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  1. Article ; Online: Social confrontation stress decreases hepatic fibroblast growth factor-21 expression in aged mice

    Wataru Tanaka / Hiroki Matsuyama / Kayoko Shimoi / Daigo Yokoyama / Hiroyuki Sakakibara

    Biochemistry and Biophysics Reports, Vol 34, Iss , Pp 101454- (2023)

    2023  

    Abstract: We previously showed that social stress exposure in mature adult mice increased blood corticosterone concentrations at 2 days, disrupted hepatic lipid metabolism-related pathway at 30 days, and increased the risk of overweight with hepatic hypertrophy at ...

    Abstract We previously showed that social stress exposure in mature adult mice increased blood corticosterone concentrations at 2 days, disrupted hepatic lipid metabolism-related pathway at 30 days, and increased the risk of overweight with hepatic hypertrophy at 90 days. To further investigate the effects of aging on the physiological responses to social stress, we conducted a study using male BALB/c mice at the ages of 2 months (mature age), 14 months (middle age) and 26 months (old age), and exposed them to confrontation stress for 2 or 7 days. Blood corticosterone concentrations were increased at 2 days of stress, and then returned to baseline concentrations. This change was observed only at 2 months of age. We further examined the effect of aging on hepatic gene expression of fibroblast growth factor-21 (Fgf21) and found that its expression was significantly decreased after 7 days of stress at 14 months of age and after 2 days of stress at 26 months of age, indicating these decreasing effects became more pronounced with age. In conclusion, our study suggests that hepatic Fgf21 expression decrease under exposure to confrontation stress at middle or more age, indicating that stress response on Fgf21 related pathway might be more pronounced with age when exposed to stress.
    Keywords Confrontation stress ; Mice ; Aging ; Fibroblast growth factor-21 ; Obesity ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Selective Consumption of Fish Oil at End of the Day Increases the Physiological Fatty Acid Compositions of Eicosapentaenoic Acid and Docosahexaenoic Acid in Mice

    Hiroki Matsuzaka / Hiroki Matsuyama / Wataru Tanaka / Hayato Tajiri / Hiroyuki Sakakibara

    Molecules, Vol 27, Iss 1271, p

    2022  Volume 1271

    Abstract: Diets with high daily fat consumption are associated with excess weight. However, the effects of fat type and consumption timing on excess weight remain unclear. We investigated the selection of a 30% ( w / w ) fat diet of soybean oil (SOY), lard (LARD), ...

    Abstract Diets with high daily fat consumption are associated with excess weight. However, the effects of fat type and consumption timing on excess weight remain unclear. We investigated the selection of a 30% ( w / w ) fat diet of soybean oil (SOY), lard (LARD), and fish oil (FISH) on the metabolic parameters of mice. Male C57BL/6 mice were divided into the double SOY-box (w-SOY), SOY-box/LARD-box (SOY-vs-LARD), or SOY-box/FISH-box (SOY-vs-FISH) groups and allowed to selectively consume for 8 weeks. The total energy intake was similar for all groups, but the mice selectively chose to consume LARD over SOY and SOY over FISH. Body weight in the SOY-vs-LARD group was significantly higher than that in the w-SOY and SOY-vs-FISH groups. Additionally, minimal but selective consumption of an omega-3 fatty-acid-rich FISH diet at the end of the active period increased the physiological fatty acid compositions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the SOY-vs-FISH group; their metabolic parameters were also lower than the SOY-vs-LARD group. In conclusion, selectively consuming small amounts of fish oil at the end of the day may prevent excess weight compared with LARD consumption.
    Keywords high-fat diet ; mice ; overweight ; omega-3/omega-6 ratio ; selectivity ; Organic chemistry ; QD241-441
    Subject code 590
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers

    Ryou Kubota / Kazutoshi Nagao / Wataru Tanaka / Ryotaro Matsumura / Takuma Aoyama / Kenji Urayama / Itaru Hamachi

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: Regulation of self-sorted nanofiber network patterns in double network hydrogels comprising supramolecular nanofibers is considered as key for potential applications. Here, the authors describe a selective construction of two distinct self-sorting ... ...

    Abstract Regulation of self-sorted nanofiber network patterns in double network hydrogels comprising supramolecular nanofibers is considered as key for potential applications. Here, the authors describe a selective construction of two distinct self-sorting network patterns, by controlling the kinetics of seed formation with dynamic covalent chemistry.
    Keywords Science ; Q
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers

    Ryou Kubota / Kazutoshi Nagao / Wataru Tanaka / Ryotaro Matsumura / Takuma Aoyama / Kenji Urayama / Itaru Hamachi

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: Regulation of self-sorted nanofiber network patterns in double network hydrogels comprising supramolecular nanofibers is considered as key for potential applications. Here, the authors describe a selective construction of two distinct self-sorting ... ...

    Abstract Regulation of self-sorted nanofiber network patterns in double network hydrogels comprising supramolecular nanofibers is considered as key for potential applications. Here, the authors describe a selective construction of two distinct self-sorting network patterns, by controlling the kinetics of seed formation with dynamic covalent chemistry.
    Keywords Science ; Q
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Surface Dissociation Effect on Phosphonic Acid Self-Assembled Monolayer Formation on ZnO Nanowires

    Kentaro Nakamura / Tsunaki Takahashi / Takuro Hosomi / Yu Yamaguchi / Wataru Tanaka / Jiangyang Liu / Masaki Kanai / Kazuki Nagashima / Takeshi Yanagida

    ACS Omega, Vol 7, Iss 1, Pp 1462-

    2021  Volume 1467

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Daily Consumption of Bilberry (Vaccinium myrtillus L.) Extracts Increases the Absorption Rate of Anthocyanins in Rats

    Nohara, Chiaki / Daigo Yokoyama / Hiroyuki Sakakibara / Masanobu Sakono / Tetsuya Sogon / Wataru Tanaka

    Journal of agricultural and food chemistry. 2018 July 03, v. 66, no. 30

    2018  

    Abstract: The effects of daily consumption of anthocyanins on bioavailability has remained unclear. In this study, we evaluated whether daily consumption affects the absorption rate of anthocyanins in rats when consumed during the active and sleep phase. Eighty ... ...

    Abstract The effects of daily consumption of anthocyanins on bioavailability has remained unclear. In this study, we evaluated whether daily consumption affects the absorption rate of anthocyanins in rats when consumed during the active and sleep phase. Eighty rats were randomly divided into two groups. The first group consumed AIN-93G control diets, and the second group consumed AIN-93G diets containing 1% bilberry extract for 2 weeks. After 12 h fast, anthocyanins were not detected in plasma of rats. Bilberry extract (500 mg/kg body weight) was then orally administered at the beginning of the diurnal light period (ZT0, sleep phase) or at the end of the diurnal light period (ZT12, active phase). Blood concentrations of anthocyanins peaked 1 h after administration in both groups. Maximum blood concentration in rats that consumed bilberry extract daily (852 nM) was higher than that in control rats (630 nM) when the extract was administered at ZT0 but not at ZT12. Daily consumption of anthocyanins increases their absorption rate, but this effect is limited to the beginning of the sleep phase.
    Keywords anthocyanins ; bilberries ; bioavailability ; blood ; body weight ; diet ; oral administration ; photophase ; rats ; sleep ; Vaccinium myrtillus
    Language English
    Dates of publication 2018-0703
    Size p. 7958-7964.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.8b02404
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Evidence for DNA cleavage caused directly by a transfer RNA-targeting toxin.

    Megumi Shigematsu / Tetsuhiro Ogawa / Wataru Tanaka / Kazutoshi Takahashi / Hiroko K Kitamoto / Makoto Hidaka / Haruhiko Masaki

    PLoS ONE, Vol 8, Iss 9, p e

    2013  Volume 75512

    Abstract: The killer yeast species Pichiaacaciae produces a heteromeric killer protein, PaT, that causes DNA damage and arrests the cell cycle of sensitive Saccharomyces cerevisiae in the S phase. However, the mechanism by which DNA damage occurs remains elusive. ... ...

    Abstract The killer yeast species Pichiaacaciae produces a heteromeric killer protein, PaT, that causes DNA damage and arrests the cell cycle of sensitive Saccharomyces cerevisiae in the S phase. However, the mechanism by which DNA damage occurs remains elusive. A previous study has indicated that Orf2p, a subunit of PaT, specifically cleaves an anticodon loop of an S. cerevisiae transfer RNA (tRNA(Gln)mcm5s2UUG). This finding raised a question about whether the DNA damage is a result of the tRNA cleavage or whether Orf2p directly associates with and cleaves the genomic DNA of sensitive yeast cells. We showed that Orf2p cleaves genomic DNA in addition to cleaving tRNA in vitro. This DNA cleavage requires the same Orf2p residue as that needed for tRNA cleavage, His299. The expression of Orf2p, in which His299 was substituted to alanine, abolished the cell cycle arrest of the host cell. Moreover, the translation impairment induced by tRNA cleavage enabled Orf2p to enter the nucleus, thereby inducing histone phosphorylation.
    Keywords Medicine ; R ; Science ; Q
    Subject code 612
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Impacts of Dams and Global Warming on Fish Biodiversity in the Indo-Burma Hotspot.

    Yuichi Kano / David Dudgeon / So Nam / Hiromitsu Samejima / Katsutoshi Watanabe / Chaiwut Grudpan / Jarungjit Grudpan / Wichan Magtoon / Prachya Musikasinthorn / Phuong Thanh Nguyen / Bounthob Praxaysonbath / Tomoyuki Sato / Koichi Shibukawa / Yukihiro Shimatani / Apinun Suvarnaraksha / Wataru Tanaka / Phanara Thach / Dac Dinh Tran / Tomomi Yamashita /
    Kenzo Utsugi

    PLoS ONE, Vol 11, Iss 8, p e

    2016  Volume 0160151

    Abstract: Both hydropower dams and global warming pose threats to freshwater fish diversity. While the extent of global warming may be reduced by a shift towards energy generation by large dams in order to reduce fossil-fuel use, such dams profoundly modify ... ...

    Abstract Both hydropower dams and global warming pose threats to freshwater fish diversity. While the extent of global warming may be reduced by a shift towards energy generation by large dams in order to reduce fossil-fuel use, such dams profoundly modify riverine habitats. Furthermore, the threats posed by dams and global warming will interact: for example, dams constrain range adjustments by fishes that might compensate for warming temperatures. Evaluation of their combined or synergistic effects is thus essential for adequate assessment of the consequences of planned water-resource developments. We made projections of the responses of 363 fish species within the Indo-Burma global biodiversity hotspot to the separate and joint impacts of dams and global warming. The hotspot encompasses the Lower Mekong Basin, which is the world's largest freshwater capture fishery. Projections for 81 dam-building scenarios revealed progressive impacts upon projected species richness, habitable area, and the proportion of threatened species as generating capacity increased. Projections from 126 global-warming scenarios included a rise in species richness, a reduction in habitable area, and an increase in the proportion of threatened species; however, there was substantial variation in the extent of these changes among warming projections. Projections from scenarios that combined the effects of dams and global warming were derived either by simply adding the two threats, or by combining them in a synergistic manner that took account of the likelihood that habitat shifts under global warming would be constrained by river fragmentation. Impacts on fish diversity under the synergistic projections were 10-20% higher than those attributable to additive scenarios, and were exacerbated as generating capacity increased-particularly if CO2 emissions remained high. The impacts of dams, especially those on river mainstreams, are likely to be greater, more predictable and more immediately pressing for fishes than the consequences of global warming. ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 910
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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