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  1. Book ; Online ; E-Book: Modeling electrochemical dynamics and signaling mechanisms in excitable cells with pathological case studies

    Watanabe, T.

    2022  

    Author's details Tetsuya Watanabe
    Keywords Neurochemistry/Methodology
    Subject code 612.8042
    Language English
    Size 1 online resource (248 pages)
    Publisher Academic Press
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-323-97270-5 ; 9780323988032 ; 978-0-323-97270-3 ; 0323988032
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Biophysical basis of physiology and calcium signaling mechanism in cardiac and smooth muscle

    Watanabe, Tetsuya

    2018  

    Author's details Tetsuya Watanabe
    Language English
    Size 1 Online-Ressource (xiii, 219 Seiten), Illustrationen
    Publisher Elsevier AP Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019693552
    ISBN 978-0-12-814951-5 ; 9780128149508 ; 0-12-814951-5 ; 0128149507
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Local Degeneration of Cilia and Nuclear Activation during Sexual Reproduction in Paramecium caudatum: (degeneration of cilia/nuclear activation/conjugation/autogamy/Paramecium).

    Watanabe, Tsuyoshi

    Development, growth & differentiation

    2023  Volume 25, Issue 1, Page(s) 113–120

    Abstract: The correlation between local degeneration of cilia and nuclear activation during chemically induced autogamy in Paramecium caudatum was studied by experimental interruption of autogamy. When the induction of autogamy was interrupted 60 min after the ... ...

    Abstract The correlation between local degeneration of cilia and nuclear activation during chemically induced autogamy in Paramecium caudatum was studied by experimental interruption of autogamy. When the induction of autogamy was interrupted 60 min after the onset of chemical induction, nuclear activation did not occur and ciliary regeneration took place at the deciliated surface. On the contrary, when it was interrupted 3 hr after the onset of induction, nuclear activation was not stopped and no reciliation was observed. At this critical stage, the deciliated zone was seen to extend to the right wall of the gullet. These findings suggest that there is a transition point in activation processes. It is conceivable that in autogamous cells that have gone beyond this transition point all processes of nuclear activation proceed, and that the ability to regenerate cilia is lost by the end of autogamy, even if the stimulus for autogamy is removed.
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/j.1440-169X.1983.00113.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 194: Show issues Location:
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  4. Article: [Surgical Equipment for Neuroendoscopic Surgery].

    Watanabe, Tadashi

    No shinkei geka. Neurological surgery

    2023  Volume 51, Issue 4, Page(s) 725–733

    Abstract: The development of endonasal endoscopic surgery has been advanced one step further by the image quality and expressiveness of endoscopes. The widespread use of HD endoscopic cameras has enabled tumor dissection, preservation of vital vessels, and ... ...

    Abstract The development of endonasal endoscopic surgery has been advanced one step further by the image quality and expressiveness of endoscopes. The widespread use of HD endoscopic cameras has enabled tumor dissection, preservation of vital vessels, and delicate dissection of nerves during endonasal surgery through the close and detailed observation of intracranial structures. The observation of high image quality is essential. In addition, instruments that can be carefully manipulated are essential for achieving this image quality. Traditionally, endoscopic surgery has relied on axial back-and-forth movement in many situations due to the inability of the instruments to move sufficiently laterally, and it has been said that precise and effective instrument movement cannot be achieved. However, the ingenuity of surgical techniques to create an adequate operative field, movements specific to endoscopic surgery, and the emergence of specialized instruments have made delicate manipulation possible. Exoscopes, which appear as adjuncts to endoscopic surgery or alternatives to microscopic surgery, have also influenced the form of endoscopic surgery because, like endoscopes, they are heads-up surgeries. Recent developments in the peripheral equipment related to neuroendoscopic surgery have been described.
    MeSH term(s) Humans ; Endoscopy/methods ; Neuroendoscopy ; Endoscopes ; Surgical Equipment
    Language Japanese
    Publishing date 2023-07-25
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 197053-7
    ISSN 1882-1251 ; 0301-2603
    ISSN (online) 1882-1251
    ISSN 0301-2603
    DOI 10.11477/mf.1436204806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Autism spectrum disorder and brain state dynamics].

    Watanabe, Takamitsu

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2023  Volume 158, Issue 2, Page(s) 154–158

    Abstract: In this review, I will present that focusing on global brain state dynamics could bring unique insights into the biological understanding of autism. To this end, I will first introduce energy landscape analysis and a novel brain stimulation method called ...

    Abstract In this review, I will present that focusing on global brain state dynamics could bring unique insights into the biological understanding of autism. To this end, I will first introduce energy landscape analysis and a novel brain stimulation method called brain-state-driven neural stimulation. Then, this article will discuss the results of the applications of these methods to autism. Finally, I will also state what such an approach reveals about the brain mechanisms underpinning ADHD.
    MeSH term(s) Humans ; Autism Spectrum Disorder ; Brain
    Language Japanese
    Publishing date 2023-03-01
    Publishing country Japan
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.22124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
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  6. Article ; Online: Features of ductal carcinoma in situ ultrasound images.

    Watanabe, Takanori

    Journal of medical ultrasonics (2001)

    2023  Volume 50, Issue 3, Page(s) 347–350

    Abstract: Ultrasound images of ductal carcinoma in situ (DCIS) show a wide range of variations from mass to non-mass lesions. This article describes the characteristics of ultrasound images of DCIS based on the BC-02 study conducted by The Japanese Association of ... ...

    Abstract Ultrasound images of ductal carcinoma in situ (DCIS) show a wide range of variations from mass to non-mass lesions. This article describes the characteristics of ultrasound images of DCIS based on the BC-02 study conducted by The Japanese Association of Breast and Thyroid Sonology (JABTS). In the BC-02 study, ultrasound images of 705 DCIS cases were classified by imaging findings. The results showed that non-mass abnormalities accounted for 60% of all lesions and masses for 40%. Looking at each subclassification, hypoechoic areas in the mammary gland were the most common (50% of the total), followed by solid masses (31%), mixed masses (9%), and abnormalities of the ducts (8%). These four classifications accounted for 98% of the total. Echogenic foci without a hypoechoic area, architectural distortion, and clustered microcysts were very rare, accounting for about 1% of the total. The ultrasound images of DCIS were characterized by a wide range of variations from masses to non-masses abnormalities, with hypoechoic areas in the mammary gland being the most common, followed by solid masses.
    MeSH term(s) Female ; Humans ; Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Ultrasonography, Mammary/methods ; Ultrasonography ; Breast/diagnostic imaging ; Thyroid Gland/pathology ; Breast Neoplasms/diagnostic imaging
    Language English
    Publishing date 2023-06-28
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-023-01334-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2695: Show issues Location:
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  7. Article ; Online: Recent advances in treatment of nodal and gastrointestinal follicular lymphoma.

    Watanabe, Takuya

    World journal of gastroenterology

    2023  Volume 29, Issue 23, Page(s) 3574–3594

    Abstract: Follicular lymphoma (FL) is the most common low-grade lymphoma, and although nodal FL is highly responsive to treatment, the majority of patients relapse repeatedly, and the disease has been incurable with a poor prognosis. However, primary FL of the ... ...

    Abstract Follicular lymphoma (FL) is the most common low-grade lymphoma, and although nodal FL is highly responsive to treatment, the majority of patients relapse repeatedly, and the disease has been incurable with a poor prognosis. However, primary FL of the gastrointestinal tract has been increasingly detected in Japan, especially due to recent advances in small bowel endoscopy and increased opportunities for endoscopic examinations and endoscopic diagnosis. However, many cases are detected at an early stage, and the prognosis is good in many cases. In contrast, in Europe and the United States, gastrointestinal FL has long been considered to be present in 12%-24% of Stage-IV patients, and the number of advanced gastrointestinal cases is expected to increase. This editorial provides an overview of the recent therapeutic advances in nodal FL, including antibody-targeted therapy, bispecific antibody therapy, epigenetic modulation, and chimeric antigen receptor T-cell therapy, and reviews the latest therapeutic manuscripts published in the past year. Based on an understanding of the therapeutic advances in nodal FL, we also discuss future possibilities for gastroenterologists to treat gastrointestinal FL, especially in advanced cases.
    MeSH term(s) Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/therapy ; Lymphoma, Follicular/pathology ; Neoplasm Recurrence, Local ; Gastrointestinal Neoplasms/pathology ; Prognosis ; Transforming Growth Factor beta
    Chemical Substances Transforming Growth Factor beta
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i23.3574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  8. Article ; Online: Gene targeted and immune therapies for nodal and gastrointestinal follicular lymphomas.

    Watanabe, Takuya

    World journal of gastroenterology

    2023  Volume 29, Issue 48, Page(s) 6179–6197

    Abstract: Follicular lymphoma (FL) is the most common indolent B-cell lymphoma (BCL) globally. Recently, its incidence has increased in Europe, the United States, and Asia, with the number of gastrointestinal FL cases expected to increase. Genetic abnormalities ... ...

    Abstract Follicular lymphoma (FL) is the most common indolent B-cell lymphoma (BCL) globally. Recently, its incidence has increased in Europe, the United States, and Asia, with the number of gastrointestinal FL cases expected to increase. Genetic abnormalities related to t(14;18) translocation, BCL2 overexpression, NF-κB pathway-related factors, histone acetylases, and histone methyltransferases cause FL and enhance its proliferation. Meanwhile, microRNAs are commonly used in diagnosing FL and predicting patient prognosis. Many clinical trials on novel therapeutics targeting these genetic abnormalities and immunomodulatory mechanisms have been conducted, resulting in a marked improvement in therapeutic outcomes for FL. Although developing these innovative therapeutic agents targeting specific genetic mutations and immune pathways has provided hope for curative options, FL treatment has become more complex, requiring combinatorial therapeutic regimens. However, optimal treatment combinations have not yet been achieved, highlighting the importance of a complete under-standing regarding the pathogenesis of gastrointestinal FL. Accordingly, this article reviews key research on the molecular pathogenesis of nodal FL and novel therapies targeting the causative genetic mutations. Moreover, the results of clinical trials are summarized, with a particular focus on treating nodal and gastrointestinal FLs.
    MeSH term(s) Humans ; Lymphoma, Follicular/drug therapy ; Lymphoma, Follicular/genetics ; MicroRNAs ; Asia ; Europe ; Immunomodulation
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i48.6179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neuromelanin? MRI of catecholaminergic neurons.

    Watanabe, Takashi

    Brain : a journal of neurology

    2023  Volume 147, Issue 3, Page(s) e24–e26

    MeSH term(s) Humans ; Neurons ; Melanins ; Magnetic Resonance Imaging
    Chemical Substances neuromelanin ; Melanins
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad393
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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.26: Show issues Location:
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  10. Book: Pictorial atlas of soilborne fungal plant pathogens and diseases

    Watanabe, Tsuneo

    (Mycology)

    2018  

    Author's details Tsuneo Watanabe
    Series title Mycology
    Language English
    Size xxi, 275 Seiten, Illustrationen, Diagramme
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book
    HBZ-ID HT019598732
    ISBN 978-1-138-29459-2 ; 1-138-29459-4
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    188/30 available for loan (reading room) Freihandmagazin (U1)

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