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  1. AU="Watkins, Jacinta L."
  2. AU="Surendra, K C"
  3. AU=Lauber Mariko
  4. AU="McGowan, Patrick O"
  5. AU="Se Young An"
  6. AU=Cholewinski Grzegorz
  7. AU="Goldenstein, Patrícia T"
  8. AU="Song, Jingrong"

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  1. Artikel ; Online: Uncovering the secrets to vibrant flowers: the role of carotenoid esters and their interaction with plastoglobules in plant pigmentation.

    Watkins, Jacinta L

    The New phytologist

    2023  Band 240, Heft 1, Seite(n) 7–9

    Mesh-Begriff(e) Esters ; Carotenoids ; Xanthophylls ; Flowers ; Pigmentation ; Gene Expression Regulation, Plant
    Chemische Substanzen Esters ; Carotenoids (36-88-4) ; Xanthophylls
    Sprache Englisch
    Erscheinungsdatum 2023-08-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.19185
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  2. Artikel ; Online: Compartmentalization at the interface of primary and alkaloid metabolism.

    Watkins, Jacinta L / Facchini, Peter J

    Current opinion in plant biology

    2022  Band 66, Seite(n) 102186

    Abstract: Plants produce many compounds used by humans as medicines, including alkaloids of the benzylisoquinoline (BIA), monoterpene indole (MIA) and tropane classes. The biosynthetic pathways of these pharmaceutical alkaloids are complex and spatially segregated ...

    Abstract Plants produce many compounds used by humans as medicines, including alkaloids of the benzylisoquinoline (BIA), monoterpene indole (MIA) and tropane classes. The biosynthetic pathways of these pharmaceutical alkaloids are complex and spatially segregated across several tissues, cell-types and organelles. This review discusses the origin of primary metabolic inputs required by these specialized biosynthetic pathways and considers aspects relevant to their spatial organization. These factors are important for alkaloid production both in the native plants and for synthetic biology pathway reconstruction in microorganisms.
    Mesh-Begriff(e) Alkaloids/metabolism ; Biosynthetic Pathways ; Plants/metabolism ; Synthetic Biology
    Chemische Substanzen Alkaloids
    Sprache Englisch
    Erscheinungsdatum 2022-02-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2022.102186
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  3. Artikel: Compartmentalization at the interface of primary and alkaloid metabolism

    Watkins, Jacinta L. / Facchini, Peter J.

    Current opinion in plant biology. 2022 Apr., v. 66

    2022  

    Abstract: Plants produce many compounds used by humans as medicines, including alkaloids of the benzylisoquinoline (BIA), monoterpene indole (MIA) and tropane classes. The biosynthetic pathways of these pharmaceutical alkaloids are complex and spatially segregated ...

    Abstract Plants produce many compounds used by humans as medicines, including alkaloids of the benzylisoquinoline (BIA), monoterpene indole (MIA) and tropane classes. The biosynthetic pathways of these pharmaceutical alkaloids are complex and spatially segregated across several tissues, cell-types and organelles. This review discusses the origin of primary metabolic inputs required by these specialized biosynthetic pathways and considers aspects relevant to their spatial organization. These factors are important for alkaloid production both in the native plants and for synthetic biology pathway reconstruction in microorganisms.
    Schlagwörter alkaloids ; biosynthesis ; indoles ; monoterpenoids ; organelles ; plant biology ; synthetic biology
    Sprache Englisch
    Erscheinungsverlauf 2022-04
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2022.102186
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  4. Artikel ; Online: Elucidation of the mescaline biosynthetic pathway in peyote (Lophophora williamsii).

    Watkins, Jacinta L / Li, Qiushi / Yeaman, Sam / Facchini, Peter J

    The Plant journal : for cell and molecular biology

    2023  Band 116, Heft 3, Seite(n) 635–649

    Abstract: Peyote (Lophophora williamsii) is an entheogenic and medicinal cactus native to the Chihuahuan desert. The psychoactive and hallucinogenic properties of peyote are principally attributed to the phenethylamine derivative mescaline. Despite the isolation ... ...

    Abstract Peyote (Lophophora williamsii) is an entheogenic and medicinal cactus native to the Chihuahuan desert. The psychoactive and hallucinogenic properties of peyote are principally attributed to the phenethylamine derivative mescaline. Despite the isolation of mescaline from peyote over 120 years ago, the biosynthetic pathway in the plant has remained undiscovered. Here, we use a transcriptomics and homology-guided gene discovery strategy to elucidate a near-complete biosynthetic pathway from l-tyrosine to mescaline. We identified a cytochrome P450 that catalyzes the 3-hydroxylation of l-tyrosine to l-DOPA, a tyrosine/DOPA decarboxylase yielding dopamine, and four substrate-specific and regiospecific substituted phenethylamine O-methyltransferases. Biochemical assays with recombinant enzymes or functional analyses performed by feeding putative precursors to engineered yeast (Saccharomyces cerevisiae) strains expressing candidate peyote biosynthetic genes were used to determine substrate specificity, which served as the basis for pathway elucidation. Additionally, an N-methyltransferase displaying broad substrate specificity and leading to the production of N-methylated phenethylamine derivatives was identified, which could also function as an early step in the biosynthesis of tetrahydroisoquinoline alkaloids in peyote.
    Mesh-Begriff(e) Mescaline/analysis ; Mescaline/chemistry ; Biosynthetic Pathways ; Phenethylamines ; Tyrosine/metabolism ; Methyltransferases/metabolism ; Cactaceae/chemistry ; Cactaceae/metabolism
    Chemische Substanzen Mescaline (RHO99102VC) ; Phenethylamines ; Tyrosine (42HK56048U) ; Methyltransferases (EC 2.1.1.-)
    Sprache Englisch
    Erscheinungsdatum 2023-09-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1088037-9
    ISSN 1365-313X ; 0960-7412
    ISSN (online) 1365-313X
    ISSN 0960-7412
    DOI 10.1111/tpj.16447
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  5. Artikel ; Online: Prospects for Carotenoid Biofortification Targeting Retention and Catabolism.

    Watkins, Jacinta L / Pogson, Barry J

    Trends in plant science

    2020  Band 25, Heft 5, Seite(n) 501–512

    Abstract: Due to the ongoing prevalence of vitamin A deficiency (VAD) in developing countries there has been a large effort towards increasing the carotenoid content of staple foods via biofortification. Common strategies used for carotenoid biofortification ... ...

    Abstract Due to the ongoing prevalence of vitamin A deficiency (VAD) in developing countries there has been a large effort towards increasing the carotenoid content of staple foods via biofortification. Common strategies used for carotenoid biofortification include altering flux through the biosynthesis pathway to direct synthesis to a specific product, generally β-carotene, or via increasing the expression of genes early in the carotenoid biosynthesis pathway. Recently, carotenoid biofortification strategies are turning towards increasing the retention of carotenoids in plant tissues either via altering sequestration within the cell or via downregulating enzymes known to cause degradation of carotenoids. To date, little attention has focused on increasing the stability of carotenoids, which may be a promising method of increasing carotenoid content in staple foods.
    Mesh-Begriff(e) Biofortification ; Biosynthetic Pathways ; Carotenoids/metabolism ; beta Carotene/metabolism
    Chemische Substanzen beta Carotene (01YAE03M7J) ; Carotenoids (36-88-4)
    Sprache Englisch
    Erscheinungsdatum 2020-01-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1305448-x
    ISSN 1878-4372 ; 1360-1385
    ISSN (online) 1878-4372
    ISSN 1360-1385
    DOI 10.1016/j.tplants.2019.12.021
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  6. Artikel: Prospects for Carotenoid Biofortification Targeting Retention and Catabolism

    Watkins, Jacinta L / Pogson, Barry J

    Trends in plant science. 2020 May, v. 25, no. 5

    2020  

    Abstract: Due to the ongoing prevalence of vitamin A deficiency (VAD) in developing countries there has been a large effort towards increasing the carotenoid content of staple foods via biofortification. Common strategies used for carotenoid biofortification ... ...

    Abstract Due to the ongoing prevalence of vitamin A deficiency (VAD) in developing countries there has been a large effort towards increasing the carotenoid content of staple foods via biofortification. Common strategies used for carotenoid biofortification include altering flux through the biosynthesis pathway to direct synthesis to a specific product, generally β-carotene, or via increasing the expression of genes early in the carotenoid biosynthesis pathway. Recently, carotenoid biofortification strategies are turning towards increasing the retention of carotenoids in plant tissues either via altering sequestration within the cell or via downregulating enzymes known to cause degradation of carotenoids. To date, little attention has focused on increasing the stability of carotenoids, which may be a promising method of increasing carotenoid content in staple foods.
    Schlagwörter beta-carotene ; biofortification ; biosynthesis ; developing countries ; enzymes ; gene expression ; plant tissues ; staple foods ; vitamin A ; vitamin A deficiency
    Sprache Englisch
    Erscheinungsverlauf 2020-05
    Umfang p. 501-512.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 1305448-x
    ISSN 1878-4372 ; 1360-1385
    ISSN (online) 1878-4372
    ISSN 1360-1385
    DOI 10.1016/j.tplants.2019.12.021
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  7. Artikel: Back to the plant: overcoming roadblocks to the microbial production of pharmaceutically important plant natural products

    Ozber, Natali / Watkins, Jacinta L / Facchini, Peter J

    Journal of industrial microbiology & biotechnology. 2020 Oct., v. 47, no. 9-10

    2020  

    Abstract: Microbial fermentation platforms offer a cost-effective and sustainable alternative to plant cultivation and chemical synthesis for the production of many plant-derived pharmaceuticals. Plant alkaloids, particularly benzylisoquinoline alkaloids and ... ...

    Abstract Microbial fermentation platforms offer a cost-effective and sustainable alternative to plant cultivation and chemical synthesis for the production of many plant-derived pharmaceuticals. Plant alkaloids, particularly benzylisoquinoline alkaloids and monoterpene indole alkaloids, and recently cannabinoids have become attractive targets for microbial biosynthesis owing to their medicinal importance. Recent advances in the discovery of pathway components, together with the application of synthetic biology tools, have facilitated the assembly of plant alkaloid and cannabinoid pathways in the microbial hosts Escherichia coli and Saccharomyces cerevisiae. This review highlights key aspects of these pathways in the framework of overcoming bottlenecks in microbial production to further improve end-product titers. We discuss the opportunities that emerge from a better understanding of the pathway components by further study of the plant, and strategies for generation of new and advanced medicinal compounds.
    Schlagwörter Escherichia coli ; Saccharomyces cerevisiae ; biosynthesis ; biotechnology ; cannabinoids ; cost effectiveness ; drugs ; fermentation ; industrial microbiology ; monoterpenoids ; synthesis ; synthetic biology
    Sprache Englisch
    Erscheinungsverlauf 2020-10
    Umfang p. 815-828.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean ; Review
    ZDB-ID 1482484-X
    ISSN 1476-5535 ; 1367-5435
    ISSN (online) 1476-5535
    ISSN 1367-5435
    DOI 10.1007/s10295-020-02300-9
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  8. Artikel ; Online: Back to the plant: overcoming roadblocks to the microbial production of pharmaceutically important plant natural products.

    Ozber, Natali / Watkins, Jacinta L / Facchini, Peter J

    Journal of industrial microbiology & biotechnology

    2020  Band 47, Heft 9-10, Seite(n) 815–828

    Abstract: Microbial fermentation platforms offer a cost-effective and sustainable alternative to plant cultivation and chemical synthesis for the production of many plant-derived pharmaceuticals. Plant alkaloids, particularly benzylisoquinoline alkaloids and ... ...

    Abstract Microbial fermentation platforms offer a cost-effective and sustainable alternative to plant cultivation and chemical synthesis for the production of many plant-derived pharmaceuticals. Plant alkaloids, particularly benzylisoquinoline alkaloids and monoterpene indole alkaloids, and recently cannabinoids have become attractive targets for microbial biosynthesis owing to their medicinal importance. Recent advances in the discovery of pathway components, together with the application of synthetic biology tools, have facilitated the assembly of plant alkaloid and cannabinoid pathways in the microbial hosts Escherichia coli and Saccharomyces cerevisiae. This review highlights key aspects of these pathways in the framework of overcoming bottlenecks in microbial production to further improve end-product titers. We discuss the opportunities that emerge from a better understanding of the pathway components by further study of the plant, and strategies for generation of new and advanced medicinal compounds.
    Mesh-Begriff(e) Alkaloids/biosynthesis ; Benzylisoquinolines/metabolism ; Biological Products/metabolism ; Escherichia coli/metabolism ; Fermentation ; Monoterpenes/metabolism ; Pharmaceutical Preparations/metabolism ; Plants/metabolism ; Saccharomyces cerevisiae/metabolism ; Synthetic Biology
    Chemische Substanzen Alkaloids ; Benzylisoquinolines ; Biological Products ; Monoterpenes ; Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2020-08-09
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1482484-X
    ISSN 1476-5535 ; 1367-5435
    ISSN (online) 1476-5535
    ISSN 1367-5435
    DOI 10.1007/s10295-020-02300-9
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  9. Artikel ; Online: Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation.

    Ozber, Natali / Carr, Samuel C / Morris, Jeremy S / Liang, Siyu / Watkins, Jacinta L / Caldo, Kristian M / Hagel, Jillian M / Ng, Kenneth K S / Facchini, Peter J

    Nature communications

    2022  Band 13, Heft 1, Seite(n) 6768

    Abstract: Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers, which compose an internal secretory system associated with phloem throughout the ... ...

    Abstract Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers, which compose an internal secretory system associated with phloem throughout the plant. The contiguous latex includes an abundance of related proteins belonging to the pathogenesis-related (PR)10 family known collectively as major latex proteins (MLPs) and representing at least 35% of the total cellular protein content. Two latex MLP/PR10 proteins, thebaine synthase and neopione isomerase, have recently been shown to catalyze late steps in morphine biosynthesis previously assigned as spontaneous reactions. Using a combination of sucrose density-gradient fractionation-coupled proteomics, differential scanning fluorimetry, isothermal titration calorimetry, and X-ray crystallography, we show that the major latex proteins are a family of alkaloid-binding proteins that display altered conformation in the presence of certain ligands. Addition of MLP/PR10 proteins to yeast strains engineered with morphine biosynthetic genes from the plant significantly enhanced the conversion of salutaridine to morphinan alkaloids.
    Mesh-Begriff(e) Papaver/genetics ; Papaver/metabolism ; Latex/chemistry ; Alkaloids/chemistry ; Benzylisoquinolines/metabolism ; Morphine ; Saccharomyces cerevisiae/metabolism
    Chemische Substanzen Latex ; Alkaloids ; Benzylisoquinolines ; Morphine (76I7G6D29C)
    Sprache Englisch
    Erscheinungsdatum 2022-11-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34313-6
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  10. Artikel ; Online: A GDSL Esterase/Lipase Catalyzes the Esterification of Lutein in Bread Wheat.

    Watkins, Jacinta L / Li, Ming / McQuinn, Ryan P / Chan, Kai Xun / McFarlane, Heather E / Ermakova, Maria / Furbank, Robert T / Mares, Daryl / Dong, Chongmei / Chalmers, Kenneth J / Sharp, Peter / Mather, Diane E / Pogson, Barry J

    The Plant cell

    2019  Band 31, Heft 12, Seite(n) 3092–3112

    Abstract: Xanthophylls are a class of carotenoids that are important micronutrients for humans. They are often found esterified with fatty acids in fruits, vegetables, and certain grains, including bread wheat ( ...

    Abstract Xanthophylls are a class of carotenoids that are important micronutrients for humans. They are often found esterified with fatty acids in fruits, vegetables, and certain grains, including bread wheat (
    Mesh-Begriff(e) Alleles ; Beta-Cryptoxanthin/metabolism ; Biocatalysis ; Carboxylic Ester Hydrolases/genetics ; Carboxylic Ester Hydrolases/metabolism ; Carotenoids/metabolism ; Esterification ; Esters/metabolism ; Lutein/metabolism ; Organ Specificity/genetics ; Oryza/metabolism ; Plants, Genetically Modified ; Plastids/metabolism ; Triglycerides/metabolism ; Triticum/embryology ; Triticum/enzymology ; Triticum/genetics ; Triticum/metabolism ; Xanthophylls/metabolism ; Zeaxanthins/metabolism
    Chemische Substanzen Beta-Cryptoxanthin ; Esters ; Triglycerides ; Xanthophylls ; Zeaxanthins ; Carotenoids (36-88-4) ; Carboxylic Ester Hydrolases (EC 3.1.1.-) ; Lutein (X72A60C9MT)
    Sprache Englisch
    Erscheinungsdatum 2019-10-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 623171-8
    ISSN 1532-298X ; 1040-4651
    ISSN (online) 1532-298X
    ISSN 1040-4651
    DOI 10.1105/tpc.19.00272
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