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  1. Article: Comparison of left versus right lateral starting position on colonoscopy: a systematic review and meta-analysis of randomized controlled trials.

    Watanabe, Jun

    Annals of gastroenterology

    2021  Volume 34, Issue 6, Page(s) 893

    Language English
    Publishing date 2021-09-14
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2021.0678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Possible relationship between rural surgical rotations during a residency period and an increased number of general surgeons in rural areas: a systematic review.

    Watanabe, Jun / Kotani, Kazuhiko

    Journal of rural medicine : JRM

    2023  Volume 18, Issue 1, Page(s) 1–7

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-01-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2768933-5
    ISSN 1880-4888 ; 1880-487X
    ISSN (online) 1880-4888
    ISSN 1880-487X
    DOI 10.2185/jrm.2022-031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Efficacy and safety of follitropin delta versus follitropin alpha/beta in infertility treatment: A systematic review and meta-analysis.

    Komiya, Shinnosuke / Watanabe, Jun / Terayama, Takero / Kamijo, Kyosuke / Okada, Hidetaka

    Reproductive medicine and biology

    2024  Volume 23, Issue 1, Page(s) e12573

    Abstract: Background: Follitropin δ may be an alternative to conventional follitropin α/β for controlled ovarian stimulation (COS) within assisted reproductive treatment (ART), but its efficacy and safety remain unknown. We performed a random-effects meta- ... ...

    Abstract Background: Follitropin δ may be an alternative to conventional follitropin α/β for controlled ovarian stimulation (COS) within assisted reproductive treatment (ART), but its efficacy and safety remain unknown. We performed a random-effects meta-analysis to compare the efficacy and safety of follitropin δ and follitropin α/β.
    Methods: We searched randomized controlled trials comparing follitropin δ and follitropin α/β using MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, and WHO-ITCRP on December 14, 2022. The primary outcomes were the live birth rate and the incidence of moderate or severe ovarian hyperstimulation syndrome (OHSS). The certainty of the evidence was assessed using the grading of recommendations assessment, development, and evaluation approach. The protocol was registered on the Open Science Framework.
    Results: Three studies involving 2682 participants were included in our meta-analysis. The results indicated that follitropin δ may result in little to no difference in live birth rates (risk ratio [RR], 1.12; 95% confidence interval [CI], 0.91-1.38; low certainty) and the incidence of moderate or severe OHSS (RR, 0.78; 95% CI, 0.48-1.26; low certainty) compared with follitropin α/β.
    Conclusion: Follitropin δ may result in little to no difference in COS compared with follitropin α/β, especially in terms of live births and safety.
    Language English
    Publishing date 2024-03-25
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2185775-1
    ISSN 1447-0578 ; 1445-5781
    ISSN (online) 1447-0578
    ISSN 1445-5781
    DOI 10.1002/rmb2.12573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6075: Show issues Location:
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  4. Article: Paraoxonase 1 and Chronic Kidney Disease: A Meta-Analysis.

    Watanabe, Jun / Kotani, Kazuhiko / Gugliucci, Alejandro

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Oxidative stress is known to be associated with the pathophysiology of chronic kidney disease (CKD). Paraoxonase 1 (PON1) is an antioxidant enzyme that has been proposed as a biomarker for CKD. While several studies have reported an association between ... ...

    Abstract Oxidative stress is known to be associated with the pathophysiology of chronic kidney disease (CKD). Paraoxonase 1 (PON1) is an antioxidant enzyme that has been proposed as a biomarker for CKD. While several studies have reported an association between serum PON1 activity and CKD, consensus based on systematically analyzed data remains necessary. We set out to conduct a meta-analysis of literature on PON1 in CKD. Electronic databases, such as MEDLINE, Embase and CENTRAL, were searched for available studies on PON1 activity in patients with CKD (without dialysis) as published before December 2022. A random-effects meta-analysis was performed. In total, 24 studies (22 studies on paraoxonase and 11 on arylesterase activity) were eligibly identified. Patients with CKD showed a lower activity of paraoxonase (standard mean difference [SMD], -1.72; 95% confidence interval [CI], -2.15 to -1.29) and arylesterase (SMD, -2.60; 95%CI, -3.96 to -1.24) than healthy controls. In the subgroup analyses, paraoxonase activity was lower in chronic kidney failure (CKF), an advanced stage of CKD, than in non-CKF. In summary, PON1 activity is low in patients with CKD, suggesting that the antioxidant defense by PON1 is impaired in CKD. The decrease in enzyme activity is pronounced in advanced CKD showing some variability depending on the substrate employed to measure PON1 activity. Further studies are warranted.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12031199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Telemental health in rural areas: a systematic review.

    Watanabe, Jun / Teraura, Hiroyuki / Nakamura, Akihisa / Kotani, Kazuhiko

    Journal of rural medicine : JRM

    2023  Volume 18, Issue 2, Page(s) 50–54

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-04-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2768933-5
    ISSN 1880-4888 ; 1880-487X
    ISSN (online) 1880-4888
    ISSN 1880-487X
    DOI 10.2185/jrm.2022-059
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  6. Article: Paraoxonase 1 Activity and Renal Replacement Therapy for Chronic Renal Failure: A Meta-Analysis.

    Watanabe, Jun / Kotani, Kazuhiko / Iwazu, Yoshitaka / Gugliucci, Alejandro

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Chronic renal failure (CRF) is associated with the development of cardiovascular disease (CVD). Paraoxonase 1 (PON1), an antioxidant enzyme, shows cardioprotective properties and has been proposed as a therapeutic marker for CRF. A systematic analysis of ...

    Abstract Chronic renal failure (CRF) is associated with the development of cardiovascular disease (CVD). Paraoxonase 1 (PON1), an antioxidant enzyme, shows cardioprotective properties and has been proposed as a therapeutic marker for CRF. A systematic analysis of the literature assessing the association between PON1 activity and renal replacement therapy (RRT) of CRF is currently lacking. Therefore, we set out to perform a meta-analysis of the available data on PON1 in RRT of CRF. We searched three electronic databases for studies on PON1 activity in CRF patients with RRT such as hemodialysis (HD), peritoneal dialysis (PD), or renal transplantation (RTx), published before June 2023. A random-effects and network meta-analysis were performed. A total of 53 studies were eligibly identified. Compared to CRF patients without RRT, RTx patients had higher paraoxonase activity (standard mean difference (SMD), 1.76, 95% confidence interval (CI), 0.76-2.75), followed by HD (SMD, 0.73; 95% CI, 0.02-1.45) and PD patients. Likewise, RTx patients had higher arylesterase activity (SMD, 1.84, 95% CI, 0.18-3.50), followed by HD and PD patients. Also, paraoxonase activity was increased after HD (SMD, 0.59, 95% CI, 0.16-1.03). In conclusion, the overall data demonstrated that PON1 activity is higher in CRF patients with RRT, particularly RTx, followed by that of HD and PD. Measuring PON1 activity can also be included to the paraclinical toolbox for the management of RRT, in addition to the understanding of CRF-related pathophysiology. Regarding the selection of RRT types and their potential to prevent CVD, more research is required.
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12155123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Vitamin C supplementation and paraoxonase 1 activity in patients on hemodialysis: a meta-analysis.

    Watanabe, Jun / Kotani, Kazuhiko / Gugliucci, Alejandro

    Archives of medical sciences. Atherosclerotic diseases

    2023  Volume 8, Page(s) e71–e74

    Language English
    Publishing date 2023-08-11
    Publishing country Poland
    Document type Journal Article
    ISSN 2451-0629
    ISSN 2451-0629
    DOI 10.5114/amsad/169981
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  8. Article: High poly-γ-glutamic acid-containing natto improves lipid metabolism and alters intestinal microbiota in mice fed a high-fat diet.

    Tamura, Motoi / Watanabe, Jun / Noguchi, Tomotsugu / Nishikawa, Takanobu

    Journal of clinical biochemistry and nutrition

    2023  Volume 74, Issue 1, Page(s) 47–56

    Abstract: Several beneficial effects of poly-γ-glutamic acid (γ-PGA) have been reported. To test whether natto, a fermented soy food rich in γ-PGA, can improve intestinal microbiota content and lipid metabolism in a high-fat diet, we compared the intestinal ... ...

    Abstract Several beneficial effects of poly-γ-glutamic acid (γ-PGA) have been reported. To test whether natto, a fermented soy food rich in γ-PGA, can improve intestinal microbiota content and lipid metabolism in a high-fat diet, we compared the intestinal microbiota content, plasma, liver, and fecal contents, and changes in gene expression in the livers and large intestines of a group of mice fed a high-fat diet supplemented with cooked soybeans (SC group) and a group fed a high-fat diet supplemented with natto (NA group) for 42 days; high-fat diet-fed mice were used as a control (Con group). Hepatic lipid levels were significantly lower, the fecal bile acid and lipid levels were significantly greater, and the
    Language English
    Publishing date 2023-09-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 632945-7
    ISSN 1880-5086 ; 0912-0009
    ISSN (online) 1880-5086
    ISSN 0912-0009
    DOI 10.3164/jcbn.23-35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2981: Show issues Location:
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  9. Article ; Online: The popliteal eminence shows that the intra-articular popliteal tendon supports posterolateral knee stability.

    Katakura, Hirotaka / Suzuki, Daisuke / Watanabe, Jun / Fujimiya, Mineko

    Anatomical science international

    2023  Volume 99, Issue 2, Page(s) 183–189

    Abstract: The intra-articular popliteal tendon (iPT) is responsible for the dynamic stability of the posterolateral part of the knee joint. In this study, the involvement of the iPT in posterolateral stability in response to knee flexion was investigated ... ...

    Abstract The intra-articular popliteal tendon (iPT) is responsible for the dynamic stability of the posterolateral part of the knee joint. In this study, the involvement of the iPT in posterolateral stability in response to knee flexion was investigated anatomically. Thirty-one knees from thirty formalin-fixed room cadavers (17 male knees, 14 female knees; average age 86.9 years) were used. The knee was prepared with the distal 1/3 of the lower femur and crus and was flexed at 0°, 30°, 60°, and 90° in a special jig to limit knee rotation. The series of movements was plotted on the coordinate system using the Quadrant method. The iPT was in strong contact with a thick cartilage area, which we called the "popliteal eminence", at the lateral condyle of the femur. The average iPT angles with respect to the femoral axis were 28.78°, 49.79°, 77.74°, and 115.44° at knee flexion of 0°, 30°, 60°, and 90°, respectively. The iPT was strongly associated with the popliteal eminence at 29.5° in Type I and 27.09° in Type II knee flexion. The iPT has been conventionally regarded as a secondary restraint of posterior movement, acting as a stabilizer. However, the iPT appears to work more positively on knee joint stability because it was in strong enough contact to create the popliteal eminence. The iPT supports the femur in the posterolateral region in mild knee flexion.
    MeSH term(s) Male ; Female ; Humans ; Aged, 80 and over ; Knee Joint/physiology ; Femur ; Lower Extremity ; Tendons ; Range of Motion, Articular/physiology ; Biomechanical Phenomena
    Language English
    Publishing date 2023-11-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2079994-9
    ISSN 1447-073X ; 1447-6959 ; 0022-7722
    ISSN (online) 1447-073X
    ISSN 1447-6959 ; 0022-7722
    DOI 10.1007/s12565-023-00749-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 219: Show issues Location:
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  10. Article: [Ⅳ. Prospects for Total Neoadjuvant Therapy for Patients with MSS Locally Advanced Rectal Cancer].

    Kagawa, Yoshinori / Ando, Koji / Watanabe, Jun

    Gan to kagaku ryoho. Cancer & chemotherapy

    2023  Volume 50, Issue 11, Page(s) 1182–1184

    MeSH term(s) Humans ; Neoadjuvant Therapy ; Rectum/pathology ; Rectal Neoplasms/therapy ; Rectal Neoplasms/pathology ; Chemoradiotherapy ; Treatment Outcome ; Neoplasm Staging ; Retrospective Studies
    Language Japanese
    Publishing date 2023-12-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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