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Article ; Online: Amino acid PET vs. RANO MRI for prediction of overall survival in patients with recurrent high grade glioma under bevacizumab therapy.

Chaban, Artem / Waschulzik, Birgit / Bernhardt, Denise / Delbridge, Claire / Schmidt-Graf, Friederike / Wagner, Arthur / Wiestler, Benedikt / Weber, Wolfgang / Yakushev, Igor

European journal of nuclear medicine and molecular imaging

2024 Volume 51, Issue 6, Page(s) 1698–1702

Abstract: Purpose: To summarize evidence on the comparative value of amino acid (AA) PET and conventional MRI for prediction of overall survival (OS) in patients with recurrent high grade glioma (rHGG) under bevacizumab therapy.: Methods: Medical databases ... ...

Abstract	Purpose: To summarize evidence on the comparative value of amino acid (AA) PET and conventional MRI for prediction of overall survival (OS) in patients with recurrent high grade glioma (rHGG) under bevacizumab therapy. Methods: Medical databases were screened for studies with individual data on OS, follow-up MRI, and PET findings in the same patient. MRI images were assessed according to the RANO criteria. A receiver operating characteristic curve analysis was used to predict OS at 9 months. Results: Five studies with a total of 72 patients were included. Median OS was significantly lower in the PET-positive than in the PET-negative group. PET findings predicted OS with a pooled sensitivity and specificity of 76% and 71%, respectively. Corresponding values for MRI were 32% and 82%. Area under the curve and sensitivity were significantly higher for PET than for MRI. Conclusion: For monitoring of patients with rHGG under bevacizumab therapy, AA-PET should be preferred over RANO MRI.
MeSH term(s)	Humans ; Bevacizumab/therapeutic use ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Glioma/pathology ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Amino Acids/therapeutic use ; Recurrence ; Female ; Neoplasm Grading ; Male ; Survival Analysis ; Middle Aged
Chemical Substances	Bevacizumab (2S9ZZM9Q9V) ; Amino Acids
Language	English
Publishing date	2024-01-17
Publishing country	Germany
Document type	Journal Article ; Comparative Study
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-024-06601-4
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Zs.A 1227: Show issues

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Book: "Quarzfeinstaub und Lungenkarzinom"

Ulm, Kurt / Waschulzik, Birgit

Ergebnisse einer Fallkontrollstudie zur Untersuchung eines Zusammenhanges zwischen einer Exposition gegenüber lungengängigem Quarzfeinstaub und dem Auftreten von Lungenkarzinomen

1998

Author's details	[Verf.: K. Ulm und B. Waschulzik]
Keywords	Lung Neoplasms / etiology ; Occupational Exposure / adverse effects ; Case-Control Studies ; Deutschland ; Quarz ; Feinstaub ; Lungenkrebs
Subject	Lungenkarzinom ; Lunge ; Quarzkristall ; Quarz
Language	German
Size	93 S. : graph. Darst.
Publisher	HVBG, Hauptverb. der Gewerblichen Berufsgenossenschaften
Publishing place	St. Augustin
Publishing country	Germany
Document type	Book
Note	Zsfassung in engl., franz. und span. Sprache
HBZ-ID	HT009135765
ISBN	3-88383-487-4 ; 978-3-88383-487-0
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Temporal Tendinitis in Craniomandibular Dysfunction (CMD) - Does it Really Exist? A Temporomandibular MRI Investigation.

Stimmer, Herbert / Grill, Florian / Waschulzik, Birgit / Nieberler, Markus / Wolff, Klaus-Dietrich / Kolk, Andreas

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

2022 Volume 194, Issue 11, Page(s) 1242–1249

Abstract: Objectives: The aim of the study was to analyze the role of temporal muscle and particularly tendon pathology in patients suffering from craniomandibular dysfunction (CMD) using magnetic resonance imaging.: Materials and methods: Retrospective ... ...

Title translation	Tendinitis temporalis bei kraniomandibulärer Dysfunktion (CMD) – Welche Rolle spielt sie wirklich? Eine MRT-Studie der Temporomandibularregion.
Abstract	Objectives: The aim of the study was to analyze the role of temporal muscle and particularly tendon pathology in patients suffering from craniomandibular dysfunction (CMD) using magnetic resonance imaging. Materials and methods: Retrospective analysis of MRI examinations was carried out with regard to temporal muscle fibrosis and fatty degeneration and particularly temporal tendon rupture, thickening, and degenerative signal alterations. Descriptive statistics and the Mann-Whitney U-test were used for statistical evaluation. Results: Structural lesions of temporal muscle parenchyma were the absolute exception. PD hyperintensity, pronounced contrast enhancement, or peritendinous fluid collections along the temporal tendon were found only to a small extent, and a (partial) rupture occurred in only one case. The tendon diameter showed only slight variability. The Mann-Whitney U-test provided no results indicating a causal connection between degenerative joint or disc disease and temporal tendon pathology. Conclusion: A large sample of 128 magnetic resonance imaging examinations provided no evidence of a major role of temporal tendinitis in clinical CMD syndrome. Key points: · Retrospective analysis of temporal tendon in CMD patients.. · Abnormal structural findings along the tendon seen only rarely.. · Obviously no crucial role of temporal tendon lesions in CMD syndrome.. Citation format: · Stimmer H, Grill F, Waschulzik B et al. Temporal Tendinitis in Craniomandibular Dysfunction (CMD) - Does it Really Exist? A Temporomandibular MRI Investigation. Fortschr Röntgenstr 2022; 194: 1242 - 1249.
MeSH term(s)	Humans ; Retrospective Studies ; Magnetic Resonance Imaging/methods ; Tendinopathy/diagnostic imaging ; Syndrome
Language	English
Publishing date	2022-05-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	554830-5
ISSN	1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
ISSN (online)	1438-9010
ISSN	0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
DOI	10.1055/a-1829-6134
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Article ; Online: Utility of Amino Acid PET in the Differential Diagnosis of Recurrent Brain Metastases and Treatment-Related Changes: A Meta-analysis.

Schlürmann, Timo / Waschulzik, Birgit / Combs, Stephanie / Gempt, Jens / Wiestler, Benedikt / Weber, Wolfgang / Yakushev, Igor

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2022 Volume 64, Issue 5, Page(s) 816–821

Abstract: Amino acid PET is an established method to assist differential diagnosis of therapy-related changes versus recurrence in gliomas. However, its diagnostic value in brain metastases is yet to be determined. The goal of this study was to summarize evidence ... ...

Abstract	Amino acid PET is an established method to assist differential diagnosis of therapy-related changes versus recurrence in gliomas. However, its diagnostic value in brain metastases is yet to be determined. The goal of this study was to summarize evidence on the diagnostic utility of amino acid PET in recurrent brain metastases.
MeSH term(s)	Humans ; Amino Acids ; Positron-Emission Tomography/methods ; Diagnosis, Differential ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/therapy ; Tyrosine ; Sensitivity and Specificity ; Methionine
Chemical Substances	Amino Acids ; Tyrosine (42HK56048U) ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2022-12-02
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.122.264803
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Article ; Online: Impact of early postoperative haemodynamic and laboratory parameters on outcome after the Fontan procedure.

Di Padua, Chiara / Osawa, Takuya / Waschulzik, Birgit / Balling, Gunter / Schaeffer, Thibault / Staehler, Helena / Piber, Nicole / Hager, Alfred / Ewert, Peter / Hörer, Jürgen / Ono, Masamichi

Cardiology in the young

2024 , Page(s) 1–8

Abstract: Objective: To identify early postoperative haemodynamic and laboratory parameters predicting outcomes following total cavopulmonary connection.: Methods: Patients who underwent total cavopulmonary connection between 2012 and 2021 were evaluated. ... ...

Abstract	Objective: To identify early postoperative haemodynamic and laboratory parameters predicting outcomes following total cavopulmonary connection. Methods: Patients who underwent total cavopulmonary connection between 2012 and 2021 were evaluated. Serial values of mean pulmonary artery pressure, mean arterial pressure, peripheral oxygen saturation, and lactate levels were collected. The influence of these variables on morbidities was analyzed. Cut-off values were calculated using the receiver operating characteristic analysis. Results: A total of 249 patients were included. All patients had previous bidirectional cavopulmonary shunt. Median age and weight at total cavopulmonary connection were 2.2 (1.8-2.7) years and 11.7 (10.7-13.4) kg, respectively. All patients were extubated in the ICU at a median of 3 (2-5) hours after ICU admission. Postoperative pulmonary artery pressure, around 12 hours after extubation, was significantly associated with chest tube drainage (p = 0.048), chylothorax (p = 0.021), ascites (p = 0.016), and adverse events (p = 0.028). Receiver operating characteristic analysis revealed a cut-off value of 13-15 mmHg for chest tube drainage and chylothorax and 17 mmHg for ascites and adverse events. Mean arterial pressure 1 hour after extubation was associated with prolonged chest tube drainage (p = 0.015) and adverse events (p = 0.008). Peripheral oxygen saturation 6 hours after extubation (p = 0.003) was associated with chest tube duration and peripheral oxygen saturation 1 hour after extubation (p < 0.001) was associated with ascites. Lactate levels on 2 Conclusions: Higher pulmonary artery pressure, lower mean arterial pressure, lower peripheral oxygen saturation, and higher lactate in early postoperative period, around 12 hours after extubation, predicted in-hospital and post-discharge adverse events following total cavopulmonary connection.
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951124000040
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Zs.A 4050: Show issues

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Article ; Online: Evaluation of Conventional MR Imaging of the Shoulder in the Diagnosis of Lesions of the Biceps Pulley.

Ebrahimi Ardjomand, Saba / Meurer, Felix / Ehmann, Yannick / Pogorzelski, Jonas / Waschulzik, Birgit / Makowski, Marcus R / Siebenlist, Sebastian / Heuck, Andreas / Woertler, Klaus / Neumann, Jan

Academic radiology

2024

Abstract: Rationale and objectives: To determine the diagnostic accuracy and reproducibility of conventional MR imaging (MRI) of the shoulder in evaluating biceps pulley lesions using arthroscopy as the standard of reference.: Methods: In a retrospective study, ...

Abstract	Rationale and objectives: To determine the diagnostic accuracy and reproducibility of conventional MR imaging (MRI) of the shoulder in evaluating biceps pulley lesions using arthroscopy as the standard of reference. Methods: In a retrospective study, MR examinations of 68 patients with arthroscopically proven torn or intact biceps pulley were assessed for the presence of pulley lesions by three radiologists. The following criteria were evaluated: displacement of the long head of the biceps tendon (LHBT) relative to the subscapularis tendon (displacement sign), subluxation/dislocation of the LHBT, the integrity of the superior glenohumeral ligament (SGHL) and the coracohumeral ligament (CHL), lesions of the supraspinatus (SSP) and subscapularis (SSC) tendons adjacent to the rotator interval, presence of biceps tendinopathy and subacromial bursitis. Results: There were 42 patients with pulley lesions in the study group. Conventional MR imaging showed an overall sensitivity of 95.2%, 88.1% and 92.9%, a specificity of 61.5%, 73.1%, and 80.8% and an accuracy of 82.4%, 82.4% and 88.2% in the diagnosis of pulley lesions. Interobserver agreement was substantial (multirater k = 0.75). Biceps tendinopathy (97.6%, 95.2%, 97.6%), defects of the SGHL (86.3%, 81.0%, 88.1%) and the displacement sign (88.1%, 81.0%, 85.7%) were the most sensitive diagnostic criteria. Subluxation/dislocation of the LHBT was insensitive (78.6%, 42.9%, 33.3%), but specific (69.2%, 100,0%, 96.2%). Conclusion: In the diagnosis of pulley lesions, conventional MR imaging is reproducible and shows high sensitivity and accuracy but moderate specificity.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1355509-1
ISSN	1878-4046 ; 1076-6332
ISSN (online)	1878-4046
ISSN	1076-6332
DOI	10.1016/j.acra.2024.01.040
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Article ; Online: Exercise-dependent changes in ventricular-arterial coupling and aortopulmonary collateral flow in Fontan patients: a real-time CMR study.

Latus, Heiner / Hofmann, Lucas / Gummel, Kerstin / Khalil, Markus / Yerebakan, Can / Waschulzik, Birgit / Schranz, Dietmar / Voges, Inga / Jux, Christian / Reich, Bettina

European heart journal. Cardiovascular Imaging

2022

Abstract: Aims: Inefficient ventricular-arterial (V-A) coupling has been described in Fontan patients and may result in adverse haemodynamics. A varying amount of aortopulmonary collateral (APC) flow is also frequently present that increases volume load of the ... ...

Abstract	Aims: Inefficient ventricular-arterial (V-A) coupling has been described in Fontan patients and may result in adverse haemodynamics. A varying amount of aortopulmonary collateral (APC) flow is also frequently present that increases volume load of the single ventricle. The aim of the study was to assess changes in V-A coupling and APC flow during exercise CMR. Methods and results: Eighteen Fontan patients (age 24 ± 3 years) and 14 controls (age 23 ± 4 years) underwent exercise CMR using a cycle ergometer. Ventricular volumetry and flow measurements in the ascending aorta (AAO), inferior (IVC), and superior (SVC) vena cava were assessed using real-time sequences during stepwise increases in work load. Measures of systemic arterial elastance Ea, ventricular elastance Ees, and V-A coupling (Ea/Ees) were assessed. APC flow was quantified as AAO - (SVC + IVC). Ea remained unchanged during all levels of exercise in both groups (P = 0.39 and P = 0.11). Ees increased in both groups (P = 0.001 and P < 0.001) with exercise but was lower in the Fontan group (P = 0.04). V-A coupling was impaired in Fontan patients at baseline (P = 0.04). Despite improvement during exercise (P = 0.002) V-A coupling remained impaired compared with controls (P = 0.001). Absolute APC flow in Fontan patients did not change during exercise even at maximum work load (P = 0.98). Conclusions: Inefficient V-A coupling was already present at rest in Fontan patients and aggravated during exercise due to a limited increase in ventricular contractility which demonstrates the importance of a limited functional reserve of the single ventricle. APC flow remained unchanged suggesting no further increase in volume load during exercise.
Language	English
Publishing date	2022-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeac001
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Article: Temporal Tendinitis in Craniomandibular Dysfunction (CMD) – Does it Really Exist? A Temporomandibular MRI Investigation

Stimmer, Herbert / Grill, Florian / Waschulzik, Birgit / Nieberler, Markus / Wolff, Klaus-Dietrich / Kolk, Andreas

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

2022 Volume 194, Issue 11, Page(s) 1242–1249

Abstract	Objectives: The aim of the study was to analyze the role of temporal muscle and particularly tendon pathology in patients suffering from craniomandibular dysfunction (CMD) using magnetic resonance imaging. Materials and Methods: Retrospective analysis of MRI examinations was carried out with regard to temporal muscle fibrosis and fatty degeneration and particularly temporal tendon rupture, thickening, and degenerative signal alterations. Descriptive statistics and the Mann-Whitney U-test were used for statistical evaluation. Results: Structural lesions of temporal muscle parenchyma were the absolute exception. PD hyperintensity, pronounced contrast enhancement, or peritendinous fluid collections along the temporal tendon were found only to a small extent, and a (partial) rupture occurred in only one case. The tendon diameter showed only slight variability. The Mann-Whitney U-test provided no results indicating a causal connection between degenerative joint or disc disease and temporal tendon pathology. Conclusion: A large sample of 128 magnetic resonance imaging examinations provided no evidence of a major role of temporal tendinitis in clinical CMD syndrome. Key Points: Retrospective analysis of temporal tendon in CMD patients. Abnormal structural findings along the tendon seen only rarely. Obviously no crucial role of temporal tendon lesions in CMD syndrome. Citation Format: Stimmer H, Grill F, Waschulzik B et al. Temporal Tendinitis in Craniomandibular Dysfunction (CMD) – Does it Really Exist? A Temporomandibular MRI Investigation. Fortschr Röntgenstr 2022; 194: 1242 – 1249
Keywords	temporal tendon ; tendinitis ; temporomandibular joint (TMJ) ; craniomandibular dysfunction (CMD) ; magnetic resonance imaging (MRI) ; head/neck ; MR-imaging ; inflammation
Language	English
Publishing date	2022-05-25
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	554830-5
ISSN	1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
ISSN (online)	1438-9010
ISSN	1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
DOI	10.1055/a-1829-6134
Database	Thieme publisher's database

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Article ; Online: Pulmonary Findings in Hospitalized COVID-19 Patients Assessed by Lung Ultrasonography (LUS) - A Prospective Registry Study.

Barner, Anna / Burian, Egon / Simon, Alexander / Castillo, Katty / Waschulzik, Birgit / Braren, Rickmer / Heemann, Uwe / Osterwalder, Joseph / Spiel, Alexander / Heim, Markus / Stock, Konrad Friedrich

Ultraschall in der Medizin (Stuttgart, Germany : 1980)

2023 Volume 44, Issue 5, Page(s) e248–e256

Abstract: Purpose: This prospective two-centre study investigated localisation-dependent lesion patterns in COVID-19 with standard lung ultrasonography (LUS) and their relationship with thoracic computed tomography (CT) and clinical parameters.: Materials and ... ...

Title translation	Lungenbefunde bei hospitalisierten COVID-19-Patienten erfasst mittels Lungensonografie (LUS) – Eine prospektive Registerstudie.
Abstract	Purpose: This prospective two-centre study investigated localisation-dependent lesion patterns in COVID-19 with standard lung ultrasonography (LUS) and their relationship with thoracic computed tomography (CT) and clinical parameters. Materials and methods: Between April 2020 and April 2021, 52 SARS-CoV-2-positive patients in two hospitals were examined by means of LUS for "B-lines", fragmented pleura, consolidation and air bronchogram in 12 lung regions and for pleural effusions. A newly developed LUS score based on the number of features present was correlated with clinical parameters (respiration, laboratory parameters) and the CT and analysed with respect to the 30- and 60-day outcome. All patients were offered an outpatient LUS follow-up. Results: The LUS and CT showed a bilateral, partially posteriorly accentuated lesion distribution pattern. 294/323 (91%) of CT-detected lesions were pleural. The LUS score showed an association with respiratory status and C-reactive protein; the correlation with the CT score was weak (Spearman's rho = 0.339, p < 0.001). High LUS scores on admission were also observed in patients who were discharged within 30 days. LUS during follow-up showed predominantly declining LUS scores. Conclusion: The LUS score reflected the clinical condition of the patients. No conclusion could be made on the prognostic value of the LUS, because of the low event rate. The LUS and CT score showed no sufficient correlation. This is probably due to different physical principles, which is why LUS could be of complementary value.
Language	English
Publishing date	2023-01-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	801064-x
ISSN	1438-8782 ; 1439-0914 ; 1431-4894 ; 0172-4614
ISSN (online)	1438-8782
ISSN	1439-0914 ; 1431-4894 ; 0172-4614
DOI	10.1055/a-2013-8045
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Article ; Online: Impact of Right Ventricular Pressure Load After Repair of Tetralogy of Fallot.

Latus, Heiner / Stammermann, Jana / Voges, Inga / Waschulzik, Birgit / Gutberlet, Matthias / Diller, Gerhard-Paul / Schranz, Dietmar / Ewert, Peter / Beerbaum, Philipp / Kühne, Titus / Sarikouch, Samir

Journal of the American Heart Association

2022 Volume 11, Issue 7, Page(s) e022694

Abstract: Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy of Fallot has been linked with favorable right ventricular remodeling but adverse outcomes. The aim of our study was to assess the hemodynamic impact and prognostic ... ...

Abstract	Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy of Fallot has been linked with favorable right ventricular remodeling but adverse outcomes. The aim of our study was to assess the hemodynamic impact and prognostic relevance of right ventricular pressure load in this population. Methods and Results A total of 296 patients with repaired tetralogy of Fallot (mean age, 17.8±7.9 years) were included in a prospective cardiovascular magnetic resonance multicenter study. Myocardial strain was quantified by feature tracking technique at study entry. Follow-up, including the need for pulmonary valve replacement, was assessed. The combined end point consisted of ventricular tachycardia and cardiac death. A higher echocardiographic RVOT peak gradient was significantly associated with smaller right ventricular volumes and less pulmonary regurgitation, but lower biventricular longitudinal strain. During a follow-up of 10.1 (0.1-12.9) years, the primary end point was reached in 19 of 296 patients (cardiac death, n=6; sustained ventricular tachycardia, n=2; and nonsustained ventricular tachycardia, n=11). A higher RVOT gradient was associated with the combined outcome (hazard ratio [HR], 1.03; 95% CI, 1.00-1.06;
MeSH term(s)	Adolescent ; Adult ; Cardiac Surgical Procedures/adverse effects ; Cardiac Surgical Procedures/methods ; Child ; Humans ; Prospective Studies ; Pulmonary Valve/diagnostic imaging ; Pulmonary Valve/surgery ; Pulmonary Valve Insufficiency/diagnostic imaging ; Pulmonary Valve Insufficiency/etiology ; Pulmonary Valve Insufficiency/surgery ; Retrospective Studies ; Tetralogy of Fallot ; Treatment Outcome ; Ventricular Pressure ; Young Adult
Language	English
Publishing date	2022-03-18
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.022694
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