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  1. Article: Correction: Carbimazole-Induced Agranulocytosis in a Previously Stable Patient: A Case Report and Literature Review.

    Khan, Zahid / Afifi, Waleed / Muhammad, Syed Aun / Warrier, Vinod

    Cureus

    2023  Volume 15, Issue 1, Page(s) c96

    Abstract: This corrects the article DOI: 10.7759/cureus.24115.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.24115.].
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c96
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Carbimazole-Induced Agranulocytosis in a Previously Stable Patient: A Case Report and Literature Review.

    Khan, Zahid / Afifi, Waleed / Muhammad, Syed Aun / Warrier, Vinod

    Cureus

    2022  Volume 14, Issue 4, Page(s) e24115

    Abstract: Carbimazole-induced agranulocytosis is a rare condition. A 48-year-old female patient with a history of hyperthyroidism for several years presented with generalized fatigue and chest pain associated with palpitations; the patient was stable on ... ...

    Abstract Carbimazole-induced agranulocytosis is a rare condition. A 48-year-old female patient with a history of hyperthyroidism for several years presented with generalized fatigue and chest pain associated with palpitations; the patient was stable on carbimazole therapy. She was previously on carbimazole 15 mg once daily (OD) and, three months later, was reduced to 10 mg OD as symptoms were controlled. She was taking propranolol, and it was stopped as she was not having any palpitations. This time, however, she presented mainly with palpitations at night associated with chest pain and generalized fatigue ongoing for the last one week. Her laboratory results showed agranulocytosis with reduced white cell count and neutrophil count in the absence of any evidence of infection. Her carbimazole was stopped, and the patient was referred to ear, nose, and throat surgeons for consideration of thyroidectomy. The patient underwent subtotal thyroidectomy, and her symptoms resolved following surgery.
    Language English
    Publishing date 2022-04-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Subarachnoid Haemorrhage in a Patient With Suspected Infective Endocarditis in a District General Hospital: A Case Report-Based Literature Review.

    Khan, Zahid / Warrier, Vinod / Muhammad, SyedAun / Mckechnie, Charlie

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21602

    Abstract: We describe the case of a 70-year-old lady who presented to a district general hospital during an evening with fevers, feeling generally unwell. She was found to have weakness in her left upper limb and went on to have tonic-clonic seizures whilst in the ...

    Abstract We describe the case of a 70-year-old lady who presented to a district general hospital during an evening with fevers, feeling generally unwell. She was found to have weakness in her left upper limb and went on to have tonic-clonic seizures whilst in the Accident and Emergency Department. CT scan of the brain showed subarachnoid haemorrhage, in absence of headache, in the right frontal, superior parietal and left occipital regions. Her C-reactive protein level was elevated at 426 mg/L and her urine dip was normal. Chest radiograph showed small bilateral pleural effusions. In addition to the above-mentioned findings on clinical examination, she also had pansystolic murmur although did not have any other feature of infective endocarditis (IE). In view of the above findings, normal chest examination and no urinary symptoms, the decision was made to treat this as a case of IE empirically. She subsequently went into fast atrial fibrillation requiring direct current (DC) cardioversion and intensive care unit admission due to hypotension. The next day, echocardiography confirmed vegetations and blood cultures were positive for
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Resolution of Thyrotoxicosis-Associated Pulmonary Hypertension With Treatment of Thyrotoxicosis: A Case-Based Report and Literature Review.

    Khan, Zahid / Mlawa, Gideon / Bashir, Mahmood / Abumedian, Mohammed / Yousif, Saeed / Gupta, Animesh / Warrier, Vinod

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21304

    Abstract: We present a case of a 41-year-old Afro-Caribbean female, who was diagnosed with thyrotoxic Graves' disease. She had a past medical history of hypertension and was on amlodipine and valsartan. There was no significant family history of note. She ... ...

    Abstract We present a case of a 41-year-old Afro-Caribbean female, who was diagnosed with thyrotoxic Graves' disease. She had a past medical history of hypertension and was on amlodipine and valsartan. There was no significant family history of note. She initially presented to Emergency Department with palpitations and excessive sweating. Her thyroid-stimulating hormone was <0.02mu/L and free triiodothyronine (T3) 29.5pmol/L at the time of diagnosis. The thyroid peroxidase antibody test was negative. She was started on carbimazole 15mg once daily and propranolol 40mg twice daily. She remained non-compliant to treatment for over two years and missed most outpatient clinic appointments and her condition remained poorly controlled during this time period. She was re-admitted to the hospital after 18 months, with high output congestive cardiac failure. An echocardiogram showed pulmonary hypertension and her right ventricular systolic pressure was measured to be 70-75mmHg. She was started on Lugol's iodine 0.2mls three times daily, propranolol 40mg three times daily, cholestyramine 4 gram four times a day, propylthiouracil 100mg four times a day. After 3 weeks of treatment, she became euthyroid and her pulmonary hypertension improved dramatically with treatment. She underwent total thyroidectomy after a few weeks and biopsies confirmed the findings of Graves' disease.
    Language English
    Publishing date 2022-01-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Rare Case of Clopidogrel-Induced Migratory Polyarthritis in a Patient With Recent Myocardial Infarction.

    Khan, Zahid / Yousif, Yousif / Mohammed, Mohammed / Khan, Ayub / Afghan, Abdullah / Muhammad, Syed Aun / Warrier, Vinod / Gupta, Animesh

    Cureus

    2022  Volume 14, Issue 2, Page(s) e22042

    Abstract: Clopidogrel is an antiplatelet drug used for secondary prevention of myocardial infarction, and it is also used in patients with cerebrovascular ischemia. Patients with acute myocardial infarction tend to be on dual antiplatelet therapy for 12 months ... ...

    Abstract Clopidogrel is an antiplatelet drug used for secondary prevention of myocardial infarction, and it is also used in patients with cerebrovascular ischemia. Patients with acute myocardial infarction tend to be on dual antiplatelet therapy for 12 months followed by aspirin lifelong to prevent the risk of stent thrombosis. The most common side effects of clopidogrel are bleeding, neutropenia, and rash; however, arthritis is also one of the rare side effects. We present a case of a 53-year-old patient who had a recent myocardial infarction and was commenced on dual antiplatelet therapy in the form of aspirin and clopidogrel. He started to have severe joint pain, particularly in his knees and shoulders, and was not able to mobilize anymore only three weeks after starting the medications. His clopidogrel was stopped and the patient showed dramatic improvement within three to four days after discontinuation with complete resolution one week later.
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Case Report on the Incidental Diagnosis of a Left Atrial Myxoma in a Patient Presenting With Right Shoulder Pain and Inter-scapular Back Pain.

    Khan, Zahid / Yousif, Yousif / Abumedian, Mohammed / Ibekwe, Mildred / Warrier, Vinod / Muhammad, Syed Aun / Gupta, Animesh

    Cureus

    2022  Volume 14, Issue 3, Page(s) e23187

    Abstract: Primary cardiac tumors are rare, and myxoma is a rare benign primary cardiac tumor in adults, commonly found within the left atrium. The presentation can vary from patients being asymptomatic to pulmonary embolism or stroke. Smaller atrial myxomas are ... ...

    Abstract Primary cardiac tumors are rare, and myxoma is a rare benign primary cardiac tumor in adults, commonly found within the left atrium. The presentation can vary from patients being asymptomatic to pulmonary embolism or stroke. Smaller atrial myxomas are usually asymptomatic, however, larger ones can cause symptoms such as dyspnea, orthopnea, cough, peripheral edema, palpitations, and fatigue. We present a case report of a 72-year-old patient presenting with right shoulder pain and chest pain on breathing to the accident and emergency department. The patient was complaining of right shoulder pain for five days and pleuritic chest pain for the last 48 hours. Initial electrocardiogram showed normal sinus rhythm, however, repeat electrocardiograms showed atrial fibrillation. An echocardiogram showed a homogeneous, relatively round mass seen in the left atrium, close to the inter-atrial septum, and close to the roof of the left atrium, and the patient underwent surgical removal of the benign tumor.
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Clinical frailty score as an independent predictor of outcome in COVID-19 hospitalised patients.

    Koduri, Gouri / Gokaraju, Sriya / Darda, Maria / Warrier, Vinod / Duta, Irina / Hayes, Fiona / Sayed, Iman El / Noeman-Ahmed, Yasser

    European geriatric medicine

    2021  Volume 12, Issue 5, Page(s) 1065–1073

    Abstract: Purpose of the study: We explored potential predictive variables associated with outcomes using baseline clinical parameters of 500 hospitalised patients with COVID -19 in a single centre, UK.: Methods: Retrospective study collecting demographic and ... ...

    Abstract Purpose of the study: We explored potential predictive variables associated with outcomes using baseline clinical parameters of 500 hospitalised patients with COVID -19 in a single centre, UK.
    Methods: Retrospective study collecting demographic and clinical characteristics of patients admitted at Southend University Hospital from 20th February to 7th May 2020.
    Results: The mean age of the cohort admitted to hospital with Covid-19 was 69.4 and 58% were over 70. Comorbidities were more frequently observed in non-survivors, whose mean Clinical Frailty Scale was significantly higher (5 vs 3) than survivors, p < 0.001. In addition, mean C-reactive protein was significantly higher.
    Conclusion: Older and frailer patients with high inflammatory markers were at risk of poor outcomes. Integrated frailty and age-based risk stratification is essential, in addition to monitoring saturation /FiO2 ratio (SFR) and inflammatory markers throughout the disease course to allow for early intervention to improve patient outcomes. A frailty-based risk-stratification approach, rather than age may prove more valuable when considering interventions in patients with multiple comorbidities.
    MeSH term(s) COVID-19 ; Comorbidity ; Frailty/diagnosis ; Humans ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2556794-9
    ISSN 1878-7657 ; 1878-7649
    ISSN (online) 1878-7657
    ISSN 1878-7649
    DOI 10.1007/s41999-021-00508-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Digital necrosis with squamous cell carcinoma of the tonsil.

    Warrier, Vinod / Ahmad, Ali / Alshatti, Yaqoub / Jafar, Ali

    International medical case reports journal

    2016  Volume 9, Page(s) 159–162

    Abstract: Background: Digital necrosis is a rare phenomenon of paraneoplastic syndrome associated with squamous cell carcinoma of the tonsil. Since 1965, more than 70 cases have been reported worldwide in the literature.: Case report: A 54-year-old male smoker ...

    Abstract Background: Digital necrosis is a rare phenomenon of paraneoplastic syndrome associated with squamous cell carcinoma of the tonsil. Since 1965, more than 70 cases have been reported worldwide in the literature.
    Case report: A 54-year-old male smoker presented with Raynaud's phenomenon, proceeding to frank gangrene of the fingers. Working up the case finally pointed toward carcinoma of the tonsil as the underlying cause - a rare paraneoplastic manifestation.
    Conclusion: No definite etiology has been found to be the cause of Raynaud's phenomenon in this case of the squamous cell carcinoma of the tonsil. A brief discussion of the literature is also presented.
    Language English
    Publishing date 2016-06-27
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2495077-4
    ISSN 1179-142X
    ISSN 1179-142X
    DOI 10.2147/IMCRJ.S106861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Future of Cross-Continental Telemedicine in the Management of Complicated Endocrine Patients and Its Suitability Based on a Case Report.

    Khan, Zahid / Mlawa, Gideon / Yousif, Yousif / Afghan, Abdullah / Balami, Dauda / Mohammed, Mohammed / Muhammad, SyedAun / Warrier, Vinod / Gupta, Animesh / Ibrahim, Maab

    Cureus

    2022  Volume 14, Issue 2, Page(s) e22174

    Abstract: Telemedicine is rapidly evolving to provide increased access to high-quality healthcare, and it has gained more traction during the current COVID-19 pandemic. Telemedicine was mostly restricted to remote areas, but with the COVID-19 pandemic, it has been ...

    Abstract Telemedicine is rapidly evolving to provide increased access to high-quality healthcare, and it has gained more traction during the current COVID-19 pandemic. Telemedicine was mostly restricted to remote areas, but with the COVID-19 pandemic, it has been adopted by hospitals and its use has increased significantly. In addition, international collaboration has also increased, and we present a case report from Nigeria whereby a patient was diagnosed with a pituitary tumor through telemedicine, and he underwent successful surgery. This case report highlights the opportunity for collaboration beyond borders and for health care professionals to work with developing countries to improve patients' care.
    Language English
    Publishing date 2022-02-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome in a Patient Taking Lamotrigine: A Case Report Based Literature Review.

    Khan, Zahid / Warrier, Vinod / Muhammad, Syed Aun / Gupta, Animesh / Yousif, Yousif / Khan, Ayub / Afghan, Abdullah / Taucius, Donatas / Abumedian, Mohammed / Ibrahim, Maab / Mohammed, Mohammed / Mlawa, Gideon

    Cureus

    2022  Volume 14, Issue 2, Page(s) e22359

    Abstract: A 29-year-old patient presented to the hospital with worsening generalized rash for the last two days from a mental health facility. The patient was commenced on lamotrigine two weeks earlier, and he developed fever and generalized macular rash on his ... ...

    Abstract A 29-year-old patient presented to the hospital with worsening generalized rash for the last two days from a mental health facility. The patient was commenced on lamotrigine two weeks earlier, and he developed fever and generalized macular rash on his body. His blood tests showed deranged liver function tests (LFTs) and clotting with raised eosinophil count, and he was treated for lamotrigine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. The patient was commenced on prednisolone 50 mg once daily with a proton pump inhibitor cover, and lamotrigine was suspended on advice from Dermatology. The patient showed improvement after 3-4 days of treatment. His skin biopsy showed prominent suppurative granulomatous folliculitis, mild perivascular chronic inflammation, and red blood cell extravasation, including the rare eosinophil. He was weaned off from prednisolone by 5 mg weekly and had complete resolution of symptoms.
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.22359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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