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  1. AU="Waters, Aubri M"
  2. AU="Tremblay, Cyntia"
  3. AU="Sharafeldin, Tamer A"
  4. AU="Alladio, Francesca"
  5. AU="Cheng, Zhiluo"
  6. AU="Silva, Dândara Santos"
  7. AU="Timmann, Dagmar"
  8. AU="Jingping, Lin"
  9. AU="Yoon, Sangwook"
  10. AU="Sedor, John R."
  11. AU="Legrand, Julien"
  12. AU="Mintz, Kevin Todd"
  13. AU="Kösters, Markus"
  14. AU="Castano-Duque, Lina"
  15. AU="Lowry, Gregory V"
  16. AU="Gao, Xiaojuan"
  17. AU="Daniłowicz-Szymanowicz, Ludmiła"
  18. AU="Weber, Jesse N"
  19. AU="Fages-Masmiquel, Ester"
  20. AU="Macias Gil, Raul"
  21. AU="Planchat, Arnaud"
  22. AU="McElrath, Erin E"
  23. AU="Koji Ueda"
  24. AU="Pillas, Diana J"
  25. AU="Thomson, Jason J"
  26. AU="Mitra, Kalyan"
  27. AU="Sanjay Desai"
  28. AU=Cox David J AU=Cox David J
  29. AU="Grebenok, Robert J."
  30. AU="Blackburne, Brittney"
  31. AU="Bortoleti, Bruna Taciane da Silva"
  32. AU="Ehrbar, Martin"
  33. AU="Lepre, Davide"
  34. AU="Olszewska, Zuzanna"
  35. AU="Vojta, Leslie"
  36. AU=Wickstrom Eric AU=Wickstrom Eric
  37. AU="Gangavarapu, Sridevi"
  38. AU="Hussein, Hazem Abdelwaheb"
  39. AU=Cai Yixin AU=Cai Yixin
  40. AU="Hüls, Anke"
  41. AU="Poondru, Srinivasu"
  42. AU="Coca, Daniel"
  43. AU="Lebeau, Paul"
  44. AU="Dehghani, Sedigheh"
  45. AU="Ishibashi, Kenji"
  46. AU="Xu, Yanhua"
  47. AU="Matera, Katarzyna"
  48. AU="Ait-Ouarab, Slimane"
  49. AU="Nicola, Coppede"
  50. AU="Dewitt, John M"
  51. AU="Sorin M. Dudea"
  52. AU="Tanusha D. Ramdin"
  53. AU="Hao, Zehui"
  54. AU="Chauhan, Aman"

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  1. Artikel ; Online: Alternative Immunization Clinics to Improve Vaccination Access during the COVID-19 Pandemic.

    Simmons, Elizabeth G / Waters, Aubri M / Robertson, Brian D / Richards, Autumns M

    Medical journal (Fort Sam Houston, Tex.)

    2021  , Heft PB 8-21-01/02/03, Seite(n) 122–127

    Abstract: The United States declared a national emergency on March 13, 2020, in response to the rapidly spreading COVID-19 pandemic after all 50 states reported laboratory-confirmed cases.1 The demand for ambulatory medical care in the US fell by almost 60% and ... ...

    Abstract The United States declared a national emergency on March 13, 2020, in response to the rapidly spreading COVID-19 pandemic after all 50 states reported laboratory-confirmed cases.1 The demand for ambulatory medical care in the US fell by almost 60% and immunization encounters at Walter Reed National Military Medical Center decreased by 76% as patients became concerned about the risk of coronavirus exposure within a clinic or hospital setting.2 Our vaccination initiatives aimed to increase our pediatric and adult immunization rates through offering two alternative immunization platforms aimed to reduce patient concerns about COVID exposure.
    Mesh-Begriff(e) Ambulatory Care Facilities ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Health Services Accessibility/organization & administration ; Humans ; Mass Vaccination/organization & administration ; Patient Acceptance of Health Care ; United States
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2021-03-05
    Dokumenttyp Journal Article
    ISSN 2694-3611
    ISSN (online) 2694-3611
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Circadian and seasonal variations in subcutaneous allergen immunotherapy reactions.

    McMurray, Jeremy C / Waters, Aubri M / Macomb, Christopher V / Brooks, Daniel I / Schwartz, David J

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2021  Band 127, Heft 5, Seite(n) 595–596

    Mesh-Begriff(e) Adolescent ; Adult ; Allergens/administration & dosage ; Allergens/immunology ; Child ; Child, Preschool ; Circadian Rhythm/immunology ; Desensitization, Immunologic/methods ; Female ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Pollen/immunology ; Rhinitis, Allergic, Seasonal/immunology ; Rhinitis, Allergic, Seasonal/pathology ; Rhinitis, Allergic, Seasonal/therapy ; Risk Factors ; Seasons ; Young Adult
    Chemische Substanzen Allergens
    Sprache Englisch
    Erscheinungsdatum 2021-08-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2021.08.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Elevated Basal Serum Tryptase: Disease Distribution and Variability in a Regional Health System.

    Waters, Aubri M / Park, Hyun J / Weskamp, Andrew L / Mateja, Allyson / Kachur, Megan E / Lyons, Jonathan J / Rosen, Benjamin J / Boggs, Nathan A

    The journal of allergy and clinical immunology. In practice

    2022  Band 10, Heft 9, Seite(n) 2424–2435.e5

    Abstract: Background: Hereditary-alpha tryptasemia (HαT) is the most common etiology for elevated basal serum tryptase (BST). However, the utility of tryptase genotyping of individuals with elevated BST in general clinical practice remains undefined. Moreover, ... ...

    Abstract Background: Hereditary-alpha tryptasemia (HαT) is the most common etiology for elevated basal serum tryptase (BST). However, the utility of tryptase genotyping of individuals with elevated BST in general clinical practice remains undefined. Moreover, studies showing associations between elevated BST and chronic kidney disease (CKD), myelodysplastic syndrome (MDS), rheumatoid arthritis, or eosinophilic esophagitis did not include tryptase genotyping.
    Objective: To determine the utility of tryptase genotyping among individuals with moderate elevations in BST at a regional health system.
    Methods: Clinical and laboratory data from 109 subjects with basal tryptase values of 7.5 ng/mL or greater who were tested for HαT or had a disorder previously linked to elevated BST were collected retrospectively by chart review.
    Results: Fifty-eight subjects had elevated BST defined as 11.5 ng/mL or greater. HαT was found in 63.8% (n = 37), 12.1% (n = 7) had CKD, and 20.7% (n = 12) had clonal myeloid disorders. A total of 6.9% (n = 4) with elevated BST had negative testing for HαT, CKD, and myeloid neoplasms. Two subjects with CKD, 1 subject with MDS, and 1 with myeloid hypereosinophilic syndrome had negative testing for HαT. Among subjects with elevated BST and more than 1 tryptase measurement, 41.5% (n = 22) had BST variability that exceeded the 20% plus 2 formula. Increased BST variability was found in subjects with HαT, all forms of mastocytosis, CKD, MDS, and those with no associated diagnosis.
    Conclusions: HαT, CKD, and clonal myeloid disorders or a combination of the 3 constitute approximately 90% of individuals with elevated BST in clinical practice. Myeloid neoplasms were over-represented in this cohort relative to population prevalence data suggesting tryptase measurement selection bias by clinicians or higher prevalence. Elevated BST is associated with increased tryptase variability, regardless of etiology.
    Mesh-Begriff(e) Humans ; Mast Cells ; Mastocytosis/diagnosis ; Myelodysplastic Syndromes/diagnosis ; Renal Insufficiency, Chronic/diagnosis ; Retrospective Studies ; Tryptases/blood
    Chemische Substanzen Tryptases (EC 3.4.21.59)
    Sprache Englisch
    Erscheinungsdatum 2022-01-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.12.031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Standardized indolent systemic mastocytosis evaluations across a healthcare system: implications for screening accuracy.

    McMurray, Jeremy C / Pacheco, Curtis S / Schornack, Brandon J / Sun, Xiaoping / Brunader, Janet A / Scott, Alexis Erica / Ariza, Juan S / Kou, Chung-Ting J / Costantino, Ryan C / Pittman, Luke M / Adams, Karla E / Waters, Aubri M / Pryor, Eric M / Lyons, Jonathan J / Metcalfe, Dean / Maric, Irina / Boggs, Nathan A

    Blood

    2024  

    Abstract: Timely diagnosis of systemic mastocytosis (SM) remains challenging due to care heterogeneity. We implemented a standardized approach for SM screening and diagnosis utilizing a novel healthcare system-wide international screening registry. A retrospective ...

    Abstract Timely diagnosis of systemic mastocytosis (SM) remains challenging due to care heterogeneity. We implemented a standardized approach for SM screening and diagnosis utilizing a novel healthcare system-wide international screening registry. A retrospective analysis assessed rates of SM, cutaneous mastocytosis (CM), and molecular diagnoses before and two years after care standardization. Accuracy of individual and combined SM screening tests - basal serum tryptase (BST) ≥11.5 and ≥20.0 ng/mL, REMA ≥2, monomorphic maculopapular CM, and elevated BST based upon tryptase genotype - was analyzed. Tryptase genotyping and high-sensitivity KIT p.D816V testing increased substantially two years following care standardization. SM diagnoses doubled from 47 to 94 and KIT p.D816V molecular diagnoses increased from 24 to 79. Mean BST and KIT p.D816V variant allele frequency (VAF) values were significantly lower in patients diagnosed after standardization. Hereditary-alpha tryptasemia prevalence was increased in SM prior to care standardization at 4/30 (13.3%) but reflected the general population prevalence two years later at 5/76 (6.6%). Elevated BST based upon genotype and BST ≥11.5 ng/mL had the highest sensitivities at 84.2% and 88.3%, respectively. Presence of monomorphic MPCM, elevated BST based upon tryptase genotype, and the combination of REMA ≥2 with elevated BST based upon tryptase genotype had specificities >90%. BST >20.0 ng/mL had low sensitivity and specificity and was not required to establish any indolent SM diagnosis. Care standardization increased SM diagnosis rates, particularly in patients with low BSTs. Stratifying BST based upon genotype had the best overall sensitivity and specificity of any indolent SM screening test and improved the REMA score specificity.
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023023347
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Hb Grifton [α87(F8)His→Pro; HBA1: C.263A > C (or HBA2)] Causes Abnormal Pulse Oximetry Measurements.

    Waters, Aubri M / Caboot, Jason B / Verhovsek, Madeleine M / Harper, David P / Forouhar, Melissa A

    Hemoglobin

    2016  Band 40, Heft 4, Seite(n) 257–259

    Abstract: An asymptomatic toddler and his mother consistently demonstrated low transcutaneous pulse oximetry (SpO2) measurements, discordant with normal arterial blood gas analyses while breathing room air. Previous evaluations by medical teams were unable to ... ...

    Abstract An asymptomatic toddler and his mother consistently demonstrated low transcutaneous pulse oximetry (SpO2) measurements, discordant with normal arterial blood gas analyses while breathing room air. Previous evaluations by medical teams were unable to identify an etiology of their perceived hypoxia. Further investigation revealed that the boy carried an abnormal variant, Hb Grifton or α87(F8)His→Pro; HBA1: c.263A > C (or HBA2), discovered on newborn screening, which was not suspected as the underlying cause of his abnormal pulse oximetry readings until an inpatient admission to our hospital for asymptomatic "hypoxia," where he was found to share these same characteristics with his mother. We showed that a difference in light absorption between the oxygenated Hb Grifton variant and oxygenated Hb A resulted in erroneous pulse oximetry values. This phenomenon has previously been reported in a handful of other variant Hbs. Astute clinical suspicion, in conjunction with laboratory testing leading to correct diagnoses of variant Hbs, may prevent expensive work-ups and unnecessary medical treatments for asymptomatic patients falsely presumed to be hypoxemic based on low pulse oximetry measurements.
    Mesh-Begriff(e) Adult ; Blood Gas Analysis ; Child, Preschool ; Diagnostic Errors ; Female ; Hemoglobins, Abnormal/analysis ; Hemoglobins, Abnormal/genetics ; Humans ; Hypoxia/diagnosis ; Male ; Oximetry/standards ; Oxyhemoglobins/analysis
    Chemische Substanzen Hemoglobins, Abnormal ; Oxyhemoglobins
    Sprache Englisch
    Erscheinungsdatum 2016-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 750615-6
    ISSN 1532-432X ; 0363-0269
    ISSN (online) 1532-432X
    ISSN 0363-0269
    DOI 10.1080/03630269.2016.1174872
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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