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Article ; Online: Pinnaplasty: Who makes the cut?

Ward, J A / Pope-Jones, S / Murison, M / Wilson-Jones, N

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2019 Volume 73, Issue 4, Page(s) 783–808

MeSH term(s)	Ear, External/surgery ; Humans ; Reconstructive Surgical Procedures/education ; Reconstructive Surgical Procedures/statistics & numerical data ; Retrospective Studies ; Surgery, Plastic/education
Language	English
Publishing date	2019-12-11
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2019.11.041
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Article ; Online: Development of a core outcome set for research and audit studies in reconstructive breast surgery.

Potter, S / Holcombe, C / Ward, J A / Blazeby, J M

The British journal of surgery

2015 Volume 102, Issue 11, Page(s) 1360–1371

Abstract: Background: Appropriate outcome selection is essential if research is to guide decision-making and inform policy. Systematic reviews of the clinical, cosmetic and patient-reported outcomes of reconstructive breast surgery, however, have demonstrated ... ...

Abstract	Background: Appropriate outcome selection is essential if research is to guide decision-making and inform policy. Systematic reviews of the clinical, cosmetic and patient-reported outcomes of reconstructive breast surgery, however, have demonstrated marked heterogeneity, and results from individual studies cannot be compared or combined. Use of a core outcome set may improve the situation. The BRAVO study developed a core outcome set for reconstructive breast surgery. Methods: A long list of outcomes identified from systematic reviews and stakeholder interviews was used to inform a questionnaire survey. Key stakeholders defined as individuals involved in decision-making for reconstructive breast surgery, including patients, breast and plastic surgeons, specialist nurses and psychologists, were sampled purposively and sent the questionnaire (round 1). This asked them to rate the importance of each outcome on a 9-point Likert scale from 1 (not important) to 9 (extremely important). The proportion of respondents rating each item as very important (score 7-9) was calculated. This was fed back to participants in a second questionnaire (round 2). Respondents were asked to reprioritize outcomes based on the feedback received. Items considered very important after round 2 were discussed at consensus meetings, where the core outcome set was agreed. Results: A total of 148 items were combined into 34 domains within six categories. Some 303 participants (51·4 per cent) (215 (49·5 per cent) of 434 patients; 88 (56·4 per cent) of 156 professionals) completed and returned the round 1 questionnaire, and 259 (85·5 per cent) reprioritized outcomes in round 2. Fifteen items were excluded based on questionnaire scores and 19 were carried forward to the consensus meetings, where a core outcome set containing 11 key outcomes was agreed. Conclusion: The BRAVO study has used robust consensus methodology to develop a core outcome set for reconstructive breast surgery. Widespread adoption by the reconstructive community will improve the quality of outcome assessment in effectiveness studies. Future work will evaluate how these key outcomes should best be measured.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Attitude of Health Personnel ; Clinical Decision-Making ; Consensus ; Delphi Technique ; Female ; Humans ; Mammaplasty ; Medical Audit/methods ; Medical Audit/standards ; Middle Aged ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/standards ; Research Design ; Surveys and Questionnaires ; United Kingdom
Language	English
Publishing date	2015-07-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1002/bjs.9883
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Article ; Online: Outcome reporting for reconstructive breast surgery: the need for consensus, consistency and core outcome sets.

Ward, J A / Potter, S / Blazeby, J M

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2012 Volume 38, Issue 11, Page(s) 1020–1021

MeSH term(s)	Esthetics ; Female ; Humans ; Mammaplasty ; Outcome Assessment (Health Care)/standards ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2012-11
Publishing country	England
Document type	Editorial
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2012.07.108
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Comparative RNA-seq for the investigation of resistance to Phytophthora root rot in the red raspberry 'Latham'

Ward, J.A / Weber, C.A

Acta horticulturae. 2012 Apr., , no. 946

2012

Abstract: Mechanisms of resistance to Phytophthora root rot (PRR) (caused by Phytophthora rubi) in the red raspberry (Rubus idaeus) 'Latham' were investigated with a genome-wide expression study. Root-tissues of 'Latham' (resistant to PRR) and 'Titan' (susceptible ...

Abstract	Mechanisms of resistance to Phytophthora root rot (PRR) (caused by Phytophthora rubi) in the red raspberry (Rubus idaeus) 'Latham' were investigated with a genome-wide expression study. Root-tissues of 'Latham' (resistant to PRR) and 'Titan' (susceptible to PRR) were sampled from controls at 48 h, 5 days, and 20 days post inoculation. Total mRNA was extracted and sequencing libraries were prepared. Over 70,600,000 quality filtered 86 nt reads were sequenced with an Illumina Genome Analyzer IIx. RNA-seq was performed with these data using a freely available bioinformatics pipeline (Bowtie-TopHat and Cufflinks). The recently completed draft genome sequence of the woodland strawberry (Fragaria vesca) was used as the reference for alignment. Of 16,956 unique and putatively expressed genes detected there were 12,823 that we considered significantly expressed because the lower bound of the 95% confidence interval did not include a FPKM of zero. Furthermore, only genes that were significantly differentially expressed after Benjamini Hochberg False Discovery Rate correction for multiple testing were considered. Between the resistant control ('Latham' un-inoculated) and resistant treatment ('Latham' inoculated) 702 genes were significantly differentially expressed with a log fold change greater than 0.5 or less than -0.5 and an FPKM >3 in either the control or treatment. Further analysis was targeted toward genes known to play a role in plant defense. Significant results include: 1) increased expression of WRKY transcription factors, 2) PR genes, and 3) key genes in the citric acid cycle and the lignin biosynthetic pathways. These results are being confirmed with quantitative RT-PCR. This study not only reveals putative mechanisms of durable resistance in 'Latham', but it demonstrates how the newly released draft genome of Fragaria vesca can be used as a resource for genome-wide expression analysis in Rubus species.
Keywords	DNA libraries ; Fragaria vesca ; Phytophthora ; Rubus idaeus ; bioinformatics ; confidence interval ; gene expression regulation ; genes ; messenger RNA ; nucleotide sequences ; resistance mechanisms ; reverse transcriptase polymerase chain reaction ; root rot ; transcription factors ; tricarboxylic acid cycle
Language	English
Size	p. 67-72.
Publishing place	International Society for Horticultural Science
Document type	Article
Note	Paper presented at the Tenth International Rubus and Ribes Symposium, held June 22-26, 2011, Zlatibor, Serbia.
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article: Should antioxidant vitamins be routinely recommended for older people?

Ward, J A

Drugs & aging

1998 Volume 12, Issue 3, Page(s) 169–175

Abstract: The hypothesis that oxidative damage due to free radicals is an important cause of aging is the subject of much research and even more interest among the public and lay media. An increasing number of older people are asking whether they should be taking ... ...

Abstract	The hypothesis that oxidative damage due to free radicals is an important cause of aging is the subject of much research and even more interest among the public and lay media. An increasing number of older people are asking whether they should be taking antioxidant vitamins, despite their considerable cost. Epidemiological and laboratory evidence indicates that oxidative damage caused by oxygen free radicals is important in many of the major diseases of older age. It is also clear that a diet high in antioxidants protects against these diseases, including many cancers and ischaemic heart disease. However, it has not been proven whether antioxidant vitamins, taken as dietary supplements, provide the same level of protection as a diet that is rich in fruit and vegetables. Although there appears to be no reason to discourage older people from taking vitamin E (tocopherols) and ascorbic acid (vitamin C), the best advice to give them is to reduce their intake of xenobiotics, to drink tea instead of coffee, and to eat liberal amounts of fruit, vegetables, nuts, soya beans and lentils. The use of beta-carotene as a dietary supplement should be discouraged.
MeSH term(s)	Aged ; Aging/drug effects ; Antioxidants/therapeutic use ; Cardiovascular Diseases/prevention & control ; Free Radicals ; Humans ; Neoplasms/prevention & control ; Vitamins/therapeutic use
Chemical Substances	Antioxidants ; Free Radicals ; Vitamins
Language	English
Publishing date	1998-03
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1075770-3
ISSN	1179-1969 ; 1170-229X
ISSN (online)	1179-1969
ISSN	1170-229X
DOI	10.2165/00002512-199812030-00001
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Zs.A 3481: Show issues

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Article ; Online: A simple model for multicomponent etching.

Fowler, A C / Ward, J A / O'Brien, S B G

Journal of colloid and interface science

2011 Volume 354, Issue 1, Page(s) 421–423

Abstract: We consider the situation where a multicomponent solid is etched using one or more acids. Of fundamental interest is the rate of surface etching but when this involves multicomponent surface reactions, it becomes unclear how the overall rate can be ... ...

Abstract	We consider the situation where a multicomponent solid is etched using one or more acids. Of fundamental interest is the rate of surface etching but when this involves multicomponent surface reactions, it becomes unclear how the overall rate can be estimated. In this paper, we sketch a simple model designed to determine the effective etching rate by means of an atomic scale model of the etching process.
Language	English
Publishing date	2011-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2010.10.056
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Article ; Online: The relationship between eosinophilia and airway remodelling in mild asthma.

Wilson, S J / Rigden, H M / Ward, J A / Laviolette, M / Jarjour, N N / Djukanović, R

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2013 Volume 43, Issue 12, Page(s) 1342–1350

Abstract: Background: Eosinophilia is a marker of corticosteroid responsiveness and risk of exacerbation in asthma; although it has been linked to submucosal matrix deposition, its relationship with other features of airway remodelling is less clear.: Objective! ...

Abstract	Background: Eosinophilia is a marker of corticosteroid responsiveness and risk of exacerbation in asthma; although it has been linked to submucosal matrix deposition, its relationship with other features of airway remodelling is less clear. Objective: The aim of this study was to investigate the relationship between airway eosinophilia and airway remodelling. Methods: Bronchial biopsies from subjects (n = 20 in each group) with mild steroid-naïve asthma, with either low (0-0.45 mm(-2)) ) or high submucosal eosinophil (23.43-46.28 mm(-2) ) counts and healthy controls were assessed for in vivo epithelial damage (using epidermal growth factor receptor staining), mucin expression, airway smooth muscle (ASM) hypertrophy and inflammatory cells within ASM. Results: The proportion of in vivo damaged epithelium was significantly greater (P = 0.02) in the high-eosinophil (27.37%) than the low-eosinophil (4.14%) group. Mucin expression and goblet cell numbers were similar in the two eosinophil groups; however, MUC-2 expression was increased (P = 0.002) in the high-eosinophil group compared with controls. The proportion of submucosa occupied by ASM was higher in both asthma groups (P = 0.021 and P = 0.046) compared with controls. In the ASM, eosinophil and T-lymphocyte numbers were higher (P < 0.05) in the high-eosinophil group than both the low-eosinophil group and the controls, whereas the numbers of mast cells were increased in the high-eosinophil group (P = 0.01) compared with controls. Conclusion: Submucosal eosinophilia is a marker (and possibly a cause) of epithelial damage and is related to infiltration of ASM with eosinophils and T lymphocytes, but is unrelated to mucus metaplasia or smooth muscle hypertrophy.
MeSH term(s)	Adult ; Airway Remodeling ; Asthma/immunology ; Asthma/metabolism ; Asthma/pathology ; Case-Control Studies ; Eosinophilia/pathology ; Female ; Goblet Cells/pathology ; Humans ; Hyperplasia ; Male ; Middle Aged ; Mucins/metabolism ; Muscle, Smooth/metabolism ; Muscle, Smooth/pathology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Young Adult
Chemical Substances	Mucins
Language	English
Publishing date	2013-11-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.12156
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Zs.A 767: Show issues

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Article: Developing molecular markers for marker assisted selection for resistance to raspberry bushy dwarf virus (RBDV) in red raspberry

Ward, J.A / Boone, W.E / Moore, P.P / Weber, C.A

Acta horticulturae. 2012 Apr., , no. 946

2012

Abstract: A modified Bulked Segregant Analysis (BSA) was applied using eight RBDV resistant and eight susceptible raspberry plants. The best markers from this effort were applied to sixty seedlings of a 'Nootka' x WSU1499 population segregating for resistance to ... ...

Abstract	A modified Bulked Segregant Analysis (BSA) was applied using eight RBDV resistant and eight susceptible raspberry plants. The best markers from this effort were applied to sixty seedlings of a 'Nootka' x WSU1499 population segregating for resistance to RBDV conferred by the Bu resistance gene. ELISA was used to identify resistant and susceptible genotypes in this population following graft inoculations. Three markers showed promise for use in Marker Assisted Selection (MAS); BC615_550, BC002_590 and BC296_425. BC615_550 proved to be the most predictive and reproducible marker and was cloned and sequenced. Specific primers were developed for this marker, resulting in the BC615_553_AluI Cleaved Amplified Polymorphic Sequence (CAPS) marker. This marker was applied to the segregating population and correctly identified the resistant plants in 58 out of 60 cases (96.7% accuracy). This marker was not present in other notable resistant sources, such as that derived from ‘Haida’ so a comparative approach based on assumed microsynteny between raspberry and strawberry was implemented. A BLAST search identified the putative location of the BC615_550 polymorphism in the diploid strawberry genome and primers were designed in candidate genes physically linked to this locus. Of note, six primer sets were designed to amplify different parts of a gene containing motifs homologous to the tobacco N-gene, a known virus resistance gene. One of the primer sets resulted in a Sequence Characterized Amplified Region (SCAR) marker, called rasp_N_gene_1202, that amplified in the resistant plants 'Nootka', 'Haida', and 'Willamette' in initial tests, while failing to amplify in the susceptible WSU1499. In the test population, this marker segregates perfectly with the original BC615_553_AluI marker. In addition to 'Nootka', 'Haida', and 'Willamette', it is present in a diverse set of known resistant genotypes including WSU 78117-1, 'Newburgh', 'Cowichan', 'Chilcotin', 'Malling Promise', 'Heritage' and 'Latham'. The marker is absent in known susceptible genotypes including 'Chilliwack', 'Tulameen', WSU 1276, 'Meeker', 'Autumn Bliss', 'Malahat' and WSU 1098. Screening of additional test populations is in progress for the evaluation of the marker’s utility in MAS for RBDV resistance in red raspberry.
Keywords	Raspberry bushy dwarf virus ; diploidy ; enzyme-linked immunosorbent assay ; genes ; genetic markers ; genotype ; loci ; marker-assisted selection ; screening ; seedlings ; strawberries ; tobacco ; viruses
Language	English
Size	p. 61-66.
Publishing place	International Society for Horticultural Science
Document type	Article
Note	Paper presented at the Tenth International Rubus and Ribes Symposium, held June 22-26, 2011, Zlatibor, Serbia.
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article: Developing community mental health services for indigenous people of northern Ontario.

Ward, J A

Arctic medical research

1991 Volume Suppl, Page(s) 256–260

Abstract: Inadequacies of three common models of mental health service delivery have been presented but each of these can contribute to an adequate system if the approach aims at the totality of mental health care. The key to service delivery and the provision of ... ...

Abstract	Inadequacies of three common models of mental health service delivery have been presented but each of these can contribute to an adequate system if the approach aims at the totality of mental health care. The key to service delivery and the provision of services in the local community by adequately trained and supervised mental health workers familiar with the culture and language and who are involved with other community workers in an inter-agency process. A major and the most important part of the work occurs in this level. This front line work must have the back-up and support of the system which has three roots. The clinical root is that of a support team of professionals, the local nursing station, hospital and the tertiary institutions. The second root is in training and education by recognized courses and other resources and the third in an adequate administration in which the indigenous population has been put in control.
MeSH term(s)	Adolescent ; Adult ; Community Mental Health Services ; Female ; Humans ; Indians, North American/psychology ; Male ; Mental Disorders/ethnology ; Mental Disorders/therapy ; Middle Aged ; Ontario
Language	English
Publishing date	1991
Publishing country	Finland
Document type	Journal Article
ZDB-ID	645088-x
ISSN	0782-226X
ISSN	0782-226X
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Article: Sanitation practices, depositional processes, and interpretive contexts of Minneapolis privies.

McCarthy, J P / Ward, J A

Historical archaeology

2007 Volume 34, Issue 1, Page(s) 111–129

MeSH term(s)	Archaeology/instrumentation ; Archaeology/methods ; Archaeology/standards ; History, 19th Century ; Minnesota ; Sanitation/classification ; Sanitation/history ; Sanitation/instrumentation ; Sanitation/methods ; Sanitation/trends
Language	English
Publishing date	2007-11-26
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	2050471-8
ISSN	2328-1103 ; 0440-9213
ISSN (online)	2328-1103
ISSN	0440-9213
DOI	10.1007/bf03373634
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