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  1. Article ; Online: Inspiratory muscle strength is related to exertional dyspnoea in heart failure with preserved ejection fraction.

    Warner, Brit / Bruhn, Eric J / Olson, Thomas P / Bissen, Thomas G / Borlaug, Barry A / Smith, Joshua R

    European journal of heart failure

    2023  Volume 25, Issue 9, Page(s) 1716–1717

    MeSH term(s) Humans ; Stroke Volume/physiology ; Heart Failure/complications ; Muscle Strength ; Dyspnea/etiology
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Letter
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Higher Work of Breathing During Exercise in Heart Failure With Preserved Ejection Fraction.

    Villarraga, Nicolas / Warner, Brit / Bruhn, Eric J / Hammer, Shane M / Bissen, Thomas G / Olson, Thomas P / Smith, Joshua R

    Chest

    2022  Volume 163, Issue 6, Page(s) 1492–1505

    Abstract: Background: It is unknown if pulmonary alterations in heart failure with preserved ejection fraction (HFpEF) impact respiratory mechanics during exercise.: Research question: Are the operating lung volumes, work of breathing (Wb), and power of ... ...

    Abstract Background: It is unknown if pulmonary alterations in heart failure with preserved ejection fraction (HFpEF) impact respiratory mechanics during exercise.
    Research question: Are the operating lung volumes, work of breathing (Wb), and power of breathing (Pb) abnormal in patients with HFpEF during exercise?
    Study design and methods: Patients with HFpEF (n = 8; median age, 71 years [interquartile range (IQR), 66-80 years]) and control participants (n = 9; median age, 68 years [IQR, 64-74 years]) performed incremental cycling to volitional exhaustion. Esophageal pressure, end-expiratory lung volume (EELV), inspiratory lung volume (EILV), and ventilatory variables were compared at similar absolute (30 and 50 L/min) and relative (45% of peak, 70% of peak, and 100% of peak) minute ventilation (V.
    Results: During exercise, EELVs were not different between patients with HFpEF and control participants (P > .13 for all). EILVs were lower in patients with HFpEF than control participants at 45% and 70% V.
    Interpretation: These data demonstrate the HFpEF syndrome is associated with pulmonary alterations eliciting a greater Pb during exercise resulting from greater inspiratory and expiratory resistive Pb.
    MeSH term(s) Humans ; Aged ; Work of Breathing ; Heart Failure ; Stroke Volume ; Lead ; Respiration ; Exercise Test ; Exercise Tolerance
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.11.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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