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  1. Article ; Online: The dilemma of epilepsy diagnosis in Pakistan.

    Waris, Abdul / Asim, Muhammad / Ullah, Ata

    Diagnosis (Berlin, Germany)

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country Germany
    Document type Letter
    ISSN 2194-802X
    ISSN (online) 2194-802X
    DOI 10.1515/dx-2024-0037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Various pharmacological agents in the pipeline against intractable epilepsy.

    Waris, Abdul / Asim, Muhammad / Ullah, Ata / Alhumaydhi, Fahad A

    Archiv der Pharmazie

    2024  , Page(s) e2400229

    Abstract: Epilepsy is a noncommunicable chronic neurological disorder affecting people of all ages, with the highest prevalence in low and middle-income countries. Despite the pharmacological armamentarium, the plethora of drugs in the market, and other treatment ... ...

    Abstract Epilepsy is a noncommunicable chronic neurological disorder affecting people of all ages, with the highest prevalence in low and middle-income countries. Despite the pharmacological armamentarium, the plethora of drugs in the market, and other treatment options, 30%-35% of individuals still show resistance to the current medication, termed intractable epilepsy/drug resistance epilepsy, which contributes to 50% of the mortalities due to epilepsy. Therefore, the development of new drugs and agents is needed to manage this devastating epilepsy. We reviewed the pipeline of drugs in "ClinicalTrials. gov," which is the federal registry of clinical trials to identify drugs and other treatment options in various phases against intractable epilepsy. A total of 31 clinical trials were found regarding intractable epilepsy. Among them, 48.4% (15) are about pharmacological agents, of which 26.6% are in Phase 1, 60% are in Phase 2, and 13.3% are in Phase 3. The mechanism of action or targets of the majority of these agents are different and are more diversified than those of the approved drugs. In this article, we summarized various pharmacological agents in clinical trials, their backgrounds, targets, and mechanisms of action for the treatment of intractable epilepsy. Treatment options other than pharmacological ones, such as devices for brain stimulation, ketogenic diets, gene therapy, and others, are also summarized.
    Language English
    Publishing date 2024-05-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.202400229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The impact of hydro-biofuel-wind-solar energy consumption and coal consumption on carbon emission in G20 countries.

    Waris, Abdul / Khan, Sher / Hronec, Martin / Suplata, Marian

    Environmental science and pollution research international

    2023  Volume 30, Issue 28, Page(s) 72503–72513

    Abstract: Globally, as a renewable source of energy, biofuel, wind, solar, and hydro energy have been increasingly valued by a range of businesses. There is no denying the advantages of using renewable energy in terms of preventing climate change and protecting ... ...

    Abstract Globally, as a renewable source of energy, biofuel, wind, solar, and hydro energy have been increasingly valued by a range of businesses. There is no denying the advantages of using renewable energy in terms of preventing climate change and protecting the environment. Therefore, this article investigates the relationship among hydro, solar, biofuel, wind, coal consumption, and CO
    MeSH term(s) Wind ; Solar Energy ; Coal ; Biofuels ; Carbon Dioxide/analysis ; Renewable Energy ; Economic Development
    Chemical Substances Coal ; Biofuels ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-05-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-27442-y
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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Altered neurotransmission in stress-induced depressive disorders: The underlying role of the amygdala in depression.

    Asim, Muhammad / Wang, Huajie / Waris, Abdul

    Neuropeptides

    2023  Volume 98, Page(s) 102322

    Abstract: Depression is the second leading cause of disability in the world population, for which currently available pharmacological therapies either have poor efficacy or have some adverse effects. Accumulating evidence from clinical and preclinical studies ... ...

    Abstract Depression is the second leading cause of disability in the world population, for which currently available pharmacological therapies either have poor efficacy or have some adverse effects. Accumulating evidence from clinical and preclinical studies demonstrates that the amygdala is critically implicated in depressive disorders, though the underlying pathogenesis mechanism needs further investigation. In this literature review, we overviewed depression and the key role of Gamma-aminobutyric acid (GABA) and Glutamate neurotransmission in depression. Notably, we discussed a new cholecystokinin-dependent plastic changes mechanism under stress and a possible antidepressant response of cholecystokinin B receptor (CCKBR) antagonist. Moreover, we discussed the fundamental role of the amygdala in depression, to discuss and understand the pathophysiology of depression and the inclusive role of the amygdala in this devastating disorder.
    MeSH term(s) Humans ; Depression ; gamma-Aminobutyric Acid ; Synaptic Transmission ; Amygdala ; Cholecystokinin/pharmacology ; Depressive Disorder/drug therapy
    Chemical Substances gamma-Aminobutyric Acid (56-12-2) ; Cholecystokinin (9011-97-6)
    Language English
    Publishing date 2023-01-20
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 9048-7
    ISSN 1532-2785 ; 0143-4179
    ISSN (online) 1532-2785
    ISSN 0143-4179
    DOI 10.1016/j.npep.2023.102322
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1592: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Correlation of retinopathy of prematurity with oxygen saturation in preterm babies in a tertiary care center: A novel guide.

    Praveen, Shahjadi / Ali, Syed Manazir / Akhtar, Naheed / Waris, Abdul

    Oman journal of ophthalmology

    2023  Volume 16, Issue 3, Page(s) 583–584

    Language English
    Publishing date 2023-10-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2484272-2
    ISSN 0974-7842 ; 0974-620X
    ISSN (online) 0974-7842
    ISSN 0974-620X
    DOI 10.4103/ojo.ojo_64_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is the bell ringing for another outbreak of Crimean-Congo hemorrhagic fever in Pakistan?

    Waris, Abdul / Anwar, Faheem / Asim, Muhammad / Bibi, Farkhanda

    Public health in practice (Oxford, England)

    2022  Volume 4, Page(s) 100319

    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Journal Article
    ISSN 2666-5352
    ISSN (online) 2666-5352
    DOI 10.1016/j.puhip.2022.100319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?-a review.

    Ahuja, Pragya / Waris, Abdul / Siddiqui, Sheelu Shafiq / Mukherjee, Amit

    Journal, genetic engineering & biotechnology

    2022  Volume 20, Issue 1, Page(s) 17

    Abstract: Background: Diabetic retinopathy (DR) is a common microvascular complication of diabetes. There is strong evidence suggesting that DR has an inheritable component. The interaction between advanced glycation end products (AGEs) and their receptor is ... ...

    Abstract Background: Diabetic retinopathy (DR) is a common microvascular complication of diabetes. There is strong evidence suggesting that DR has an inheritable component. The interaction between advanced glycation end products (AGEs) and their receptor is integral in the pathogenesis of diabetic retinopathy and its various complications, retinopathy being one of them.
    Overview and methodology: This review discusses the existing literature on the association between single nucleotide variants (SNV) of AGER gene and the risk of DR. It also discusses the current understanding of the AGE-AGER pathway in diabetic retinopathy. Through our article we have tried to consolidate all the available information about these SNVs associated with diabetic retinopathy in a succinct tabular form. Additionally, a current understanding of the AGE-AGER interaction and its deleterious effects on the cells of the retina has been discussed in detail to provide comprehensive information about the topic to the reader. A literature review was performed on PubMed, Cochrane Library, and Google Scholar for studies to find existing literature on the association between AGER gene SNVs and the risk, progression and severity of developing DR. This article will encourage scientific communication and discussion about possibly devising genetic markers for an important cause of blindness both in developed and developing countries, i.e., diabetic retinopathy.
    Result: Based on genetic studies done in Indian and Chinese population G82S(rs2070600) was positively associated with Diabetic Retinopathy. Patients of diabetic retinopathy in Caucasian population had -T374A(rs1800624) polymorphism. + 20T/A was found to be associated with the disease in a study done in UK. Association with G1704T(rs184003) was seen in Chinese and Malaysian population. A Chinese study found its association with CYB242T. -T429C(rs1800625) SNV was not associated with DR in any of the studies. G2245A(rs55640627) was positively associated with the disease process in Malaysian population. It was not associated in Malaysian and Chinese population. Promoter variant rs1051993 has also been found to a susceptible SNV in the Chinese population.
    Conclusion: While providing a comprehensive review of the existing information, we would like to emphasize on a large, multi-centric, trial with a much larger and varied population base to definitely determine these single nucleotide variants predisposing diabetic individuals.
    Language English
    Publishing date 2022-01-31
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2637420-1
    ISSN 2090-5920 ; 1687-157X ; 2090-5920
    ISSN (online) 2090-5920
    ISSN 1687-157X ; 2090-5920
    DOI 10.1186/s43141-022-00297-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Monkeypox virus: A sexual transmission and beyond.

    Waheed, Summaiya / Aziz, Shukrullah / Waris, Abdul / Jabbar, Abdul / Ullah, Irfan

    Journal of medical virology

    2022  Volume 95, Issue 1, Page(s) e28333

    MeSH term(s) Humans ; Monkeypox virus ; Mpox (monkeypox)/epidemiology ; Disease Outbreaks
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28333
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Bilateral serous retinal detachment: an unusual complication of HELLP syndrome.

    Haque, Obaid Imtiyazul / Waris, Abdul / Rizvi, Syed Asghar

    BMJ case reports

    2021  Volume 14, Issue 3

    Abstract: A 23-year-old primigravida presented to the emergency department with reports of headache. On examination, her blood pressure was found to be 190/140 mm Hg. Her laboratory results were notable for proteinuria, deranged liver function and low platelets. ... ...

    Abstract A 23-year-old primigravida presented to the emergency department with reports of headache. On examination, her blood pressure was found to be 190/140 mm Hg. Her laboratory results were notable for proteinuria, deranged liver function and low platelets. She was diagnosed with HELLP syndrome and was delivered via caesarean section. She noticed diminution of vision 2 days after delivery. Fundus examination revealed bilateral serous retinal detachment involving the maculae. She was managed conservatively and had complete recovery of her vision by 3 weeks postpartum.
    MeSH term(s) Adult ; Cesarean Section ; Female ; Fundus Oculi ; HELLP Syndrome/diagnosis ; Humans ; Postpartum Period ; Pregnancy ; Retinal Detachment/diagnosis ; Retinal Detachment/etiology ; Young Adult
    Language English
    Publishing date 2021-03-02
    Publishing country England
    Document type Journal Article ; Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-233282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The contemporary immunoassays for HIV diagnosis: a concise overview.

    Abdullah / Din, Misbahud / Waris, Abdul / Khan, Muddasir / Ali, Sajjad / Muhammad, Riaz / Salman, Muhammad

    Asian biomedicine : research, reviews and news

    2023  Volume 17, Issue 1, Page(s) 3–12

    Abstract: Recent advances in human immunodeficiency virus (HIV) diagnostics have improved the management of disease progression significantly, which have also boosted the efficacy of antiviral therapies. The detection of HIV at the earliest is very important. A ... ...

    Abstract Recent advances in human immunodeficiency virus (HIV) diagnostics have improved the management of disease progression significantly, which have also boosted the efficacy of antiviral therapies. The detection of HIV at the earliest is very important. A highly recognized and effective virological biomarker for acute HIV infections is p24 antigen. This brief overview is based on advances of HIV diagnosis while focusing on the latest HIV testing technologies including HIV-specific antigens detecting assays of both anti-HIV antibodies and p24 antigen. In addition to other emerging molecular diagnostics for acute HIV infection, the utilization of p24 antigen has been summarized. Moreover, it has been explained how these immunoassays have reduced the window period for detection of HIV in the acute stage of infection.
    Language English
    Publishing date 2023-08-07
    Publishing country Thailand
    Document type Journal Article ; Review
    ZDB-ID 2583850-7
    ISSN 1875-855X ; 1875-855X
    ISSN (online) 1875-855X
    ISSN 1875-855X
    DOI 10.2478/abm-2023-0038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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