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  1. Article ; Online: COVID-19 and abnormal uterine bleeding: potential associations and mechanisms.

    Maybin, Jacqueline A / Watters, Marianne / Rowley, Bethan / Walker, Catherine A / Sharp, Gemma C / Alvergne, Alexandra

    Clinical science (London, England : 1979)

    2024  Volume 138, Issue 4, Page(s) 153–171

    Abstract: The impact of COVID-19 on menstruation has received a high level of public and media interest. Despite this, uncertainty exists about the advice that women and people who menstruate should receive in relation to the expected impact of SARS-CoV-2 ... ...

    Abstract The impact of COVID-19 on menstruation has received a high level of public and media interest. Despite this, uncertainty exists about the advice that women and people who menstruate should receive in relation to the expected impact of SARS-CoV-2 infection, long COVID or COVID-19 vaccination on menstruation. Furthermore, the mechanisms leading to these reported menstrual changes are poorly understood. This review evaluates the published literature on COVID-19 and its impact on menstrual bleeding, discussing the strengths and limitations of these studies. We present evidence consistent with SARS-CoV-2 infection and long COVID having an association with changes in menstrual bleeding parameters and that the impact of COVID vaccination on menstruation appears less significant. An overview of menstrual physiology and known causes of abnormal uterine bleeding (AUB) is provided before discussing potential mechanisms which may underpin the menstrual disturbance reported with COVID-19, highlighting areas for future scientific study. Finally, consideration is given to the effect that menstruation may have on COVID-19, including the impact of the ovarian sex hormones on acute COVID-19 severity and susceptibility and reported variation in long COVID symptoms across the menstrual cycle. Understanding the current evidence and addressing gaps in our knowledge in this area are essential to inform public health policy, direct the treatment of menstrual disturbance and facilitate development of new therapies, which may reduce the severity of COVID-19 and improve quality of life for those experiencing long COVID.
    MeSH term(s) Female ; Humans ; Endometrium ; Post-Acute COVID-19 Syndrome ; Quality of Life ; COVID-19 Vaccines ; COVID-19/complications ; SARS-CoV-2 ; Menstruation/physiology ; Uterine Hemorrhage/etiology ; Menstruation Disturbances/complications
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.220: Show issues Location:
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  2. Article ; Online: The Menstrual Endometrium: From Physiology to Future Treatments.

    Watters, Marianne / Martínez-Aguilar, Rocío / Maybin, Jacqueline A

    Frontiers in reproductive health

    2022  Volume 3, Page(s) 794352

    Abstract: Abnormal uterine bleeding (AUB) is experienced by up to a third of women of reproductive age. It can cause anaemia and often results in decreased quality of life. A range of medical and surgical treatments are available but are associated with side ... ...

    Abstract Abnormal uterine bleeding (AUB) is experienced by up to a third of women of reproductive age. It can cause anaemia and often results in decreased quality of life. A range of medical and surgical treatments are available but are associated with side effects and variable effectiveness. To improve the lives of those suffering from menstrual disorders, delineation of endometrial physiology is required. This allows an increased understanding of how this physiology may be disturbed, leading to uterine pathologies. In this way, more specific preventative and therapeutic strategies may be developed to personalise management of this common symptom. In this review, the impact of AUB globally is outlined, alongside the urgent clinical need for improved medical treatments. Current knowledge of endometrial physiology at menstruation is discussed, focusing on endocrine regulation of menstruation and local endometrial inflammation, tissue breakdown, hypoxia and endometrial repair. The contribution of the specialised endometrial vasculature and coagulation system during menstruation is highlighted. What is known regarding aberrations in endometrial physiology that result in AUB is discussed, with a focus on endometrial disorders (AUB-E) and adenomyosis (AUB-A). Gaps in existing knowledge and areas for future research are signposted throughout, with a focus on potential translational benefits for those experiencing abnormal uterine bleeding. Personalisation of treatment strategies for menstrual disorders is then examined, considering genetic, environmental and demographic characteristics of individuals to optimise their clinical management. Finally, an ideal model of future management of AUB is proposed. This would involve targeted diagnosis of specific endometrial aberrations in individuals, in the context of holistic medicine and with due consideration of personal circumstances and preferences.
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2021.794352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Uterine miR-877-3p and let-7a-5p are increased during simulated menstruation in a mouse model.

    Watters, Marianne / Walker, Catherine A / Murray, Alison A / Nicol, Moira / Maybin, Jacqueline A

    Reproduction & fertility

    2022  Volume 3, Issue 1, Page(s) L3–L5

    Abstract: Heavy periods are common and debilitating, but we do not fully understand how they are caused. Increased understanding of menstrual bleeding could result in new treatments for problematic periods. Low oxygen levels are present in the womb lining during a ...

    Abstract Heavy periods are common and debilitating, but we do not fully understand how they are caused. Increased understanding of menstrual bleeding could result in new treatments for problematic periods. Low oxygen levels are present in the womb lining during a period. These low oxygen levels help trigger the repair process required to stop menstrual bleeding. MicroRNAs (miRNAs) are small molecules that can affect cell function, and some are regulated by oxygen levels. We examined whether such miRNAs were present in the womb lining during a period. To overcome the variability present in humans, we studied the womb of mice given hormones to mimic the human menstrual cycle. We revealed that two miRNAs known to be regulated by oxygen levels were increased in the womb during menstruation. These miRNAs may help regulate menstrual blood loss and merit further study as a potential target for future treatments for heavy periods.
    MeSH term(s) Animals ; Disease Models, Animal ; Female ; Menorrhagia ; Menstruation ; Mice ; MicroRNAs ; Oxygen ; Uterus
    Chemical Substances MIRN877 microRNA, mouse ; MicroRNAs ; mirnlet7 microRNA, human ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2633-8386
    ISSN (online) 2633-8386
    DOI 10.1530/RAF-21-0112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phenytoin-induced hypothermia.

    Watters, Marianne / Wilson, Hilary / Everitt, Pamela

    BMJ case reports

    2019  Volume 12, Issue 1

    Abstract: A 60-year-old man with cerebral palsy and epilepsy was admitted with acute lethargy and deterioration in coordination. He was noted to be hypothermic at 35°C on admission. Routine work-up revealed toxic levels of phenytoin. No cause of hypothermia could ... ...

    Abstract A 60-year-old man with cerebral palsy and epilepsy was admitted with acute lethargy and deterioration in coordination. He was noted to be hypothermic at 35°C on admission. Routine work-up revealed toxic levels of phenytoin. No cause of hypothermia could be identified but as his phenytoin levels normalised, his body temperature also improved. There are three other reported cases of phenytoin- induced hypothermia in the literature. Could this be a rare cause of hypothermia?
    MeSH term(s) Aftercare ; Ataxia/diagnosis ; Ataxia/etiology ; Cytochrome P-450 CYP1A2 Inducers/toxicity ; Diagnosis, Differential ; Humans ; Hypothermia/chemically induced ; Hypothermia/diagnosis ; Lethargy/diagnosis ; Lethargy/etiology ; Male ; Middle Aged ; Phenytoin/blood ; Phenytoin/toxicity ; Treatment Outcome
    Chemical Substances Cytochrome P-450 CYP1A2 Inducers ; Phenytoin (6158TKW0C5)
    Language English
    Publishing date 2019-01-22
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2018-227443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Short versus extended progesterone supplementation for luteal phase support in fresh IVF cycles: a systematic review and meta-analysis.

    Watters, Marianne / Noble, Matt / Child, Tim / Nelson, Scott

    Reproductive biomedicine online

    2019  Volume 40, Issue 1, Page(s) 143–150

    Abstract: This review and meta-analysis aim to assess the effect of prolonged progesterone support on pregnancy outcomes in women undergoing fresh embryo transfer after IVF/intracytoplasmic sperm injection (ICSI). Two independent authors searched Embase, MEDLINE ... ...

    Abstract This review and meta-analysis aim to assess the effect of prolonged progesterone support on pregnancy outcomes in women undergoing fresh embryo transfer after IVF/intracytoplasmic sperm injection (ICSI). Two independent authors searched Embase, MEDLINE and grey literature from inception to January 2019 for randomized controlled trials (RCT) of prolonged progesterone support versus early cessation. Risk of bias was assessed. Outcome measures were live birth, miscarriage and ongoing pregnancy rate. The study was registered with PROSPERO (CRD42018088605). Seven trials involving 1627 participants were included: three reported live birth rate (672/830), seven the miscarriage rate (178/1627) and seven the ongoing pregnancy rate (1351/1627). Clinical outcomes were similar between early progesterone cessation versus progesterone continuation: live birth rate (risk ratio [RR] 0.94, 95% confidence interval [CI] 0.88-1.00), miscarriage rate (RR 0.91, 95% CI 0.69-1.20) and ongoing pregnancy rate (RR 0.98, 95% CI 0.91-1.05). Ongoing pregnancy rates were similar when analyses were restricted to those with cessation of progesterone on the day of a positive human chorionic gonadotrophin (RR 0.93, 95% CI 0.83-1.06). This meta-analysis suggests that prolonged progesterone support may be unnecessary after fresh embryo transfer. Further larger RCT would be useful to corroborate and lead to standardized duration of progesterone luteal phase support across IVF/ICSI centres.
    MeSH term(s) Female ; Fertilization in Vitro/methods ; Humans ; Luteal Phase ; Ovulation Induction/methods ; Progesterone/administration & dosage ; Time Factors
    Chemical Substances Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2019-10-24
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2113823-0
    ISSN 1472-6491 ; 1472-6483
    ISSN (online) 1472-6491
    ISSN 1472-6483
    DOI 10.1016/j.rbmo.2019.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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