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Article: Interferoninduktion in Lymphozyten durch Anwendung eines bakteriellen Lysats.

Schubert, K / Bergmann, K C / Waschke, S

Zeitschrift fur Erkrankungen der Atmungsorgane

1985 Volume 165, Issue 1, Page(s) 48–52

Abstract: A polyvalent bacterial lysate (IRS 19) could be shown to induce interferon (IFN) in peripheral mononuclear leukocytes isolated from human and mouse blood by density gradient centrifugation. Upon stimulation with optimal doses of the inducer, the cells of ...

Title translation	Interferon induction in lymphocytes using a bacterial lysate.
Abstract	A polyvalent bacterial lysate (IRS 19) could be shown to induce interferon (IFN) in peripheral mononuclear leukocytes isolated from human and mouse blood by density gradient centrifugation. Upon stimulation with optimal doses of the inducer, the cells of both species produced 1000 to 2000 IU IFN/ml when cultured for up to 72 hours. In both systems the interferon was released to the culture supernatants in a first wave from one to four hours after addition of the inducer and in a second beyond the 16th hour of incubation increasing up to 72 hours, this time, reaching a 10 fold higher titer.
MeSH term(s)	Animals ; Antigens, Bacterial/immunology ; Bacterial Vaccines/immunology ; Cytopathogenic Effect, Viral ; Female ; Humans ; Interferon Inducers/immunology ; Interferons/metabolism ; Lymphocytes/immunology ; Mice
Chemical Substances	Antigens, Bacterial ; Bacterial Vaccines ; IRS 19 vaccine ; Interferon Inducers ; Interferons (9008-11-1)
Language	German
Publishing date	1985
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	219659-1
ISSN	0303-657X
ISSN	0303-657X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Biphasic production of immune interferon during mitogen-induced blastogenesis of human peripheral blood mononuclear leukocytes.

Venker, P / Waschke, S R

Biomedica biochimica acta

1985 Volume 44, Issue 4, Page(s) 573–583

Abstract: Peripheral blood mononuclear leukocytes of 14 healthy blood donors stimulated by concanavalin A were shown to exhibit a biphasic pattern of the production kinetics of interferon. Maximum interferon titers were determined in the culture supernatants 8 and ...

Abstract	Peripheral blood mononuclear leukocytes of 14 healthy blood donors stimulated by concanavalin A were shown to exhibit a biphasic pattern of the production kinetics of interferon. Maximum interferon titers were determined in the culture supernatants 8 and 48 h after addition of the mitogen. Both the early and late interferon production could be abolished by actinomycin D treatment of the induced cells implying that they depend on mitogen-stimulated de novo synthesis of cellular RNA. Under the conditions used the interferon mRNA was accumulated in treated cells during the first 4 h of incubation. The kinetics as well as the efficiency of concanavalin A-induced interferon production turned out to strictly depend on the nature of the protein source added to the culture medium. Only fetal calf serum and calf serum as compared to human albumin or pooled gamma globulin-free human plasma were found to give the highest interferon yields in true biphasic production pattern, thus explaining, at least in part, the differing data obtained by several investigators working with this particular interferon production system.
MeSH term(s)	Concanavalin A/pharmacology ; Dactinomycin/pharmacology ; Humans ; In Vitro Techniques ; Interferon-gamma/biosynthesis ; Interferons/biosynthesis ; Kinetics ; Leukocytes/metabolism ; Mitogens/pharmacology ; RNA/biosynthesis ; Time Factors ; Uridine/metabolism
Chemical Substances	Mitogens ; Concanavalin A (11028-71-0) ; Dactinomycin (1CC1JFE158) ; RNA (63231-63-0) ; Interferon-gamma (82115-62-6) ; Interferons (9008-11-1) ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	1985
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283559-9
ISSN	0232-766X
ISSN	0232-766X
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Article: Impact of chemotherapy regimen and hematopoietic growth factor on mobilization and collection of peripheral blood stem cells in cancer patients.

Nowrousian, M R / Waschke, S / Bojko, P / Welt, A / Schuett, P / Ebeling, P / Flasshove, M / Moritz, T / Schuette, J / Seeber, S

Annals of oncology : official journal of the European Society for Medical Oncology

2003 Volume 14 Suppl 1, Page(s) i29–36

Abstract: Various chemotherapy regimens, combined with recombinant human granulocyte colony-stimulating factor(rhG-CSF) or recombinant granulocyte-macrophage CSF (rhGM-CSF) are used in cancer patients to mobilize and collect peripheral blood stem cells (PBSC). In ... ...

Abstract	Various chemotherapy regimens, combined with recombinant human granulocyte colony-stimulating factor(rhG-CSF) or recombinant granulocyte-macrophage CSF (rhGM-CSF) are used in cancer patients to mobilize and collect peripheral blood stem cells (PBSC). In this retrospective study, we evaluated and compared the efficacy of such regimens in 262 patients with different types of malignant diseases. The following chemotherapy regimens were applied: ifosfamide-etoposide-cisplatin or bleomycin (n = 96; mainly patients with testicular cancer); ifosfamide-etoposide plus or minus cytosine arabinoside (Ara-C) or vincristine (VCR)(n = 52; mainly patients with lymphoma); cyclophosphamide-anthracycline (n = 53; mainly patients with breast cancer); intermediate to high dose (ID-HD) cyclophosphamide (n = 37; mainly patients with breast or ovarian cancer. or multiple myeloma; and others (n = 24). rhG-CSF or rhGM-CSF, each at an average daily dose of 5 microg/kg body weight, were used in 166 and 96 patients, respectively. The study evaluated and compared the efficacy of these two cytokines. In patients receiving rhG-CSF, CD34+ cells could be collected earlier (median: day 14 versus day 16) and there was a significantly higher white blood cell count (WBC)(median 11,350 versus 5550/microl) and CD34+ cell count (median 88 versus 43/microl) at the start of apheresis, and a significantly higher CD34+ cell yield (median 7.4 x 10(6) versus 4.6 x 10(6)/kg) than in patients who receivedrhGM-CSF. Among the various chemotherapeutic regimens used, each combined with rhG-CSF, ifosfamide-etoposide plus or minus Ara-C or VCR mobilized a significantly higher number of CD34+ cells (median 119/microl) and produced a significantly higher harvest of these cells (median 13 x 10(6)/kg) than cyclophosphamide-anthracycline (median 87/microl and 7 x 10(6)/kg, respectively) or ID-HD cyclophosphamide (median 59/microl and 5 x I 0(6)/kg, respectively). Ifosfamide-etoposide plus or minus Ara-C or VCR was also superior to ifosfamide-etoposide-cisplatin or bleomycin (median 78/microl and 9 x 10(6)/kg, respectively), but at borderline significance. The outcome of PBSC mobilization and collection appeared to be negatively influenced by the number of relapses before the current salvage treatment. These data indicate that mobilization and collection of PBSCstrongly depend on the type of hematopoietic growth factor and chemotherapeutic regimen used. The data further show rhG-CSF is a more effective growth factor than rhGM-CSF and ifosfamide-etoposide-based regimens, particularly ifosfamide-etoposide plus or minus Ara-C or VCR, are highly effective regimens in mobilizing and collecting CD34+ cells.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte-Macrophage Colony-Stimulating Factor/administration & dosage ; Hematopoietic Cell Growth Factors/administration & dosage ; Hematopoietic Cell Growth Factors/blood ; Hematopoietic Stem Cell Mobilization/methods ; Humans ; Logistic Models ; Neoplasms/blood ; Neoplasms/drug therapy ; Neoplasms/surgery ; Peripheral Blood Stem Cell Transplantation/methods ; Predictive Value of Tests ; Recombinant Proteins ; Retrospective Studies
Chemical Substances	Hematopoietic Cell Growth Factors ; Recombinant Proteins ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	English
Publishing date	2003
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1093/annonc/mdg706
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Article: 5-hydroxymethyl-2'-deoxyuridine, a normal DNA constituent in certain Bacillus subtilis phages is cytostatic for mammalian cells.

Waschke, S / Reefschlagër, J / Bärwolff, D / Langen, P

Nature

1975 Volume 255, Issue 5510, Page(s) 629–630

MeSH term(s)	Animals ; Bacillus subtilis ; Bacteriophages/analysis ; Cell Division/drug effects ; Cell Line ; Cricetinae ; DNA, Viral/analysis ; Deoxyuridine/analogs & derivatives ; Deoxyuridine/isolation & purification ; Deoxyuridine/pharmacology ; Embryo, Mammalian ; Fibroblasts ; HeLa Cells ; Humans ; Kidney ; L Cells (Cell Line) ; Mice
Chemical Substances	DNA, Viral ; Deoxyuridine (W78I7AY22C)
Language	English
Publishing date	1975-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/255629a0
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Article: Fortschritte der medizinischen Virologie. V. Interferon.

Presber, H W / Waschke, S R

Zeitschrift fur arztliche Fortbildung

1981 Volume 75, Issue 6, Page(s) 277–285

Title translation	Progress in virology. 5. Interferon.
MeSH term(s)	Antiviral Agents ; Diphtheria Toxoid/therapeutic use ; Humans ; Immunity, Cellular ; Interferon Inducers/therapeutic use ; Interferons ; Kinetics ; Lymphokines ; Molecular Conformation ; Neoplasms/therapy
Chemical Substances	Antiviral Agents ; Diphtheria Toxoid ; Interferon Inducers ; Lymphokines ; Interferons (9008-11-1)
Language	German
Publishing date	1981-03-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	210142-7
ISSN	0044-2178
ISSN	0044-2178
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Article: Induction and augmentation of mitogen-induced immune interferon production in human lymphocytes by a synthetic thymopoietin pentapeptide.

Diezel, W / Waschke, S R / Forner, K

Biomedica biochimica acta

1984 Volume 43, Issue 6, Page(s) K9–12

MeSH term(s)	Concanavalin A/pharmacology ; Humans ; In Vitro Techniques ; Interferon Inducers/pharmacology ; Interferon-gamma/biosynthesis ; Lymphocytes/metabolism ; Mitogens/pharmacology ; Peptide Fragments/pharmacology ; Thymopentin ; Thymopoietins/pharmacology ; Thymus Hormones/pharmacology
Chemical Substances	Interferon Inducers ; Mitogens ; Peptide Fragments ; Thymopoietins ; Thymus Hormones ; Concanavalin A (11028-71-0) ; Interferon-gamma (82115-62-6) ; Thymopentin (O3Y80ZF13F)
Language	English
Publishing date	1984
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283559-9
ISSN	0232-766X
ISSN	0232-766X
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Article: Detection of interferon in the sera of patients with psoriasis, and its enhancement by PUVA treatment.

Diezel, W / Waschke, S R / Sönnichsen, N

The British journal of dermatology

1983 Volume 109, Issue 5, Page(s) 549–552

Abstract: Interferon-like activity could be detected in the sera of nineteen psoriatic patients (interferon titres between 8 and 64 i.u./ml), whereas healthy controls were negative. Following PUVA treatment the interferon levels increased significantly (interferon ...

Abstract	Interferon-like activity could be detected in the sera of nineteen psoriatic patients (interferon titres between 8 and 64 i.u./ml), whereas healthy controls were negative. Following PUVA treatment the interferon levels increased significantly (interferon titres between 32 and 128 i.u./ml). An enhanced interferon production could explain some of the immunological phenomena connected with PUVA treatment.
MeSH term(s)	Adult ; Female ; Humans ; Interferons/blood ; Male ; Middle Aged ; PUVA Therapy ; Photochemotherapy ; Psoriasis/drug therapy ; Psoriasis/immunology
Chemical Substances	Interferons (9008-11-1)
Language	English
Publishing date	1983-11
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/j.1365-2133.1983.tb07677.x
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Article: Ein Beitrag zur Kultivierung von Säugetierzellen in Suspension

Reefschläger, J / Waschke, S R / Kotschate, R

Zeitschrift fur medizinische Labortechnik

1974 Volume 15, Issue 5, Page(s) 289–295

Title translation	Cultivation of mammalian cells in suspension.
MeSH term(s)	Animals ; Cells, Cultured ; Cricetinae ; Culture Media ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Mammals ; Suspensions
Chemical Substances	Culture Media ; Suspensions
Language	German
Publishing date	1974
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	525061-4
ISSN	0044-3069
ISSN	0044-3069
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Article: Interferon induction in human lymphocytes by complexes of vinyl copolymers with polynucleotides.

Waschke, K / Waschke, S R / Hoffmann, S / Witkowski, W

Acta biologica et medica Germanica

1979 Volume 38, Issue 5-6, Page(s) 739–744

Abstract: Analogues of the dsRNA poly(I).poly(C), namely double-stranded like complexes of poly(I) or poly(C), respectively, with corresponding vinyl nucleobases copolymerized with various vinyl compounds are highly effective interferon inducers in human ... ...

Abstract	Analogues of the dsRNA poly(I).poly(C), namely double-stranded like complexes of poly(I) or poly(C), respectively, with corresponding vinyl nucleobases copolymerized with various vinyl compounds are highly effective interferon inducers in human lymphocyte cultures. Like poly(I).poly(C) they stimulate the liberation of an inhibitor(s) of interferon activity and, moreover, display mitogenic effect. With respect to the extent of these effects the various inducers differ considerably.
MeSH term(s)	DNA/biosynthesis ; Humans ; Interferon Inducers ; Interferons/biosynthesis ; Lymphocytes/drug effects ; Lymphocytes/metabolism ; Mitogens ; Poly I-C/pharmacology ; Polyribonucleotides/pharmacology ; Polyvinyls/pharmacology ; Structure-Activity Relationship ; Thymidine/blood
Chemical Substances	Interferon Inducers ; Mitogens ; Polyribonucleotides ; Polyvinyls ; DNA (9007-49-2) ; Interferons (9008-11-1) ; Poly I-C (O84C90HH2L) ; Thymidine (VC2W18DGKR)
Language	English
Publishing date	1979
Publishing country	Germany
Document type	Journal Article
ZDB-ID	62-0
ISSN	0001-5318
ISSN	0001-5318
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Article: Decrease of HLA-DR antigen expression by human monocytes during cultivation in absence of exogenous or endogenous interferon-gamma.

Volk, H D / Waschke, S R / Diezel, W / Grunow, R / von Baehr, R / Fiebig, H

Immunology letters

1985 Volume 10, Issue 2, Page(s) 103–107

Abstract: The kinetics of HLA-DR antigen expression by human peripheral blood monocytes during cultivation in vitro was studied. Immediately after separation by glass adherence, about 60% of monocytes expressed DR antigens as judged by indirect fluorescence ... ...

Abstract	The kinetics of HLA-DR antigen expression by human peripheral blood monocytes during cultivation in vitro was studied. Immediately after separation by glass adherence, about 60% of monocytes expressed DR antigens as judged by indirect fluorescence staining with a monoclonal antibody (BL-DR/1). Monocytes carefully depleted of lymphocytes, gradually lost their DR antigens during cultivation in the absence of exogenous interferon-gamma (IFN-gamma). However, addition of a few lymphocytes to the adherent cells prevented the decrease of DR antigen expression. Furthermore, it was shown that doses as low as 1 IU/ml of IFN-gamma are sufficient to induce DR antigen expression by cultured monocytes. Experiments with cyclosporin A suggest that lymphocytes contaminating the monocyte preparations can produce spontaneously sufficient amounts of IFN-gamma for maintenance of the DR antigens on monocytes.
MeSH term(s)	Cells, Cultured ; Cyclosporins/pharmacology ; HLA-DR Antigens ; Histocompatibility Antigens Class II ; Humans ; Interferon-gamma/immunology ; Interferon-gamma/pharmacology ; Kinetics ; Monocytes/drug effects ; Monocytes/immunology
Chemical Substances	Cyclosporins ; HLA-DR Antigens ; Histocompatibility Antigens Class II ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	1985
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	445150-8
ISSN	1879-0542 ; 0165-2478
ISSN (online)	1879-0542
ISSN	0165-2478
DOI	10.1016/0165-2478(85)90184-1
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