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  1. Article ; Online: Examining the Dose-Response Relationship between Physical Activity and Health Outcomes.

    Wasfy, Meagan M / Lee, I-Min

    NEJM evidence

    2022  Volume 1, Issue 12, Page(s) EVIDra2200190

    Abstract: Physical Activity and Health and LongevityPhysical activity is a powerful tool to improve health. This article reviews the evidence supporting a relationship between physical activity and health outcomes, including mortality, and discusses the optimal ... ...

    Abstract Physical Activity and Health and LongevityPhysical activity is a powerful tool to improve health. This article reviews the evidence supporting a relationship between physical activity and health outcomes, including mortality, and discusses the optimal dose of physical activity.
    MeSH term(s) Exercise ; Outcome Assessment, Health Care
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDra2200190
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  2. Article ; Online: Case Discussion on 'Return-to-Play' for the Athlete Following COVID-19 Infection.

    Moulson, Nathaniel / Wasfy, Meagan

    Rhode Island medical journal (2013)

    2021  Volume 104, Issue 6, Page(s) 8–12

    MeSH term(s) Athletes ; COVID-19 ; Humans ; Myocarditis ; Return to Sport ; SARS-CoV-2
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 419430-5
    ISSN 2327-2228 ; 0363-7913
    ISSN (online) 2327-2228
    ISSN 0363-7913
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  3. Article ; Online: Right Heart Resilience and Atrial Fibrillation Risk in Long-Term Endurance Athletes.

    Petek, Bradley J / Hayes, Dolphurs M / Wasfy, Meagan M

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2022  Volume 35, Issue 12, Page(s) 1269–1272

    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Athletes ; Physical Endurance ; Risk Factors
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2022.09.019
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  4. Article ; Online: Exercise in Heart Failure: The Added Pressure Is Worth the Payoff.

    Churchill, Timothy W / Wasfy, Meagan M

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2020  Volume 33, Issue 2, Page(s) 157–160

    MeSH term(s) Echocardiography ; Exercise ; Heart Failure ; Humans ; Stroke Volume
    Language English
    Publishing date 2020-04-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2019.12.003
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  5. Article ; Online: A Cyclist on a Tricyclic: Exercise Intolerance Due to Chronotropic Incompetence.

    Tanayan, Christopher / Reddy, Satyajit / Shah, Ankit B / Wasfy, Meagan M

    JACC. Case reports

    2022  Volume 4, Issue 20, Page(s) 1335–1340

    Abstract: Depression in athletes is prevalent, and antidepressant treatment may have a cardiovascular impact. We present a case, documented by serial exercise testing, of exertional intolerance due to chronotropic incompetence associated with tricyclic ... ...

    Abstract Depression in athletes is prevalent, and antidepressant treatment may have a cardiovascular impact. We present a case, documented by serial exercise testing, of exertional intolerance due to chronotropic incompetence associated with tricyclic antidepressant use. This case underscores the importance of understanding the mechanism of action and side effects of antidepressants. (
    Language English
    Publishing date 2022-10-19
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2022.05.038
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  6. Article: Cardiopulmonary Exercise Testing in Athletes: Expect the Unexpected.

    Petek, Bradley J / Gustus, Sarah K / Wasfy, Meagan M

    Current treatment options in cardiovascular medicine

    2021  Volume 23, Issue 7

    Abstract: Purpose of review: Cardiopulmonary exercise testing (CPET) is a tool designed to assess the integrated function of the cardiac, pulmonary, vascular and musculoskeletal systems to produce an exercise effort. CPET may be performed for performance purposes ...

    Abstract Purpose of review: Cardiopulmonary exercise testing (CPET) is a tool designed to assess the integrated function of the cardiac, pulmonary, vascular and musculoskeletal systems to produce an exercise effort. CPET may be performed for performance purposes as part of optimizing a training program or for clinical purposes in athletes with established cardiovascular disease or in those with symptoms suggestive of cardiopulmonary pathology. Most normative values used for CPET parameters have been derived in the general population, in whom there will be expected differences in exercise physiology as compared to a trained athlete. In this review, our goal is to examine current available data on expected findings on CPET in athletes, highlight how these differ from the general population-derived normative values, and identify areas in need of further research to optimize the application of CPET in athletes.
    Recent findings: Athletes demonstrate differences in exercise hemodynamic and gas exchange profiles as compared to non-athletes including: higher cardiac output, faster heart rate recovery, higher peak V̇O
    Summary: CPET is an important tool to optimize performance and assess for underlying pathology in an athletic population. The impact of routine, vigorous physical activity on exercise physiology should be integrated into determination of what constitutes a normal CPET result in an athletic individual.
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057337-6
    ISSN 1534-3189 ; 1092-8464
    ISSN (online) 1534-3189
    ISSN 1092-8464
    DOI 10.1007/s11936-021-00928-z
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  7. Article ; Online: Truth About Physical Fitness and Risk of Acute Myocardial Infarction: The HUNT Is On.

    Wasfy, Meagan M / Baggish, Aaron L

    Journal of the American Heart Association

    2019  Volume 8, Issue 9, Page(s) e012567

    MeSH term(s) Cardiorespiratory Fitness ; Humans ; Myocardial Infarction ; Physical Fitness
    Language English
    Publishing date 2019-03-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.119.012567
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  8. Article: ECG findings in professional rugby players using international screening recommendations.

    McHugh, Clíodhna / Petek, Bradley / Grant, Aubrey J / Gustus, Sarah / van Dyk, Nicol / Hind, Karen / Wilson, Fiona / Wasfy, Meagan

    BMJ open sport & exercise medicine

    2024  Volume 10, Issue 1, Page(s) e001813

    Abstract: Background: While World Rugby guidelines do not mandate the inclusion of an electrocardiogram (ECG) for all players, this is required for entry into international rugby competitions. We, therefore, sought to describe sport-specific normative ECG values ... ...

    Abstract Background: While World Rugby guidelines do not mandate the inclusion of an electrocardiogram (ECG) for all players, this is required for entry into international rugby competitions. We, therefore, sought to describe sport-specific normative ECG values and evaluate the performance of contemporary athlete ECG guidelines in male and female professional rugby players.
    Methods: We retrospectively analysed professional rugby players' ECGs (n=356, male 79%) obtained during preparticipation screening (2010-2022), comparing by sex and playing position (forwards vs backs). ECGs were categorised as normal 'training-related', borderline and abnormal findings, as defined by the 2017 International Recommendations.
    Results: 84% of players had one or more normal, 'training-related' findings, with males having a higher prevalence than females (91% vs 60%, p<0.001). Most ECG findings did not vary by position. No female player had borderline or abnormal ECG findings. Borderline findings were present in 3% (n=12/356) of players. Abnormal findings were present in 2% (n=7/356) of players. Overall, 2.2% of ECGs were 'positive' (n=8/356, including n=1 ECG with two borderline findings).
    Conclusions: The application of contemporary ECG interpretation criteria resulted in a low positivity rate isolated to male players. These results help inform the logistic feasibility of ECG-inclusive screening, which is already required to enter major tournaments.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2817580-3
    ISSN 2055-7647
    ISSN 2055-7647
    DOI 10.1136/bmjsem-2023-001813
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  9. Article: Cardiac Adaption to Exercise Training: the Female Athlete.

    Petek, Bradley J / Wasfy, Meagan M

    Current treatment options in cardiovascular medicine

    2018  Volume 20, Issue 8, Page(s) 68

    Abstract: Purpose of review: The number of female athletes participating in sports has increased exponentially over the past century. While cardiac adaptations to exercise have been well described, female athletes have been underrepresented in many prior studies. ...

    Abstract Purpose of review: The number of female athletes participating in sports has increased exponentially over the past century. While cardiac adaptations to exercise have been well described, female athletes have been underrepresented in many prior studies. More recently, important research has embraced gender as an important biologic variable. We will review this work in order to examine how gender influences the impact of exercise on the heart.
    Recent findings: Exercise-induced cardiac remodeling (EICR) manifests slightly differently in male and female athletes. Specifically, female athletes have fewer signs of EICR on the electrocardiogram than male athletes, though are more likely to have anterior T wave inversions in the absence of cardiac disease. Cardiac enlargement due to exercise follows a different pattern in female versus male athletes, with females having similar chamber size when adjusted for body size but lower left ventricular mass. Recent research also suggests that female masters athletes may be less likely to have excess coronary disease, atrial fibrillation, and myocardial fibrosis, all of which have been posited though not proven to be sequelae of long-term endurance exercise in males. Gender appears to be an important modifier of the relationship between exercise and associated cardiac remodeling. The biological mechanisms underlying gender-based differences in EICR are poorly understood and will be an important area of future research.
    Language English
    Publishing date 2018-07-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057337-6
    ISSN 1534-3189 ; 1092-8464
    ISSN (online) 1534-3189
    ISSN 1092-8464
    DOI 10.1007/s11936-018-0659-2
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  10. Article ; Online: Long-term risk of cardiovascular disease after traumatic brain injury: screening and prevention.

    Izzy, Saef / Grashow, Rachel / Radmanesh, Farid / Chen, Patrick / Taylor, Herman / Formisano, Rita / Wilson, Fiona / Wasfy, Meagan / Baggish, Aaron / Zafonte, Ross

    The Lancet. Neurology

    2023  Volume 22, Issue 10, Page(s) 959–970

    Abstract: Traumatic brain injury (TBI) is highly prevalent among individuals participating in contact sports, military personnel, and in the general population. Although it is well known that brain injury can cause neurological and psychiatric complications, ... ...

    Abstract Traumatic brain injury (TBI) is highly prevalent among individuals participating in contact sports, military personnel, and in the general population. Although it is well known that brain injury can cause neurological and psychiatric complications, evidence from studies on individuals exposed to a single or repetitive brain injuries suggests an understudied association between TBI and the risk of developing chronic cardiovascular diseases and risk factors for cardiovascular disease. Several studies have shown that people without pre-existing comorbidities who sustain a TBI have a significantly higher risk of developing chronic cardiovascular disease, than people without TBI. Similar observations made in military and professional American-style football cohorts suggest causal pathways through which modifiable cardiovascular risk factors might mediate the relationship between brain injury and chronic neurological diseases. A better understanding of cardiovascular disease risk after TBI combined with a proactive, targeted screening programme might mitigate long-term morbidity and mortality in individuals with TBI, and improve their quality of life.
    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Quality of Life ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries ; Football
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00241-7
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