats (control and CUMS rats) to quantify the phase information transmission. Results: Rats subjected to CUMS showed a decrease in exploratory behavior. The WPLI within the mPFC and the BLA showed strikingly higher phase synchrony at theta frequencies (4-12 Hz) than other frequency bands during exploratory behavior in both the control and CUMS groups. The results of theta PTE from the mPFC to BLA showed that PTE was significantly decreased in the CUMS group compared with the control group. Discussions: These findings demonstrated that attenuated phase information transfer might restrain exploratory behavior in CUMS rats.
Language	English
Publishing date	2023-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2023.1145721
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Book ; Online: Two-Winner Election Using Favorite-Candidate Voting Rule

Ren, Zeyu / Wang, Zihe

2022

Abstract: We investigate two-winner election problem seeking to minimize the social cost. We are interested in strategy-proof mechanisms where each voter only reports a single candidate. In our model, candidates and voters are located in Euclidean space and ... ...

Abstract	We investigate two-winner election problem seeking to minimize the social cost. We are interested in strategy-proof mechanisms where each voter only reports a single candidate. In our model, candidates and voters are located in Euclidean space and candidates' locations are known to the mechanism. The quality of a mechanism is measured by its distortion, defined as the worst-case ratio between the social cost achieved by the mechanism and the optimal one. We find that the ratio between the maximum and minimum distances among every two candidates plays a vital role in the distortion of mechanisms. When there are three candidates, the problem is solved mainly by previous work. We mainly focus on the problem with at least four candidates. When voters and candidates are embedded in 1-dimensional space, we establish several lower bounds of the distortion. When voters and candidates are embedded in at least 3-dimensional space, we give a tight bound of the distortion.
Keywords	Computer Science - Computer Science and Game Theory
Publishing date	2022-05-19
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ae-Based Failure Warning Mechanism During Cemented Paste Backfilling

Ma Chunde / Wang Zihe / Xu Jiaqing / Tan Guanshuang / Lv Zhihai

E3S Web of Conferences, Vol 350, p

Experimental Investigation

2022 Volume 01013

Abstract: To research the AE warning mechanism of cemented paste backfilling (CPB), the uniaxial compression test with AE monitoring was carried out on CPB. The effects of different moisture content, cement proportion, and loading rate on AE characteristics of CPB ...

Abstract	To research the AE warning mechanism of cemented paste backfilling (CPB), the uniaxial compression test with AE monitoring was carried out on CPB. The effects of different moisture content, cement proportion, and loading rate on AE characteristics of CPB were analyzed. And a damage model based on AE is established. The results show that the increase of water content, gypsum content, and loading rate can enhance the ductility of CPB and lengthen the AE warning area. However, the increase of moisture content will lead to the delay of AE signal peak, which is bad for the early warning. With the increase of loading rate, the failure mode of specimens gradually changes from splitting failure to shear failure. The cracks produced under different failure modes can correspond to the peaks of AE signals. The damage model based on AE shows that the damage process of CPB samples can be divided into three stages, linear-exponential-linear. The experimental results can further research the optimal conditions for ae monitoring of backfill, and provide a theoretical basis for ae monitoring and warning of backfill.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Optimal Pricing Schemes for Identical Items with Time-Sensitive Buyers

Liu, Zhengyang / Shan, Liang / Wang, Zihe

2023

Abstract: Time or money? That is a question! In this paper, we consider this dilemma in the pricing regime, in which we try to find the optimal pricing scheme for identical items with heterogenous time-sensitive buyers. We characterize the revenue-optimal solution ...

Abstract	Time or money? That is a question! In this paper, we consider this dilemma in the pricing regime, in which we try to find the optimal pricing scheme for identical items with heterogenous time-sensitive buyers. We characterize the revenue-optimal solution and propose an efficient algorithm to find it in a Bayesian setting. Our results also demonstrate the tight ratio between the value of wasted time and the seller's revenue, as well as that of two common-used pricing schemes, the k-step function and the fixed pricing. To explore the nature of the optimal scheme in the general setting, we present the closed forms over the product distribution and show by examples that positive correlation between the valuation of the item and the cost per unit time could help increase revenue. To the best of our knowledge, it is the first step towards understanding the impact of the time factor as a part of the buyer cost in pricing problems, in the computational view. Comment: 11pages, 2 figures
Keywords	Computer Science - Computer Science and Game Theory
Subject code	303
Publishing date	2023-04-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Improved Approximation Ratios of Fixed-Price Mechanisms in Bilateral Trades

Liu, Zhengyang / Ren, Zeyu / Wang, Zihe

2023

Abstract: We continue the study of the performance for fixed-price mechanisms in the bilateral trade problem, and improve approximation ratios of welfare-optimal mechanisms in several settings. Specifically, in the case where only the buyer distribution is known, ... ...

Abstract	We continue the study of the performance for fixed-price mechanisms in the bilateral trade problem, and improve approximation ratios of welfare-optimal mechanisms in several settings. Specifically, in the case where only the buyer distribution is known, we prove that there exists a distribution over different fixed-price mechanisms, such that the approximation ratio lies within the interval of [0.71, 0.7381]. Furthermore, we show that the same approximation ratio holds for the optimal fixed-price mechanism, when both buyer and seller distributions are known. As a result, the previously best-known (1 - 1/e+0.0001)-approximation can be improved to $0.71$. Additionally, we examine randomized fixed-price mechanisms when we receive just one single sample from the seller distribution, for both symmetric and asymmetric settings. Our findings reveal that posting the single sample as the price remains optimal among all randomized fixed-price mechanisms.
Keywords	Computer Science - Computer Science and Game Theory
Subject code	519
Publishing date	2023-03-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Cost Minimization for Equilibrium Transition

Huang, Haoqiang / Wang, Zihe / Wei, Zhide / Zhang, Jie

2023

Abstract: In this paper, we delve into the problem of using monetary incentives to encourage players to shift from an initial Nash equilibrium to a more favorable one within a game. Our main focus revolves around computing the minimum reward required to facilitate ...

Abstract	In this paper, we delve into the problem of using monetary incentives to encourage players to shift from an initial Nash equilibrium to a more favorable one within a game. Our main focus revolves around computing the minimum reward required to facilitate this equilibrium transition. The game involves a single row player who possesses $m$ strategies and $k$ column players, each endowed with $n$ strategies. Our findings reveal that determining whether the minimum reward is zero is NP-complete, and computing the minimum reward becomes APX-hard. Nonetheless, we bring some positive news, as this problem can be efficiently handled if either $k$ or $n$ is a fixed constant. Furthermore, we have devised an approximation algorithm with an additive error that runs in polynomial time. Lastly, we explore a specific case wherein the utility functions exhibit single-peaked characteristics, and we successfully demonstrate that the optimal reward can be computed in polynomial time. Comment: To appear in the proceeding of AAAI2024
Keywords	Computer Science - Computer Science and Game Theory
Publishing date	2023-12-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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