Article: Axon Guidance Molecules in the Islets of Langerhans.
2022 Volume 13, Page(s) 869780
Abstract: The islets of Langerhans, responsible for regulating blood glucose in vertebrates, are clusters of endocrine cells distributed throughout the exocrine pancreas. The spatial architecture of the different cell types within the islets controls cell-cell ... ...
Abstract | The islets of Langerhans, responsible for regulating blood glucose in vertebrates, are clusters of endocrine cells distributed throughout the exocrine pancreas. The spatial architecture of the different cell types within the islets controls cell-cell communication and impacts their ability to collectively regulate glucose. Islets rely on a range of chemotactic and adhesive cues to establish and manage intercellular relationships. Growing evidence indicates that axon guidance molecules such as Slit-Robo, Semaphorin-Neuropilin, Ephrin-Eph, and Netrins, influence endocrine progenitors' cell migration to establish correct architecture during islet morphogenesis, as well as directly regulating physical cell-cell communication in the mature islet to coordinate hormone secretion. In this mini-review, we discuss what is known and not yet known about how axon guidance molecules contribute to islet morphogenesis and function. |
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MeSH term(s) | Animals ; Axon Guidance ; Cell Communication ; Endocrine Cells ; Islets of Langerhans/metabolism |
Language | English |
Publishing date | 2022-04-14 |
Publishing country | Switzerland |
Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural |
ZDB-ID | 2592084-4 |
ISSN | 1664-2392 |
ISSN | 1664-2392 |
DOI | 10.3389/fendo.2022.869780 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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