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  1. Article ; Online: Insect hypersensitivity beyond bee and wasp venom allergy.

    Hemmer, Wolfgang / Wantke, Felix

    Allergologie select

    2020  Volume 4, Page(s) 97–104

    Abstract: The bites of blood-feeding insects regularly induce sensitization to salivary proteins and cause local hypersensitivity reactions in over 90% of the population, representing either an IgE-mediated immediate wheal and flare reaction or a T cell-driven ... ...

    Abstract The bites of blood-feeding insects regularly induce sensitization to salivary proteins and cause local hypersensitivity reactions in over 90% of the population, representing either an IgE-mediated immediate wheal and flare reaction or a T cell-driven delayed papule. Long-lasting large local reactions and bullous reactions may cause significant discomfort and reduction in quality-of-life. Anaphylaxis is rarely reported though proven for several insects, above all mosquitoes, horse flies, and kissing bugs. Recently, salivary gland proteins have been thoroughly studied in some blood-feeding insect species, and several allergens have been identified. Interestingly, many of them belong to the same protein families as the well-known honeybee and wasp venom allergens (phospholipases, hyaluronidases, antigens 5, serine proteases) though sequence identities are mostly low. There is still insufficient evidence for the proposed cross-reactivity between salivary proteins from blood-feeding insects and Hymenoptera venom allergens.
    Language English
    Publishing date 2020-11-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02123E
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Allergy screening with extract-based skin prick tests demonstrates higher sensitivity over in vitro molecular allergy testing.

    Gureczny, Tobias / Heindl, Benjamin / Klug, Livia / Wantke, Felix / Hemmer, Wolfgang / Wöhrl, Stefan

    Clinical and translational allergy

    2023  Volume 13, Issue 2, Page(s) e12220

    Abstract: Background: As extract-based skin testing as well as in vitro tests for major allergens have their own advantages, both procedures are usually performed in routine settings. In times of shortages in medical staff and supplies, we asked ourselves, how ... ...

    Abstract Background: As extract-based skin testing as well as in vitro tests for major allergens have their own advantages, both procedures are usually performed in routine settings. In times of shortages in medical staff and supplies, we asked ourselves, how many patients would be underdiagnosed, if only one test could be used.
    Methods: In a retrospective analysis, we investigated a cohort of 2646 patients seen by a single physician in a large Austrian outpatient allergy clinic in 2018. Only patients with an allergen source-specific history and pairs of extract-based skin prick (SPT) and in vitro molecular allergy tests to major allergens were included.
    Results: For all tested allergen sources, sensitivity was higher for SPT than for sIgE-based molecular allergy testing. Concerning 1006 birch pollen-allergic patients, 791 (78.6%) had positive results with both tests, while 153 (15.2%) only with the SPT and 62 (6.2%) only with the sIgE to Bet v1. The other allergen sources showed similar results: For house dust mite 816/1120 (72.9%), grass pollen 1077/1416 (76.1%) and cat 433/622 (69.6%) remained test-positive with both procedures, whereas in 276 (24.6%), 224 (15.8%) and 173 (27.8%) times only the SPT and 28 (2.5%), 115 (8.1%) and 16 (2.6%) times only the sIgE to Der p1/2/23, Phl p1/5 and Fel d1 showed a positive result. Each comparison was statistically significant (each p < 0.0001, Chi-squared test).
    Conclusions: Screening for allergy with major molecular allergens has lower sensitivity when compared with extract-based skin tests. A combination of both is required for an optimal sensitivity.
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12220
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  3. Article: Asthma bronchiale bei Erwachsenen - Update 2015

    Wantke, Felix

    Arzt & Praxis

    2015  Volume 69, Issue 1011, Page(s) 8

    Language German
    Document type Article
    ZDB-ID 1224197-0
    ISSN 0048-5128
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 868: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article: Schimmelpilze - allergische und irritative Erkrankungen

    Wantke, Felix

    Arzt & Praxis

    2013  Volume 67, Issue 994, Page(s) 122

    Language German
    Document type Article
    ZDB-ID 1224197-0
    ISSN 0048-5128
    Database Current Contents Medicine

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  5. Article ; Online: Molecular sensitization patterns in animal allergy: Relationship with clinical relevance and pet ownership.

    Hemmer, Wolfgang / Sestak-Greinecker, Gabriele / Braunsteiner, Tobias / Wantke, Felix / Wöhrl, Stefan

    Allergy

    2021  Volume 76, Issue 12, Page(s) 3687–3696

    Abstract: Background: In vitro diagnosis using single molecules is increasingly complementing conventional extract-based diagnosis. We explored in routine patients with animal allergy to what extent molecules can explain polysensitization and identify primary ... ...

    Abstract Background: In vitro diagnosis using single molecules is increasingly complementing conventional extract-based diagnosis. We explored in routine patients with animal allergy to what extent molecules can explain polysensitization and identify primary sensitizers and how individual IgE patterns correlate with previous pet ownership and clinical relevance.
    Methods: Serum samples from 294 children and adults with suspect allergic rhino-conjunctivitis or asthma and a positive skin prick test to cat, dog and/or horse were tested by ImmunoCAP for IgE antibodies against eleven different allergens from cat (Fel d 1,2,4,7), dog (Can f 1,2,3,4,5,6) and horse (Equ c 1).
    Results: Patients monosensitized to cat (40.8%) or dog (6.1%) showed simple IgE patterns dominated by Fel d 1 (93%) and Can f 5 (67%), respectively. Double-sensitization to cat+dog (25.9%), cat+horse (5.4%) and polysensitization (20.7%) was associated with an increasing prevalence of the cross-reactive lipocalins Fel d 4/Can f 6/Equ c 1 and Fel d 7/Can f 1. While these lipocalins were not reliable markers for genuine sensitization per se, comparison of sIgE levels may give a clue on the primary sensitizer. Sensitizations to dog appeared to result from cross-reactivity with cat in 48%, with half of these sensitizations lacking clinical relevance. Individual sensitization patterns strongly mirrored current or previous pet ownership with the exception of Fel d 1 which regularly caused sensitization also in non-owners.
    Conclusions: Allergen components can reasonably illuminate the molecular basis of animal (poly)sensitization in the majority of patients and are helpful in distinguishing between primary sensitization and sometimes less relevant cross-reactivity.
    MeSH term(s) Allergens ; Animals ; Asthma/diagnosis ; Asthma/therapy ; Cats ; Dogs ; Horses ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/therapy ; Immunoglobulin E/blood ; Immunologic Tests ; Ownership ; Pets/immunology
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2021-05-31
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 125: Show issues

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  6. Article: Fortbildung. Allergien im Alter

    Wantke, Felix

    Der Mediziner

    2011  Volume 20, Issue 1/2, Page(s) 18

    Language German
    Document type Article
    ZDB-ID 2041853-X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5443: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Chronisch obstruktive Lungenerkrankungen - Asthma bronchiale und COPD Neue und bewährte Therapien im Überblick

    Wantke, Felix

    Der Mediziner

    2010  Volume 19, Issue 3, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 2041853-X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5443: Show issues Location:
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  8. Article ; Online: Drug-specific history, skin and in vitro tests can reduce the need for drug provocation tests in betalactam-hypersensitivity.

    Wöhrl, Stefan / Ostermayer, Christian / Sesztak-Greinecker, Gabriele / Jarisch, Reinhart / Hemmer, Wolfgang / Wantke, Felix

    Allergology international : official journal of the Japanese Society of Allergology

    2020  Volume 70, Issue 2, Page(s) 244–251

    Abstract: Background: Many patients report questionable drug hypersensitivity reactions (DHR) to betalactam antibiotics. A workup is required for objectivation. Direct drug provocation tests (DPTs) omitting a prior allergy workup are increasingly recommended as ... ...

    Abstract Background: Many patients report questionable drug hypersensitivity reactions (DHR) to betalactam antibiotics. A workup is required for objectivation. Direct drug provocation tests (DPTs) omitting a prior allergy workup are increasingly recommended as the primary diagnostic approach. However, apart from the risk of severe side effects, DPTs often are a scarce resource in overloaded healthcare-systems. We investigated how many cases can be solved by drug-specific history, drug-specific IgE, and skin tests obviating the need for DPT.
    Methods: We conducted a chart review in a retrospective cohort of 932 patients in an allergy outpatient centre from 2016 to 2017. Patients had been submitted to drug-specific history and specific IgE-, skin prick-, intradermal- and patch-tests with early and late readings with a series of penicillins and cephalosporins but DPTs were no option.
    Results: Overall, positive in vitro and/or skin tests were found in 96/932 (10.3%) patients. Drug-specific IgE was detected in 40/932 (4.3%) patients, 61/787 (7.8%) patients had positive skin tests. In vitro tests to Pencillin V showed the highest rate of positivity 24/479 (5.0%) and early readings of ampicillin the highest amongst the skin tests (3/49, 6.1%). Immediate skin tests were more often positive than delayed ones (75:45). The combination of all parameters including drug-specific history solved 346/932 (37.1%) cases while 586/932 (62.9%) remained unresolved. Self-reported DHR could be less often confirmed in females and young children (p < 0.05).
    Conclusions: Testing with betalactams applying simple, cheap, and safe skin and blood tests can solve a third of DHR-cases on a high throughput scale.
    MeSH term(s) Adolescent ; Adult ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/immunology ; Child ; Child, Preschool ; Cross Reactions ; Drug Hypersensitivity/blood ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/immunology ; Female ; Humans ; Immunoglobulin E/blood ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Retrospective Studies ; Skin Tests ; Tryptases/blood ; Young Adult ; beta-Lactams/adverse effects ; beta-Lactams/immunology
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams ; Immunoglobulin E (37341-29-0) ; Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2020-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2020.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5248: Show issues Location:
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  9. Article: Anaphylaxie

    Wantke, Felix

    Der Mediziner

    2006  Volume -, Issue 12, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 2041853-X
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Food allergy to millet and cross-reactivity with rice, corn and other cereals.

    Hemmer, Wolfgang / Sesztak-Greinecker, Gabriele / Wöhrl, Stefan / Wantke, Felix

    Allergology international : official journal of the Japanese Society of Allergology

    2016  Volume 66, Issue 3, Page(s) 490–492

    Language English
    Publishing date 2016-12-09
    Publishing country England
    Document type Letter
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2016.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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