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Article: Prognostic value of coronary computed tomography angiography compared to radionuclide myocardial perfusion imaging in patients With coronary stents.

Abazid, Rami M / Romsa, Jonathan G / Warrington, James C / Akincioglu, Cigdem / Smettei, Osama A / Bureau, Yves / Tzemos, Nikolaos / Vezina, William C

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1087113

Abstract: Objectives: The aim of this study is to compare the prognostic value of coronary computed tomography angiography (CCTA) with single-photon emission computed tomography (SPECT) in predicting cardiovascular events in patients with stents.: Design: ... ...

Abstract	Objectives: The aim of this study is to compare the prognostic value of coronary computed tomography angiography (CCTA) with single-photon emission computed tomography (SPECT) in predicting cardiovascular events in patients with stents. Design: Retrospective analysis. Setting: University Hospital, London, Ontario Canada Participants: Between January 2007 and December 2018, 119 patients post-percutaneous coronary intervention (PCI) who were referred for hybrid imaging with CTA and 2-day rest/stress SPECT were enrolled. Primary and secondary outcome measures: Patients were followed for any major adverse cardiovascular event (MACE) including: All-cause mortality, Non-fatal myocardial infarction (MI), Unplanned revascularization, Cerebrovascular accident and hospitalization for arrhythmia or heart failure. We define hard cardiac events (HCE) as: cardiac death, non-fatal MI or unplanned revascularization. We used two cut-off values to define obstructive lesions with CCTA ≥50% and ≥70% in any coronary segment. SPECT scan defined as abnormal in the presence of >5% reversible myocardial perfusion defect. Results: During the follow-up period of 7.2 ± 3.4 years. 45/119 (37.8%) patients experienced 57 MACE: Ten deaths (2 cardiac deaths and 8 of non-cardiac deaths), 29 acute coronary syndrome including non-fatal MI (25 required revascularization), 7 hospitalizations for heart failure, 6 cerebrovascular accidents and 5 new atrial fibrillation. 31 HCEs were reported. Cox regression analysis showed that obstructive coronary stenosis (≥50% and ≥70%) and abnormal SPECT were associated of MACE ( Conclusion: Obstructive coronary artery stenosis on CCTA can predict MACE and HCE. However, abnormal SPECT can only predict MACE but not HCE in patients post-PCI with a follow-up period of approximately 7 years.
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1087113
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Article ; Online: Complementary role of computed tomography angiography with fixed perfusion defects on SPECT myocardial perfusion imaging.

Abazid, Rami M / Sallam, Yasmine T / Romsa, Jonathan G / Warrington, James C / Akincioglu, Cigdem / De, Sabe / Tzemos, Nikolaos / Vezina, William C

European journal of hybrid imaging

2022 Volume 6, Issue 1, Page(s) 3

Abstract: Purpose: We present this case series exploring the complementary role of coronary computed tomography angiography (CCTA) to SPECT myocardial perfusion imaging (MPI) in the detection of myocardial necrosis.: Methods: A cardiac hybrid imaging database ... ...

Abstract	Purpose: We present this case series exploring the complementary role of coronary computed tomography angiography (CCTA) to SPECT myocardial perfusion imaging (MPI) in the detection of myocardial necrosis. Methods: A cardiac hybrid imaging database search identified 144 patients with a previous history of ST-segment elevation myocardial infarction treated with coronary revascularization. CCTA and MPI scans were evaluated to determine whether CCTA had an added value to MPI in detecting myocardial necrosis. Results: Five patients with patent stents and/or bypass grafts and both fixed perfusion defects on MPI and sub-endocardial hypo-perfusion on CCTA were identified. The extent and location of the perfusion defects were closely correlated between the CCTA and SPECT MPI images. Conclusion: In this series, CCTA and SPECT MPI were found to play a complementary role in the assessment of fixed perfusion defect, with CCTA adding specificity to the diagnosis of myocardial necrosis.
Language	English
Publishing date	2022-02-01
Publishing country	England
Document type	Journal Article
ISSN	2510-3636
ISSN (online)	2510-3636
DOI	10.1186/s41824-021-00124-z
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Article ; Online: Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy.

Sistani, Golmehr / Zukotynski, Katherine A / Akincioglu, Cigdem / Romsa, Jonathan G / Warrington, James C

Clinical nuclear medicine

2020 Volume 46, Issue 2, Page(s) e112–e113

Abstract: Abstract: A 35-year-old man with a history of renal transplant, congenital cystinosis, and diabetes was admitted to the hospital with fever, bilateral parotid gland swelling, and acute renal failure. He had 99mTc-HMPAO-WBC (99mTc- ... ...

Abstract	Abstract: A 35-year-old man with a history of renal transplant, congenital cystinosis, and diabetes was admitted to the hospital with fever, bilateral parotid gland swelling, and acute renal failure. He had 99mTc-HMPAO-WBC (99mTc-hexamethylpropyleneamineoxime white blood cell) imaging for the evaluation of possible parotitis. There was intense radiopharmaceutical uptake along the right internal jugular vein extending to the right sigmoid and transverse and superior sagittal sinuses, suggestive of infective thrombophlebitis or Lemierre syndrome. This study illustrates the value of 99mTc-HMPAO-WBC imaging as a tool for evaluating thrombophlebitis, particularly in patients with renal failure in whom contrast-enhanced CT may not be possible.
MeSH term(s)	Adult ; Cavernous Sinus Thrombosis/diagnostic imaging ; Humans ; Jugular Veins/diagnostic imaging ; Leukocytes/metabolism ; Male ; Radionuclide Imaging ; Technetium Tc 99m Exametazime
Chemical Substances	Technetium Tc 99m Exametazime (3B744AG22N)
Language	English
Publishing date	2020-10-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003352
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Article: Coronary artery calcium progression after coronary artery bypass grafting surgery.

Abazid, Rami M / Romsa, Jonathan G / Akincioglu, Cigdem / Warrington, James C / Bureau, Yves / Kiaii, Bob / Vezina, William C

Open heart

2021 Volume 8, Issue 1

Abstract: Objectives: Accelerated atherosclerosis is a well-established phenomenon after coronary artery bypass grafting surgery (CABG). In this study, we analysed coronary artery calcium (CCS) progression after CABG.: Methods: We retrospectively measured the ... ...

Abstract	Objectives: Accelerated atherosclerosis is a well-established phenomenon after coronary artery bypass grafting surgery (CABG). In this study, we analysed coronary artery calcium (CCS) progression after CABG. Methods: We retrospectively measured the CCS Agatston score (AS), volume score (VS) and mass score (MS) of 39 patients before and after CABG. The annualised CCS change and annualised CCS percent change of each coronary artery, coronary artery segments proximal and distal to anastomosis were analysed. Results: Mean age at the time of the surgery was 59.8±8.5 years. Follow-up period between the first and second CT scans was 6.7±2.8 (range, 1.1-12.8) years. Annualised CCS percent change (AS, VS and MS) of the coronary segments proximal-to-anastomosis did not differ from that of the non-grafted coronary arteries as follow: segments proximal-to-anastomosis: median (Q1-Q3) 12.8 (5.0-37.4), 13.7 (6.1-41.1) and 14.9 (5.4-53.7), left main coronary artery 12.6 (7.4-43.8), 22.0 (8.1-44.4) and 18.2 (7.3-57.4), non-grafted left circumflex artery: 13.5 (4.4-38.1), 10.5 (2.9-45.2) and 11.5 (7.1-47.9) and non-grafted right coronary artery: 31.4 (14.4-74.5), 25.2 (16.7-62.0) and 31.3 (23.8-85.6), respectively. Likewise, annualised percent change (AS, VS and MS) was similar between the native coronary arteries. Multivariate regression analysis showed that diabetes mellitus was the only predictor of annualised percent progression of the total CCS of >15% (HR, 8.12; 95% CI, 1.05 to 26.6; p=0.04). Conclusion: The CCS post-CABG did not follow an accelerated progression process. Among coronary artery disease risk factors, diabetes mellitus is the only predictor of annualised CCS percent progression of >15% post-CABG.
MeSH term(s)	Atherosclerosis/diagnosis ; Atherosclerosis/metabolism ; Atherosclerosis/surgery ; Calcium/metabolism ; Coronary Angiography/methods ; Coronary Artery Bypass ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/metabolism ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tomography, X-Ray Computed/methods
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2747269-3
ISSN	2053-3624
ISSN	2053-3624
DOI	10.1136/openhrt-2021-001684
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Article ; Online: Complementary role of hybrid imaging with SPECT myocardial perfusion and coronary CT angiography in hypertrophic cardiomyopathy.

Abazid, Rami M / Romsa, Jonathan G / Warrington, James C / Akincioglu, Cigdem / Stodilka, Robert Z / Vezina, William C

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2021 Volume 29, Issue 5, Page(s) 2716–2720

MeSH term(s)	Cardiomyopathy, Hypertrophic/diagnostic imaging ; Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Humans ; Myocardial Perfusion Imaging/methods ; Perfusion ; Tomography, Emission-Computed, Single-Photon/methods
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-020-02497-3
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Article ; Online: Coronary sinus to left atrium fistula on computed tomography angiography: Differentiation from unroofed coronary sinus with literature review.

Abazid, Rami M / Goha, Ahmed / Romsa, Jonathan G / Warrington, James C / Akincioglu, Cigdem / Stodilka, Robert Z / Kiaii, Bob / Vezina, William C

Journal of cardiovascular computed tomography

2020 Volume 15, Issue 2, Page(s) e15–e17

MeSH term(s)	Computed Tomography Angiography ; Coronary Sinus/diagnostic imaging ; Coronary Vessel Anomalies ; Fistula ; Heart Atria/diagnostic imaging ; Heart Septal Defects, Atrial ; Humans ; Predictive Value of Tests
Language	English
Publishing date	2020-11-13
Publishing country	United States
Document type	Case Reports ; Review
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2020.11.003
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Zs.A 6761: Show issues

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Article ; Online: Boot-Shaped Heart After Robotic Coronary Assist Bypass Surgery.

Abazid, Rami M / Akincioglu, Cigdem / Warrington, James C / Romsa, Jonathan G / Stodilka, Robert Z / Kiaii, Bob / Fox, Stephanie / Vezina, William C

JACC. Cardiovascular imaging

2020 Volume 13, Issue 11, Page(s) 2430–2434

MeSH term(s)	Coronary Artery Bypass ; Humans ; Predictive Value of Tests ; Robotic Surgical Procedures ; Robotics ; Treatment Outcome
Language	English
Publishing date	2020-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2020.01.028
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Zs.A 6846: Show issues

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Article: Hiatal hernia after robotic-assisted coronary artery bypass graft surgery.

Abazid, Rami M / Khatami, Alireza / Romsa, Jonathan G / Warrington, James C / Akincioglu, Cigdem / Stodilka, Robert Z / Fox, Stephanie / Kiaii, Bob / Vezina, William C

Journal of thoracic disease

2021 Volume 13, Issue 2, Page(s) 575–581

Abstract: Background: The aim of the present study is to determine the incidence/progression of hiatal hernia (HH) after robotic-assisted coronary artery bypass grafting (RA-CABG) surgery.: Methods: We reviewed the pre- and post-operative computed tomography ( ... ...

Abstract	Background: The aim of the present study is to determine the incidence/progression of hiatal hernia (HH) after robotic-assisted coronary artery bypass grafting (RA-CABG) surgery. Methods: We reviewed the pre- and post-operative computed tomography (CT) of 491 patients who underwent RA-CABG between 2000 and 2017. Post-operative CT was acquired prospectively in a research protocol. CT was reviewed to assess the presence and the size of HH. Results: We found 444/491 (90.4%) had pre-operative CT, while 201/491 (40.9%) had post-operative CT. In total, 155/491 (31.6%) had both pre- and long-term post-operative CT with a mean follow-up of 6.2 (±3.5) years. HH was more prevalent on post-operative CT, 64/155 (41.3%) compared to pre-operative CT, 44/155 (28.4%), P<0.0001. The diameter of pre-existing HH 2.8 (±1.8) cm was significantly greater after surgery 3.9 (±2.5) cm, P<0.0001. As well the volume of the pre-existing HH 5.8 (4.4-9.2) mL (quartile) was significantly greater after surgery 14.1 (7.2-64.9) mL, P<0.0001. 20/155 (12.9%) had a newly developed HH after RA-CABG. A binary multivariate regression including HH risk factors showed that male gender is a predictor of developing a HH after RA-CABG with Hazard Ratio of 3.038, confidence interval (1.10-8.43), P=0.033. Conclusions: RA-CABG is associated with an increased risk of developing HH and increases the size of pre-existing HH.
Language	English
Publishing date	2021-02-24
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-20-2557
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Article ; Online: Tc-99m pyrophosphate left atrial uptake in patients with atrial fibrillation and cardiac amyloidosis.

Abazid, Rami M / Romsa, Jonathan G / Warrington, James C / Stodilka, Robert Z / Davey, Ryan A / De, Sabe / Laidley, David L / Vezina, William C / Akincioglu, Cigdem

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2021 Volume 29, Issue 5, Page(s) 2731–2733

MeSH term(s)	Amyloidosis/complications ; Amyloidosis/diagnostic imaging ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnostic imaging ; Cardiomyopathies/diagnostic imaging ; Diphosphates ; Heart ; Humans ; Technetium Tc 99m Pyrophosphate
Chemical Substances	Diphosphates ; Technetium Tc 99m Pyrophosphate (5L76I61H2B)
Language	English
Publishing date	2021-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-020-02508-3
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Article ; Online: Very high coronary artery calcium score with normal myocardial perfusion SPECT imaging is associated with a moderate incidence of severe coronary artery disease.

Yuoness, Salem A / Goha, Ahmed M / Romsa, Jonathan G / Akincioglu, Cigdem / Warrington, James C / Datta, Sudip / Massel, David R / Martell, Rafael / Gambhir, Sanjay / Urbain, Jean-Luc C / Vezina, William C

European journal of nuclear medicine and molecular imaging

2015 Volume 42, Issue 10, Page(s) 1542–1550

Abstract: Purpose: Myocardial perfusion imaging (MPI) has limitations in the presence of balanced multivessel disease (MVD) and left main (LM) coronary artery disease, occasionally resulting in false-normal results despite the high cardiovascular risk associated ... ...

Abstract	Purpose: Myocardial perfusion imaging (MPI) has limitations in the presence of balanced multivessel disease (MVD) and left main (LM) coronary artery disease, occasionally resulting in false-normal results despite the high cardiovascular risk associated with this condition. The purpose of this study was to assess the incidence of severe coronary artery disease (CAD) in the presence of a very high Agatston coronary artery calcium (CAC) score (>1,000) in stable symptomatic patients without known CAD but with normal MPI results. Methods: A total of 2,659 prospectively acquired consecutive patients were referred for MPI and evaluation of CAC score by CT. Of this patient population, 8 % (222/2,659) had ischemia without myocardial infarction (MI) on MPIand 11 % (298/2,659) had abnormal MPI (MI and/or ischemia). On presentation 1 % of the patients (26/2,659) were symptomatic, had a CAC score >1,000 and normal MPI results. The definition of normal MPI was strict and included a normal hemodynamic response without ischemic ECG changes and normal imaging, particularly absence of transient ischemic dilation. All of these 26 patients with a CAC score >1,000 and normal MPI findings underwent cardiac catheterization. Results: Of these 26 patients, 58 % (15/26) had severe disease (≥70 % stenosis) leading to revascularization. Of this group, 47 % (7/15) underwent percutaneous intervention, and 53 % (8/15) underwent coronary artery bypass grafting. All of these 15 patients had either MVD (14/15) or LM coronary artery disease (1/15), and represented 0.6 % (15/2,659) of all referred patients (95 % CI 0.3 - 0.9 %). The majority, 90 % (8/9), had severe CAD with typical chest pain. Conclusion: A very high CAC score (>1,000) with normal MPI in a small subset of symptomatically stable patients was associated with a moderate incidence of severe CAD (95 % CI 37 - 77 %). Larger studies and/or a meta-analysis of small studies are needed to more precisely estimate the incidence of CAD in this population. This study also supports the concept that a normal MPI result in patients with severe CAD may be due to balanced MVD.
MeSH term(s)	Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Causality ; Comorbidity ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Myocardial Perfusion Imaging/statistics & numerical data ; Ontario/epidemiology ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Severity of Illness Index ; Sex Distribution ; Tomography, Emission-Computed, Single-Photon/statistics & numerical data ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/epidemiology
Language	English
Publishing date	2015-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-015-3072-z
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