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  1. Article ; Online: Synthesis and biological evaluation of novel

    Saito, Haruka / Watanabe, Hiroyuki / Ono, Masahiro

    Bioorganic & medicinal chemistry letters

    2024  Volume 99, Page(s) 129625

    Abstract: The ghrelin receptor (GHSR) is known to regulate various physiological processes including appetite, food intake, and growth hormone release. Its expression is mainly observed in the brain, pancreas, stomach, and intestine. However, the functions of the ... ...

    Abstract The ghrelin receptor (GHSR) is known to regulate various physiological processes including appetite, food intake, and growth hormone release. Its expression is mainly observed in the brain, pancreas, stomach, and intestine. However, the functions of the receptor have not been fully elucidated. GHSR imaging with positron emission tomography (PET) is expected to further understanding of the functions and pathologies of the receptor. In this study, we newly designed and synthesized diaminopyrimidine derivatives ([
    MeSH term(s) Animals ; Mice ; Brain/diagnostic imaging ; Brain/metabolism ; Positron-Emission Tomography/methods ; Pyrimidines ; Receptors, Ghrelin/metabolism ; Tissue Distribution ; Fluorine Radioisotopes/chemistry
    Chemical Substances 2,4-diaminopyrimidine (156-81-0) ; Pyrimidines ; Receptors, Ghrelin ; Fluorine Radioisotopes
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2024.129625
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    Zs.A 3203: Show issues Location:
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  2. Article ; Online: Synthesis and evaluation of novel trifunctional chelating agents for pretargeting approach using albumin binder to improve tumor accumulation.

    Tsuchihashi, Shohei / Nakashima, Kazuma / Watanabe, Hiroyuki / Ono, Masahiro

    Nuclear medicine and biology

    2024  Volume 132-133, Page(s) 108911

    Abstract: Introduction: The pretargeting approach consists of in vivo ligation between pre-injected antibodies and low-molecular-weight radiolabeled effectors. The advantage of the pretargeting approach is to improve a tumor-to-background ratio, but the ... ...

    Abstract Introduction: The pretargeting approach consists of in vivo ligation between pre-injected antibodies and low-molecular-weight radiolabeled effectors. The advantage of the pretargeting approach is to improve a tumor-to-background ratio, but the disadvantage is to compromise tumor accumulation. In this study, we applied albumin binder (ALB) to the pretargeting approach to overcome low tumor accumulation.
    Methods: We synthesized two novel trifunctional effectors containing an ALB moiety, a chelator, and a different tetrazine and two corresponding effectors without an ALB moiety. Albumin-binding assays and stability assays were performed using
    Results: In albumin-binding assays, ALB-containing effectors exhibited a marked binding to albumin. Two ALB-containing effectors showed the difference in the reactivity and the slight difference in the stability. In biodistribution studies without the pretargeting approach, two ALB-containing effectors showed different pharmacokinetics in blood retention. With the pretargeting approach, the tumor accumulation was improved by the introduction of ALB and the highest tumor accumulation was observed in using the ALB-containing effector with higher blood retention.
    Conclusion: These results suggest that the application of ALB to the pretargeting approach is effective to improve tumor accumulation, and the structure of tetrazine influences the utility of ALB-containing effectors.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1138098-6
    ISSN 1872-9614 ; 0883-2897 ; 0969-8051
    ISSN (online) 1872-9614
    ISSN 0883-2897 ; 0969-8051
    DOI 10.1016/j.nucmedbio.2024.108911
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  3. Article ; Online: Fundamental evaluation regarding the relationship between albumin-binding and tumor accumulation of PSMA-targeting radioligands.

    Kazuta, Nobuki / Tsuchihashi, Shohei / Watanabe, Hiroyuki / Ono, Masahiro

    Annals of nuclear medicine

    2024  

    Abstract: Objective: The marked success of prostate-specific membrane antigen (PSMA)-targeting radioligands with albumin binder (ALB) is attributed to the improvement of blood retention and tumor accumulation. [: Method: The [: Results: The [: Conclusions! ...

    Abstract Objective: The marked success of prostate-specific membrane antigen (PSMA)-targeting radioligands with albumin binder (ALB) is attributed to the improvement of blood retention and tumor accumulation. [
    Method: The [
    Results: The [
    Conclusions: These results indicate that the moderate reversible binding of ALB with albumin, not covalent binding, may play a critical role in enhancing the tumor accumulation of PSMA-targeting radioligands.
    Language English
    Publishing date 2024-04-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1146984-5
    ISSN 1864-6433 ; 0914-7187
    ISSN (online) 1864-6433
    ISSN 0914-7187
    DOI 10.1007/s12149-024-01930-8
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    Zs.A 3657: Show issues Location:
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  4. Article ; Online: Risk of chromosomal aberration in spermatozoa during intracytoplasmic sperm injection.

    Watanabe, Hiroyuki

    The Journal of reproduction and development

    2018  Volume 64, Issue 5, Page(s) 371–376

    Abstract: Intracytoplasmic sperm injection (ICSI) has become critical for the treatment of severe male infertility. The principal feature of ICSI is the direct injection of spermatozoon into an oocyte, which facilitates the production of fertilized embryos ... ...

    Abstract Intracytoplasmic sperm injection (ICSI) has become critical for the treatment of severe male infertility. The principal feature of ICSI is the direct injection of spermatozoon into an oocyte, which facilitates the production of fertilized embryos regardless of semen characteristics, such as sperm concentration and motility. However, the chromosomal integrity of ICSI zygotes is degraded compared to that of zygotes obtained via in vitro fertilization. This chromosomal damage may occur due to the injection of non-capacitated, acrosome-intact spermatozoa, which never enter the oocytes under natural fertilization. Furthermore, it is possible that the in vitro incubation and pre-treatment of spermatozoa during ICSI results in DNA damage. Chromosomal aberrations in embryos induce early pregnancy losses. However, these issues may be overcome by embryo production using gametes with guaranteed chromosomal integrity. Because conventional chromosome analysis requires fixing cells to obtain the chromosome spreads, embryos cannot be produced using the nucleus that has been analyzed. On the other hand, genome cloning using androgenic or gynogenic embryos provides an additional nucleus for chromosome analysis following embryo production. Thus, this review aims to highlight the hazardous nature of chromosomal aberrations in sperm during ICSI and to introduce a method for the prezygotic examination for chromosomal aberrations.
    MeSH term(s) Abortion, Spontaneous ; Acrosome ; Cell Nucleus/metabolism ; Chromatin/metabolism ; Chromosome Aberrations ; DNA/analysis ; DNA Damage ; Female ; Humans ; Infertility, Male ; Male ; Oocytes/metabolism ; Pregnancy ; Sperm Injections, Intracytoplasmic/adverse effects ; Spermatozoa/abnormalities ; Zygote
    Chemical Substances Chromatin ; DNA (9007-49-2)
    Language English
    Publishing date 2018-07-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2039060-9
    ISSN 1348-4400 ; 0916-8818
    ISSN (online) 1348-4400
    ISSN 0916-8818
    DOI 10.1262/jrd.2018-040
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  5. Article: [An example of the socio-economic rehabilitation program for ex-leprosy patients in Vietnam and its evaluation by the patients].

    Watanabe, Hiroyuki

    Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association

    2018  Volume 85, Issue 3, Page(s) 133–152

    Abstract: One of the leprosy treatment centers (hospital X) in Vietnam offers loan programs to start work as part of the socio-economic rehabilitation program for ex-leprosy patients. The aim of this study is to examine and evaluate the contents of the program ... ...

    Abstract One of the leprosy treatment centers (hospital X) in Vietnam offers loan programs to start work as part of the socio-economic rehabilitation program for ex-leprosy patients. The aim of this study is to examine and evaluate the contents of the program from the ex-leprosy patients’ perspective. The interview group was sub-divided into three groups: male/female and the younger group. A focus group interview method was used to collect qualitative data. The participant program group revealed that their income increased and their health condition improved; moreover, they evaluated the program highly as they can borrow business loan at no interest. Meanwhile, the participants were challenged with a few problems: the frequency in the illness of the livestock and the forcible discounting in the livestock’s price by the customers who use the excuse that the livestock has been raised by ex-leprosy patients. The younger group had concerns regarding the program; they were worried about the repayment of the business loan. Both groups noted points to improve the current program especially in terms of changing the loan repayment schedule and loan volume. Therefore, the program has to be adapted to the needs of ex-leprosy patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Leprosy ; Male ; Middle Aged ; Program Evaluation ; Social Class ; Training Support/standards ; Vietnam ; Workload ; Young Adult
    Language Japanese
    Publishing date 2018-08-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2495704-5
    ISSN 1884-314X ; 1342-3681
    ISSN (online) 1884-314X
    ISSN 1342-3681
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    Zs.A 277: Show issues Location:
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  6. Article ; Online: Carotid Web and High-Risk Patent Foramen Ovale With Cryptogenic Stroke.

    Takafuji, Hiroya / Obunai, Kotaro / Makihara, Yu / Kato, Nahoko / Watanabe, Hiroyuki

    JACC. Cardiovascular interventions

    2024  

    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2024.01.312
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    Zs.A 6669: Show issues Location:
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  7. Article ; Online: Synthesis and evaluation of

    Kazuta, Nobuki / Watanabe, Hiroyuki / Ono, Masahiro

    Journal of labelled compounds & radiopharmaceuticals

    2023  Volume 66, Issue 10, Page(s) 298–307

    Abstract: Granzyme B is an attractive target as a biomarker for contributing to improve the treatment with immune checkpoint inhibitor (ICI). In this study, we designed ... ...

    Abstract Granzyme B is an attractive target as a biomarker for contributing to improve the treatment with immune checkpoint inhibitor (ICI). In this study, we designed novel
    MeSH term(s) Mice ; Animals ; Tissue Distribution ; Granzymes ; Tomography, Emission-Computed, Single-Photon/methods ; Neoplasms ; Autoradiography ; Cell Line, Tumor
    Chemical Substances Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.4045
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    Zs.A 1332: Show issues Location:
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  8. Article: Aphasic mild cognitive impairment in prodromal dementia with Lewy bodies.

    Watanabe, Hiroyuki / Hikida, Sakura / Ikeda, Manabu / Mori, Etsuro

    Frontiers in neurology

    2023  Volume 14, Page(s) 1128566

    Abstract: Introduction: This study aimed to determine the characteristics of aphasic mild cognitive impairment (aphasic MCI), which is characterized by a progressive and relatively prominent language impairment compared with other cognitive impairments, in the ... ...

    Abstract Introduction: This study aimed to determine the characteristics of aphasic mild cognitive impairment (aphasic MCI), which is characterized by a progressive and relatively prominent language impairment compared with other cognitive impairments, in the prodromal phase of dementia with Lewy bodies (DLB).
    Methods: Of the 26 consecutive patients with aphasic MCI who had been prospectively recruited at our hospital, 8 patients were diagnosed with prodromal DLB and underwent language, neurological, neuropsychological, and neuroimaging (
    Results: In our aphasic MCI cohort, the clinical diagnosis of probable prodromal DLB accounted for more than 30% of cases; therefore, the presence of language impairment in prodromal DLB was not very uncommon. Five patients were diagnosed with progressive anomic aphasia and three with logopenic progressive aphasia. Anomic aphasia was characterized by apparent anomia but relatively preserved repetition and comprehension ability and logopenic progressive aphasia by anomia, phonemic paraphasia, and impaired repetition. IMP-SPECT revealed hypoperfusion of the temporal and parietal lobes in the left hemisphere in all but one patient. All patients who underwent cholinesterase inhibitor therapy with donepezil showed improvement in general cognitive function, including language function.
    Discussion: The clinical and imaging features of aphasic MCI in prodromal DLB are similar to those observed in Alzheimer's disease. Progressive fluent aphasia, such as progressive anomic aphasia and logopenic progressive aphasia, is one of the clinical presentations in prodromal state of DLB. Our findings provide further insight into the clinical spectrum of prodromal DLB and may contribute to the development of medication for progressive aphasia caused by cholinergic insufficiency.
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2023.1128566
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  9. Article ; Online: Circulating Neuroactive Steroid Levels in a Patient With Schizophrenia Who Showed Periodic Catatonia.

    Muneoka, Katsumasa / Shirayama, Yukihiko / Watanabe, Hiroyuki / Kimura, Hiroshi

    JCEM case reports

    2023  Volume 1, Issue 1, Page(s) luad009

    Abstract: Catatonia is an abnormal psychological and behavioral state related to stress. The treatment strategy suggests the involvement of neuroactive steroids in its pathophysiology. We report a hospitalized patient with schizophrenia in whom a catatonic state ... ...

    Abstract Catatonia is an abnormal psychological and behavioral state related to stress. The treatment strategy suggests the involvement of neuroactive steroids in its pathophysiology. We report a hospitalized patient with schizophrenia in whom a catatonic state occurred 7 times in 5.5 years. Blood levels of steroid hormones and adrenocorticotropic hormone (ACTH) were measured during the catatonic state and in the intervals between catatonic states (non-catatonic states). Cortisol and dehydroepiandrosterone sulfate (DHEAS) were significantly higher during catatonia than in the non-catatonic state. Cortisol significantly correlated with the ACTH level, whereas blood DHEAS and progesterone correlated only during the non-catatonic state. In addition, the cortisol to DHEAS ratios did not differ between catatonic and non-catatonic states. Although the correlating elevations of ACTH and cortisol implied activation of the hypothalamic-pituitary-adrenal axis (HPA-axis) in the catatonic state, DHEAS levels did not seem to increase in a manner dependent on the HPA-axis or the production of progesterone. The results suggest that the catatonic state was a neuroendocrinological state of HPA-axis activation with comparable increases in DHEAS levels.
    Language English
    Publishing date 2023-02-13
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad009
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  10. Article ; Online: Hoechst-tagged radioiodinated BODIPY derivative for Auger-electron cancer therapy.

    Onoue, Ryotaro / Watanabe, Hiroyuki / Ono, Masahiro

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 7, Page(s) 928–931

    Abstract: Targeted radionuclide therapy using Auger electrons is a promising strategy in cancer treatment. A DNA-binding Hoechst-tagged radioiodinated BODIPY derivative ([ ...

    Abstract Targeted radionuclide therapy using Auger electrons is a promising strategy in cancer treatment. A DNA-binding Hoechst-tagged radioiodinated BODIPY derivative ([
    MeSH term(s) Humans ; Electrons ; HeLa Cells ; DNA ; Neoplasms/drug therapy
    Chemical Substances Iodine-125 (GVO776611R) ; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; DNA (9007-49-2)
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc05405a
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