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  1. AU="Watterson, Claire"
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  1. Artikel: Improving paediatric prescribing practice in a district general hospital through implementation of a quality improvement programme.

    Donnelly, Peter / Lawson, Sara / Watterson, Claire

    BMJ quality improvement reports

    2015  Band 4, Heft 1

    Abstract: Prescribing errors are a well recognised cause of adverse incidents and have a direct effect on patients.[1] This impacts on the doctor-family relationship and results in breakdown of trust and communication.[2] This quality improvement project was ... ...

    Abstract Prescribing errors are a well recognised cause of adverse incidents and have a direct effect on patients.[1] This impacts on the doctor-family relationship and results in breakdown of trust and communication.[2] This quality improvement project was carried out in the paediatric ward of a district general hospital in Northern Ireland. A retrospective analysis of paediatric prescribing errors between January and December 2013 identified two errors that were felt to be secondary to under-reporting. A baseline audit was subsequently performed that highlighted 32 errors across 12 drug charts. A driver diagram identified three components contributing to prescribing errors and relevant tests of change were developed. The three primary drivers included: education and communication, practical prescribing changes, and medicine reconciliation. Seven interventions were implemented sequentially over a six month period and their effectiveness assessed by a prospective drug chart audit. Ten drug charts were selected at random by the staff nurse allocated to medications on the day of audit. The charts were audited using a predesigned proforma and the total number of errors counted. These were subcategorised and results displayed in graphical format after each intervention. Seven audit cycles were completed in total after each intervention was put into practice. The number of errors (including percentage change following each intervention) is as follows: intervention 1: 32 (+19%); Intervention 2: 31 (+15%); Intervention 3: 17 (-37%); Intervention 4: 12 (-56%); Intervention 5: 15 (-44%); Intervention 6: 7 (-74%); Intervention 7: 10 (-63%). In conclusion, permanent and successful measures are needed to reduce prescribing errors in order to minimise the impact of staff changeover and knowledge deficits.
    Sprache Englisch
    Erscheinungsdatum 2015-09-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2677829-4
    ISSN 2050-1315
    ISSN 2050-1315
    DOI 10.1136/bmjquality.u206996.w3769
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Post-COVID-19 paediatric inflammatory multisystem syndrome: association of ethnicity, key worker and socioeconomic status with risk and severity.

    Broad, Jonathan / Forman, Julia / Brighouse, James / Sobande, Adebola / McIntosh, Alysha / Watterson, Claire / Boot, Elizabeth / Montgomery, Felicity / Gilmour, Iona / Tan, Joy / Fogarty, Mary Johanna / Gomez, Xabier / Cheung, Ronny / Lillie, Jon / Shivamurthy, Vinay / Handforth, Jenny / Miller, Owen

    Archives of disease in childhood

    2021  Band 106, Heft 12, Seite(n) 1218–1225

    Abstract: Objectives: Patients from ethnic minority groups and key workers are over-represented among adults hospitalised or dying from COVID-19. In this population-based retrospective cohort, we describe the association of ethnicity, socioeconomic and family key ...

    Abstract Objectives: Patients from ethnic minority groups and key workers are over-represented among adults hospitalised or dying from COVID-19. In this population-based retrospective cohort, we describe the association of ethnicity, socioeconomic and family key worker status with incidence and severity of Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 (PIMS-TS).
    Setting: Evelina London Children's Hospital (ELCH), the tertiary paediatric hospital for the South Thames Retrieval Service (STRS) region.
    Participants: 70 children with PIMS-TS admitted 14 February 2020-2 June 2020.
    Outcome measures: Incidence and crude ORs are presented, comparing ethnicity and socioeconomic status of our cohort and the catchment population, using census data and Index of Multiple Deprivation (IMD). Regression is used to estimate the association of ethnicity and IMD with admission duration and requirement for intensive care, inotropes and ventilation.
    Results: Incidence was significantly higher in children from black (25.0 cases per 100 000 population), Asian (6.4/100 000) and other (17.8/100 000) ethnic groups, compared with 1.6/100 000 in white ethnic groups (ORs 15.7, 4.0 and 11.2, respectively). Incidence was higher in the three most deprived quintiles compared with the least deprived quintile (eg, 8.1/100 000 in quintile 1 vs 1.6/100 000 in quintile 5, OR 5.2). Proportions of families with key workers (50%) exceeded catchment proportions. Admission length of stay was 38% longer in children from black ethnic groups than white (95% CI 4% to 82%; median 8 days vs 6 days). 9/10 children requiring ventilation were from black ethnic groups.
    Conclusions: Children in ethnic minority groups, living in more deprived areas and in key worker families are over-represented. Children in black ethnic groups had longer admissions; ethnicity may be associated with ventilation requirement.This project was registered with the ELCH audit and service evaluation team, ref. no 11186.
    Mesh-Begriff(e) COVID-19/complications ; COVID-19/economics ; COVID-19/epidemiology ; COVID-19/ethnology ; England/epidemiology ; Ethnicity ; Health Personnel ; Humans ; Incidence ; Length of Stay ; Poverty Areas ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Social Class ; Systemic Inflammatory Response Syndrome/economics ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/ethnology
    Sprache Englisch
    Erscheinungsdatum 2021-03-16
    Erscheinungsland England
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2020-320388
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A comparative analysis of acute-phase proteins as inflammatory biomarkers in preclinical toxicology studies: implications for preclinical to clinical translation.

    Watterson, Claire / Lanevschi, Anne / Horner, Judith / Louden, Calvert

    Toxicologic pathology

    2009  Band 37, Heft 1, Seite(n) 28–33

    Abstract: Recently, in early clinical development, a few biologics and small molecules intended as antitumor or anti-inflammatory agents have caused a severe adverse pro-inflammatory systemic reaction also known as systemic inflammatory response syndrome (SIRS). ... ...

    Abstract Recently, in early clinical development, a few biologics and small molecules intended as antitumor or anti-inflammatory agents have caused a severe adverse pro-inflammatory systemic reaction also known as systemic inflammatory response syndrome (SIRS). This toxicity could result from expected pharmacological effects of a therapeutic antibody and/or from interaction with antigens expressed on cells/tissues other than the intended target. Clinical monitoring of SIRS is challenging because of the narrow diagnostic window to institute a successful intervening therapeutic strategy prior to acute circulatory collapse. Furthermore, for these classes of therapeutic agents, studies in animals have low predictive ability to identify potential human hazards. In vitro screens with human cells, though promising, need further development. Therefore, identification of improved preclinical diagnostic markers of SIRS will enable clinicians to select applicable markers for clinical testing and avoid potentially catastrophic events. There is limited preclinical toxicology data describing the interspecies performance of acute-phase proteins because the response time, type, and duration of major acute-phase proteins vary significantly between species. This review will attempt to address this intellectual gap, as well as the use and applicability of acute-phase proteins as preclinical to clinical translational biomarkers of SIRS.
    Mesh-Begriff(e) Acute-Phase Proteins/metabolism ; Animals ; Biomarkers/metabolism ; Disease Models, Animal ; Dogs ; Drug Evaluation, Preclinical ; Humans ; Mice ; Rats ; Systemic Inflammatory Response Syndrome/chemically induced ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/metabolism ; Toxicity Tests/methods ; Xenobiotics/toxicity
    Chemische Substanzen Acute-Phase Proteins ; Biomarkers ; Xenobiotics
    Sprache Englisch
    Erscheinungsdatum 2009-01
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Review
    ZDB-ID 841009-4
    ISSN 1533-1601 ; 0192-6233
    ISSN (online) 1533-1601
    ISSN 0192-6233
    DOI 10.1177/0192623308329286
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch ; Online: Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS)

    White, Marie / Tiesman, Bianca / Handforth, Jennifer / Kenny, Julia / the Evelina PIMS TS working group, / Handforth, Jenny / Watterson, Claire / Meesters, Kevin / Fogarty, Mary-Jo / Broad, Jonathan / Martinez-Alier, Nuria / Demirjian, Alicia / Tebruegge, Marc / Alonso, Alejandro / Shah, Tish / Finemore, Anna / Blackburn, Fran / Parish, Emma / Cheung, Ronny /
    Trecchi, Nadia / Jackman, John / Butler, Mark / Ramachandran, Rohana / Roueche, Alice / Macaulay, Chloe / Lemer, Claire / Montgomery, Felicity / Sobande, Debbie / Kamal, Ajanta / Shivamurthy, Vinay / Wilkinson, Nick / Brighouse, James / Arenas, Sara / Christiansen, Nanna / Wan, Mandy / Miller, Owen / Mathur, Sujeev / Wong, James / Theocharis, Paraskevi / Stewart, Kirsty / Kabir, Saleha / Peacock, Kelly / Pushparajah, Kuberan / Savis, Alex / Regan, Will / Pascall, Emma / Cleary, Aoife / Uy, Mirasol / Heard, Hannah / Carter, Michael / Tibby, Shane / Lillie, Jon / Riphagen, Shelley / MacDougall, Marilyn / Ben Griffths, Xabi Gomez / Waters, Gareth / Minen, Federico / Nyman, Andrew / Goulden, Miriam Fine / Sa, Mario / Lim, Ming / Bryne, Susan / Cadwgan, Jill / Lim, JP / Singh, Rahul / Tang, Shan / Lumsden, Dan / Senior, Sam / McMurtrie, Sarah / Foster, Emily / Norridge, Matthew / Emberson, Stephanie / Marr, Stacey / Felton, Victoria / Reid, Chris / Adalat, Shazia / Balasubramanian, Ramnath / Jones, Helen / Alamelu, Jay / Insua, Baba

    the Evelina Experience

    2020  

    Schlagwörter Editorial ; covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-01 00:00:00.0
    Verlag BMJ Publishing Group Ltd
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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