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Article: New vistas in anti-inflammatory therapy.

Wardle, N

2001 Volume 88, Issue 4, Page(s) 289–295

MeSH term(s)	Animals ; Anti-Inflammatory Agents/immunology ; Anti-Inflammatory Agents/therapeutic use ; Humans ; Hydroxyeicosatetraenoic Acids/therapeutic use ; Interleukins/therapeutic use ; Leukotrienes/therapeutic use ; Lipoxins ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Hydroxyeicosatetraenoic Acids ; Interleukins ; Leukotrienes ; Lipoxins ; NF-kappa B ; lipoxin A4
Language	English
Publishing date	2001-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	207121-6
ISSN	1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
ISSN (online)	1423-0186 ; 2235-3186
ISSN	1660-8151 ; 0028-2766
DOI	10.1159/000046011
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Article ; Online: Oxidized zirconium versus cobalt-chrome femoral heads in total hip arthroplasty: a multicentre prospective randomized controlled trial with ten years' follow-up.

Kayani, Babar / Baawa-Ameyaw, Joanna / Fontalis, Andreas / Tahmassebi, Jenni / Wardle, Nick / Middleton, Robert / Stephen, Arthur / Hutchinson, James / Haddad, Fares S

The bone & joint journal

2022 Volume 104-B, Issue 7, Page(s) 833–843

Abstract: Aims: This study reports the ten-year wear rates, incidence of osteolysis, clinical outcomes, and complications of a multicentre randomized controlled trial comparing oxidized zirconium (OxZr) versus cobalt-chrome (CoCr) femoral heads with ultra-high ... ...

Abstract	Aims: This study reports the ten-year wear rates, incidence of osteolysis, clinical outcomes, and complications of a multicentre randomized controlled trial comparing oxidized zirconium (OxZr) versus cobalt-chrome (CoCr) femoral heads with ultra-high molecular weight polyethylene (UHMWPE) and highly cross-linked polyethylene (XLPE) liners in total hip arthroplasty (THA). Methods: Patients undergoing primary THA were recruited from four institutions and prospectively allocated to the following treatment groups: Group A, CoCr femoral head with XLPE liner; Group B, OxZr femoral head with XLPE liner; and Group C, OxZr femoral head with UHMWPE liner. All study patients and assessors recording outcomes were blinded to the treatment groups. The outcomes of 262 study patients were analyzed at ten years' follow-up. Results: Patients in Group C were associated with increased mean liner wear rates compared to patients in Group A (0.133 mm/yr (SD 0.21) vs 0.031 mm/yr (SD 0.07), respectively; p < 0.001) and Group B (0.133 mm/yr (SD 0.21) vs 0.022 mm/yr (SD 0.05), respectively; p < 0.001) at ten years' follow-up. Patients in Group C were also associated with increased risk of osteolysis and aseptic loosening requiring revision surgery, compared with patients in Group A (7/133 vs 0/133, respectively; p = 0.007) and Group B (7/133 vs 0/135, respectively; p = 0.007). There was a non-statistically significant trend towards increased mean liner wear rates in Group A compared with Group B (0.031 mm/yr (SD 0.07) vs 0.022 mm/yr (SD 0.05), respectively; p = 0.128). All three groups were statistically comparable preoperatively and at ten years' follow-up when measuring normalized Western Ontario and McMaster Universities Osteoarthritis Index (p = 0.410), 36-Item Short Form Health Survey (p = 0.465 mental, p = 0.713 physical), and pain scale scores (p = 0.451). Conclusion: The use of UHMWPE was associated with progressively increased annual liner wear rates after THA compared to XLPE. At ten years' follow-up, the group receiving UHMWPE demonstrated an increased incidence of osteolysis and aseptic loosening requiring revision surgery compared to XLPE. Femoral heads composed of OxZr were associated with trend towards reduced wear rates compared to CoCr, but this did not reach statistical significance and did not translate to any differences in osteolysis, functional outcomes, or revision surgery between the two femoral head components. Cite this article:
MeSH term(s)	Arthroplasty, Replacement, Hip/adverse effects ; Chromium Alloys ; Cobalt ; Femur Head/surgery ; Follow-Up Studies ; Hip Prosthesis/adverse effects ; Humans ; Osteolysis/surgery ; Polyethylene ; Prospective Studies ; Prosthesis Design ; Prosthesis Failure ; Zirconium
Chemical Substances	Chromium Alloys ; Cobalt (3G0H8C9362) ; Polyethylene (9002-88-4) ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2022-07-01
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.104B7.BJJ-2021-1673.R1
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Article: Glomerulosclerosis: the final pathway is clarified, but can we deal with the triggers?

Wardle, N

Nephron

1996 Volume 73, Issue 1, Page(s) 1–7

MeSH term(s)	Glomerulonephritis/etiology ; Glomerulonephritis/metabolism ; Glomerulonephritis/physiopathology ; Glomerulosclerosis, Focal Segmental/etiology ; Glomerulosclerosis, Focal Segmental/metabolism ; Glomerulosclerosis, Focal Segmental/physiopathology ; Humans ; Transforming Growth Factor beta/physiology
Chemical Substances	Transforming Growth Factor beta
Language	English
Publishing date	1996
Publishing country	Switzerland
Document type	Editorial ; Review
ZDB-ID	207121-6
ISSN	1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
ISSN (online)	1423-0186 ; 2235-3186
ISSN	1660-8151 ; 0028-2766
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Zs.A 169: Show issues

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Article: Minimal-change nephropathy: how does the immune system affect the glomerulus.

Wardle, N

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

1993 Volume 8, Issue 8, Page(s) 787

MeSH term(s)	Cytokines/immunology ; Humans ; Mast Cells/immunology ; Nephrosis, Lipoid/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	1993
Publishing country	England
Document type	Letter
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/8.8.787
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

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Article ; Online: Statistical techniques to estimate the SARS-CoV-2 infection fatality rate

Mieskolainen, Mikael / Bainbridge, Robert / Buchmueller, Oliver / Lyons, Louis / Wardle, Nicholas

medRxiv

Abstract: The determination of the infection fatality rate (IFR) for the novel SARS-CoV-2 coronavirus is a key aim for many of the field studies that are currently being undertaken in response to the pandemic. The IFR together with the basic reproduction number R0, ...

Abstract	The determination of the infection fatality rate (IFR) for the novel SARS-CoV-2 coronavirus is a key aim for many of the field studies that are currently being undertaken in response to the pandemic. The IFR together with the basic reproduction number R0, are the main epidemic parameters describing severity and transmissibility of the virus, respectively. The IFR can be also used as a basis for estimating and monitoring the number of infected individuals in a population, which may be subsequently used to inform policy decisions relating to public health interventions and lockdown strategies. The interpretation of IFR measurements requires the calculation of confidence intervals. We present a number of statistical methods that are relevant in this context and develop an inverse problem formulation to determine correction factors to mitigate time-dependent effects that can lead to biased IFR estimates. We also review a number of methods to combine IFR estimates from multiple independent studies, provide example calculations throughout this note and conclude with a summary and "best practice" recommendations. The developed code is available online.
Keywords	covid19
Language	English
Publishing date	2020-11-22
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.11.19.20235036
Database	COVID19

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Article ; Online: Proximal anterior cruciate ligament avulsion treated with TightRope® fixation device.

Wardle, N S / Haddad, F S

Annals of the Royal College of Surgeons of England

2012 Volume 94, Issue 2, Page(s) e96–8

Abstract: Anterior cruciate ligament injury is an uncommon finding in children but when it does occur it is usually a result of tibial avulsion or, less commonly, a midsubstance tear. It is generally agreed that surgical fixation is a necessity. We present a case ... ...

Abstract	Anterior cruciate ligament injury is an uncommon finding in children but when it does occur it is usually a result of tibial avulsion or, less commonly, a midsubstance tear. It is generally agreed that surgical fixation is a necessity. We present a case of proximal anterior cruciate ligament avulsion and a new method of fixation.
MeSH term(s)	Accidental Falls ; Anterior Cruciate Ligament/surgery ; Anterior Cruciate Ligament Injuries ; Anterior Cruciate Ligament Reconstruction/instrumentation ; Anterior Cruciate Ligament Reconstruction/methods ; Arthroscopy/instrumentation ; Arthroscopy/methods ; Child ; Female ; Humans ; Internal Fixators ; Magnetic Resonance Imaging ; Tibial Fractures/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2012-02-16
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/003588412X13171221589216
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Article: What is HUS and what is TTP?

Wardle, N

Nephron

1988 Volume 50, Issue 4, Page(s) 389

MeSH term(s)	Hemolytic-Uremic Syndrome/classification ; Hemolytic-Uremic Syndrome/diagnosis ; Hemolytic-Uremic Syndrome/immunology ; Humans ; Purpura, Thrombotic Thrombocytopenic/classification ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/immunology
Language	English
Publishing date	1988
Publishing country	Switzerland
Document type	Letter
ZDB-ID	207121-6
ISSN	1423-0186 ; 2235-3186 ; 1660-8151 ; 0028-2766
ISSN (online)	1423-0186 ; 2235-3186
ISSN	1660-8151 ; 0028-2766
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Zs.A 169: Show issues

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Article: Understanding leukotrienes.

Wardle, N

British journal of hospital medicine

1986 Volume 35, Issue 6, Page(s) 382, 384, 386–7

Abstract: The leukotrienes of white cells are powerful pharmacological mediators that are implicated in many immunological reactions. The most powerful effects (bronchoconstriction and mucus secretion) are seen in asthma. The circulatory effects are local, except ... ...

Abstract	The leukotrienes of white cells are powerful pharmacological mediators that are implicated in many immunological reactions. The most powerful effects (bronchoconstriction and mucus secretion) are seen in asthma. The circulatory effects are local, except perhaps in endotoxin shock. Apart from corticosteroids, there are as yet no inhibitors in use in therapeutics.
MeSH term(s)	Animals ; Asthma/physiopathology ; Humans ; Inflammation/physiopathology ; Leukotriene B4/antagonists & inhibitors ; Leukotriene B4/physiology ; Lipoxygenase/metabolism ; Lung/physiopathology ; Lymphocytes/metabolism ; Prostaglandin-Endoperoxide Synthases/pharmacology ; SRS-A/antagonists & inhibitors ; SRS-A/physiology
Chemical Substances	SRS-A ; Leukotriene B4 (1HGW4DR56D) ; Lipoxygenase (EC 1.13.11.12) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1)
Language	English
Publishing date	1986-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604230-2
ISSN	1759-7390 ; 0007-1064 ; 1462-3935 ; 1750-8460
ISSN (online)	1759-7390
ISSN	0007-1064 ; 1462-3935 ; 1750-8460
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Zs.A 651: Show issues

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Article: A self-administered questionnaire for basal osteoarthritis of the thumb.

Citron, N / Hulme, C E / Wardle, N

The Journal of hand surgery, European volume

2007 Volume 32, Issue 5, Page(s) 524–528

Abstract: Basal osteoarthritis of the thumb is a common condition for which numerous operations have been proposed without any particular one having been shown to be superior. One of the problems in evaluating the results of surgery is that there is no validated ... ...

Abstract	Basal osteoarthritis of the thumb is a common condition for which numerous operations have been proposed without any particular one having been shown to be superior. One of the problems in evaluating the results of surgery is that there is no validated outcome score specifically for the condition. The purpose of this study was to construct a self-administered questionnaire (the Nelson score) to assess the outcome following surgery for this condition and to test its properties. Correlating the questionnaire score with physical findings on clinical examination showed external validity and test-retest reliability was high. Simultaneous administration of the score with the DASH score, both before and after surgery, showed it to be more sensitive to change (P=0.056). In addition, it is shorter than the DASH score, which may make it more acceptable to patients.
MeSH term(s)	Activities of Daily Living ; Functional Laterality ; Hand Strength ; Humans ; Motor Skills ; Osteoarthritis/surgery ; Outcome and Process Assessment (Health Care)/statistics & numerical data ; Postoperative Complications/etiology ; Reproducibility of Results ; Surveys and Questionnaires
Language	English
Publishing date	2007-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2272801-6
ISSN	2043-6289 ; 1753-1934
ISSN (online)	2043-6289
ISSN	1753-1934
DOI	10.1016/J.JHSE.2007.03.015
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Article ; Online: Five-year comparison of wear using oxidised zirconium and cobalt-chrome femoral heads in total hip arthroplasty: a multicentre randomised controlled trial.

Jassim, S S / Patel, S / Wardle, N / Tahmassebi, J / Middleton, R / Shardlow, D L / Stephen, A / Hutchinson, J / Haddad, F S

The bone & joint journal

2015 Volume 97-B, Issue 7, Page(s) 883–889

Abstract: Oxidised zirconium (OxZi) has been developed as an alternative bearing surface for femoral heads in total hip arthroplasty (THA). This study has investigated polyethylene wear, functional outcomes and complications, comparing OxZi and cobalt-chrome (CoCr) ...

Abstract	Oxidised zirconium (OxZi) has been developed as an alternative bearing surface for femoral heads in total hip arthroplasty (THA). This study has investigated polyethylene wear, functional outcomes and complications, comparing OxZi and cobalt-chrome (CoCr) as part of a three-arm, multicentre randomised controlled trial. Patients undergoing THA from four institutions were prospectively randomised into three groups. Group A received a CoCr femoral head and highly cross-linked polyethylene (XLPE) liner; Group B received an OxZi femoral head and XLPE liner; Group C received an OxZi femoral head and ultra-high molecular weight polyethylene (UHMWPE) liner. At five years, 368 patients had no statistically significant differences in short-form-36 (p = 0.176 mental, p = 0.756 physical), Western Ontario and McMaster Universities Osteoarthritis Index (p = 0.847), pain scores (p = 0.458) or complications. The mean rate of linear wear was 0.028 mm/year (standard deviation (SD) 0.010) for Group A, 0.023 mm/year (SD 0.010) for Group B, and 0.09 mm/year (SD 0.045) for Group C. Penetration was significantly higher in the UHMWPE liner group compared with both XLPE liner groups (p < 0.001) but no significant difference was noted between CoCr and OxZi when articulating with XLPE (p = 0.153). In this, the largest randomised study of this bearing surface, it appears that using a XLPE acetabular liner is more important in reducing THA component wear than the choice of femoral head bearing, at mid-term follow-up. There is a non-significant trend towards lower wear, coupling OxZi rather than CoCr with XLPE but long-term analysis is required to see if this observation changes with time and becomes significant.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Hip ; Chromium Alloys ; Female ; Femur Head ; Hip Prosthesis ; Humans ; Male ; Materials Testing ; Middle Aged ; Polyethylene ; Polyethylenes ; Prospective Studies ; Prosthesis Design ; Time Factors ; Zirconium
Chemical Substances	Chromium Alloys ; Polyethylenes ; ultra-high molecular weight polyethylene ; Polyethylene (9002-88-4) ; Zirconium (C6V6S92N3C)
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.97B7.35285
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