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  1. Article ; Online: Reconstitution of Golgi Biogenesis in Permeabilized Trypanosoma brucei Cells.

    Warren, Graham

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2557, Page(s) 53–60

    Abstract: The protozoan parasite, Trypanosoma brucei, offers a simple system to study the growth and duplication of the Golgi. Cell lines stably expressing a photoactivatable GFP attached to an endogenous Golgi protein are permeabilized using digitonin. ... ...

    Abstract The protozoan parasite, Trypanosoma brucei, offers a simple system to study the growth and duplication of the Golgi. Cell lines stably expressing a photoactivatable GFP attached to an endogenous Golgi protein are permeabilized using digitonin. Photoactivation followed by imaging can then be used to follow the formation of the new Golgi.
    MeSH term(s) Animals ; Trypanosoma brucei brucei/metabolism ; Golgi Apparatus/metabolism ; Digitonin/pharmacology ; Digitonin/metabolism ; Parasites/metabolism ; Protozoan Proteins/metabolism
    Chemical Substances Digitonin (KOO5CM684H) ; Protozoan Proteins
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2639-9_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acuity of Proprioceptive Localization Varies with Body Region.

    Darling, Warren G / Yem, Joshua

    Neuroscience

    2023  Volume 516, Page(s) 100–112

    Abstract: We accurately sense locations of objects touching various points on the body and, if they are irritants, make accurate rapid movements to remove them. Such movements require accurate proprioception of orientation and motion of the reaching limb and of ... ...

    Abstract We accurately sense locations of objects touching various points on the body and, if they are irritants, make accurate rapid movements to remove them. Such movements require accurate proprioception of orientation and motion of the reaching limb and of the target. However, it is unknown whether acuity of these sensations is similar for different points on the body. We investigated accuracy of comfortable speed reaching movements of the right index-tip by 10 subjects (five females) to touch 12 different body locations with and without vision with the body part stationary in different locations and moving in different directions. Reaching movements to points on the face/head and trunk had mean errors averaging less than 0.2 cm greater than under vision conditions. Mean errors for reaches to touch points on the left arm and digits were less accurate (p < 0.05), but average less than 1 cm relative to vision conditions. Mean errors for reaches to touch points on the left lower limb were least accurate (p < 0.05), with mean errors averaging 1.5-3.1 cm relative to movements made with vision. We conclude that there is high proprioceptive acuity for locations of points on axial structures and the left upper limb including the digits, which contrasts with previous reports of greatly distorted proprioceptive maps of the face/head and hand. Apparently low proprioceptive acuity for points on the leg may be task sensitive as many lower limb motor tasks can be performed accurately without vision.
    MeSH term(s) Female ; Humans ; Human Body ; Psychomotor Performance ; Proprioception ; Movement ; Hand
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2023.02.015
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    Zs.A 1215: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: The Therapeutic Treatment of Infected Tooth Root-Canals.

    Warren, G W

    The American journal of dental science

    2019  Volume 32, Issue 6, Page(s) 246–251

    Language English
    Publishing date 2019-02-12
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Physiognomical Significance of the Face and Teeth.

    Warren, G W

    The American journal of dental science

    2019  Volume 26, Issue 4, Page(s) 181–184

    Language English
    Publishing date 2019-02-12
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Present Status of Dental Knowledge in the Medical Profession.

    Warren, G W

    The American journal of dental science

    2019  Volume 28, Issue 7, Page(s) 307–311

    Language English
    Publishing date 2019-03-14
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Proprioceptive acuity for landmarks on the hand and digits.

    Darling, Warren G / Zuck, Bennett I / Mikhail, Lavena / Adhikari, Jharna

    Experimental brain research

    2024  Volume 242, Issue 2, Page(s) 491–503

    Abstract: Previous work using visually guided reaches to localize landmarks on a hidden hand has suggested that proprioceptive acuity for hand targets is low and representation of hand dimensions is highly distorted (e.g., hand width estimated to be 60% wider than ...

    Abstract Previous work using visually guided reaches to localize landmarks on a hidden hand has suggested that proprioceptive acuity for hand targets is low and representation of hand dimensions is highly distorted (e.g., hand width estimated to be 60% wider than actual hand width). We re-examined these issues using a pure proprioceptive task in which 20 blindfolded subjects reached in a single movement without terminal corrections to touch the right index-tip to landmarks of the left hand placed in various locations in 3D space. Subjects were also tested with vision allowed to estimate minimal errors. Based on previous reports of high proprioceptive acuity for some hand landmarks, we hypothesized that the proprioceptive representation of the hand was much less distorted than described previously and that errors were not correlated with target hand location. Mean distance errors in proprioceptively guided reaches to the landmarks averaged less than 3 cm and were only 0.5-1.3 cm larger than when vision was allowed. Errors were not correlated with hand location in most subjects. Distortions of hand width averaged less than 20% wider than actual width and were not correlated with hand location in most subjects. We conclude that relatively accurate proprioceptive awareness of locations of hand/digit structures and dimensions is available for use in control of hand movements, which are executed largely subconsciously. Studying acuity of proprioception using conscious perceptual tasks and involving vision may not provide accurate measures of proprioceptive acuity as used by the motor system.
    MeSH term(s) Humans ; Hand ; Upper Extremity ; Movement ; Proprioception ; Vision, Ocular ; Psychomotor Performance
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-023-06761-z
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    Zs.A 278: Show issues Location:
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  7. Article ; Online: Physiological responses of European sea bass (Dicentrarchus labrax) exposed to increased carbon dioxide and reduced seawater salinities.

    Caneos, Warren G / Shrivastava, Jyotsna / Ndugwa, Moses / De Boeck, Gudrun

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 496

    Abstract: Background: The iono- and osmoregulatory capacities of marine teleosts, such as European sea bass (Dicentrarchus labrax) are expected to be challenged by high carbon dioxide exposure, and the adverse effects of elevated CO: Methods: Following ... ...

    Abstract Background: The iono- and osmoregulatory capacities of marine teleosts, such as European sea bass (Dicentrarchus labrax) are expected to be challenged by high carbon dioxide exposure, and the adverse effects of elevated CO
    Methods: Following acclimation to different salinities for two weeks, fish were exposed to present-day (400 µatm) and future (1000 µatm) atmospheric CO
    Results: A transient but significant increase in the blood pH of exposed fish acclimated at 10 ppt (day 1) and 2.5 ppt (day 21) was observed possibly due to an overshoot of the blood HCO
    Conclusion: Juvenile sea bass were relatively successful in keeping acid base balance under an ocean acidification scenario. However, this came at a cost for ionoregulation with reduced NKA, NKCC and Rhbg expression rates as a consequence.
    MeSH term(s) Animals ; Bass/genetics ; Carbon Dioxide ; Ammonia ; Hydrogen-Ion Concentration ; Seawater ; Macaca mulatta ; Glycoproteins ; RNA, Messenger
    Chemical Substances Carbon Dioxide (142M471B3J) ; Ammonia (7664-41-7) ; Glycoproteins ; RNA, Messenger
    Language English
    Publishing date 2024-04-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-024-09460-2
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  8. Article ; Online: Advances in understanding the effects of in utero exposure to chemicals [version 1; peer review

    Warren G. Foster

    F1000Research, Vol

    2 approved]

    2019  Volume 8

    Abstract: The uterine environment in which a foetus develops is critical to infant, child, and adult health. Adverse intra-uterine environments have been linked to increased risk for neurobehavioral disorders and metabolic and cardiovascular disease. Rapid cell ... ...

    Abstract The uterine environment in which a foetus develops is critical to infant, child, and adult health. Adverse intra-uterine environments have been linked to increased risk for neurobehavioral disorders and metabolic and cardiovascular disease. Rapid cell division, tissue growth, differentiation, and organization of major organs are all features rendering the developing foetus sensitive to insult from exogenous chemicals. Therefore, interest in measurement of developmental exposure to environmental chemicals during critical periods of foetal development has grown. However, determining the consequences of developmental exposure to toxic chemicals presents epidemiologists, toxicologists, and regulatory health authorities with numerous important challenges. Improvements in analytical methods have led to greater sensitivity and thus detection of chemical residues at far lower concentrations, yet the biological relevance of the documented exposure is often unknown and difficult to determine. Although the benefit of quantifying exposure during critical windows of development is well recognized, access to appropriate biological fluids at relevant periods of development continues to pose a challenge. Moreover, knowledge gaps in the toxicological data together with lack of mechanistic insight make interpretation difficult and challenge confidence in conclusions of the human health consequences. Herein, a brief overview of several important issues central to understanding the consequences of developmental exposure to environmental toxicants is considered.
    Keywords Medicine ; R ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Current endometriosis care and opportunities for improvement.

    Pickett, Charlotte / Foster, Warren G / Agarwal, Sanjay

    Reproduction & fertility

    2023  

    Abstract: Endometriosis is a chronic disease associated with debilitating pain that affects many people assigned female at birth, from menarche through menopause, not just causing pain and infertility, but also negatively impacting quality of life, participation ... ...

    Abstract Endometriosis is a chronic disease associated with debilitating pain that affects many people assigned female at birth, from menarche through menopause, not just causing pain and infertility, but also negatively impacting quality of life, participation in daily activities, productivity and income. It is associated with increased incidence of obstetric and neonatal complications, depression, other chronic diseases, and substantial healthcare costs. Despite the profound negative impact of endometriosis on quality of life, current treatment options remain sub-optimal and many patients express dissatisfaction with current care. The prevailing acute-care, single-provider model in which the provider works in relative isolation and thus with limited therapeutic strategies readily available, proves inadequate for treating endometriosis. Patients would benefit from earlier diagnosis and referral to a center capable of providing a comprehensive and multi-modal management plan that utilizes a chronic care model. Often this can only be achieved through multidisciplinary teams of providers with expertise in endometriosis. Researchers need to agree on standardized core outcome measures, relevant to patients with endometriosis and the healthcare system as a whole. Only through increased education and recognition of endometriosis as a chronic disease can we achieve better treatment outcomes.
    Language English
    Publishing date 2023-07-01
    Publishing country England
    Document type Journal Article
    ISSN 2633-8386
    ISSN (online) 2633-8386
    DOI 10.1530/RAF-22-0091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Satisfaction With Governmental Risk Communication Both Increases and Decreases COVID-19 Mitigation Behaviours.

    Evensen, Darrick / Warren, George / Bouder, Frederic

    International journal of public health

    2023  Volume 68, Page(s) 1604966

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics/prevention & control ; Europe/epidemiology ; Communication ; Personal Satisfaction
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2023.1604966
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