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Article ; Online: Control strategy and mechanism for satellite droplet reduction.

Wang, Ziyue / Liu, Liansheng

2023 Volume 643, Page(s) 123228

Abstract: Satellite droplets accompanying the formation of monodispersed particles have serious negative effects in the fields of medicine and food, especially in pill preparation. Therefore, it is of great significance to study control strategy and mechanism for ... ...

Abstract	Satellite droplets accompanying the formation of monodispersed particles have serious negative effects in the fields of medicine and food, especially in pill preparation. Therefore, it is of great significance to study control strategy and mechanism for satellite droplet reduction. This paper proposes a simple and efficient device, Drainage Assisted Dropper (DAD), which adds a stainless-steel needle to the center of General Dropper (GD). Experimental and numerical results show the number and volume of satellite droplets of the dripping formed by DAD are significantly reduced compared to those formed by GD. DAD can reduce the liquid volume of satellite droplets with a reduction rate of 87 %, while reducing the size of the primary droplet and increasing the interval between the adjacent primary droplets. Compared with GD, DAD has a smaller cross-sectional area and a larger wetted area, which results in a smaller downward velocity of the liquid. The drainage assisted needle of DAD changes the dripping flow pattern at the outlet of the dropper near the breaking time, causing the residual liquid to be subjected to a higher additional pressure. Less liquid is replenished to the filament, resulting in the filament with a shorter length and a smaller liquid volume. DAD proposed here has a clear development potential and application value in the fields of pharmaceuticals, food, agriculture, and manufacturing.
Language	English
Publishing date	2023-07-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123228
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Article ; Online: Study on Amplification Effect of Wind Turbine Blade Stopping Position on Vortex Induced Vibration of Tower

Wang Ziyue / Jiao Shoulei / Zhang Guowei / Chen Xiaoxu

E3S Web of Conferences, Vol 375, p

2023 Volume 02006

Abstract: This project takes XX unit as the analysis object to study the first-order vibration wind speed of wind turbine under shutdown vibration. The vortex-induced vibration response is calculated and the displacement under resonant wind speed is calculated by ... ...

Abstract	This project takes XX unit as the analysis object to study the first-order vibration wind speed of wind turbine under shutdown vibration. The vortex-induced vibration response is calculated and the displacement under resonant wind speed is calculated by fluid-solid coupling method. The above analysis techniques and methods are forward-looking and advanced in vibration characteristics of domestic wind turbines. On the basis of fluid dynamics analysis, the suppression measures are studied emphatically. Through the optimization and comparison of different inhibition schemes, the effect of inhibition measures was quantitatively analyzed. The analysis shows that the vibration characteristics of wind turbine with high flexible tower has its own particularity. The first order vibration probability and vibration displacement can be effectively reduced by pneumatic method and external measures.
Keywords	wind turbine ; vibration characteristics ; first-order vibration ; fluid-solid ; Environmental sciences ; GE1-350
Subject code	690 ; 621
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Self-adaptive attention fusion for multimodal aspect-based sentiment analysis.

Wang, Ziyue / Guo, Junjun

Mathematical biosciences and engineering : MBE

2022 Volume 21, Issue 1, Page(s) 1305–1320

Abstract: Multimodal aspect term extraction (MATE) and multimodal aspect-oriented sentiment classification (MASC) are two crucial subtasks in multimodal sentiment analysis. The use of pretrained generative models has attracted increasing attention in aspect-based ... ...

Abstract	Multimodal aspect term extraction (MATE) and multimodal aspect-oriented sentiment classification (MASC) are two crucial subtasks in multimodal sentiment analysis. The use of pretrained generative models has attracted increasing attention in aspect-based sentiment analysis (ABSA). However, the inherent semantic gap between textual and visual modalities poses a challenge in transferring text-based generative pretraining models to image-text multimodal sentiment analysis tasks. To tackle this issue, this paper proposes a self-adaptive cross-modal attention fusion architecture for joint multimodal aspect-based sentiment analysis (JMABSA), which is a generative model based on an image-text selective fusion mechanism that aims to bridge the semantic gap between text and image representations and adaptively transfer a textual-based pretraining model to the multimodal JMASA task. We conducted extensive experiments on two benchmark datasets, and the experimental results show that our model significantly outperforms other state of the art approaches by a significant margin.
Language	English
Publishing date	2022-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2024056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Causal relationship between gut microbiota and myasthenia gravis: a two-sample Mendelian randomization study.

Mi, Chuanhao / Hou, Ajiao / Wang, Ziyue / Qi, Xianghua / Teng, Jing

Frontiers in neurology

2024 Volume 15, Page(s) 1309530

Abstract: Background: Previous observational studies have provided cumulative data linking gut microbiota to myasthenia gravis (MG). However, the causal link between the two remains unexplored. Hence, the current study was performed to explore the causal link ... ...

Abstract	Background: Previous observational studies have provided cumulative data linking gut microbiota to myasthenia gravis (MG). However, the causal link between the two remains unexplored. Hence, the current study was performed to explore the causal link between them. Methods: Mendelian randomization (MR) analysis was conducted using the summary statistics of 211 gut microbiota taxa and the largest genome-wide association studies (GWAS) for MG currently available. The inverse variance-weighted (IVW), MR-Egger, weighted median, and weighted mode methods were employed to ascertain the causal influence. Sensitivity studies utilizing several methodologies were then used to assess the robustness of the findings. Lastly, to evaluate reverse causality, a reverse MR analysis was performed. Results: Seven suggestive causal associations between the gastrointestinal microbiota and MG were identified based on the outcomes of the MR analysis. Specifically, phylum Actinobacteria (OR: 0.602, 95% CI: 0.405-0.896, Conclusion: The MR investigation has substantiated the suggestive causal connection between gut microbiota and MG, which may provide helpful insights for innovative therapeutic and preventative approaches for MG. Further randomized controlled trials are needed to elucidate the gut microbiota's precise role and therapeutic potential in the pathogenesis of MG.
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1309530
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Article ; Online: Preparation of modified humic acid/TiO

Gong, Xuankun / Sawut, Amatjan / Simayi, Rena / Wang, Ziyue / Feng, Yurou

Soft matter

2024 Volume 20, Issue 13, Page(s) 2937–2954

Abstract: A novel composite hydrogel with exceptional adsorption and photocatalytic properties was synthesized using modified coal-based humic acid (HA-C), modified titanium dioxide ( ... ...

Abstract	A novel composite hydrogel with exceptional adsorption and photocatalytic properties was synthesized using modified coal-based humic acid (HA-C), modified titanium dioxide (TiO
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2191476-X
ISSN	1744-6848 ; 1744-683X
ISSN (online)	1744-6848
ISSN	1744-683X
DOI	10.1039/d3sm01749d
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Article ; Online: Elaidic acid leads to mitochondrial dysfunction via mitochondria-associated membranes triggers disruption of mitochondrial calcium fluxes

Liu, Hui / Li, Xuenan / Wang, Ziyue / Li, Lu / Li, Yucai / Yan, Haiyang / Yuanyuan

Food Science and Human Wellness. 2024 Jan., v. 13, no. 1 p.287-298

2024

Abstract: Elaidic acid (EA) stimulation can lead to endoplasmic reticulum stress (ERS), accompanied by a large release of Ca²⁺, and ultimately the activation of NLRP3 inflammasome in Kupffer cells (KCs). Mitochondrial instability or dysfunction may be the key ... ...

Abstract	Elaidic acid (EA) stimulation can lead to endoplasmic reticulum stress (ERS), accompanied by a large release of Ca²⁺, and ultimately the activation of NLRP3 inflammasome in Kupffer cells (KCs). Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome, and sustained Ca²⁺ transfer can result in mitochondrial dysfunction. We focused on KCs to explore the damage to mitochondria by EA. After EA stimulation, cells produced an oxidative stress (OS) response with a significant increase in ROS release. Immunoprecipitation experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca²⁺ led to Ca²⁺ accumulation in the mitochondrial matrix via mitochondria-associated membranes (MAMs). This was accompanied by a significant release of mROS, loss of MMP and ATP, and a significant increase in mitochondrial permeability transition pore opening, ultimately leading to mitochondrial instability. These findings confirmed the mechanism that EA induced mitochondrial Ca²⁺ imbalance in KCs via MAM, ultimately leading to mitochondrial dysfunction. Meanwhile, EA induced OS and the decrease of MMP and ATP in rat liver, and significant lesions were found in liver mitochondria. Swelling of the inner mitochondrial cristae and mitochondrial vacuolization occurred, with a marked increase in lipid droplets.
Keywords	calcium ; elaidic acid ; endoplasmic reticulum stress ; food science ; humans ; inflammasomes ; liver ; mitochondria ; oxidative stress ; permeability ; precipitin tests ; rats ; Elaidic acid (EA) ; Mitochondria-associated membranes (MAMs) ; Endoplasmic reticulum ; Mitochondria dysfunction
Language	English
Dates of publication	2024-01
Size	p. 287-298.
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	2712869-6
ISSN	2213-4530
ISSN	2213-4530
DOI	10.26599/FSHW.2022.9250024
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: SEINE

Zhang, Ye / Cai, Linghan / Wang, Ziyue / Zhang, Yongbing

Structure Encoding and Interaction Network for Nuclei Instance Segmentation

2024

Abstract: Nuclei instance segmentation in histopathological images is of great importance for biological analysis and cancer diagnosis but remains challenging for two reasons. (1) Similar visual presentation of intranuclear and extranuclear regions of chromophobe ... ...

Abstract	Nuclei instance segmentation in histopathological images is of great importance for biological analysis and cancer diagnosis but remains challenging for two reasons. (1) Similar visual presentation of intranuclear and extranuclear regions of chromophobe nuclei often causes under-segmentation, and (2) current methods lack the exploration of nuclei structure, resulting in fragmented instance predictions. To address these problems, this paper proposes a structure encoding and interaction network, termed SEINE, which develops the structure modeling scheme of nuclei and exploits the structure similarity between nuclei to improve the integrality of each segmented instance. Concretely, SEINE introduces a contour-based structure encoding (SE) that considers the correlation between nuclei structure and semantics, realizing a reasonable representation of the nuclei structure. Based on the encoding, we propose a structure-guided attention (SGA) that takes the clear nuclei as prototypes to enhance the structure learning for the fuzzy nuclei. To strengthen the structural learning ability, a semantic feature fusion (SFF) is presented to boost the semantic consistency of semantic and structure branches. Furthermore, a position enhancement (PE) method is applied to suppress incorrect nuclei boundary predictions. Extensive experiments demonstrate the superiority of our approaches, and SEINE achieves state-of-the-art (SOTA) performance on four datasets. The code is available at \href{https://github.com/zhangye-zoe/SEINE}{https://github.com/zhangye-zoe/SEINE}. Comment: 10 pages, 12 figures, 6 tables, submitted to TMI
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence
Subject code	006 ; 004
Publishing date	2024-01-18
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficacy of Acupuncture-Related Therapy for Migraine: A Systematic Review and Network Meta-Analysis.

Liu, Yinqin / Wang, Yan / Mi, Chuanhao / Wang, Ziyue / Han, Yu / Qi, Xianghua / Ding, Xiao

Journal of pain research

2024 Volume 17, Page(s) 1107–1132

Abstract: Objective: Migraine is a common neurological disorder, which resulting in significant societal and personal burdens. Acupuncture has attracted widespread attention in migraine prophylaxis and treatment in recent years. Although some studies have ... ...

Abstract	Objective: Migraine is a common neurological disorder, which resulting in significant societal and personal burdens. Acupuncture has attracted widespread attention in migraine prophylaxis and treatment in recent years. Although some studies have confirmed the effectiveness of acupuncture therapy in treating migraines, there is still a lack of comprehensive evaluation regarding the comparison between different types of migraines and various acupuncture therapies. Furthermore, certain special acupuncture methods have not received sufficient attention and research. Therefore, the objective of this study is to summarize and expand upon previous research, update existing evidence, and compare the efficacy of different acupuncture therapies for migraine. We aim to provide stronger evidence-based support for clinical practice through this study, thereby promoting wider application of acupuncture therapy in migraine treatment. Methods: A exhaustive and methodical search was conducted across the nine databases: PubMed, EMBASE, Web of Science, Scopus, the Cochrane Library, CBM, CNKI, WANFANG and VIP Data. The Visual Analog Scale (VAS) scores, migraine attack frequency, duration, days of attack and adverse effects were observation indicators. Results: This study included 34 studies involving a total of 3365 migraineurs. The results of the study demonstrated that acupuncture therapy reduced VAS scores of migraine patients better compared to medication (MD=-1.29, 95% CI=[-1.67,-0.92]) and exhibited greater efficacy in reducing the frequency of migraine attacks (MD=-1.95, 95% CI=[-3.06,-0.85]), the duration of attacks (MD=- 3.29, 95% CI=[-4.65,-1.93]), and days of attack (MD=-1.02, 95% CI=[-1.58,-0.47]). Significant heterogeneity suggested that different acupuncture therapies had varying effects, and that the efficacy of the same therapy may also vary in different migraine types. In the context of network meta-analysis, the SUCRA of acupuncture therapies for reducing VAS scores was ranked as special acupuncture method (98.3%), acupuncture plus medicine (71.9%), and acupuncture (54.5%). Blood-letting and cupping was the most effective treatment for lowering the frequency of migraine attacks. The most effective treatment for shortening the duration of migraine was acupuncture plus medication (81.2%). When it comes to decreasing the days of migraine, acupuncture (80.3%) came out on top. 14 studies reported the occurrence of adverse effects, of which 4 studies had no adverse effects in the test group. Conclusion: Initial findings indicate that acupuncture-related therapy exhibits superior effectiveness in the treatment of migraine and clinical decision-making should be patient-specific.
Language	English
Publishing date	2024-03-15
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2495284-9
ISSN	1178-7090
ISSN	1178-7090
DOI	10.2147/JPR.S452971
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Article ; Online: Mechanism of apoptosis induced by the combined action of acrylamide and Elaidic acid through endoplasmic reticulum stress injury.

Yuan, Yuan / Wang, Xinwei / Li, Lu / Wang, Ziyue / Li, Wenliang / Pang, Yong / Yan, Haiyang

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 189, Page(s) 114733

Abstract: Thermal processing of food is likely to form acrylamide (AA) and elaidic acid (EA), which are both mainly metabolized by the liver. The two substances are associated with the pathogenesis of liver disease. In the current study, we investigated the toxic ... ...

Abstract	Thermal processing of food is likely to form acrylamide (AA) and elaidic acid (EA), which are both mainly metabolized by the liver. The two substances are associated with the pathogenesis of liver disease. In the current study, we investigated the toxic effects of the combined action of AA and EA on HSC-T6 cells, and the mechanism of apoptosis exacerbated by the co-exposure. The results showed a synergistic effect of AA and EA, which exacerbated the damage and oxidative stress (OS) in HSC-T6. Meanwhile, the expression of endoplasmic reticulum stress (ERS) proteins, such as GRP78 and CHOP, was increased, the ERS pathway was activated, and Ca
Language	English
Publishing date	2024-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114733
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Article: Discovery of novel photocaged ERK1/2 inhibitors as light-controlled anticancer agents

Chen, Rui / Wang, Ziyue / Liu, Lihong / Pan, Zhengying

Chemical communications. 2022 Apr. 14, v. 58, no. 31

2022

Abstract: Although extracellular regulated protein kinases (ERKs) are considered important targets for the treatment of various cancers, the occurrence of severe side effects in clinical trials restricts the development of ERK inhibitors. Here, we developed the ... ...

Abstract	Although extracellular regulated protein kinases (ERKs) are considered important targets for the treatment of various cancers, the occurrence of severe side effects in clinical trials restricts the development of ERK inhibitors. Here, we developed the first series of photocaged ERK inhibitors, which can be selectively activated by UV irradiation to release a highly potent ERK inhibitor in multiple cancer cell lines including A375, A549 and HCT116, and Compound 2 demonstrated clear anticancer activity in a zebrafish xenograft model. In conclusion, photocaged ERK inhibitor 2 provides a new strategy for precise cancer therapy.
Keywords	Danio rerio ; antineoplastic activity ; cancer therapy ; models ; neoplasm cells ; ultraviolet radiation ; xenotransplantation
Language	English
Dates of publication	2022-0414
Size	p. 4901-4904.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc00456a
Database	NAL-Catalogue (AGRICOLA)

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