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  1. Article ; Online: Comment on: "A Transatlantic Viewpoint on the Role of Pallidal Stimulation for Parkinson's Disease".

    Xie, Tao / Warnke, Peter C

    Movement disorders : official journal of the Movement Disorder Society

    2024  Volume 39, Issue 4, Page(s) 760–761

    MeSH term(s) Humans ; Parkinson Disease/therapy ; Deep Brain Stimulation/methods ; Globus Pallidus/physiology
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Letter
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epilepsy surgery at its best: randomised prospective controlled trials in neurosurgery are no magic.

    Warnke, Peter C

    Journal of neurology, neurosurgery, and psychiatry

    2018  Volume 90, Issue 3, Page(s) 249

    MeSH term(s) Epilepsy/surgery ; Epilepsy, Temporal Lobe ; Humans ; Neurosurgery ; Neurosurgical Procedures ; Prospective Studies
    Language English
    Publishing date 2018-10-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2017-317683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Commentary: Cystic Craniopharyngiomas: Microsurgical or Stereotactic Treatment?

    Warnke, Peter C

    Neurosurgery

    2017  Volume 80, Issue 5, Page(s) 744–745

    MeSH term(s) Craniopharyngioma ; Humans ; Imaging, Three-Dimensional ; Pituitary Neoplasms
    Language English
    Publishing date 2017-03-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyx031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cognitive outcomes in patients with essential tremor treated with deep brain stimulation: a systematic review.

    Al Ali, Jamal / Lacy, Maureen / Padmanaban, Mahesh / Abou Chaar, Widad / Hagy, Hannah / Warnke, Peter C / Xie, Tao

    Frontiers in human neuroscience

    2024  Volume 18, Page(s) 1319520

    Abstract: Introduction: Essential tremor (ET) is a common neurological disease. Deep brain stimulation (DBS) to the thalamic ventral intermediate nucleus (VIM) or the adjacent structures, such as caudal zona incerta/ posterior subthalamic area (cZi/PSA), can be ... ...

    Abstract Introduction: Essential tremor (ET) is a common neurological disease. Deep brain stimulation (DBS) to the thalamic ventral intermediate nucleus (VIM) or the adjacent structures, such as caudal zona incerta/ posterior subthalamic area (cZi/PSA), can be effective in treating medication refractory tremor. However, it is not clear whether DBS can cause cognitive changes, in which domain, and to what extent if so.
    Methods: We systematically searched PubMed and the Web of Science for available publications reporting on cognitive outcomes in patients with ET who underwent DBS following the PICO (population, intervention, comparators, and outcomes) concept. The PRISMA guideline for systematic reviews was applied.
    Results: Twenty relevant articles were finally identified and included for review, thirteen of which were prospective (one also randomized) studies and seven were retrospective. Cognitive outcomes included attention, memory, executive function, language, visuospatial function, and mood-related variables. VIM and cZi/PSA DBS were generally well tolerated, although verbal fluency and language production were affected in some patients. Additionally, left-sided VIM DBS was associated with negative effects on verbal abstraction, word recall, and verbal memory performance in some patients.
    Conclusion: Significant cognitive decline after VIM or cZi/PSA DBS in ET patients appears to be rare. Future prospective randomized controlled trials are needed to meticulously study the effect of the location, laterality, and stimulation parameters of the active contacts on cognitive outcomes while considering possible medication change post-DBS, timing, standard neuropsychological battery, practice effects, the timing of assessment, and effect size as potential confounders.
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2024.1319520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Technical note: accuracy and precision in stereotactic stem cell transplantation.

    Satzer, David / Warnke, Peter C

    Acta neurochirurgica

    2019  Volume 161, Issue 10, Page(s) 2059–2064

    Abstract: Background: While multiple trials have employed stereotactic stem cell transplantation, injection techniques have received little critical attention. Precise cell delivery is critical for certain applications, particularly when targeting deep nuclei.: ...

    Abstract Background: While multiple trials have employed stereotactic stem cell transplantation, injection techniques have received little critical attention. Precise cell delivery is critical for certain applications, particularly when targeting deep nuclei.
    Methods: Ten patients with a history of ischemic stroke underwent CT-guided stem cell transplantation. Cells were delivered along 3 tracts adjacent to the infarcted area. Intraoperative air deposits and postoperative T2-weighted MRI fluid signals were mapped in relation to calculated targets.
    Results: The deepest air deposit was found 4.5 ± 1.0 mm (mean ± 2 SEM) from target. The apex of the T2-hyperintense tract was found 2.8 ± 0.8 mm from target. On average, air pockets were found anterior (1.2 ± 1.1 mm, p = 0.04) and superior (2.4 ± 1.0 mm, p < 0.001) to the target; no directional bias was noted for the apex of the T2-hyperintense tract. Location and distribution of air deposits were variable and were affected by the relationship of cannula trajectory to stroke cavity.
    Conclusions: Precise stereotactic cell transplantation is a little-studied technical challenge. Reflux of cell suspension and air, and the structure of the injection tract affect delivery of cell suspensions. Intraoperative CT allows assessment of delivery and potential trajectory correction.
    MeSH term(s) Basal Ganglia/diagnostic imaging ; Basal Ganglia/surgery ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neuronavigation/adverse effects ; Neuronavigation/methods ; Neuronavigation/standards ; Postoperative Complications/etiology ; Stem Cell Transplantation/adverse effects ; Stem Cell Transplantation/methods ; Stem Cell Transplantation/standards
    Language English
    Publishing date 2019-07-04
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-019-03964-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Extent of parahippocampal ablation is associated with seizure freedom after laser amygdalohippocampotomy.

    Satzer, David / Tao, James X / Warnke, Peter C

    Journal of neurosurgery

    2021  Volume 135, Issue 6, Page(s) 1742–1751

    Abstract: Objective: The authors aimed to examine the relationship between mesial temporal subregion ablation volume and seizure outcome in a diverse cohort of patients who underwent stereotactic laser amygdalohippocampotomy (SLAH) for mesial temporal lobe ... ...

    Abstract Objective: The authors aimed to examine the relationship between mesial temporal subregion ablation volume and seizure outcome in a diverse cohort of patients who underwent stereotactic laser amygdalohippocampotomy (SLAH) for mesial temporal lobe epilepsy (MTLE).
    Methods: Seizure outcomes and pre- and postoperative images were retrospectively reviewed in patients with MTLE who underwent SLAH at a single institution. Mesial temporal subregions and the contrast-enhancing ablation volume were manually segmented. Pre- and postoperative MR images were coregistered to assess anatomical ablation. Postoperative MRI and ablation volumes were also spatially normalized, enabling the assessment of seizure outcome with heat maps.
    Results: Twenty-eight patients with MTLE underwent SLAH, 15 of whom had mesial temporal sclerosis (MTS). The rate of Engel class I outcome at 1 year after SLAH was 39% overall: 47% in patients with MTS and 31% in patients without MTS. The percentage of parahippocampal gyrus (PHG) ablated was higher in patients with an Engel class I outcome (40% vs 25%, p = 0.04). Subregion analysis revealed that extent of ablation in the parahippocampal cortex (35% vs 19%, p = 0.03) and angular bundle (64% vs 43%, p = 0.02) was positively associated with Engel class I outcome. The degree of amygdalohippocampal complex (AHC) ablated was not associated with seizure outcome (p = 0.30).
    Conclusions: Although the AHC was the described target of SLAH, seizure outcome in this cohort was associated with degree of ablation for the PHG, not the AHC. Complete coverage of both the AHC and PHG is technically challenging, and more work is needed to optimize seizure outcome after SLAH.
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2020.11.JNS203261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Increased apathy post-interstitial laser capsulotomy for refractory obsessive-compulsive disorder.

    Hagy, Hannah A / Lacy, Maureen / Turchmanovych-Hienkel, Nataliya / Grant, Jon E / Biro, Daniel / Warnke, Peter C

    Journal of neurology, neurosurgery, and psychiatry

    2024  

    Abstract: Background: MRI guided laser interstitial thermal therapy (M-LITT) capsulotomy has proven to be efficacious in decreasing refractory obsessive-compulsive disorder (OCD) related symptomatology yet capsulotomy either via radiosurgery or radiofrequency ... ...

    Abstract Background: MRI guided laser interstitial thermal therapy (M-LITT) capsulotomy has proven to be efficacious in decreasing refractory obsessive-compulsive disorder (OCD) related symptomatology yet capsulotomy either via radiosurgery or radiofrequency ablation has in some patients led to increased apathy following surgery. The current case series aims to investigate objective patient-reported change in apathy, disinhibition, depression, and executive dysfunction following anterior capsulotomy via M-LITT for OCD.
    Methods: Ten consecutive patients pre- and post-M-LITT completed measures of OCD, apathy, disinhibition, executive dysfunction, and depression (M
    Results: Positive post-surgical change was noted in OCD symptomatology with >65% reporting a partial or full response. However, six patients endorsed increased apathy with half of the non-responders (e.g., less than <24% score reduction on Y-BOCS) reporting increases in apathy. Patients reported relatively stable disinhibition and executive dysfunction, while over half reported a decrease in depression symptoms. Two of the non-responders and one responder endorsed increased apathy despite stable or improved depression symptoms, disinhibition, and executive dysfunction.
    Conclusions: Most patients in the current cohort achieved full-or-partial OCD recovery. Yet, 60% of patients also reported significant increases in apathy, despite experiencing a decrease in depression symptoms, with stable disinhibition and executive dysfunction. Despite these promising improvements in OCD symptomatology following M-LITT, further investigations of the impact of surgery and lesion location on apathy levels is clearly warranted using objective, quantifiable methods.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2023-333117
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  8. Article ; Online: Tailored Hemispherotomy Using Tractography-Guided Laser Interstitial Thermal Therapy.

    Mendoza-Elias, Nasya / Satzer, David / Henry, Julia / Nordli, Douglas R / Warnke, Peter C

    Operative neurosurgery (Hagerstown, Md.)

    2023  Volume 24, Issue 6, Page(s) e407–e413

    Abstract: Background: Medically refractory hemispheric epilepsy is a devastating disease with significant lifetime costs and social burden. Functional hemispherotomy is a highly effective treatment for hemispheric epilepsy but is associated with significant ... ...

    Abstract Background: Medically refractory hemispheric epilepsy is a devastating disease with significant lifetime costs and social burden. Functional hemispherotomy is a highly effective treatment for hemispheric epilepsy but is associated with significant complication rates. Percutaneous hemispherotomy through laser interstitial thermal therapy (LITT) based on morphological MRI has been recently described in a single patient but not replicated in the literature.
    Objective: To describe the first 2 cases of tractography-guided interstitial laser hemispherotomy and their short-term outcomes.
    Methods: Two 11-year-old male patients with medically refractory epilepsy secondary to perinatal large vessel infarcts were referred for hemispherotomy. Both patients underwent multitrajectory LITT to disconnect the remaining pathological hemisphere, using tractography to define targets and assess structural outcomes.
    Results: Both cases had minor complication of small intraventricular/subarachnoid hemorrhage not requiring additional intervention. Both patients remain seizure-free at all follow-up visits.
    Conclusion: LITT hemispherotomy can produce seizure freedom with short hospitalization and recovery. Tractography allows surgical planning to be tailored according to individual patient anatomy, which often is distorted in perinatal stroke. Minimally invasive procedures offer the greatest potential for seizure freedom without the risks of an open hemispherotomy.
    MeSH term(s) Male ; Humans ; Epilepsy/surgery ; Treatment Outcome ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/surgery ; Magnetic Resonance Imaging/methods ; Stroke ; Cerebral Hemorrhage
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2767575-0
    ISSN 2332-4260 ; 2332-4252
    ISSN (online) 2332-4260
    ISSN 2332-4252
    DOI 10.1227/ons.0000000000000650
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  9. Article ; Online: Deep brain stimulation surgery under general anaesthesia with microelectrode recording: the best of both worlds or a little bit of everything?

    Warnke, Peter C

    Journal of neurology, neurosurgery, and psychiatry

    2014  Volume 85, Issue 10, Page(s) 1063

    MeSH term(s) Anesthesia, General/adverse effects ; Deep Brain Stimulation/methods ; Deep Sedation/adverse effects ; Female ; Humans ; Male ; Parkinson Disease/therapy ; Subthalamic Nucleus/physiology
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2014-307745
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  10. Article ; Online: Frame-Based Stereotactic Endoscopic Third Ventriculostomy-Toward Improved Precision and Minimizing Morbidities.

    Chen, Clark C / Freeman, David / Warnke, Peter C

    World neurosurgery

    2020  Volume 140, Page(s) e240–e246

    Abstract: Background: Endoscopic third ventriculostomy (ETV) is a widely accepted treatment for obstructive hydrocephalus. For most practitioners, this procedure will be performed without navigation guidance. Without such guidance, the complications associated ... ...

    Abstract Background: Endoscopic third ventriculostomy (ETV) is a widely accepted treatment for obstructive hydrocephalus. For most practitioners, this procedure will be performed without navigation guidance. Without such guidance, the complications associated with the procedure have ranged from 1% to 8%. We hypothesized that the discrepancy between the surface bony anatomy and internal cranial anatomy contributes to the morbidities associated with ETV. We tested this hypothesis by comparing the position of the entry point defined by the classic Kocher's point relative to the ideal entry point that would result in no manipulation of the endoscope defined by frame-based stereotaxis.
    Methods: The cranial computed tomography scan of 58 patients who had undergone frame-based stereotactic ETV was reformatted into 3-dimensional renderings. The location of this entry point was compared with the Kocher point, as determined by the external bony anatomy.
    Results: Overall, >70% of the burr holes that provided an ideal trajectory to the third ventricle were ≥0.5 cm from the Kocher point in both the sagittal and the coronal planes. Median deviations of 0.74 and 0.81 cm in the coronal (P < 0.01) and sagittal (P < 0.0001) planes were observed.
    Conclusion: The use of stereotactic endoscopic techniques increase the safety of third ventriculostomy by adding precision and reducing otherwise unnecessary surgical maneuvering.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Hydrocephalus/surgery ; Male ; Middle Aged ; Neuroendoscopy/methods ; Neuronavigation/methods ; Retrospective Studies ; Third Ventricle/surgery ; Ventriculostomy/methods
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.05.040
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