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  1. Article ; Online: Ultrasound-guided femoral nerve blocks are not superior to ultrasound-guided fascia iliaca blocks for fractured neck of femur.

    Cooper, Alannah L / Nagree, Yusuf / Goudie, Adrian / Watson, Peter R / Arendts, Glenn

    Emergency medicine Australasia : EMA

    2018  Volume 31, Issue 3, Page(s) 393–398

    Abstract: Objective: To determine if an ultrasound-guided femoral nerve block (FNB) is superior to an ultrasound-guided fascia iliaca compartment block (FICB) in providing pain relief to patients with a neck of femur or proximal femoral fracture.: Methods: A ... ...

    Abstract Objective: To determine if an ultrasound-guided femoral nerve block (FNB) is superior to an ultrasound-guided fascia iliaca compartment block (FICB) in providing pain relief to patients with a neck of femur or proximal femoral fracture.
    Methods: A double-blind randomised controlled trial was conducted. All participants received two blocks, one active and one placebo. An active FICB was administered to 52 participants and 48 participants received an active FNB.
    Results: Analysis was completed on data collected from 100 participants. Most patients were elderly and the majority were female. Both FICB and FNB achieved clinically significant mean reductions in pain scores (2.62 for FICB and 2.3 for FNB). There was no significant difference in reduction in pain scores between the two cohorts, P = 0.408.
    Conclusions: Ultrasound-guided FNB is not superior to ultrasound-guided FICB, with both facilitating an equivalent analgesia effect in patients with a neck of femur or proximal femur fracture.
    MeSH term(s) Aged ; Aged, 80 and over ; Analgesia/methods ; Analgesia/standards ; Analgesia/statistics & numerical data ; Double-Blind Method ; Fascia/drug effects ; Female ; Femoral Artery/drug effects ; Femoral Neck Fractures/complications ; Femoral Neck Fractures/drug therapy ; Humans ; Male ; Middle Aged ; Nerve Block/methods ; Nerve Block/standards ; Nerve Block/statistics & numerical data ; Pain Measurement/methods ; Ultrasonography, Interventional/methods ; Ultrasonography, Interventional/standards ; Ultrasonography, Interventional/statistics & numerical data
    Language English
    Publishing date 2018-09-09
    Publishing country Australia
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2161824-0
    ISSN 1742-6723 ; 1742-6731 ; 1035-6851
    ISSN (online) 1742-6723
    ISSN 1742-6731 ; 1035-6851
    DOI 10.1111/1742-6723.13172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5940: Show issues Location:
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  2. Article ; Online: An examination of costs, charges, and payments for inpatient psychiatric treatment in community hospitals.

    Stensland, Michael / Watson, Peter R / Grazier, Kyle L

    Psychiatric services (Washington, D.C.)

    2012  Volume 63, Issue 7, Page(s) 666–671

    Abstract: Objective: Hospitalization is a critical component of treatment for individuals with serious and persistent mental illness. Despite its resource intensity, the costs of inpatient psychiatric hospitalizations in the United States are not well understood. ...

    Abstract Objective: Hospitalization is a critical component of treatment for individuals with serious and persistent mental illness. Despite its resource intensity, the costs of inpatient psychiatric hospitalizations in the United States are not well understood. The objective of this research was to provide cost estimates for inpatient psychiatric care.
    Methods: Using Premier's Perspective Comparative Database, supplemented with the MarketScan database, this study estimated the average charges, cost to provide care, and amount of reimbursement for inpatient psychiatric care in 418 community-based hospitals in 2006 (N=261,996 hospitalizations).
    Results: Charges were 2.5 times higher than the hospitals' reported costs to deliver care. Reimbursed amounts indicated by MarketScan were similar to the reported costs to deliver care. The average cost to deliver care was highest for Medicare and lowest for the uninsured: schizophrenia treatment, $8,509 for 11.1 days and $5,707 for 7.4 days, respectively; bipolar disorder treatment, $7,593 for 9.4 days and $4,356 for 5.5 days; depression treatment, $6,990 for 8.4 days and $3,616 for 4.4 days; drug use disorder treatment, $4,591 for 5.2 days and $3,422 for 3.7 days; and alcohol use disorder treatment, $5,908 for 6.2 days and $4,147 for 3.8 days.
    Conclusions: Consistent with past research, the results suggest that previous attempts to control pricing may have led to unintended consequences, including a large gap between charges and reimbursed amounts, potential cost shifting between payers, and potentially extended lengths of stay to offset reduced per diems. The lack of transparency in pricing makes it challenging to estimate the cost to society for a day of psychiatric hospitalization.
    MeSH term(s) Cost Allocation ; Hospital Charges/statistics & numerical data ; Hospital Costs/statistics & numerical data ; Hospitalization/economics ; Hospitals, Community/economics ; Humans ; Insurance, Health, Reimbursement/statistics & numerical data ; Length of Stay/economics ; Medicaid/economics ; Medically Uninsured ; Medicare/economics ; Mental Disorders/economics ; Mental Disorders/therapy ; United States
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.201100402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 416: Show issues Location:
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  3. Article ; Online: Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.

    Roschewski, Mark / Dunleavy, Kieron / Abramson, Jeremy S / Powell, Bayard L / Link, Brian K / Patel, Prapti / Bierman, Philip J / Jagadeesh, Deepa / Mitsuyasu, Ronald T / Peace, David / Watson, Peter R / Hanna, Wahid T / Melani, Christopher / Lucas, Andrea N / Steinberg, Seth M / Pittaluga, Stefania / Jaffe, Elaine S / Friedberg, Jonathan W / Kahl, Brad S /
    Little, Richard F / Bartlett, Nancy L / Fanale, Michelle A / Noy, Ariela / Wilson, Wyndham H

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2020  Volume 38, Issue 22, Page(s) 2519–2529

    Abstract: Purpose: Burkitt lymphoma is an aggressive B-cell lymphoma curable with dose-intensive chemotherapy derived from pediatric leukemia regimens. Treatment is acutely toxic with late sequelae. We hypothesized that dose-adjusted etoposide, doxorubicin, ... ...

    Abstract Purpose: Burkitt lymphoma is an aggressive B-cell lymphoma curable with dose-intensive chemotherapy derived from pediatric leukemia regimens. Treatment is acutely toxic with late sequelae. We hypothesized that dose-adjusted etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone, and rituximab (DA-EPOCH-R) may obviate the need for highly dose-intensive chemotherapy in adults with Burkitt lymphoma.
    Methods: We conducted a multicenter risk-adapted study of DA-EPOCH-R in untreated adult Burkitt lymphoma. Low-risk patients received three cycles without CNS prophylaxis, and high-risk patients received six cycles with intrathecal CNS prophylaxis or extended intrathecal treatment if leptomeninges were involved. The primary endpoint was event-free survival (EFS), and secondary endpoints were toxicity and predictors of EFS and overall survival (OS).
    Results: Between 2010 and 2017, 113 patients were enrolled across 22 centers, and 98 (87%) were high risk. The median age was 49 (range, 18-86) years, and 62% were ≥ 40 years. Bone marrow and/or CSF was involved in 29 (26%) of patients, and 28 (25%) were HIV positive. At a median follow-up of 58.7 months, EFS and OS were 84.5% and 87.0%, respectively, and EFS was 100% and 82.1% in low- and high-risk patients. Therapy was equally effective across age groups, HIV status, and International Prognostic Index risk groups. Involvement of the CSF identified the group at greatest risk for early toxicity-related death or treatment failure. Five treatment-related deaths (4%) occurred during therapy. Febrile neutropenia occurred in 16% of cycles, and tumor lysis syndrome was rare.
    Conclusion: Risk-adapted DA-EPOCH-R therapy is effective in adult Burkitt lymphoma regardless of age or HIV status and was well tolerated. Improved therapeutic strategies for adults with CSF involvement are needed (funded by the National Cancer Institute; ClinicalTrials.gov identifier: NCT01092182).
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Burkitt Lymphoma/drug therapy ; Burkitt Lymphoma/pathology ; Cyclophosphamide/administration & dosage ; Doxorubicin/administration & dosage ; Etoposide/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prednisone/administration & dosage ; Prognosis ; Risk Factors ; Rituximab/administration & dosage ; Survival Rate ; Vincristine/administration & dosage ; Young Adult
    Chemical Substances Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Etoposide (6PLQ3CP4P3) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.20.00303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
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    Zs.MO 650: Show issues

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  4. Article ; Online: Dietary antioxidant and mineral intake in humans is associated with reduced risk of esophageal adenocarcinoma but not reflux esophagitis or Barrett's esophagus.

    Murphy, Seamus J / Anderson, Lesley A / Ferguson, Heather R / Johnston, Brian T / Watson, Peter R / McGuigan, Jim / Comber, Harry / Reynolds, John V / Murray, Liam J / Cantwell, Marie M

    The Journal of nutrition

    2010  Volume 140, Issue 10, Page(s) 1757–1763

    Abstract: The role of antioxidants in the pathogenesis of reflux esophagitis (RE), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) remains unknown. We evaluated the associations among dietary antioxidant intake and these diseases. We performed an ... ...

    Abstract The role of antioxidants in the pathogenesis of reflux esophagitis (RE), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) remains unknown. We evaluated the associations among dietary antioxidant intake and these diseases. We performed an assessment of dietary antioxidant intake in a case control study of RE (n = 219), BE (n = 220), EAC (n = 224), and matched population controls (n = 256) (the Factors Influencing the Barrett's Adenocarcinoma Relationship study) using a modification of a validated FFQ. We found that overall antioxidant index, a measure of the combined intake of vitamin C, vitamin E, total carotenoids, and selenium, was associated with a reduced risk of EAC [odds ratio (OR) = 0.57; 95% CI = 0.33-0.98], but not BE (OR = 0.95; 95% CI = 0.53-1.71) or RE (OR = 1.60; 95% CI = 0.86-2.98), for those in the highest compared with lowest category of intake. Those in the highest category of vitamin C intake had a lower risk of EAC (OR = 0.37; 95% CI = 0.21-0.66; P-trend = 0.001) and RE (OR = 0.46; 95% CI = 0.24-0.90; P-trend = 0.03) compared with those in the lowest category. Vitamin C intake was not associated with BE, and intake of vitamin E, total carotenoids, zinc, copper, or selenium was not associated with EAC, BE, or RE. In conclusion, the overall antioxidant index was associated with a reduced risk of EAC. Higher dietary intake of vitamin C was associated with a reduced risk of EAC and RE. These results suggest that antioxidants may play a role in the pathogenesis of RE and EAC and may be more important in terms of progression rather than initiation of the disease process.
    MeSH term(s) Adenocarcinoma/prevention & control ; Aged ; Antioxidants/administration & dosage ; Ascorbic Acid/administration & dosage ; Barrett Esophagus/prevention & control ; Carotenoids/administration & dosage ; Case-Control Studies ; Copper/administration & dosage ; Diet ; Esophageal Neoplasms/prevention & control ; Female ; Gastroesophageal Reflux/prevention & control ; Humans ; Male ; Middle Aged ; Minerals/administration & dosage ; Odds Ratio ; Risk Factors ; Selenium/administration & dosage ; Vitamin E/administration & dosage ; Zinc/administration & dosage
    Chemical Substances Antioxidants ; Minerals ; Vitamin E (1406-18-4) ; Carotenoids (36-88-4) ; Copper (789U1901C5) ; Selenium (H6241UJ22B) ; Zinc (J41CSQ7QDS) ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2010-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.3945/jn.110.124362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.205: Show issues Location:
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  5. Article: Plasma concentrations of glucagon-like peptide-2 in adult patients with treated and untreated coeliac disease.

    Caddy, Grant R / Ardill, Joy E S / Fillmore, Davina / Caldwell, Carolyn M / McKibben, Bronac M / Gardiner, Keith R / Watson, Peter R G

    European journal of gastroenterology & hepatology

    2005  Volume 18, Issue 2, Page(s) 195–202

    Abstract: Background: Coeliac disease is a common chronic inflammatory enteropathy characterized by villous atrophy and crypt hyperplasia in the small intestine. The mechanism of the intestinal damage in coeliac disease remains unclear. Glucagon-like peptide (GLP) ...

    Abstract Background: Coeliac disease is a common chronic inflammatory enteropathy characterized by villous atrophy and crypt hyperplasia in the small intestine. The mechanism of the intestinal damage in coeliac disease remains unclear. Glucagon-like peptide (GLP)-2 is an enterotrophic peptide that causes crypt hyperplasia and intestinal cell proliferation. We postulate that GLP-2 may be involved in the mucosal changes found in coeliac disease.
    Objectives: To study plasma concentrations of GLP-2 in untreated patients with coeliac disease and determine the response to a gluten-free diet (GFD).
    Methods: A 440 kcal gluten-free test meal was given to seven controls and 12 coeliac patients at three time intervals: (1) before commencing a GFD; (2) 3 months after a GFD; and (3) 9 months after a GFD. Serial blood sampling was performed over a 2-h period. Each sample was analysed using radioimmunoassay for GLP-2, GLP-1, N-terminal glucagon (N-glucagon) and C-terminal glucagon (C-glucagon).
    Results: Untreated coeliac patients had significantly higher basal and peak GLP-2 and N-glucagon plasma concentrations compared with controls. After 3 months on a GFD, there was a significant decrease in basal GLP-2 plasma concentrations. There was no significant difference between GLP-1 or C-glucagon in untreated coeliac patients compared with controls.
    Conclusion: This is the first reported study of GLP-2 in coeliac disease. After a GFD there is recovery of the intestine and a reduction in the GLP-2 trophic response. Our findings support the theory that GLP-2 may be part of the mucosal healing and maintenance mechanisms in coeliac disease.
    MeSH term(s) Adult ; Celiac Disease/blood ; Celiac Disease/diet therapy ; Female ; Follow-Up Studies ; Glucagon/blood ; Glucagon-Like Peptide 1/blood ; Glucagon-Like Peptide 2 ; Glucagon-Like Peptides/blood ; Glutens/administration & dosage ; Humans ; Male ; Middle Aged ; Radioimmunoassay ; Treatment Outcome
    Chemical Substances Glucagon-Like Peptide 2 ; Glucagon-Like Peptides (62340-29-8) ; Glutens (8002-80-0) ; Glucagon-Like Peptide 1 (89750-14-1) ; Glucagon (9007-92-5)
    Language English
    Publishing date 2005-09-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/00042737-200602000-00013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2932: Show issues Location:
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  6. Article: Dietary Antioxidant and Mineral Intake in Humans Is Associated with Reduced Risk of Esophageal Adenocarcinoma but Not Reflux Esophagitis or Barrett's Esophagus

    Murphy, Seamus J / Anderson, Lesley A / Ferguson, Heather R / Johnston, Brian T / Watson, Peter R / McGuigan, Jim / Comber, Harry / Reynolds, John V / Murray, Liam J / Cantwell, Marie M

    Journal of nutrition. 2010 Oct., v. 140, no. 10

    2010  

    Abstract: The role of antioxidants in the pathogenesis of reflux esophagitis (RE), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) remains unknown. We evaluated the associations among dietary antioxidant intake and these diseases. We performed an ... ...

    Abstract The role of antioxidants in the pathogenesis of reflux esophagitis (RE), Barrett's esophagus (BE), and esophageal adenocarcinoma (EAC) remains unknown. We evaluated the associations among dietary antioxidant intake and these diseases. We performed an assessment of dietary antioxidant intake in a case control study of RE (n = 219), BE (n = 220), EAC (n = 224), and matched population controls (n = 256) (the Factors Influencing the Barrett's Adenocarcinoma Relationship study) using a modification of a validated FFQ. We found that overall antioxidant index, a measure of the combined intake of vitamin C, vitamin E, total carotenoids, and selenium, was associated with a reduced risk of EAC [odds ratio (OR) = 0.57; 95% CI = 0.33-0.98], but not BE (OR = 0.95; 95% CI = 0.53-1.71) or RE (OR = 1.60; 95% CI = 0.86-2.98), for those in the highest compared with lowest category of intake. Those in the highest category of vitamin C intake had a lower risk of EAC (OR = 0.37; 95% CI = 0.21-0.66; P-trend = 0.001) and RE (OR = 0.46; 95% CI = 0.24-0.90; P-trend = 0.03) compared with those in the lowest category. Vitamin C intake was not associated with BE, and intake of vitamin E, total carotenoids, zinc, copper, or selenium was not associated with EAC, BE, or RE. In conclusion, the overall antioxidant index was associated with a reduced risk of EAC. Higher dietary intake of vitamin C was associated with a reduced risk of EAC and RE. These results suggest that antioxidants may play a role in the pathogenesis of RE and EAC and may be more important in terms of progression rather than initiation of the disease process.
    Keywords vitamin-mineral supplements ; selenium ; carotenoids ; ascorbic acid ; vitamin E ; antioxidants ; copper ; zinc ; dietary minerals ; esophageal neoplasms ; adenocarcinoma ; esophageal diseases ; gastroesophageal reflux ; pathogenesis ; disease prevention
    Language English
    Dates of publication 2010-10
    Size p. 1757-1763.
    Publishing place American Society for Nutrition
    Document type Article
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
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    Z 774: Show issues

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  7. Book: Animal traction

    Watson, Peter R / Davis, Richard / Chakroff, Marilyn / Kaufman, Marilyn / Conn, Mary

    (Manual / Peace Corps. Information Collection & Exchange ; no. M-12)

    1981  

    Institution Peace Corps (U.S.). / Information Collection and Exchange.
    TransCentury Corporation
    Author's details written by: Peter R. Watson ; edited by: Richard Davis, Marilyn S. Chakroff; illustrated by: Marilyn Kaufman, Mary Conn. --
    Series title Manual / Peace Corps. Information Collection & Exchange ; no. M-12
    Keywords Draft animals. ; Animal-powered engines.
    Language English
    Size v, 244 p. :, ill. ;, 27 cm. --
    Publisher Peace Corps, Information Collection & Exchange
    Publishing place Washington, D.C
    Document type Book
    Note Publication produced for Peace Corps by the TransCentury Corporation, Washington, D.C., under contract no. 79-043-0129. ; "August 1981." ; Includes index.
    Database NAL-Catalogue (AGRICOLA)

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