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  1. Article ; Online: Inceptor intercepts insulin signaling in pancreatic β-cells.

    Watada, Hirotaka

    Journal of diabetes investigation

    2021  Volume 12, Issue 9, Page(s) 1540–1541

    MeSH term(s) Insulin/metabolism ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Signal Transduction
    Chemical Substances Insulin
    Language English
    Publishing date 2021-07-04
    Publishing country Japan
    Document type Journal Article ; Comment
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13596
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  2. Article: Current understanding of the effect of sodium-glucose co-transporter-2 inhibitors in Asian patients with diabetes mellitus.

    Watada, Hirotaka

    Diabetology international

    2020  Volume 11, Issue 3, Page(s) 242–244

    Language English
    Publishing date 2020-06-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2574501-3
    ISSN 2190-1686 ; 2190-1678
    ISSN (online) 2190-1686
    ISSN 2190-1678
    DOI 10.1007/s13340-020-00443-9
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  3. Article ; Online: Clinical evidence regarding factors linking metabolic abnormal obesity to pancreatic β-cell dysfunction.

    Watada, Hirotaka

    Journal of diabetes investigation

    2020  Volume 11, Issue 4, Page(s) 798–800

    MeSH term(s) Adipocytes/metabolism ; Animals ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Insulin-Secreting Cells/metabolism ; Obesity/complications ; Obesity/metabolism
    Language English
    Publishing date 2020-05-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13264
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  4. Article ; Online: Evidence-based comparison of glucagon-like peptide receptor agonists and sodium-glucose cotransporter 2 inhibitors.

    Watada, Hirotaka

    Journal of diabetes investigation

    2019  Volume 11, Issue 1, Page(s) 17–19

    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Glucagon-Like Peptide Receptors ; Glucagon-Like Peptides ; Glucose ; Humans ; Sodium
    Chemical Substances Glucagon-Like Peptide Receptors ; Glucagon-Like Peptides (62340-29-8) ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-09-17
    Publishing country Japan
    Document type Journal Article ; Comment
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.13131
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  5. Article ; Online: Unappreciated role of low-density lipoprotein receptor-related protein 1 in pancreatic β cells: Multiple roles of low-density lipoprotein receptor-related protein 1 in glucose and lipid metabolism.

    Watada, Hirotaka

    Journal of diabetes investigation

    2018  Volume 10, Issue 2, Page(s) 216–218

    MeSH term(s) Adipocytes/metabolism ; Animals ; Glucose/metabolism ; Hepatocytes/metabolism ; Humans ; Insulin-Secreting Cells/metabolism ; Lipid Metabolism ; Low Density Lipoprotein Receptor-Related Protein-1/metabolism
    Chemical Substances Low Density Lipoprotein Receptor-Related Protein-1 ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2018-10-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.12933
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  6. Article ; Online: Efficacy, safety and tolerability of imeglimin in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials.

    Hagi, Katsuhiko / Nitta, Masahiro / Watada, Hirotaka / Kaku, Kohei / Ueki, Kohjiro

    Journal of diabetes investigation

    2023  Volume 14, Issue 11, Page(s) 1246–1261

    Abstract: Aims/introduction: This meta-analysis aimed to evaluate the efficacy and safety/tolerability of imeglimin, a novel oral antihyperglycemic agent, administered as monotherapy and adjunctive therapy in patients with type 2 diabetes mellitus.: Materials ... ...

    Abstract Aims/introduction: This meta-analysis aimed to evaluate the efficacy and safety/tolerability of imeglimin, a novel oral antihyperglycemic agent, administered as monotherapy and adjunctive therapy in patients with type 2 diabetes mellitus.
    Materials and methods: Parallel-group randomized controlled trials comparing imeglimin with placebo in adults with type 2 diabetes mellitus were included. Risk ratios or weighted mean differences (WMD) and 95% confidence intervals (CIs) were calculated using random effects models. The primary outcome for efficacy was the change in glycated hemoglobin (HbA1c). Secondary outcomes included other efficacy-related outcomes, specific adverse events, and changes in body weight and lipid parameters.
    Results: Nine randomized controlled trials (n = 1,655) were included. When analyzed by dose, there was a significant difference in glycated hemoglobin (%) between imeglimin monotherapy and placebo at doses >1,000 mg twice daily (1,000 mg: studies N = 3, patients n = 517, WMD = -0.714, P < 0.001; 1,500 mg: N = 5, n = 448, WMD = -0.531, P = 0.020; 2,000 mg: N = 1, n = 149, WMD = -0.450, P = 0.005). Imeglimin adjunctive therapy significantly improved glycated hemoglobin over placebo at doses of 1,000 mg (N = 1, n = 214, WMD = -0.600, P < 0.001) and 1,500 mg (N = 2, n = 324, WMD = -0.576, P < 0.001). Subgroup analysis of the primary outcome showed that imeglimin was effective regardless of chronic kidney disease category, with studies carried out in Japan and in patients with lower body mass index showing a trend toward improved imeglimin efficacy. There were no significant differences between imeglimin and placebo in the risk of all-cause discontinuation and the proportion of patients who presented with at least one adverse event.
    Conclusions: Imeglimin is efficacious, safe, and well tolerated as monotherapy and adjunctive therapy.
    MeSH term(s) Adult ; Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/chemically induced ; Hypoglycemic Agents/adverse effects ; Glycated Hemoglobin ; Randomized Controlled Trials as Topic
    Chemical Substances Hypoglycemic Agents ; imeglimin (UU226QGU97) ; Glycated Hemoglobin
    Language English
    Publishing date 2023-08-23
    Publishing country Japan
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14070
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  7. Article ; Online: Effect of patient characteristics on the efficacy and safety of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus: A post-hoc analysis of two randomized, placebo-controlled trials.

    Hagi, Katsuhiko / Kochi, Kenji / Watada, Hirotaka / Kaku, Kohei / Ueki, Kohjiro

    Journal of diabetes investigation

    2023  Volume 14, Issue 9, Page(s) 1101–1109

    Abstract: Aims/introduction: Substantial variability in demographic and clinical characteristics exists among patients with type 2 diabetes mellitus, which may impact treatment. This post-hoc analysis evaluated the efficacy and safety of imeglimin 1,000 mg twice ... ...

    Abstract Aims/introduction: Substantial variability in demographic and clinical characteristics exists among patients with type 2 diabetes mellitus, which may impact treatment. This post-hoc analysis evaluated the efficacy and safety of imeglimin 1,000 mg twice daily (BID) monotherapy in type 2 diabetes mellitus patients according to demographic and clinical characteristics.
    Materials and methods: Data were pooled from two placebo-controlled, 24 week, randomized, double-blind studies in adults with type 2 diabetes mellitus. Outcomes (least squares mean [LSM] change in HbA1c from baseline to week 24, and safety) were analyzed according to subgroups based on demographics, clinical characteristics, and comorbidities.
    Results: The difference in LSM change in HbA1c from baseline to week 24 was statistically significant for imeglimin vs placebo in all patient subgroups analyzed (P < 0.05 each), including demographics (age, body mass index), clinical characteristics (duration of type 2 diabetes mellitus, chronic kidney disease [CKD] stage, and prior medication use) and comorbidities (hypertension, dyslipidemia, risk of hepatic fibrosis and liver function parameter status). A statistically significant separation from placebo in HbA1c was observed at week 4 and maintained through week 24. No new safety concerns were identified with imeglimin in any patient subpopulations.
    Conclusions: The efficacy and safety of imeglimin was demonstrated across patient subgroups, irrespective of baseline demographic and clinical characteristics. Our findings confirm the efficacy and safety of imeglimin across a broad spectrum of patients with type 2 diabetes mellitus.
    MeSH term(s) Adult ; Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/chemically induced ; Hypoglycemic Agents ; Glycated Hemoglobin ; East Asian People ; Treatment Outcome ; Double-Blind Method
    Chemical Substances Hypoglycemic Agents ; imeglimin (UU226QGU97) ; Glycated Hemoglobin
    Language English
    Publishing date 2023-06-01
    Publishing country Japan
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14035
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  8. Article: New role for alpha cells as a source for new beta cells.

    Watada, Hirotaka

    Journal of diabetes investigation

    2014  Volume 2, Issue 1, Page(s) 43–44

    Language English
    Publishing date 2014-04-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/j.2040-1124.2010.00069.x
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  9. Article: [Diabetes mellitus related common medical disorders: recent progress in diagnosis and treatment. Topics: I. Pathophysiology, diagnosis and treatment; 11. Atherosclerosis].

    Watada, Hirotaka

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2013  Volume 102, Issue 4, Page(s) 902–906

    MeSH term(s) Atherosclerosis/diagnosis ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Blood Glucose/metabolism ; Diabetes Complications/diagnosis ; Diabetes Complications/drug therapy ; Humans ; Hypertension/diagnosis ; Hypertension/etiology ; Risk Factors
    Chemical Substances Blood Glucose
    Language Japanese
    Publishing date 2013-05-21
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.102.902
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  10. Article: New factors secreted from islets expand β-cell mass.

    Watada, Hirotaka

    Journal of diabetes investigation

    2013  Volume 4, Issue 4, Page(s) 347–348

    Language English
    Publishing date 2013-04-26
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.12079
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