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Article ; Online: Use of magnetic resonance imaging-guided radiotherapy for breast cancer: a scoping review protocol.

Elliott, Sarah / Berlangieri, Alexandra / Wasiak, Jason / Chao, Michael / Foroudi, Farshad

2021 Volume 10, Issue 1, Page(s) 44

Abstract: Background: In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated with ... ...

Abstract	Background: In recent years, we have seen the incorporation of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence of the new technology of MR linacs. However, the significant health care resources associated with this advanced technology impact immediate widespread use and availability. There are currently limited studies to demonstrate the clinical effectiveness and inform decision-making on the use of MRI in radiotherapy. The objective of this scoping review is to identify and map the existing evidence surrounding the clinical implementation of MRI-guided radiotherapy in patients with breast cancer. It also aims to identify challenges and knowledge gaps in the literature. Methods: We will perform a comprehensive search in MEDLINE and EMBASE databases from January 2010 onwards. Grey literature sources will include the WHO International Clinical Trials Registry Platform. We will include systematic reviews, randomised and non-randomised controlled studies published in English. Literature should examine the use of magnetic resonance imaging-guided radiotherapy in adults with breast cancer, regardless of cancer stage or severity. Two reviewers will independently screen all titles, abstracts and full-text reports. Data will be extracted and summarised using qualitative (e.g. content and thematic analysis) methods and presented in tables. Discussion: The results from this review will consolidate the evidence surrounding MRI-guided radiotherapy for breast cancer, contributing to the development and optimisation of patient selection, simulation, planning, treatment delivery, quality assurance and research, to help improve patient outcomes, cancer care and treatment for women with breast cancer. Systematic review registration: The protocol is available on Open Science Framework at DOI https://doi.org/10.17605/OSF.IO/8TEV6.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/radiotherapy ; Delivery of Health Care ; Female ; Humans ; Review Literature as Topic
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-021-01594-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Use of magnetic resonance image-guided radiotherapy for breast cancer: a scoping review.

Berlangieri, Alexandra / Elliott, Sarah / Wasiak, Jason / Chao, Michael / Foroudi, Farshad

Journal of medical radiation sciences

2021 Volume 69, Issue 1, Page(s) 122–133

Abstract: In recent years, we have seen the integration of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence MR linear accelerators (MR-linac). Currently, there are limited studies to demonstrate the clinical effectiveness of ... ...

Abstract	In recent years, we have seen the integration of magnetic resonance imaging (MRI) simulators into radiotherapy centres and the emergence MR linear accelerators (MR-linac). Currently, there are limited studies to demonstrate the clinical effectiveness of MRI guided radiotherapy (MRIgRT) treatment for breast cancer patients. The objective of this scoping review was to identify and map the existing evidence surrounding the clinical implementation of MRIgRT for breast cancer patients. We also identified the challenges and knowledge gaps in the literature. The scoping review was reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) extension for Scoping Reviews reporting guidelines. Titles and abstracts were screened by two independent reviewers. Quantitative and qualitative data were extracted and summarised using thematically organised tables. Results identify that accelerated partial breast irradiation (APBI) is the most common form of treatment for MRIgRT. The presence of the magnet does not affect target coverage or violate organ at risk (OAR) constraints compared to standard radiotherapy methods. Consideration is advised for skin and chest wall (CW) due to the electron return effect (ERE) and areas such as armpit and chin due to the electron stream effect (ESE). Clinically, bolus has been used to protect and prevent unwanted dose in these areas. Overall treatment for APBI on the MR-linac is feasible.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/radiotherapy ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Radiation Oncology ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Image-Guided/methods
Language	English
Publishing date	2021-09-15
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2734841-6
ISSN	2051-3909 ; 2051-3909
ISSN (online)	2051-3909
ISSN	2051-3909
DOI	10.1002/jmrs.545
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Article ; Online: Response to 'Response to 'Chemical burns: Diphoterine untangled' by KS Alexander [Burns 2017]'.

Alexander, K Skaria / Wasiak, Jason / Cleland, Heather

Burns : journal of the International Society for Burn Injuries

2018 Volume 44, Issue 4, Page(s) 1012–1013

MeSH term(s)	Burns ; Burns, Chemical ; Eye Burns ; Humans ; Organic Chemicals
Chemical Substances	Organic Chemicals ; diphoterine
Language	English
Publishing date	2018-02-01
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2017.12.007
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Article ; Online: Appraisal of systematic reviews on the management of peri-implant diseases with two methodological tools.

Faggion, Clovis Mariano / Monje, Alberto / Wasiak, Jason

Journal of clinical periodontology

2018 Volume 45, Issue 6, Page(s) 754–766

Abstract: Aim: This study aimed to evaluate and compare the performance of two methodological instruments to appraise systematic reviews and to identify potential disagreements of systematic review authors regarding risk of bias (RoB) evaluation of randomized ... ...

Abstract	Aim: This study aimed to evaluate and compare the performance of two methodological instruments to appraise systematic reviews and to identify potential disagreements of systematic review authors regarding risk of bias (RoB) evaluation of randomized controlled trials (RCTs) included in systematic reviews on peri-implant diseases. Material/methods: We searched Medline, Web of Science, Cochrane Library, PubMed Central, and Google Scholar for systematic reviews on peri-implant diseases published before July 11, 2017. Two authors independently evaluated the RoB and methodological quality of the systematic reviews by applying the Risk of Bias in Systematic Reviews (ROBIS) tool and Assessing the Methodological Quality of Systematic Reviews (AMSTAR) checklist, respectively. We assessed the RoB scores of the same RCTs published in different systematic reviews. Results: Of the 32 systematic reviews identified, 23 reviews addressed the clinical topic of peri-implantitis. A high RoB was detected for most systematic reviews (n=25) using ROBIS, whilst five systematic reviews displayed low methodological quality by AMSTAR. Almost 30% of the RoB comparisons (for the same RCTs) had different RoB ratings across systematic reviews. Conclusions: The ROBIS tool appears to provide more conservative results than AMSTAR checklist. Considerable disagreement was found among systematic review authors rating the same RCT included in different systematic reviews.
MeSH term(s)	Bias ; Humans ; Peri-Implantitis/therapy ; Randomized Controlled Trials as Topic ; Research Design ; Systematic Reviews as Topic
Language	English
Publishing date	2018-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.12893
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Zs.A 1003: Show issues

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Article ; Online: Burns: dressings.

Wasiak, Jason / Cleland, Heather

BMJ clinical evidence

2015 Volume 2015

Abstract: Introduction: Burns are classified according to depth. This overview concerns the treatments for partial-thickness burns, which can be expected or have the potential to heal spontaneously (superficial partial-thickness and mid-dermal partial-thickness ... ...

Abstract	Introduction: Burns are classified according to depth. This overview concerns the treatments for partial-thickness burns, which can be expected or have the potential to heal spontaneously (superficial partial-thickness and mid-dermal partial-thickness burns). Injuries that involve the deeper part of the dermis and require surgical treatments to achieve healing are not the focus of this overview. Methods and outcomes: We conducted a systematic overview and aimed to answer the following clinical question: What are the effects of treatments for partial-thickness burns? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this review). Results: At this update, searching of electronic databases retrieved 322 studies. After deduplication and removal of conference abstracts, 193 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 160 studies and the further review of 33 full publications. Of the 33 full articles evaluated, two systematic reviews and two RCTs were added at this update. We performed a GRADE evaluation for 30 PICO combinations. Conclusions: In this systematic overview, we categorised the efficacy for 10 interventions, based on information relating to the effectiveness and safety of alginate dressing, biosynthetic dressing, chlorhexidine-impregnated paraffin gauze dressing, hydrocolloid dressing, hydrogel dressing, paraffin gauze dressing, polyurethane film, silicone-coated nylon dressing, silver-impregnated dressing, and silver sulfadiazine cream.
Language	English
Publishing date	2015-07-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2393858-4
ISSN	1752-8526 ; 1757-0816 ; 1475-9225
ISSN (online)	1752-8526
ISSN	1757-0816 ; 1475-9225
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Article ; Online: A survey of prevalence of narrative and systematic reviews in five major medical journals.

Faggion, Clovis Mariano / Bakas, Nikolaos P / Wasiak, Jason

BMC medical research methodology

2017 Volume 17, Issue 1, Page(s) 176

Abstract: Background: Systematic reviews may provide less biased evidence than narrative reviews because they observe a strict methodology, similarly to primary studies. Hence, for clinical research questions, systematic reviews should be the study design of ... ...

Abstract	Background: Systematic reviews may provide less biased evidence than narrative reviews because they observe a strict methodology, similarly to primary studies. Hence, for clinical research questions, systematic reviews should be the study design of choice. It would be important to evaluate the prevalence and characteristics of narrative and systematic reviews published in prominent medical journals. Researchers and clinicians give great value to articles published in such scientific journals. This study sought to evaluate the prevalence and characteristics of narrative and systematic reviews in the five highest-ranked general medical journals and investigate the associations among type of review, number of citations, and impact factor (IF). Methods: We surveyed the five highest-ranked medical journals (The New England Journal of Medicine, The Lancet, The Journal of the American Medical Association, The BMJ, and Annals of Internal Medicine) for narrative and systematic reviews published between June 2015 and June 2016. We independently selected and extracted the data from the reviews by strictly following the pre-determined eligibility criteria (Systematic and narrative reviews that focused on the management of diseases). We conducted regression analyses to investigate the associations among review type, number of citations, and IF. We also descriptively reported narrative reviews containing some methodology that might be reproducible. Results: Two hundred seventy-five reviews were included: 75 (27%) systematic; 126 (46%) narrative with some methodology reported, and 74 (27%) narrative reviews. In comparison to systematic reviews, narrative reviews were more frequently published in journals with higher IF (risk ratio [RR] = 1.114 (95% CI 1.080 to 1.149). Systematic reviews received more citations than narrative reviews (group formed by narrative and narrative with some methodology reported (RR = 0.985 95% CI 0.978 to 0.991). Conclusions: Non-systematic evidence is the most prevalent type of evidence in reviews published in the five highest-ranked general medical journals. Narrative reviews were more frequently published in journals with higher IF. We recommend that journals limit their space for narrative information, and to address clinical research questions, these journals consider publishing systematic evidence exclusively.
MeSH term(s)	Data Mining/methods ; Humans ; Medical Writing/standards ; Medicine ; Periodicals as Topic/standards ; Periodicals as Topic/statistics & numerical data ; Publishing/standards ; Publishing/statistics & numerical data ; Review Literature as Topic
Language	English
Publishing date	2017--28
Publishing country	England
Document type	Journal Article
ISSN	1471-2288
ISSN (online)	1471-2288
DOI	10.1186/s12874-017-0453-y
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Article ; Online: Chemical burns: Diphoterine untangled.

Alexander, K Skaria / Wasiak, Jason / Cleland, Heather

Burns : journal of the International Society for Burn Injuries

2017 Volume 44, Issue 4, Page(s) 752–766

Abstract: Objective: Diphoterine is a hypertonic, amphoteric, polyvalent and chelating decontamination solution used in the treatment of cutaneous and ocular chemical burns. Due to infrequent use by emergency physicians along with the small number of available ... ...

Abstract	Objective: Diphoterine is a hypertonic, amphoteric, polyvalent and chelating decontamination solution used in the treatment of cutaneous and ocular chemical burns. Due to infrequent use by emergency physicians along with the small number of available studies, its debate in the literature as to its efficacy and safety remains inconclusive. Methods: A structured literature search was performed in MEDLINE, EMBASE BIOLOGICAL ABSTRACTS and TOXNET to June 2016 for original English-language studies reporting on the safety and effectiveness of Diphoterine. Methodological and reporting quality of pre-clinical animal studies was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool and Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines. Clinical studies were assessed using Chambers' criteria. Results: 13 studies (seven in the pre-clinical, five in the clinical setting and one mixed) met the study inclusion criteria. Pre-clinical studies showed a faster resolution of pH and reduced tissue necrosis with Diphoterine. Clinical studies showed reduced tissue necrosis/severity of symptoms, faster pH resolution and a reduction in pain when using Diphoterine. No adverse events were attributable to Diphoterine. Reporting and methodology of the studies was poor or showed a high risk of bias. Conclusions: Diphoterine appears to be safe to use and is probably superior to other rinsing solutions. However, immediate decontamination is imperative and if Diphoterine is not available a different rinsing solution should be used. The methodology of the published literature for Diphoterine is generally poor and future publications should use the frameworks given as templates.
MeSH term(s)	Burns, Chemical/drug therapy ; Eye Burns/chemically induced ; Eye Burns/drug therapy ; Humans ; Organic Chemicals/therapeutic use ; Skin/injuries
Chemical Substances	Organic Chemicals ; diphoterine
Language	English
Publishing date	2017-10-10
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2017.09.017
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Article ; Online: Surveying Retracted Studies and Notices Within the Field of Radiation Oncology.

Wasiak, Jason / Hamilton, Daniel George / Foroudi, Farshad / Faggion, Clovis M

International journal of radiation oncology, biology, physics

2018 Volume 102, Issue 3, Page(s) 660–665

Abstract: Purpose: The purpose of this study was to characterize retracted studies within the field of radiation oncology.: Methods and materials: Computerized searches were performed in Ovid MEDLINE, PubMed, Ovid EMBASE, and the Cochrane Library up to May ... ...

Abstract	Purpose: The purpose of this study was to characterize retracted studies within the field of radiation oncology. Methods and materials: Computerized searches were performed in Ovid MEDLINE, PubMed, Ovid EMBASE, and the Cochrane Library up to May 2017 looking for retracted studies using the terms "retraction note," "retracted note," "withdrawn" and "radiotherapy," and "radiation oncology." Additional studies were identified by hand-searching 10 discipline-specific journals. Two authors independently screened papers and then extracted author demographics, journal characteristics, and retraction-specific variables. Results: Of the 58 studies identified, the most common reasons for retraction were misconduct (43%), methodological error (21%), authorship issues (5%), unknown causes (5%), and journal (administrative) errors (3%). A total of 13 systematic reviews or protocols (22%) were withdrawn from the Cochrane Library for being out-of-date or redundant. All but one retracted study and retraction notice were available in portable document format. Of the 57 retrieved papers, 79% were identified as retracted via in-text notations or watermarks. Overall median time to retraction was 44 months (interquartile range, 11-98 months). However, 42 studies (72%) were still cited after retraction notices were published. Conclusions: A retracted study within the field of radiation oncology remains a relatively uncommon event. Although promising, our data suggest that the majority of these retracted articles continue to be cited as valid research. As such, there is still a need for clinicians to remain vigilant with their academic rigor and good clinical research practices. There is an urgent need for publication houses to foster universal publishing standards along with discipline-specific retraction guidelines.
MeSH term(s)	Authorship ; Bibliometrics ; Biomedical Research/standards ; Humans ; MEDLINE ; Medical Errors ; PubMed ; Publishing/standards ; Radiation Oncology/methods ; Radiation Oncology/standards ; Scientific Misconduct ; Surveys and Questionnaires
Language	English
Publishing date	2018-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2018.06.028
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Zs.A 1218: Show issues

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Article ; Online: An analysis of retractions of dental publications.

Faggion, Clovis Mariano / Ware, Robert S / Bakas, Nikolaos / Wasiak, Jason

Journal of dentistry

2018 Volume 79, Page(s) 19–23

Abstract: Objectives: To comprehensively report on the characteristics of retracted publications in the field of dentistry.: Methods: We searched MEDLINE (via PubMed), PubMed Central, Web of Science and Google Scholar databases for dental retracted articles ... ...

Abstract	Objectives: To comprehensively report on the characteristics of retracted publications in the field of dentistry. Methods: We searched MEDLINE (via PubMed), PubMed Central, Web of Science and Google Scholar databases for dental retracted articles from database inception to 02 July 2018. In addition, we scanned the search engine Google Scholar, and the website, Retraction Watch (www.retractionwatch.com), for retracted dental articles. Two researchers independently screened titles, abstracts and full text of search results. Descriptive data was collected on each retracted article including reason for retraction, study type, journal impact factor, and time between publication and retraction. Regression models were used to evaluate the association between journal impact factor and retraction characteristics. Results: A total of 138 retractions of dental articles were included. Reasons for retraction were misconduct (N = 100, 72.5%), with the most frequently reported misconduct being overlap/plagiarism and innacurate/falsified conducting and reporting (N = 53, 38.4%). In vitro (N = 39, 28.3%), case reports (N = 29, 21%) and narrative reviews (N = 19, 13.8%) were study design most frequently identified in retracted articles. The median time between article publication and date of retraction notice was 1 year (interquartile-range [IQR] = 0-2 years). More than half of the retracted articles (n = 82, 59.4%) were cited post-retraction. A retracted article reporting a randomized controlled trial was more likely to appear in journal with higher impact factor than a retracted case report (mean difference [MD] = 2.2; 95% confidence interval [CI] = 1.2,3.1. Articles retracted after 2012 were likely to appear in journals with a lower impact factor (MD=-1.3; 95%CI=-1.8, 0.8). Conclusions: Research misconduct is the main reason for retraction of dental articles. A substantial proportion of these articles were still being cited after their retraction. Clinical significance: This report of dental retraction articles informs that more transparency is needed with data reporting in dentistry to improve writing practices in dentistry. A more complete report of retractions and their causes would provide more accurate information to inform researchers and editors to avoid or reduce future cases of retractions. More complete and accurate reporting would increase the overall trust in dental research.
MeSH term(s)	Journal Impact Factor ; Plagiarism ; Publishing ; Research Design ; Scientific Misconduct
Language	English
Publishing date	2018-09-08
Publishing country	England
Document type	Journal Article
ZDB-ID	186068-9
ISSN	1879-176X ; 0300-5712
ISSN (online)	1879-176X
ISSN	0300-5712
DOI	10.1016/j.jdent.2018.09.002
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Zs.A 860: Show issues

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Article ; Online: Factors predicting health status and recovery of hand function after hand burns in the second year after hospital discharge.

Knight, Amber / Wasiak, Jason / Salway, Jacqueline / O'Brien, Lisa

Burns : journal of the International Society for Burn Injuries

2017 Volume 43, Issue 1, Page(s) 100–106

Abstract: Introduction: Hands are the most commonly burnt body part given humans' innate response to guard their face from injury, and are known to have detrimental functional and psychological consequences. Conflicting evidence exists regarding the impact of ... ...

Abstract	Introduction: Hands are the most commonly burnt body part given humans' innate response to guard their face from injury, and are known to have detrimental functional and psychological consequences. Conflicting evidence exists regarding the impact of hand burns on long-term health status and global functioning. The objective of this study was to identify patient and clinical characteristics that predict health status and hand function of people at 12-24 months after hand burn. Methods: The Burns Specific Health Scale-Brief (BSHS-B) and the Brief Michigan Hand Outcome Questionnaire (Brief MHQ) were administered to community-dwelling adults who were between one and two years after admission to a statewide burns service for burns including one or both hands. Demographic, injury, and treatment data were collected to identify which factors predict health status and hand function in the second year after admission. Linear regression analyses adjusted for total burn surface area and burn depth were conducted to identify important predictors or outcomes. Results: The sample (n=41) was 80.5% male, with a mean age of 44.5 years and total body surface area (TBSA) of 8.4%. Psychiatric illness (regression coefficient -56.6, confidence interval (95% CI) -76.70, -36.49) and female gender (-20.3; 95% CI -0.77, -40.29) were key predictors of poorer global health status on the BSHS-B. Females also scored worse on body image (-5.35; 95% CI -1.83, -8.87) and work (-4.13; 95% CI -0.64, -7.62) domains of BSHS-B. The need for reconstructive or secondary surgery (-38.84; 95% CI -58.04, -19.65) and female gender (-16.30; 95% CI -4.03, -28.57) were important predictors of poorer hand function. Conclusion: Women and those with a history of psychiatric illness are particularly vulnerable to poorer outcomes in health status and/or hand function after burns, and may benefit from more intensive rehabilitation support and long-term follow-up.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Body Image/psychology ; Burns/psychology ; Burns/rehabilitation ; Burns/surgery ; Female ; Follow-Up Studies ; Hand Injuries/psychology ; Hand Injuries/rehabilitation ; Hand Injuries/surgery ; Health Status ; Humans ; Length of Stay ; Male ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Middle Aged ; Prognosis ; Range of Motion, Articular ; Reconstructive Surgical Procedures/statistics & numerical data ; Recovery of Function ; Risk Factors ; Sex Factors ; Skin Transplantation ; Victoria ; Young Adult
Language	English
Publishing date	2017-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2016.07.025
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