LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: Anthracene-bridged sensitizers for environmentally compatible dye-sensitized solar cells: In silico modelling and prediction.

    Islam, Fakhar / Waqas, Ahsan / Khan, Shabir / Ali, Amir / Sattar, Abdul / Tariq, Muhammad Adeel / Arshad, Muhammad / Mehboob, Muhammad Yasir

    Journal of molecular graphics & modelling

    2023  Volume 122, Page(s) 108496

    Abstract: Advancement in solar cells has gained the attention of researchers due to increasing demand and renewable energy sources. Modeling of electron absorbers and donors has been performed extensively for the development of efficient solar cells. In this ... ...

    Abstract Advancement in solar cells has gained the attention of researchers due to increasing demand and renewable energy sources. Modeling of electron absorbers and donors has been performed extensively for the development of efficient solar cells. In this regard, efforts are being made for designing effective units for the active layer of solar cells. In this study, CXC22 was utilized as a reference in which acetylenic anthracene acted as a π bridge and infrastructure was D-π-A. We theoretically designed four novel dye-sensitized solar cells JU1-JU4 by utilizing reference molecules to improve the photovoltaic and optoelectronic properties. All designed molecules differ from R by donor moiety modifications. Different approaches were done to R and all molecules to explore different analyses like binding energies, excitation energies, dipole moment, TDM (transition density matrix), PDOS (partial density of states), absorption maxima, and charge transfer analysis. For the evaluation of results, we used the DFT technique and the findings demonstrated that the JU3 molecule showed a better redshift absorption value (761 nm) as compared to all other molecules due to the presence of anthracene in the donor moiety which lengthens the conjugation. JU3 was proven to be the best candidate among all due to improved excitation energy (1.69), low energy band gap (1.93), higher λ
    MeSH term(s) Computer Simulation ; Acetylene ; Alkynes ; Anthracenes
    Chemical Substances anthracene (EH46A1TLD7) ; Acetylene (OC7TV75O83) ; Alkynes ; Anthracenes
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2023.108496
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3491: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Recent Developments in Artificial Super-Wettable Surfaces Based on Bioinspired Polymeric Materials for Biomedical Applications.

    Abbas, Ansar / Zhang, Chen / Asad, Muhammad / Waqas, Ahsan / Khatoon, Asma / Hussain, Sameer / Mir, Sajjad Husain

    Polymers

    2022  Volume 14, Issue 2

    Abstract: Inspired by nature, significant research efforts have been made to discover the diverse range of biomaterials for various biomedical applications such as drug development, disease diagnosis, biomedical testing, therapy, etc. Polymers as bioinspired ... ...

    Abstract Inspired by nature, significant research efforts have been made to discover the diverse range of biomaterials for various biomedical applications such as drug development, disease diagnosis, biomedical testing, therapy, etc. Polymers as bioinspired materials with extreme wettable properties, such as superhydrophilic and superhydrophobic surfaces, have received considerable interest in the past due to their multiple applications in anti-fogging, anti-icing, self-cleaning, oil-water separation, biosensing, and effective transportation of water. Apart from the numerous technological applications for extreme wetting and self-cleaning products, recently, super-wettable surfaces based on polymeric materials have also emerged as excellent candidates in studying biological processes. In this review, we systematically illustrate the designing and processing of artificial, super-wettable surfaces by using different polymeric materials for a variety of biomedical applications including tissue engineering, drug/gene delivery, molecular recognition, and diagnosis. Special attention has been paid to applications concerning the identification, control, and analysis of exceedingly small molecular amounts and applications permitting high cell and biomaterial cell screening. Current outlook and future prospects are also provided.
    Language English
    Publishing date 2022-01-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14020238
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Early Allograft Dysfunction Following Liver Transplant: Impact of Obesity, Diabetes, and Red Blood Cell Transfusion.

    Hudcova, Jana / Qasmi, Syed Talha / Ruthazer, Robin / Waqas, Ahsan / Haider, Syed Basit / Schumann, Roman

    Transplantation proceedings

    2020  Volume 53, Issue 1, Page(s) 119–123

    Abstract: Purpose: We examined the role of obesity and intraoperative red blood cell (RBC) and platelet transfusion in early allograft dysfunction (EAD) following liver transplantation (LT).: Methods: This is a retrospective analysis of 239 adult deceased- ... ...

    Abstract Purpose: We examined the role of obesity and intraoperative red blood cell (RBC) and platelet transfusion in early allograft dysfunction (EAD) following liver transplantation (LT).
    Methods: This is a retrospective analysis of 239 adult deceased-donor LT recipients over a 10-year period. EAD was defined by Olthoff's criteria. Data collection included donor (D) and recipient (R) age, body mass index (BMI) ≥ 35 kg/m
    Results: EAD occurred in 85 recipients (36%). Macrosteatosis data were available for 199 donors. In the multivariate analyses, BMI-D ≥ 35 kg/m
    Conclusion: We found a significant independent association of donor obesity and intraoperative RBC transfusion with EAD but no such association for platelet administration, MELD score, age, recipient obesity, and diabetes.
    MeSH term(s) Adult ; Cohort Studies ; Diabetes Mellitus ; Erythrocyte Transfusion/adverse effects ; Female ; Humans ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Obesity/complications ; Primary Graft Dysfunction/etiology ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2020-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2020.02.168
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Stereoselective Pharmacokinetics and Chiral Inversions of Some Chiral Hydroxy Group Drugs.

    Chen, Fuxin / Bai, Qiaoxiu / Wang, Qingfeng / Chen, Suying / Ma, Xiaoxian / Cai, Changlong / Wang, Danni / Waqas, Ahsan / Gong, Pin

    Current pharmaceutical biotechnology

    2020  Volume 21, Issue 15, Page(s) 1632–1644

    Abstract: Background: Chiral safety, especially chiral drug inversion in vivo, is the top priority of current scientific research. Medicine researchers and pharmacists often ignore that one enantiomer will be converted or partially converted to another enantiomer ...

    Abstract Background: Chiral safety, especially chiral drug inversion in vivo, is the top priority of current scientific research. Medicine researchers and pharmacists often ignore that one enantiomer will be converted or partially converted to another enantiomer when it is ingested in vivo. So that, in the context that more than 50% of the listed drugs are chiral drugs, it is necessary and important to pay attention to the inversion of chiral drugs.
    Methods: The metabolic and stereoselective pharmacokinetic characteristics of seven chiral drugs with one chiral center in the hydroxy group were reviewed in vivo and in vitro including the possible chiral inversion of each drug enantiomer. These seven drugs include (S)-Mandelic acid, RS-8359, Tramadol, Venlafaxine, Carvedilol, Fluoxetine and Metoprolol.
    Results: The differences in stereoselective pharmacokinetics could be found for all the seven chiral drugs, since R and S isomers often exhibit different PK and PD properties. However, not every drug has shown the properties of one direction or two direction chiral inversion. For chiral hydroxyl group drugs, the redox enzyme system may be one of the key factors for chiral inversion in vivo.
    Conclusion: In vitro and in vivo chiral inversion is a very complex problem and may occur during every process of ADME. Nowadays, research on chiral metabolism in the liver has the most attention, while neglecting the chiral transformation of other processes. Our review may provide the basis for the drug R&D and the safety of drugs in clinical therapy.
    MeSH term(s) Alcohol Dehydrogenase/metabolism ; Animals ; Humans ; Liver/enzymology ; Mandelic Acids/chemistry ; Mandelic Acids/pharmacokinetics ; Molecular Structure ; Nitriles/chemistry ; Nitriles/pharmacokinetics ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Pyrimidines/chemistry ; Pyrimidines/pharmacokinetics ; Species Specificity ; Stereoisomerism ; Structure-Activity Relationship
    Chemical Substances Mandelic Acids ; Nitriles ; Pharmaceutical Preparations ; Pyrimidines ; RS 8359 (79U9T1HIX9) ; ADH1B protein, human (EC 1.1.1.1) ; Alcohol Dehydrogenase (EC 1.1.1.1) ; mandelic acid (NH496X0UJX)
    Language English
    Publishing date 2020-07-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201021666200727144053
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Effect of early allograft dysfunction on outcomes following liver transplantation.

    Hudcova, Jana / Scopa, Caitlin / Rashid, Jawad / Waqas, Ahsan / Ruthazer, Robin / Schumann, Roman

    Clinical transplantation

    2017  Volume 31, Issue 2

    Abstract: Early allograft dysfunction (EAD) following liver transplantation (LT) remains a challenge for patients and clinicians. We retrospectively analyzed the effect of pre-defined EAD on outcomes in a 10-year cohort of deceased-donor LT recipients with clearly ...

    Abstract Early allograft dysfunction (EAD) following liver transplantation (LT) remains a challenge for patients and clinicians. We retrospectively analyzed the effect of pre-defined EAD on outcomes in a 10-year cohort of deceased-donor LT recipients with clearly defined exclusion criteria. EAD was defined by at least one of the following: AST or ALT >2000 IU/L within first-week post-LT, total bilirubin ≥10 mg/dL, and/or INR ≥1.6 on post-operative day 7. Ten patients developed primary graft failure and were analyzed separately. EAD occurred in 86 (36%) recipients in a final cohort of 239 patients. In univariate and multivariate analyses, EAD was significantly associated with mechanical ventilation ≥2 days or death on days 0, 1, PACU/SICU stay >2 days or death on days 0-2 and renal failure (RF) at time of hospital discharge (all P<.05). EAD was also significantly associated with higher one-year graft loss in both uni- and multivariate Cox hazard analyses (P=.0203 and .0248, respectively). There was no difference in patient mortality between groups in either of the Cox proportional hazard models. In conclusion, we observed significant effects of EAD on short-term post-LT outcomes and lower graft survival.
    MeSH term(s) Adult ; Allografts ; Boston/epidemiology ; Female ; Follow-Up Studies ; Graft Rejection/epidemiology ; Graft Rejection/etiology ; Graft Survival ; Humans ; Incidence ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Postoperative Complications ; Primary Graft Dysfunction/epidemiology ; Primary Graft Dysfunction/etiology ; Prognosis ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2017
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.12887
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Pre-emptive antibiotic therapy to reduce ventilator-associated pneumonia: "thinking outside the box".

    Craven, Donald E / Hudcova, Jana / Lei, Yuxiu / Craven, Kathleen A / Waqas, Ahsan

    Critical care (London, England)

    2016  Volume 20, Issue 1, Page(s) 300

    Abstract: Mechanically ventilated, intubated patients are at increased risk for tracheal colonization with bacterial pathogens that may progress to heavy bacterial colonization, ventilator-associated tracheobronchitis (VAT), and/or ventilator-associated pneumonia ( ...

    Abstract Mechanically ventilated, intubated patients are at increased risk for tracheal colonization with bacterial pathogens that may progress to heavy bacterial colonization, ventilator-associated tracheobronchitis (VAT), and/or ventilator-associated pneumonia (VAP). Previous studies report that 10 to 30 % of patients with VAT progress to VAP, resulting in increased morbidity and significant acute and chronic healthcare costs. Several natural history studies, randomized, controlled trials, and a meta-analysis have reported antibiotic treatment for VAT can reduce VAP, ventilator days, length of intensive care unit (ICU) stay, and patient morbidity and mortality. We discuss early diagnostic criteria, etiologic agents, and benefits of initiating, early, appropriate intravenous or aerosolized antibiotic(s) to treat VAT and reduce VAP, to improve patient outcomes by reducing lung damage, length of ICU stay, and healthcare costs.
    Language English
    Publishing date 2016-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1466-609X
    ISSN (online) 1466-609X
    ISSN 1466-609X
    DOI 10.1186/s13054-016-1472-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top