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  1. Article: A Low-Prevalence Single-Nucleotide Polymorphism in the Sensor Kinase PhoR in

    Waturuocha, Uchenna Watson / Krishna, M S / Malhotra, Vandana / Dixit, Narendra M / Saini, Deepak Kumar

    Frontiers in microbiology

    2021  Volume 12, Page(s) 724482

    Abstract: The genome sequencing ... ...

    Abstract The genome sequencing of
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.724482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mycobacterium tuberculosis PknK Substrate Profiling Reveals Essential Transcription Terminator Protein Rho and Two-Component Response Regulators PrrA and MtrA as Novel Targets for Phosphorylation.

    Malhotra, Vandana / Okon, Blessing P / Satsangi, Akash T / Das, Sumana / Waturuocha, Uchenna Watson / Vashist, Atul / Clark-Curtiss, Josephine E / Saini, Deepak Kumar

    Microbiology spectrum

    2022  Volume 10, Issue 2, Page(s) e0135421

    Abstract: The Mycobacterium tuberculosis protein kinase K regulates growth adaptation by facilitating mycobacterial survival in response to a variety ... ...

    Abstract The Mycobacterium tuberculosis protein kinase K regulates growth adaptation by facilitating mycobacterial survival in response to a variety of
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Carbon/metabolism ; DNA/metabolism ; Gene Expression Regulation, Bacterial ; Humans ; Mycobacterium tuberculosis/metabolism ; Nitrogen/metabolism ; Phosphorylation/genetics ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Tuberculosis
    Chemical Substances Bacterial Proteins ; Carbon (7440-44-0) ; DNA (9007-49-2) ; Protein Kinases (EC 2.7.-) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01354-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A high-frequency single nucleotide polymorphism in the MtrB sensor kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties.

    Waturuocha, Uchenna Watson / P J, Athira / Singh, Krishna Kumar / Malhotra, Vandana / Krishna, M S / Saini, Deepak Kumar

    PloS one

    2021  Volume 16, Issue 9, Page(s) e0256664

    Abstract: The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. Although the lineages of these clinical strains can be traced back to common ancestor/s, there exists a plethora ... ...

    Abstract The DNA polymorphisms found in clinical strains of Mycobacterium tuberculosis drive altered physiology, virulence, and pathogenesis in them. Although the lineages of these clinical strains can be traced back to common ancestor/s, there exists a plethora of difference between them, compared to those that have evolved in the laboratory. We identify a mutation present in ~80% of clinical strains, which maps in the HATPase domain of the sensor kinase MtrB and alters kinase and phosphatase activities, and affects its physiological role. The changes conferred by the mutation were probed by in-vitro biochemical assays which revealed changes in signaling properties of the sensor kinase. These changes also affect bacterial cell division rates, size and membrane properties. The study highlights the impact of DNA polymorphisms on the pathophysiology of clinical strains and provides insights into underlying mechanisms that drive signal transduction in pathogenic bacteria.
    MeSH term(s) Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial ; Humans ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Mycobacterium tuberculosis/pathogenicity ; Polymorphism, Single Nucleotide ; RNA-Binding Proteins/genetics ; Signal Transduction ; Transcription Factors/genetics ; Tuberculosis/microbiology ; Virulence
    Chemical Substances Bacterial Proteins ; MtrB protein, Bacteria ; RNA-Binding Proteins ; Transcription Factors
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0256664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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