Article ; Online: Fentanyl buccal tablet for breakthrough cancer pain in clinical practice: results of the non-interventional prospective study ErkentNIS.
2017 Volume 26, Issue 2, Page(s) 491–497
Abstract: Purpose: Several patients with advanced cancer suffer from breakthrough cancer pain (BTcP). BTcP is pain exacerbation despite opioid baseline therapy. Fentanyl buccal tablet (FBT) is a rapid-onset opioid for the treatment of BTcP. The aim of this study ... ...
Abstract | Purpose: Several patients with advanced cancer suffer from breakthrough cancer pain (BTcP). BTcP is pain exacerbation despite opioid baseline therapy. Fentanyl buccal tablet (FBT) is a rapid-onset opioid for the treatment of BTcP. The aim of this study is to document the feasibility of FBT in patients with BTcP. Methods: The study was performed in 64 centers. Basic pain score was rated on a numeric rating scale (NRS) before and after treatment. BTcP episodes, baseline opioid therapy, and FBT dose were rated as well as individual dose titration, findings on tolerability, patient satisfaction, and safety of the drug. Results: Two hundred sixty-three patients were available for analysis. Patients rated a basic pain score of 6 (range 2-10) points on an NRS and described an average of 2 to 5 BTcP episodes per day. After titration of FBT, BTcP control was achieved within 5 min in 36%, within 10 min in 68%, and within 15 min in 95%. Basic pain score decreased to a mean NRS of 4 and BTcP episodes decreased to < 1 to 3 episodes per day. BTcP control, onset of action of FBT, potency of FBT, tolerability of FBT, and safety of FBT were rated as excellent or good by 89 to 99% of the patients. Adverse drug reactions were registered in 3%. Conclusions: Treatment with FBT led to rapid pain relief and reductions in the number of BTcP episodes and patient satisfaction was rated as excellent or good. |
---|---|
MeSH term(s) | Administration, Buccal ; Adult ; Aged ; Aged, 80 and over ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/therapeutic use ; Breakthrough Pain/drug therapy ; Cancer Pain/drug therapy ; Data Collection ; Drug-Related Side Effects and Adverse Reactions/drug therapy ; Female ; Fentanyl/administration & dosage ; Fentanyl/therapeutic use ; Humans ; Male ; Middle Aged ; Neoplasms/drug therapy ; Pain Management ; Pain Measurement ; Patient Satisfaction ; Prospective Studies ; Tablets/therapeutic use |
Chemical Substances | Analgesics, Opioid ; Tablets ; Fentanyl (UF599785JZ) |
Language | English |
Publishing date | 2017-08-28 |
Publishing country | Germany |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1134446-5 |
ISSN | 1433-7339 ; 0941-4355 |
ISSN (online) | 1433-7339 |
ISSN | 0941-4355 |
DOI | 10.1007/s00520-017-3853-y |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Zs.A 3697: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.