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  1. Article ; Online: Proximal migration of in-stent neoatherosclerosis debris following cutting balloon angioplasty leading to catastrophic no-flow phenomenon.

    Watanabe, Nobuhiro / Yamamoto, Hiroyuki / Takaya, Tomofumi

    Coronary artery disease

    2024  Volume 35, Issue 2, Page(s) 162–163

    MeSH term(s) Humans ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon/adverse effects ; Stents ; Treatment Outcome
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/MCA.0000000000001310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3039: Show issues Location:
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  2. Article ; Online: Entrapment of the Impella device by the guiding catheter: a cautionary pitfall of Impella-protected percutaneous coronary intervention.

    Yamamoto, Hiroyuki / Watanabe, Nobuhiro / Matsuo, Koki / Takaya, Tomofumi

    European heart journal. Case reports

    2024  Volume 8, Issue 3, Page(s) ytae096

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytae096
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  3. Article ; Online: Editorial: Mechanisms and Effectiveness of Complementary and Alternative Medicine for Pain Management.

    Watanabe, Nobuhiro / Piché, Mathieu

    Frontiers in pain research (Lausanne, Switzerland)

    2022  Volume 3, Page(s) 863751

    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-561X
    ISSN (online) 2673-561X
    DOI 10.3389/fpain.2022.863751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Excimer laser coronary atherectomy with distal protection for neoatherosclerosis rupture: a case report.

    Watanabe, Nobuhiro / Yamamoto, Hiroyuki / Kawahara, Kunimitsu / Takaya, Tomofumi

    European heart journal. Case reports

    2023  Volume 8, Issue 1, Page(s) ytad626

    Abstract: Background: Neoatherosclerosis, a prominent contributor to in-stent restenosis (ISR), persists as a formidable challenge during percutaneous coronary intervention. Excimer laser coronary atherectomy (ELCA) and embolic protection devices may help reduce ... ...

    Abstract Background: Neoatherosclerosis, a prominent contributor to in-stent restenosis (ISR), persists as a formidable challenge during percutaneous coronary intervention. Excimer laser coronary atherectomy (ELCA) and embolic protection devices may help reduce coronary flow disturbance from procedure-related distal embolization.
    Case summary: A 71-year-old man experienced in-stent neoatherosclerosis rupture-related non-ST segment elevation myocardial infarction. Multidisciplinary intracoronary imaging, including intravascular ultrasound and optical coherence tomography (OCT), suggested that the ISR was caused by a neoatherosclerosis rupture that can potentially lead to distal embolization. Excimer laser coronary atherectomy (fluence, 45 mJ/mm
    Discussion: Excimer laser coronary atherectomy reduces soft plaque and thrombus burden, which can reduce the occurrence of distal embolization in select cases. In the case of this patient, procedure-related distal embolization may have been induced by the heightened photomechanical effects resulting from the use of the highest setting in ELCA under increased intracoronary arterial pressure caused by continuous saline injection during ELCA. Concomitant distal protection during ELCA may be more feasible for preventing coronary flow disturbance in patients with a large amount of neoatherosclerosis.
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad626
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  5. Article ; Online: Combined intracoronary nitroprusside infusion during prolonged perfusion balloon inflation for ST-segment elevation myocardial infarction.

    Yamamoto, Hiroyuki / Yoshida, Chiaki / Watanabe, Nobuhiro / Takaya, Tomofumi

    European heart journal. Case reports

    2023  Volume 7, Issue 12, Page(s) ytad609

    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytad609
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  6. Article ; Online: Mild thermal stimulation of the buttock skin increases urinary voiding efficiency in anesthetized rats.

    Iimura, Kaori / Watanabe, Nobuhiro / Hotta, Harumi

    Autonomic neuroscience : basic & clinical

    2022  Volume 242, Page(s) 103022

    Abstract: In the present study, we examined the effects of mild thermal stimulation of the skin on voiding efficiency using urethane-anesthetized rats with reduced voiding efficiency. Spontaneous urination was induced by infusing saline. For each voiding, the ... ...

    Abstract In the present study, we examined the effects of mild thermal stimulation of the skin on voiding efficiency using urethane-anesthetized rats with reduced voiding efficiency. Spontaneous urination was induced by infusing saline. For each voiding, the voiding efficiency was calculated from the voided volume and the bladder capacity measured. A Peltier thermode was attached to the buttock skin to apply stimulation: cooling between to 25 °C and 35 °C, every 20 s throughout the saline infusion. The voiding efficiency was 29 ± 9 % (mean ± SD) before stimulation and increased significantly by 10-15 % during stimulation. During thermal stimulation, the maximum vesical pressure during micturition was unchanged, but the urethral relaxation duration was significantly prolonged. Applying local anesthesia to the stimulated skin area abolished the changes in voiding efficiency in response to thermal stimulation. These results suggest that the excitation of cutaneous thermoreceptive afferents modulates urethral function during urination, thereby improving voiding efficiency.
    MeSH term(s) Animals ; Buttocks ; Muscle Contraction/physiology ; Rats ; Urethra/physiology ; Urinary Bladder ; Urination/physiology
    Language English
    Publishing date 2022-09-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2022.103022
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    Zs.A 1533: Show issues Location:
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  7. Article ; Online: Sympathetic modulation of hindlimb muscle contractility is altered in aged rats.

    Hotta, Harumi / Iimura, Kaori / Watanabe, Nobuhiro / Suzuki, Harue / Sugie, Masamitsu / Shigemoto, Kazuhiro

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 7504

    Abstract: It has recently been demonstrated that reflex excitation of muscle sympathetic nerves triggered by muscle contraction contributes to the maintenance of tetanic force (TF) in rat hindlimb muscles. We hypothesized that this feedback mechanism between the ... ...

    Abstract It has recently been demonstrated that reflex excitation of muscle sympathetic nerves triggered by muscle contraction contributes to the maintenance of tetanic force (TF) in rat hindlimb muscles. We hypothesized that this feedback mechanism between the contraction of hindlimb muscles and the lumbar sympathetic nerves declines during aging. In this study, we examined the contribution of sympathetic nerves on skeletal muscle contractility in young adult (4-9 months old, n = 11) and aged (32-36 months old, n = 11) male and female rats. The tibial nerve was electrically stimulated to measure the TF of the triceps surae muscles resulting from motor nerve activation before and after cutting or stimulating (at 5-20 Hz) the lumbar sympathetic trunk (LST). The TF amplitude decreased by cutting the LST in the young and aged groups; however, the magnitude of the decrease in TF following transection of the LST in the aged rats (6.2%) was significantly (P = 0.02) smaller compared with that in the young rats (12.9%). The TF amplitude was increased by LST stimulation at ≥ 5 Hz in the young and ≥ 10 Hz in the aged groups. The overall TF response to LST stimulation was not significantly different between the two groups; however, an increase in muscle tonus resulting from LST stimulation, independent of motor nerve stimulation, was significantly (P = 0.03) greater in aged compared with young rats. The sympathetic contribution to support motor nerve-induced muscle contraction declined, whereas sympathetic-mediated muscle tonus, independent of motor nerve activity, was augmented in aged rats. These changes in sympathetic modulation of hindlimb muscle contractility may underlie the reduction of skeletal muscle strength during voluntary contraction and rigidity of motion during senescence.
    MeSH term(s) Rats ; Male ; Female ; Animals ; Hindlimb ; Muscle, Skeletal/physiology ; Reflex/physiology ; Muscle Contraction/physiology ; Lower Extremity ; Sympathetic Nervous System/physiology ; Electric Stimulation/methods
    Language English
    Publishing date 2023-05-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33821-9
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  8. Article ; Online: Effects of gentle mechanical skin stimulation on subjective symptoms and joint range of motions in people with chronic neck and shoulder discomfort.

    Watanabe, Nobuhiro / Nara, Marina / Suzuki, Shihoko / Sugie, Masamitsu / Yamamoto, Takao / Hotta, Harumi

    The journal of physiological sciences : JPS

    2023  Volume 73, Issue 1, Page(s) 4

    Abstract: This study aimed to examine the efficacy of a 2-week self-administered gentle mechanical skin stimulation on chronic neck and shoulder discomfort. In participants (n = 12) with chronic neck and shoulder discomfort, subjective measures of pain sensation, ... ...

    Abstract This study aimed to examine the efficacy of a 2-week self-administered gentle mechanical skin stimulation on chronic neck and shoulder discomfort. In participants (n = 12) with chronic neck and shoulder discomfort, subjective measures of pain sensation, discomfort, and difficulty in moving using a visual analog scale (VAS, 0-10) and objective measures of 12 different joint range of motions (ROMs) for the cervical and shoulder regions, using a digital goniometer, were collected before and after self-care with contact acupuncture, called microcones. The self-care for 2 weeks significantly (p < 0.001) decreased all VAS scores to 2.2-2.3 from baseline values of 6.0-7.4. Of the 12 ROMs tested, 8 were significantly increased (p < 0.013). This open-label study suggests the use of self-care with microcones in improving subjective symptoms and joint ROMs in people suffering from chronic neck and shoulder discomfort. However, a randomized, double-blind, controlled clinical trial is needed to further investigate the efficacy and safety of microcones.
    MeSH term(s) Humans ; Shoulder ; Neck Pain/therapy ; Pain Measurement ; Range of Motion, Articular ; Treatment Outcome
    Language English
    Publishing date 2023-03-29
    Publishing country Japan
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-023-00862-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.360: Show issues Location:
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  9. Article ; Online: Gentle Perineal Skin Stimulation for Control of Nocturia.

    Hotta, Harumi / Watanabe, Nobuhiro

    Anatomical record (Hoboken, N.J. : 2007)

    2019  Volume 302, Issue 10, Page(s) 1824–1836

    Abstract: One of the major causes of nocturia is overactive bladder (OAB). Somatic afferent nerve stimuli are used for treating OAB. However, clinical evidence for the efficacy of this treatment is insufficient due to the lack of appropriate control stimuli. ... ...

    Abstract One of the major causes of nocturia is overactive bladder (OAB). Somatic afferent nerve stimuli are used for treating OAB. However, clinical evidence for the efficacy of this treatment is insufficient due to the lack of appropriate control stimuli. Studies on anesthetized animals, which eliminate emotional factors and placebo effects, have demonstrated an influence of somatic stimuli on urinary bladder functions and elucidated the underlying mechanisms. In general, the effects of somatic stimuli are dependent on the modality, location, and physical characteristics of the stimulus. Recently we showed that gentle stimuli applied to the perineal skin using a soft elastomer roller inhibited micturition contractions to a greater extent than a roller with a hard surface. Studies aiming to elucidate the neural mechanisms of gentle stimulation-induced inhibition reported that 1-10 Hz discharges of low-threshold cutaneous mechanoreceptive Aβ, Aδ, and C fibers evoked during stimulation with an elastomer roller inhibited the micturition reflex by activating the spinal cord opioid system, thereby reducing both ascending and descending transmission between bladder and pontine micturition center. The present review will provide a brief summary of (1) the effect of somatic electrical stimulation on the micturition reflex, (2) the effect of gentle mechanical skin stimulation on the micturition reflex, (3) the afferent, efferent, and central mechanisms underlying the effects of gentle stimulation, and (4) a translational clinical study demonstrating the efficacy of gentle skin stimuli for treating nocturia in the elderly with OAB by using the two roller types inducing distinct effects on rat micturition contractions. Anat Rec, 302:1824-1836, 2019. © 2019 American Association for Anatomy.
    MeSH term(s) Afferent Pathways/physiopathology ; Animals ; Disease Models, Animal ; Efferent Pathways/physiopathology ; Humans ; Muscle Contraction/physiology ; Nocturia/etiology ; Nocturia/physiopathology ; Nocturia/therapy ; Perineum ; Pons/physiopathology ; Rats ; Skin/innervation ; Touch/physiology ; Transcutaneous Electric Nerve Stimulation/methods ; Treatment Outcome ; Urinary Bladder/innervation ; Urinary Bladder/physiopathology ; Urinary Bladder, Overactive/complications ; Urinary Bladder, Overactive/physiopathology ; Urinary Bladder, Overactive/therapy
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.24135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Maintenance of contractile force of the hind limb muscles by the somato-lumbar sympathetic reflexes.

    Hotta, Harumi / Iimura, Kaori / Watanabe, Nobuhiro / Shigemoto, Kazuhiro

    The journal of physiological sciences : JPS

    2021  Volume 71, Issue 1, Page(s) 15

    Abstract: This study aimed to clarify whether the reflex excitation of muscle sympathetic nerves induced by contractions of the skeletal muscles modulates their contractility. In anesthetized rats, isometric tetanic contractions of the triceps surae muscles were ... ...

    Abstract This study aimed to clarify whether the reflex excitation of muscle sympathetic nerves induced by contractions of the skeletal muscles modulates their contractility. In anesthetized rats, isometric tetanic contractions of the triceps surae muscles were induced by electrical stimulation of the intact tibial nerve before and after transection of the lumbar sympathetic trunk (LST), spinal cord, or dorsal roots. The amplitude of the tetanic force (TF) was reduced by approximately 10% at 20 min after transection of the LST, spinal cord, or dorsal roots. The recorded postganglionic sympathetic nerve activity from the lumbar gray ramus revealed that both spinal and supraspinal reflexes were induced in response to the contractions. Repetitive electrical stimulation of the cut peripheral end of the LST increased the TF amplitude. Our results indicated that the spinal and supraspinal somato-sympathetic nerve reflexes induced by contractions of the skeletal muscles contribute to the maintenance of their own contractile force.
    MeSH term(s) Animals ; Electric Stimulation ; Hindlimb/innervation ; Hindlimb/physiology ; Isometric Contraction/physiology ; Male ; Muscle Contraction/physiology ; Muscle Strength/physiology ; Muscle, Skeletal/innervation ; Muscle, Skeletal/physiology ; Rats, Inbred F344 ; Reflex/physiology ; Spinal Nerve Roots/physiology ; Sympathetic Nervous System/physiology ; Rats
    Language English
    Publishing date 2021-05-21
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-021-00799-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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