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Article ; Online: Carnosic Acid Shows Higher Neuroprotective Efficiency than Edaravone or Ebselen in In Vitro Models of Neuronal Cell Damage.

Jantas, Danuta / Warszyński, Piotr / Lasoń, Władysław

2023 Volume 29, Issue 1

Abstract: This study compared the neuroprotective efficacy of three antioxidants-the plant-derived carnosic acid (CA), and two synthetic free radical scavengers: edaravone (ED) and ebselen (EB)-in in vitro models of neuronal cell damage. Results showed that CA ... ...

Abstract	This study compared the neuroprotective efficacy of three antioxidants-the plant-derived carnosic acid (CA), and two synthetic free radical scavengers: edaravone (ED) and ebselen (EB)-in in vitro models of neuronal cell damage. Results showed that CA protected mouse primary neuronal cell cultures against hydrogen peroxide-induced damage more efficiently than ED or EB. The neuroprotective effects of CA were associated with attenuation of reactive oxygen species level and increased mitochondrial membrane potential but not with a reduction in caspase-3 activity. None of the tested substances was protective against glutamate or oxygen-glucose deprivation-evoked neuronal cell damage, and EB even increased the detrimental effects of these insults. Further experiments using the human neuroblastoma SH-SY5Y cells showed that CA but not ED or EB attenuated the cell damage induced by hydrogen peroxide and that the composition of culture medium is the critical factor in evaluating neuroprotective effects in this model. Our data indicate that the neuroprotective potential of CA, ED, and EB may be revealed in vitro only under specific conditions, with their rather narrow micromolar concentrations, relevant cellular model, type of toxic agent, and exposure time. Nevertheless, of the three compounds tested, CA displayed the most consistent neuroprotective effects.
MeSH term(s)	Humans ; Animals ; Mice ; Edaravone/pharmacology ; Neuroprotective Agents/pharmacology ; Hydrogen Peroxide/pharmacology ; Neuroblastoma ; Azoles/pharmacology ; Glutamic Acid ; Abietanes ; Organoselenium Compounds ; Isoindoles
Chemical Substances	Edaravone (S798V6YJRP) ; ebselen (40X2P7DPGH) ; salvin (LI791SXT24) ; Neuroprotective Agents ; Hydrogen Peroxide (BBX060AN9V) ; Azoles ; Glutamic Acid (3KX376GY7L) ; Abietanes ; Organoselenium Compounds ; Isoindoles
Language	English
Publishing date	2023-12-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29010119
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Article ; Online: Neuroprotective effects of polyacrylic acid (PAA) conjugated cerium oxide against hydrogen peroxide- and 6-OHDA-induced SH-SY5Y cell damage.

Meenambal, Rugmani / Kruk, Tomasz / Gurgul, Jacek / Warszyński, Piotr / Jantas, Danuta

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18534

Abstract: Cerium oxide nanoparticles have been widely investigated against neurodegenerative diseases due to their antioxidant properties that aid in quenching reactive oxygen species. In this study, polyacrylic acid conjugated cerium oxide (PAA-CeO) nanoparticles ...

Abstract	Cerium oxide nanoparticles have been widely investigated against neurodegenerative diseases due to their antioxidant properties that aid in quenching reactive oxygen species. In this study, polyacrylic acid conjugated cerium oxide (PAA-CeO) nanoparticles were synthesized in a 50-60 nm size range with a zeta potential of - 35 mV. X-ray photoelectron spectroscopy analysis revealed a mixed valence state of Ce
MeSH term(s)	Humans ; Reactive Oxygen Species/pharmacology ; Hydrogen Peroxide/toxicity ; Oxidopamine/pharmacology ; Neuroprotective Agents/pharmacology ; Caspase 3/pharmacology ; Neuroblastoma ; Cell Line, Tumor ; Apoptosis ; Cell Survival
Chemical Substances	Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Oxidopamine (8HW4YBZ748) ; Neuroprotective Agents ; carbopol 940 (4Q93RCW27E) ; ceric oxide (619G5K328Y) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45318-6
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Article ; Online: Beyond esterase-like activity of serum albumin. Histidine-(nitro)phenol radical formation in conversion cascade of p-nitrophenyl acetate and the role of infrared light.

Kowacz, Magdalena / Warszyński, Piotr

Journal of molecular recognition : JMR

2019 Volume 32, Issue 8, Page(s) e2780

Abstract: Serum albumin, recognized mainly for its capacity to act as a carrier protein for many compounds, can also actively transform some organic molecules. As a starting point in this study, we consider esterase-like activity of bovine serum albumin (BSA) ... ...

Abstract	Serum albumin, recognized mainly for its capacity to act as a carrier protein for many compounds, can also actively transform some organic molecules. As a starting point in this study, we consider esterase-like activity of bovine serum albumin (BSA) toward p-nitrophenyl acetate (p-NPA). Our results reveal that the reaction goes beyond ester hydrolysis step. In fact, the transformation product, p-nitrophenol (p-NP), becomes a substrate for further reaction with BSA in which its nitro group in subtracted and released in the form of HNO
MeSH term(s)	Animals ; Cattle ; Electron Transport ; Esterases/metabolism ; Histidine/chemistry ; Histidine/metabolism ; Hydrolysis ; Infrared Rays ; Nitrophenols/metabolism ; Nitrous Acid/metabolism ; Serum Albumin, Bovine/chemistry ; Serum Albumin, Bovine/metabolism
Chemical Substances	Nitrophenols ; Serum Albumin, Bovine (27432CM55Q) ; Histidine (4QD397987E) ; 4-nitrophenyl acetate (830-03-5) ; Esterases (EC 3.1.-) ; Nitrous Acid (T2I5UM75DN)
Language	English
Publishing date	2019-02-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1015084-5
ISSN	1099-1352 ; 0952-3499
ISSN (online)	1099-1352
ISSN	0952-3499
DOI	10.1002/jmr.2780
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Article ; Online: Physicochemical Features and Applicability of Newly Fabricated Phytopharmaceutical-Loaded Hydrogel Alginate Microcarriers with Viscoelastic Polyelectrolyte Coatings.

Szczęsna-Górniak, Weronika / Weżgowiec, Joanna / Tsirigotis-Maniecka, Marta / Szyk-Warszyńska, Lilianna / Michna, Aneta / Warszyński, Piotr / Saczko, Jolanta / Wilk, Kazimiera A

Chemphyschem : a European journal of chemical physics and physical chemistry

2024 Volume 25, Issue 4, Page(s) e202300758

Abstract: The design of novel polymeric carrier systems with functional coatings is of great interest for delivering various bioactive molecules. Microcapsules coated with polyelectrolyte (PE) films provide additional functionality and fine-tuning advantages ... ...

Abstract	The design of novel polymeric carrier systems with functional coatings is of great interest for delivering various bioactive molecules. Microcapsules coated with polyelectrolyte (PE) films provide additional functionality and fine-tuning advantages essential for controlled drug release. We developed hydrogel microcarriers coated with functional PE films with encapsulated substances of natural origin, resveratrol (RES), curcumin (CUR), and epigallocatechin gallate (EGCG), which have cytotoxic and chemopreventive properties. Alginate (ALG) based microparticles were loaded with phytopharmaceuticals using the emulsification method, and then their surface was modified with PE coatings, such as chitosan (CHIT) or poly(allylamine hydrochloride) (PAH). The morphology and mean diameter of microcarriers were characterised by scanning electron microscopy, encapsulation efficiency was determined by UV-Vis spectroscopy, whereas the physicochemical properties of functional PE layers were studied using quartz crystal microbalance with dissipation monitoring and streaming potential measurements. The release profiles of active compounds from the hydrogel microparticles were described using the Peppas-Sahlin model. The cytotoxic effect of designed delivery systems was studied by evaluating their impact on the proliferation, mitochondrial metabolic function, and lipid peroxidation level of 5637 human bladder cancer cells. The present work demonstrates that the physicochemical and biological features of fabricated microcarriers can be controlled by the type of encapsulated anti-cancer agent and PE coating.
MeSH term(s)	Humans ; Polyelectrolytes/chemistry ; Alginates/chemistry ; Hydrogels ; Polymers ; Resveratrol ; Antineoplastic Agents
Chemical Substances	Polyelectrolytes ; Alginates ; Hydrogels ; Polymers ; Resveratrol (Q369O8926L) ; Antineoplastic Agents
Language	English
Publishing date	2024-01-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2025223-7
ISSN	1439-7641 ; 1439-4235
ISSN (online)	1439-7641
ISSN	1439-4235
DOI	10.1002/cphc.202300758
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Article ; Online: The Influence of the Surface Chemistry of Cellulose Nanocrystals on Ethyl Lauroyl Arginate Foam Stability.

Czakaj, Agnieszka / Chatzigiannakis, Emmanouil / Vermant, Jan / Krzan, Marcel / Warszyński, Piotr

Polymers

2022 Volume 14, Issue 24

Abstract: Guanidine-based surfactant ethyl lauroyl arginate (LAE) and cellulose nanocrystals (CNCs) form complexes of enhanced surface activity when compared to pure surfactants. The LAE-CNC mixtures show enhanced foaming properties. The dynamic thin-film balance ... ...

Abstract	Guanidine-based surfactant ethyl lauroyl arginate (LAE) and cellulose nanocrystals (CNCs) form complexes of enhanced surface activity when compared to pure surfactants. The LAE-CNC mixtures show enhanced foaming properties. The dynamic thin-film balance technique (DTFB) was used to study the morphology, drainage and rupture of LAE-CNC thin liquid films under constant driving pressure. A total of three concentrations of surfactant and the corresponding mixtures of LAE with sulfated (sCNC) and carboxylated (cCNC) cellulose nanocrystals were studied. The sCNC and cCNC suspension with LAE formed thin films, with stability increasing with surfactant concentration and with complex rheological properties. In the presence of LAE, the aggregation of CNC was observed. While the sCNC aggregates were preferentially present in the film volume with a small fraction at the surface, the cCNC aggregates, due to their higher hydrophobicity, were preferentially located at film interfaces, forming compact layers. The presence of both types of aggregates decreased the stability of the thin liquid film compared to the one for the LAE solution with the same concentration. The addition of CNC to LAE was critical for foam formation, and foam stability was in qualitative agreement with the thin films' lifetimes. The foam volume increased with the LAE concentration. However, there was an optimum surfactant concentration to achieve stable foam. In particular, the very resistant foam was obtained with cCNC suspensions that formed the interfaces with a complex structure and rheology. On the other hand, at high LAE concentrations, the aggregates of CNC may exhibit antifoaming properties.
Language	English
Publishing date	2022-12-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14245402
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Article ; Online: Influence of Eu

Meenambal, Rugmani / Kruk, Tomasz / Jakubowska, Klaudia / Gurgul, Jacek / Szczepanowicz, Krzysztof / Szczęch, Marta / Szyk-Warszyńska, Lilianna / Warszyński, Piotr / Jantas, Danuta

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: Cerium oxide nanoparticles (CeONPs) exhibiting antioxidant properties are investigated as potential tools for neurodegenerative diseases. Here, we synthesized polyacrylic acid conjugated cerium oxide (CeO) nanoparticles, and further to enhance their ... ...

Abstract	Cerium oxide nanoparticles (CeONPs) exhibiting antioxidant properties are investigated as potential tools for neurodegenerative diseases. Here, we synthesized polyacrylic acid conjugated cerium oxide (CeO) nanoparticles, and further to enhance their neuroprotective effect, Eu
MeSH term(s)	Humans ; Neuroprotection ; Hydrogen Peroxide ; Neuroblastoma ; Nanoparticles/chemistry ; Acrylic Resins ; Cerium
Chemical Substances	ceric oxide (619G5K328Y) ; carbopol 940 (4Q93RCW27E) ; Hydrogen Peroxide (BBX060AN9V) ; Acrylic Resins ; Cerium (30K4522N6T)
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052501
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Article ; Online: Ethyl Lauroyl Arginate, an Inherently Multicomponent Surfactant System.

Czakaj, Agnieszka / Jarek, Ewelina / Krzan, Marcel / Warszyński, Piotr

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 19

Abstract: Ethyl lauroyl arginate (LAE) is an amino acid-based cationic surfactant with low toxicity and antimicrobial activity. It is widely used as a food preservative and component for food packaging. When stored, LAE decomposes by hydrolysis into surface-active ...

Abstract	Ethyl lauroyl arginate (LAE) is an amino acid-based cationic surfactant with low toxicity and antimicrobial activity. It is widely used as a food preservative and component for food packaging. When stored, LAE decomposes by hydrolysis into surface-active components Nα-lauroyl-l-arginine (LAS) or dodecanoic (lauric) acid. There are only a limited number of reports considering the mechanism of surface activity of LAE. Thus, we analysed the surface tension isotherm of LAE with analytical standard purity in relation to LAE after prolonged storage. We used quantum mechanical density functional theory (DFT) computations to determine the preferred hydrolysis path and discuss the possibility of forming highly surface-active heterodimers, LAE-dodecanoate anion, or LAE-LAS. Applying molecular dynamics simulations, we determined the stability of those dimers linked by electrostatic interactions and hydrogen bonds. We used the adsorption model of surfactant mixtures to successfully describe the experimental surface tension isotherms. The real part surface dilational modulus determined by the oscillation drop method follows a diffusional transport mechanism. However, the nonlinear response of the surface tension could be observed for LAE concentration close to and above Critical Micelle Concentration (CMC). Nonlinearity originates from the presence of micelles and the reorganisation of the interfacial layer.
Language	English
Publishing date	2021-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26195894
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Article: Adsorption of cationic multicharged surfactants at liquid–gas interface

Warszyński, Piotr / Szyk-Warszyńska, Lilianna / Wilk, Kazimiera A. / Lamch, Łukasz

Current opinion in colloid & interface science. 2022 June, v. 59

2022

Abstract: We present the review of the existing methods for describing adsorption at fluid interfaces that may be applicable for multiple charge cationic surfactant structures of various architectures—multiheaded (e.g., dicephalic) structures and multimeric ... ...

Abstract	We present the review of the existing methods for describing adsorption at fluid interfaces that may be applicable for multiple charge cationic surfactant structures of various architectures—multiheaded (e.g., dicephalic) structures and multimeric surfactants (e.g., dimeric (so-called gemini), trimeric, tetrameric, etc.). We discuss the role of the prefactor the in the Gibbs adsorption equation originating from the number of charges present in the adsorbed layer and the reasons for the deviation from its thermodynamic value. We present several models of adsorption that can be used to describe surface tension isotherms and appreciate the role of prof. Peter Kralchevski in their development. Application of molecular dynamics methods combined with the approach based on the thermodynamic models of multicharged surfactant adsorption may lead to an explanation of some experimentally observed phenomena and can provide the basis for the development of novel materials designated for a variety of applications.
Keywords	adsorption ; cationic surfactants ; equations ; molecular dynamics ; surface tension ; thermodynamics
Language	English
Dates of publication	2022-06
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019683-0
ISSN	1359-0294
ISSN	1359-0294
DOI	10.1016/j.cocis.2022.101577
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Customizing polyelectrolytes through hydrophobic grafting.

Szczęsna, Weronika / Ciejka, Justyna / Szyk-Warszyńska, Lilianna / Jarek, Ewelina / Wilk, Kazimiera A / Warszyński, Piotr

Advances in colloid and interface science

2022 Volume 306, Page(s) 102721

Abstract: This up-to-date review describes the design, fabrication approaches, properties and applications that have been employed in the field of hydrophobically decorated polyelectrolytes (HD-PEs), used as functionalized building blocks for speciality materials ... ...

Abstract	This up-to-date review describes the design, fabrication approaches, properties and applications that have been employed in the field of hydrophobically decorated polyelectrolytes (HD-PEs), used as functionalized building blocks for speciality materials with tuneable features. These include, in particular, synthetic strategies for modification/hydrophobization of polyelectrolytes, self-organization of HD-PEs in aqueous systems, adsorption phenomena and applications in the field of surface chemistry. Rationally engineered HD-PEs can be achieved via either step-growth copolymerization of different reactive end groups of monomers, followed by appropriate post-synthesis treatment or as a result of decoration of a given polymer backbone with hydrophobic side groups. The influence of HD-PEs' chemical structure on their self-assembling and interfacial properties is dependent on the overall hydrophobicity, i.e. length, number and type of side chains stretched out to charged segment, number, type and strength of ionizable groups. We also conclude that the linking entity structure (ester, secondary amide, etc.) between the hydrophobic side chain and the charged polyelectrolyte backbone in the tailor-made HD-PEs plays a crucial role in self-aggregation behaviour in water and at interfaces. The examples of the unique ability of HD-PEs to adsorb at hydrophilic and hydrophobic interfaces is discussed considering the effect of the self-aggregation on the interfacial properties.
MeSH term(s)	Adsorption ; Hydrophobic and Hydrophilic Interactions ; Polyelectrolytes/chemistry ; Polymers/chemistry ; Water/chemistry
Chemical Substances	Polyelectrolytes ; Polymers ; Water (059QF0KO0R)
Language	English
Publishing date	2022-06-16
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	210507-x
ISSN	1873-3727 ; 0001-8686
ISSN (online)	1873-3727
ISSN	0001-8686
DOI	10.1016/j.cis.2022.102721
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Zs.A 2716: Show issues

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Article ; Online: Multiheaded Cationic Surfactants with Dedicated Functionalities: Design, Synthetic Strategies, Self-Assembly and Performance.

Lamch, Łukasz / Szczęsna, Weronika / Balicki, Sebastian J / Bartman, Marcin / Szyk-Warszyńska, Liliana / Warszyński, Piotr / Wilk, Kazimiera A

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 15

Abstract: Contemporary research concerning surfactant science and technology comprises a variety of requirements relating to the design of surfactant structures with widely varying architectures to achieve physicochemical properties and dedicated functionality. ... ...

Abstract	Contemporary research concerning surfactant science and technology comprises a variety of requirements relating to the design of surfactant structures with widely varying architectures to achieve physicochemical properties and dedicated functionality. Such approaches are necessary to make them applicable to modern technologies, such as nanostructure engineering, surface structurization or fine chemicals, e.g., magnetic surfactants, biocidal agents, capping and stabilizing reagents or reactive agents at interfaces. Even slight modifications of a surfactant's molecular structure with respect to the conventional single-head-single-tail design allow for various custom-designed products. Among them, multicharge structures are the most intriguing. Their preparation requires specific synthetic routes that enable both main amphiphilic compound synthesis using appropriate step-by-step reaction strategies or coupling approaches as well as further derivatization toward specific features such as magnetic properties. Some of the most challenging aspects of multicharge cationic surfactants relate to their use at different interfaces for stable nanostructures formation, applying capping effects or complexation with polyelectrolytes. Multiheaded cationic surfactants exhibit strong antimicrobial and antiviral activity, allowing them to be implemented in various biomedical fields, especially biofilm prevention and eradication. Therefore, recent advances in synthetic strategies for multiheaded cationic surfactants, their self-aggregation and performance are scrutinized in this up-to-date review, emphasizing their applications in different fields such as building blocks in nanostructure engineering and their use as fine chemicals.
Language	English
Publishing date	2023-08-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28155806
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