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  1. Book: Oxford textbook of neurorehabilitation

    Dietz, Volker / Ward, Nick

    (Oxford textbooks in clinical neurology)

    2020  

    Title variant Neurorehabilitation
    Author's details edited by Volker Dietz, Nick S. Ward
    Series title Oxford textbooks in clinical neurology
    Keywords Nervous system/Diseases/Patients/Rehabilitation
    Subject code 616.8043
    Language English
    Size xiv, 542 Seiten, Illustrationen, 28 cm
    Edition Second edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020543097
    ISBN 978-0-19-882495-4 ; 9780191863790 ; 0-19-882495-5 ; 0191863793
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1055 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book ; Online ; E-Book: Sepsis

    Ward, Nicholas S. / Levy, Mitchell M.

    definitions, pathophysiology and the challenge of bedside management

    (Respiratory medicine)

    2017  

    Author's details Nicholas S. Ward, Mitchell M. Levy editors
    Series title Respiratory medicine
    Keywords Acute renal failure ; Bundled therapy ; Coagulation system ; Hemodynamic support ; Hyper inflammation ; Organ failure
    Subject code 610
    Language English
    Size 1 Online-Ressource (xi, 271 Seite), Illustrationen, Diagramme
    Publisher Humana Press
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019412382
    ISBN 978-3-319-48470-9 ; 9783319484686 ; 3-319-48470-2 ; 3319484680
    DOI 10.1007/978-3-319-48470-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Integrative Research on Organic Matter Cycling Across Aquatic Gradients, 2nd Edition

    Ward, Nicholas D. / Bianchi, Thomas S. / Medeiros, Patricia M. / Seidel, Michael / Keil, Richard G. / Robinson, Carol

    2020  

    Keywords Science: general issues ; Oceanography (seas) ; Carbon ;  organic matter ;  river ;  estuarine ;  marine ;  atmosphere ;  dynamics ;  ecosystem ;  interface ;  transition
    Size 1 electronic resource (203 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231575
    ISBN 9782889661541 ; 2889661547
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: Integrative Research on Organic Matter Cycling Across Aquatic Gradients

    G. Keil, Richard / Robinson, Carol / Seidel, Michael / M. Medeiros, Patricia / S. Bianchi, Thomas / Ward, Nicholas D.

    2017  

    Abstract: The goal of this research topic was to motivate innovative research that blurs traditional disciplinary and geographical boundaries. As the scientific community continues to gain momentum and knowledge about how the natural world functions, it is ... ...

    Abstract The goal of this research topic was to motivate innovative research that blurs traditional disciplinary and geographical boundaries. As the scientific community continues to gain momentum and knowledge about how the natural world functions, it is increasingly important that we recognize the interconnected nature of earth systems and embrace the complexities of ecosystem transitions. We are pleased to present this body of work, which embodies the spirit of research spanning across the terrestrial-aquatic continuum, from mountains to the sea. Sincerely, The Editors
    Keywords Science (General) ; Oceanography ; Physical geography
    Size 1 electronic resource (201 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020095917
    ISBN 9782889452125 ; 2889452123
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Can We Determine Optimal Dosing of Doctors in the ICU?

    Agarwal, Ankita / Ward, Nicholas S

    Critical care medicine

    2022  Volume 50, Issue 12, Page(s) 1831–1833

    MeSH term(s) Humans ; Physicians ; Intensive Care Units
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Initial diagnosis of extranodal NK/T-cell lymphoma in pericardial fluid with concomitant hemophagocytic lymphohistiocytosis (HLH).

    Khasawneh, Amani / McGuinness, Georgeann / Ward, Nicholas

    Journal of hematopathology

    2023  Volume 17, Issue 1, Page(s) 27–36

    Abstract: Extranasal natural killer/T-cell lymphoma arising in the heart is rare and typically presents with non-specific clinical symptoms, necessitating a biopsy for a definitive diagnosis. We report an unusual case of a 48-year-old male who initially presented ... ...

    Abstract Extranasal natural killer/T-cell lymphoma arising in the heart is rare and typically presents with non-specific clinical symptoms, necessitating a biopsy for a definitive diagnosis. We report an unusual case of a 48-year-old male who initially presented with chest pain and shortness of breath. Subsequent diagnosis via pericardial fluid analysis, including flow cytometry and immunohistochemical stains, revealed extranasal NK/T-cell lymphoma without sinonasal involvement. The analysis identified neoplastic lymphoid cells expressing CD2, cytoplasmic CD3, Epstein-Barr virus, and CD56 and exhibiting increased Ki-67 staining. Additionally, the patient developed hemophagocytosis lymphocytosis secondary to NK/T cell lymphoma. Treatment included an interleukin-1 receptor antagonist (anakinra), dexamethasone, rituximab, and etoposide. Unfortunately, the patient's condition rapidly deteriorated, leading to multiorgan failure and eventual demise. Given the rarity of this lymphoma, early diagnosis based on a high suspicion level provides the best chance for improved overall survival.
    MeSH term(s) Male ; Humans ; Middle Aged ; Pericardial Fluid ; Epstein-Barr Virus Infections ; Lymphohistiocytosis, Hemophagocytic/complications ; Herpesvirus 4, Human ; Pericardial Effusion/diagnosis ; Lymphoma, Extranodal NK-T-Cell/complications ; Interleukin 1 Receptor Antagonist Protein ; Lymphoma, T-Cell, Peripheral
    Chemical Substances Interleukin 1 Receptor Antagonist Protein
    Language English
    Publishing date 2023-12-26
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2438687-X
    ISSN 1865-5785 ; 1868-9256
    ISSN (online) 1865-5785
    ISSN 1868-9256
    DOI 10.1007/s12308-023-00572-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Erdheim-Chester Disease with BRAF V600E Mutation and a Concomitant Myeloid Malignancy Sharing NRAS and IDH2 Mutations.

    Prabhakaran, Nitya / Jour, George / Balar, Arjun / Ward, Nicholas

    Acta haematologica

    2023  Volume 146, Issue 3, Page(s) 245–251

    Abstract: Erdheim-Chester disease (ECD) is a rare clonal histiocytic process that is characterized by a foamy (xanthomatous) proliferation often associated with Touton giant cells. The diagnosis is often challenging and not exclusively a histologic diagnosis, as ... ...

    Abstract Erdheim-Chester disease (ECD) is a rare clonal histiocytic process that is characterized by a foamy (xanthomatous) proliferation often associated with Touton giant cells. The diagnosis is often challenging and not exclusively a histologic diagnosis, as it requires correlation with unique clinical, radiographic, and recently described molecular findings. Activating mutations involving the MAPK pathway including BRAF, ARAF, N/KRAS, and MEK are recurrent in the disease. However, it is increasingly being described that mutations associated with clonal hematopoiesis are also found in bone marrow specimens of patients with ECD, as well as higher frequency of overt concomitant myeloid malignancy including acute myeloid leukemia, myeloproliferative neoplasms, myelodysplastic syndromes, and mixed myeloproliferative neoplasms/myelodysplastic syndromes. Herein, we report a unique case of a patient presenting with BRAFV600E-positive ECD with peripheral blood findings consistent with a concurrent myeloid malignancy featuring co-occurrence of NRAS and IDH2 mutations.
    MeSH term(s) Humans ; Erdheim-Chester Disease/diagnosis ; Erdheim-Chester Disease/genetics ; Erdheim-Chester Disease/complications ; Proto-Oncogene Proteins B-raf/genetics ; Mutation ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics ; Myeloproliferative Disorders/complications ; Neoplasms/complications ; Myelodysplastic Syndromes/complications ; Membrane Proteins/genetics ; GTP Phosphohydrolases/genetics
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1) ; NRAS protein, human (EC 3.6.1.-) ; Membrane Proteins ; GTP Phosphohydrolases (EC 3.6.1.-)
    Language English
    Publishing date 2023-02-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000528550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.145: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Co-occurring rearrangements of

    Klairmont, Matthew M / Ward, Nicholas

    Leukemia & lymphoma

    2021  Volume 63, Issue 2, Page(s) 506–508

    MeSH term(s) Dual-Specificity Phosphatases/genetics ; Gene Rearrangement ; Humans ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Lymphoma, Large-Cell, Anaplastic/genetics ; Lymphoma, Large-Cell, Anaplastic/pathology ; Mitogen-Activated Protein Kinase Phosphatases/genetics ; Receptor Protein-Tyrosine Kinases ; Transcription Factors/genetics ; Tumor Suppressor Proteins/genetics
    Chemical Substances TP63 protein, human ; Transcription Factors ; Tumor Suppressor Proteins ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Mitogen-Activated Protein Kinase Phosphatases (EC 3.1.3.16) ; DUSP22 protein, human (EC 3.1.3.48) ; Dual-Specificity Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1984457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Community Support for Harm Reduction and Treatment of Opioid Use Disorder.

    Hanson, Bridget L / Finley, Kari / Otto, Jay / Ward, Nicholas J / Banik, Swagata

    Journal of community health

    2024  

    Abstract: As the opioid epidemic continues, availability of evidence-based strategies for harm reduction and treatment in communities is critical to reduce overdose and other consequences of opioid use disorder. Community members' support of harm reduction and ... ...

    Abstract As the opioid epidemic continues, availability of evidence-based strategies for harm reduction and treatment in communities is critical to reduce overdose and other consequences of opioid use disorder. Community members' support of harm reduction and treatment services is needed for new programs and to maintain existent programs. This study sought to understand beliefs and attitudes associated with support for three community-based strategies to address opioid misuse and addiction: naloxone, needle exchange, and medication-assisted treatment. We conducted a cross-sectional online survey with 545 adults. Results of the survey showed that participants supported all three strategies, with the strongest support for medication-assisted treatment. Multiple regression showed that stigma and perceived stigma were significant predictors for all three strategies, with inverse relationships. Stigmatizing beliefs predicted less support while perceiving stigma among others was associated with greater support for the strategies. Normative beliefs also significantly predicted support for all three strategies, such that stronger belief that others were supportive of each strategy was associated with greater support for that strategy. Other predictors varied across the three strategies. Support for harm reduction and treatment programs in communities affected by the opioid epidemic may be bolstered by reducing stigma and increasing normative beliefs. Stronger support for medication-assisted treatment may be leveraged and extended to harm reduction strategies. Results of our study contribute insights for bolstering community support for harm reduction and treatment, which is vital for adoption and maintenance of these important programs.
    Language English
    Publishing date 2024-02-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 426631-6
    ISSN 1573-3610 ; 0094-5145
    ISSN (online) 1573-3610
    ISSN 0094-5145
    DOI 10.1007/s10900-023-01278-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1386: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Large granular lymphocytic leukemia cured by allogeneic stem cell transplant: a case report.

    Carey, Edward / Ward, Nicholas / Abdul-Hay, Maher

    Journal of medical case reports

    2022  Volume 16, Issue 1, Page(s) 227

    Abstract: Background: Large granular lymphocytic leukemia is a rare lymphocytic neoplasm that can pose a treatment challenge in patients with severe neutropenia in whom conventional therapies fail. We report one of the first cases in which allogeneic stem cell ... ...

    Abstract Background: Large granular lymphocytic leukemia is a rare lymphocytic neoplasm that can pose a treatment challenge in patients with severe neutropenia in whom conventional therapies fail. We report one of the first cases in which allogeneic stem cell therapy was used as treatment for large granular lymphocytic leukemia. We report and discuss the case of a 42-year-old white Caucasian female who, despite multiple therapies including methotrexate, cyclophosphamide, prednisone, cyclosporine, and pentostatin, continued to show severe neutropenia and recurrent infections. The patient was treated successfully and cured by allogeneic stem cell transplant without any major complications.
    Conclusions: The significant importance of this case report is the introduction of a new treatment algorithm for challenging cases of T-cell large granular lymphocytic leukemia in which standard care fails. We hope that this case report will raise awareness of the potential benefits of allogeneic stem cell transplant in the treatment of aggressive forms of T-cell large granular lymphocytic leukemia.
    MeSH term(s) Adult ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Large Granular Lymphocytic/therapy ; Neutropenia/complications ; Neutropenia/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2022-06-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-022-03447-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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