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  1. AU="Wattacheril, Julia"
  2. AU="Wangen, Patrice"
  3. AU="Mayuri Gupta"
  4. AU=Basta Giuseppina
  5. AU="Karppinen, Maarit"
  6. AU="Rounis, Konstantinos"
  7. AU="Perrier, Prunelle"
  8. AU=Chisari Emanuele AU=Chisari Emanuele
  9. AU="Sibiya, Maureen Nokuthula"
  10. AU="Gokce, Emine"
  11. AU="Muth, Christiane"
  12. AU="Cüneyt Orhan Kara"
  13. AU="Arnberg, Fabian"
  14. AU="Rana, Shubham"
  15. AU="Hugen, Cory M"
  16. AU="Andres M. Rubiano"
  17. AU="Nicole Matejka"
  18. AU="Nunes, Pedro M. Sales"
  19. AU="Sánchez-Montero, María Teresa"
  20. AU="Jiexin Zhang"
  21. AU=Mladinic M
  22. AU="Canfarotta, Michael W"
  23. AU="Merani, Shaheed"
  24. AU="Tarver, James E"
  25. AU=Wirestam Lina
  26. AU="Karen Martz"
  27. AU="Yadav, Kanhaiya L."
  28. AU="Girmay, Tigisty"
  29. AU="Hain, Sofia"
  30. AU="de Kler, R C F"
  31. AU="Veness, R."

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  1. Artikel ; Online: Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease.

    Wattacheril, Julia

    Gastroenterology clinics of North America

    2019  Band 49, Heft 1, Seite(n) 141–149

    Abstract: Nonalcoholic fatty liver disease (NAFLD) represents a global public health burden. NAFLD, while strongly associated with the metabolic syndrome, can occur independently from existing metabolic diseases. In addition to liver-related disease burden and ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) represents a global public health burden. NAFLD, while strongly associated with the metabolic syndrome, can occur independently from existing metabolic diseases. In addition to liver-related disease burden and mortality, significant extrahepatic disease outcomes coexist with NAFLD, including cardiovascular diseases, chronic kidney disease, and type 2 diabetes. Management of these comorbidities contributes to the overall public health burden of NAFLD. These extrahepatic manifestations require healthcare interventions that are vigilant in monitoring for progression of liver disease while simultaneously managing overall morbidity and mortality from other organ systems.
    Mesh-Begriff(e) Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2019-12-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 92114-2
    ISSN 1558-1942 ; 0889-8553
    ISSN (online) 1558-1942
    ISSN 0889-8553
    DOI 10.1016/j.gtc.2019.10.002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Response to Braillon.

    Phipps, Meaghan / Wattacheril, Julia

    The American journal of gastroenterology

    2021  Band 116, Heft 3, Seite(n) 617–618

    Mesh-Begriff(e) Carcinoma, Hepatocellular ; Female ; Humans ; Liver Neoplasms ; United States
    Sprache Englisch
    Erscheinungsdatum 2021-07-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001180
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Using epigenomics to understand cellular responses to environmental influences in diseases.

    Wattacheril, Julia J / Raj, Srilakshmi / Knowles, David A / Greally, John M

    PLoS genetics

    2023  Band 19, Heft 1, Seite(n) e1010567

    Abstract: It is a generally accepted model that environmental influences can exert their effects, at least in part, by changing the molecular regulators of transcription that are described as epigenetic. As there is biochemical evidence that some epigenetic ... ...

    Abstract It is a generally accepted model that environmental influences can exert their effects, at least in part, by changing the molecular regulators of transcription that are described as epigenetic. As there is biochemical evidence that some epigenetic regulators of transcription can maintain their states long term and through cell division, an epigenetic model encompasses the idea of maintenance of the effect of an exposure long after it is no longer present. The evidence supporting this model is mostly from the observation of alterations of molecular regulators of transcription following exposures. With the understanding that the interpretation of these associations is more complex than originally recognised, this model may be oversimplistic; therefore, adopting novel perspectives and experimental approaches when examining how environmental exposures are linked to phenotypes may prove worthwhile. In this review, we have chosen to use the example of nonalcoholic fatty liver disease (NAFLD), a common, complex human disease with strong environmental and genetic influences. We describe how epigenomic approaches combined with emerging functional genetic and single-cell genomic techniques are poised to generate new insights into the pathogenesis of environmentally influenced human disease phenotypes exemplified by NAFLD.
    Mesh-Begriff(e) Humans ; Non-alcoholic Fatty Liver Disease/genetics ; Epigenesis, Genetic ; Epigenomics ; Environmental Exposure/adverse effects ; Phenotype
    Sprache Englisch
    Erscheinungsdatum 2023-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1010567
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: AGA Clinical Practice Update on the Role of Noninvasive Biomarkers in the Evaluation and Management of Nonalcoholic Fatty Liver Disease: Expert Review.

    Wattacheril, Julia J / Abdelmalek, Manal F / Lim, Joseph K / Sanyal, Arun J

    Gastroenterology

    2023  Band 165, Heft 4, Seite(n) 1080–1088

    Abstract: Description: The purpose of this American Gastroenterological Association (AGA) Clinical Practice Update Expert Review is to provide clinicians with guidance on the use of noninvasive tests (NITs) in the evaluation and management of patients with ... ...

    Abstract Description: The purpose of this American Gastroenterological Association (AGA) Clinical Practice Update Expert Review is to provide clinicians with guidance on the use of noninvasive tests (NITs) in the evaluation and management of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD affects nearly 30% of the global population and is a growing cause of end-stage liver disease and liver-related health care resource utilization. However, only a minority of all patients with NAFLD experience a liver-related outcome. It is therefore critically important for clinicians to assess prognosis and identify those with increased risk of disease progression and negative clinical outcomes at the time of initial assessment. It is equally important to assess disease trajectory over time, particularly in response to currently available therapeutic approaches. The reference standard for assessment of prognosis and disease monitoring is histologic examination of liver biopsy specimens. There are, however, many limitations of liver biopsies and their reading that have limited their use in routine practice. The utilization of NITs facilitates risk stratification of patients and longitudinal assessment of disease progression for patients with NAFLD. This clinical update provides best practice advice based on a review of the literature on the utilization of NITs in the management of NAFLD for clinicians. Accordingly, a combination of available evidence and consensus-based expert opinion, without formal rating of the strength and quality of the evidence, was used to develop these best practice advice statements.
    Methods: This Expert Review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership and underwent internal peer review by the Clinical Practice Updates Committee and external peer review through standard procedures of Gastroenterology. These best practice advice statements were drawn from a review of the published literature and from expert opinion. Because systematic reviews were not performed, these best practice advice statements do not carry formal ratings of the quality of evidence or strength of the presented considerations. Best Practice Advice Statements BEST PRACTICE ADVICE 1: NITs can be used for risk stratification in the diagnostic evaluation of patients with NAFLD. BEST PRACTICE ADVICE 2: A Fibrosis 4 Index score <1.3 is associated with strong negative predictive value for advanced hepatic fibrosis and may be useful for exclusion of advanced hepatic fibrosis in patients with NAFLD. BEST PRACTICE ADVICE 3: A combination of 2 or more NITs combining serum biomarkers and/or imaging-based biomarkers is preferred for staging and risk stratification of patients with NAFLD whose Fibrosis 4 Index score is >1.3. BEST PRACTICE ADVICE 4: Use of NITs in accordance with manufacturer's specifications (eg, not in patients with ascites or pacemakers) can minimize risk of discordant results and adverse events. BEST PRACTICE ADVICE 5: NITs should be interpreted with context and consideration of pertinent clinical data (eg, physical examination, biochemical, radiographic, and endoscopic) to optimize positive predictive value in the identification of patients with advanced fibrosis. BEST PRACTICE ADVICE 6: Liver biopsy should be considered for patients with NIT results that are indeterminate or discordant; conflict with other clinical, laboratory, or radiologic findings; or when alternative etiologies for liver disease are suspected. BEST PRACTICE ADVICE 7: Serial longitudinal monitoring using NITs for assessment of disease progression or regression may inform clinical management (ie, response to lifestyle modification or therapeutic intervention). BEST PRACTICE ADVICE 8: Patients with NAFLD and NITs results suggestive of advanced fibrosis (F3) or cirrhosis (F4) should be considered for surveillance of liver complications (eg, hepatocellular carcinoma screening and variceal screening per Baveno criteria). Patients with NAFLD and NITs suggestive of advanced hepatic fibrosis (F3) or (F4), should be monitored with serial liver stiffness measurement; vibration controlled transient elastography; or magnetic resonance elastography, given its correlation with clinically significant portal hypertension and clinical decompensation.
    Mesh-Begriff(e) Humans ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/therapy ; Non-alcoholic Fatty Liver Disease/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/therapy ; Liver/diagnostic imaging ; Liver/pathology ; Disease Progression ; Biomarkers
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-08-04
    Erscheinungsland United States
    Dokumenttyp Review ; Practice Guideline
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.06.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Non-alcoholic fatty liver disease (NAFLD) in non-obese individuals.

    Phipps, Meaghan / Wattacheril, Julia

    Frontline gastroenterology

    2019  Band 11, Heft 6, Seite(n) 478–483

    Abstract: Individuals with non-alcoholic fatty liver disease (NAFLD) who lack classical risk factors also have the ability to develop nonalcoholic steatohepatitis (NASH) and progression to more advanced liver disease. The pathophysiology and risk factors for the ... ...

    Abstract Individuals with non-alcoholic fatty liver disease (NAFLD) who lack classical risk factors also have the ability to develop nonalcoholic steatohepatitis (NASH) and progression to more advanced liver disease. The pathophysiology and risk factors for the development of NAFLD in non-obese persons are not fully understood but seem to be closely related to insulin resistance, atherogenic dyslipidaemia and alterations in body composition, with some patients harbouring predisposing genetic polymorphisms. In normal-weight individuals, also called 'lean', there is limited potential for effective lifestyle change in disease management. Additionally, biological mechanisms underlying the development of NASH in non-obese individuals may reveal novel targets for intervention. In this review, the authors discuss the clinical, histological and genetic features and risk factors for non-obese NAFLD and highlight gaps in knowledge and areas for future research.
    Sprache Englisch
    Erscheinungsdatum 2019-12-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2521857-8
    ISSN 2041-4137
    ISSN 2041-4137
    DOI 10.1136/flgastro-2018-101119
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Bariatric Surgery in the Peritransplant Period.

    Pomenti, Sydney / Mehta, Sanket / Guo, Averill / Wattacheril, Julia

    Clinical liver disease

    2021  Band 17, Heft 4, Seite(n) 282–291

    Sprache Englisch
    Erscheinungsdatum 2021-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1052
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  7. Artikel: Health Disparities in Screening, Diagnosis, and Treatment of Hepatocellular Carcinoma.

    Guo, Averill / Pomenti, Sydney / Wattacheril, Julia

    Clinical liver disease

    2021  Band 17, Heft 5, Seite(n) 353–358

    Sprache Englisch
    Erscheinungsdatum 2021-06-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.1057
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  8. Artikel: Investigating the Relationship Between Rare Genetic Variants and Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease.

    Wattacheril, Julia / Kleinstein, Sarah E / Shea, Patrick R / Wilson, Laura A / Subramanian, G Mani / Myers, Robert P / Lefkowitch, Jay / Behling, Cynthia / Xanthakos, Stavra A / Goldstein, David B

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Background and aims: Nonalcoholic Fatty Liver Disease (NAFLD) is a complex human disease. Common genetic variation in the patatin-like phospholipase domain containing 3 (: Methods: Whole exome sequencing data was generated for 229 pediatric patients ... ...

    Abstract Background and aims: Nonalcoholic Fatty Liver Disease (NAFLD) is a complex human disease. Common genetic variation in the patatin-like phospholipase domain containing 3 (
    Methods: Whole exome sequencing data was generated for 229 pediatric patients diagnosed with NAFLD recruited from the NASH Clinical Research Network (NASH CRN). Case-control single variant and gene-based collapsing analyses were used to test for rare variants that were enriched or depleted within the pediatric NAFLD cohort specifically for advanced fibrosis (cases) versus those without fibrosis (controls) or six other histologic characteristics. Exome data from non-NAFLD population controls were also used for additional analyses. All results were adjusted for multiple testing using a Bonferroni correction.
    Results: No genome-wide significant associations were found between rare variation and presence of advanced fibrosis or NASH, nor the severity of steatosis, inflammation, or hepatocellular ballooning. Significantly, no enrichment of rare variants in
    Conclusion: In a cohort of children with histologically proven NAFLD, no genome-wide significant associations were found between rare genetic variation and advanced fibrosis or six other histologic features. Of particular interest was the lack of association with genes of interest in adults:
    Sprache Englisch
    Erscheinungsdatum 2024-03-04
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.03.02.24303632
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Lean NAFLD: An Underrecognized Outlier.

    Wattacheril, Julia / Sanyal, Arun J

    Current hepatology reports

    2016  Band 15, Heft 2, Seite(n) 134–139

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is commonly diagnosed in obese or overweight individuals. However, lean individuals with NAFLD are not rare but represent one significant end of the phenotypic spectrum of NAFLD. Although initial observations ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is commonly diagnosed in obese or overweight individuals. However, lean individuals with NAFLD are not rare but represent one significant end of the phenotypic spectrum of NAFLD. Although initial observations between obese and lean NAFLD reveal some metabolic parallels, these associations vary widely given differences in study populations and metabolic parameters assessed. The role of body composition in risk assessment is significant and incompletely assessed during most clinical encounters. Recent multinational investigation reveals an increased mortality in lean individuals with NASH. Many aspects of lean NAFLD need further exploration including epidemiology, clinical risk assessment, histologic changes unique to lean NAFLD, genetic and pathophysiologic mechanisms predisposing at risk individuals, natural history and treatment strategies in this underrecognized population.
    Sprache Englisch
    Erscheinungsdatum 2016-04-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2813071-6
    ISSN 2195-9595 ; 2195-9595 ; 1540-3416
    ISSN (online) 2195-9595
    ISSN 2195-9595 ; 1540-3416
    DOI 10.1007/s11901-016-0302-1
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  10. Artikel: [Titelangabe fehlt]

    Wattacheril, Julia / Chalasani, Naga

    Clinical liver disease

    2014  Band 2, Heft Suppl 5, Seite(n) 103–105

    Titelübersetzung Papel de la cirugía bariátrica en el manejo de la enfermedad hepática por hígado graso no alcohólico.
    Sprache Spanisch
    Erscheinungsdatum 2014-01-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.285
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