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  1. Article: Intraosseous vascular access. Devices, sites & rationale for I0 use.

    Wayne, Marvin A

    JEMS : a journal of emergency medical services

    2007  Volume 32, Issue 10, Page(s) S23–5

    MeSH term(s) Contraindications ; Emergency Medical Services ; Humans ; Infusions, Intraosseous/economics ; Infusions, Intraosseous/instrumentation ; Infusions, Intraosseous/methods ; United States
    Language English
    Publishing date 2007-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1292428-3
    ISSN 0197-2510
    ISSN 0197-2510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol.

    Peacock, W Frank / Maisel, Alan S / Mueller, Christian / Anker, Stefan D / Apple, Fred S / Christenson, Robert H / Collinson, Paul / Daniels, Lori B / Diercks, Deborah B / Somma, Salvatore Di / Filippatos, Gerasimos / Headden, Gary / Hiestand, Brian / Hollander, Judd E / Kaski, Juan C / Kosowsky, Joshua M / Nagurney, John T / Nowak, Richard M / Schreiber, Donald /
    Vilke, Gary M / Wayne, Marvin A / Than, Martin

    Clinical and experimental emergency medicine

    2022  Volume 9, Issue 2, Page(s) 140–145

    Abstract: Objective: To determine the utility of a highly sensitive troponin assay when utilized in the emergency department.: Methods: The FAST-TRAC study prospectively enrolled >1,500 emergency department patients with suspected acute coronary syndrome ... ...

    Abstract Objective: To determine the utility of a highly sensitive troponin assay when utilized in the emergency department.
    Methods: The FAST-TRAC study prospectively enrolled >1,500 emergency department patients with suspected acute coronary syndrome within 6 hours of symptom onset and 2 hours of emergency department presentation. It has several unique features that are not found in the majority of studies evaluating troponin. These include a very early presenting population in whom prospective data collection of risk score parameters and the physician's clinical impression of the probability of acute coronary syndrome before any troponin data were available. Furthermore, two gold standard diagnostic definitions were determined by a pair of cardiologists reviewing two separate data sets; one that included all local troponin testing results and a second that excluded troponin testing so that diagnosis was based solely on clinical grounds. By this method, a statistically valid head-to-head comparison of contemporary and high sensitivity troponin testing is obtainable. Finally, because of a significant delay in sample processing, a unique ability to define the molecular stability of various troponin assays is possible.
    Trial registration: ClinicalTrials.gov Identifier NCT00880802.
    Language English
    Publishing date 2022-06-30
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2383-4625
    ISSN 2383-4625
    DOI 10.15441/ceem.21.154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparison of traditional versus video laryngoscopy in out-of-hospital tracheal intubation.

    Wayne, Marvin A / McDonnell, Mannix

    Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors

    2010  Volume 14, Issue 2, Page(s) 278–282

    Abstract: Background: Out-of-hospital tracheal intubation is controversial because of questions regarding its safety as well as its impact on patient care. Factors contributing to the controversy include failed intubations, number of attempts required, prolonged ... ...

    Abstract Background: Out-of-hospital tracheal intubation is controversial because of questions regarding its safety as well as its impact on patient care. Factors contributing to the controversy include failed intubations, number of attempts required, prolonged periods without ventilation, and misplaced tracheal tubes. However, the most important factors are the decision-making and clinical skills of the intubator. Unfortunately, the limited number of outcome studies adds to the controversy. New technology, the video laryngoscope, has been introduced to facilitate tracheal intubation. At least one model of video laryngoscope (GlideScope Ranger) has been designed for out-of-hospital use. In an effort to assess the effect this technology might have on out-of-hospital intubation, a study comparing traditional laryngoscopy (TL) versus video laryngoscopy (VL) was performed. The study endpoint was the number of attempts to achieve intubation. Data were also collected on time to intubate, nonventilated periods, unrecognized misplaced tubes, and complications of the procedure.
    Methods: Data were collected on 300 consecutive patients, 6 years of age or older, weighing at least 20 kg, who were intubated using TL. They were compared with data on 315 patients who were intubated using VL. All intubations were confirmed by visualization where possible, auscultation, misting, and capnography. In addition, all were continuously monitored by capnography.
    Results: The average time to intubate in the VL group was 21 seconds (range 8-43 seconds) versus 42 seconds (range 28-90 seconds) in the TL group. The average number of attempts was 1.2 (range 1-3) in the VL group versus 2.3 (range 1-4) in the TL group. Successful intubation was 97% in the VL group versus 95% in the TL group. There were no unrecognized misplaced tubes in either group. For failed intubations, an alternative airway was successful in 99% of the VL group and 99% of the TL group. Maximum nonventilated time during any one intubation attempt was 37 seconds in the VL group and 55 seconds in the TL group.
    Conclusions: The numbers of attempts were significantly reduced in the VL group. This suggests that the use of VL has a positive effect on the number of attempts to achieve tracheal intubation.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Emergency Medical Services ; Female ; Humans ; Intubation, Intratracheal/instrumentation ; Intubation, Intratracheal/methods ; Laryngoscopes ; Male ; Microscopy, Video ; Middle Aged ; Northwestern United States ; Young Adult
    Language English
    Publishing date 2010-04
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1461751-1
    ISSN 1545-0066 ; 1090-3127
    ISSN (online) 1545-0066
    ISSN 1090-3127
    DOI 10.3109/10903120903537189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The association of health status and providing consent to continued participation in an out-of-hospital cardiac arrest trial performed under exception from informed consent.

    Salzman, Joshua G / Frascone, Ralph J / Burkhart, Nathan / Holcomb, Richard / Wewerka, Sandi S / Swor, Robert A / Mahoney, Brian D / Wayne, Marvin A / Domeier, Robert M / Olinger, Michael L / Aufderheide, Tom P / Lurie, Keith G

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2015  Volume 22, Issue 3, Page(s) 347–353

    Abstract: Objectives: Emergency medical research performed under federal regulation 21 § CFR 50.24 provides a means to protect human subjects and investigate novel time-sensitive treatments. Although prospective individual consent is not required for studies ... ...

    Abstract Objectives: Emergency medical research performed under federal regulation 21 § CFR 50.24 provides a means to protect human subjects and investigate novel time-sensitive treatments. Although prospective individual consent is not required for studies conducted under this regulation, consent from a legally authorized representative (LAR) or the patient at the earliest feasible opportunity is required to obtain short- and long-term outcome data. The objective of this study was to determine which demographic, cardiac arrest, and patient outcome characteristics predicted the likelihood of obtaining informed consent following enrollment under exception from informed consent in a multicenter cardiac arrest study.
    Methods: This investigation was an analysis of data collected during a multisite, randomized, controlled, out-of-hospital cardiac arrest clinical trial performed under 21 § CFR 50.24. Research personnel attempted to obtain informed consent from LARs and subjects for medical records review of primary outcome data, as well as consent for neurologic outcome assessments up to 1 year post-cardiac arrest. Hospital discharge and neurologic status were obtained from public records and/or medical records up until the time consent was formally denied, in accordance with federal regulations and guidance. Local institutional review boards also allowed medical records review for cases where consent was neither obtained nor declined despite multiple consent attempts. Patient demographic, cardiac arrest, and clinical outcome characteristics were analyzed in univariate multinomial regression models, with consent status (obtained, denied, neither obtained nor denied) as the dependent variable. A multivariate multinomial logistic regression was then performed. An exploratory secondary analysis following the same process was performed after assigning patients who neither consented nor declined to the declined consent group.
    Results: Among a total study population of 1,655 cardiac arrest subjects, 457 were transported and had consent attempted (27.6%). The survival status and neurologic function at the time of hospital discharge were known in 440 of 457 (96%) subjects. In the multivariate analysis, initial rhythm of ventricular fibrillation/ventricular tachycardia (VF/VT) and survival with good neurologic outcome were strong predictors of obtaining consent (odds ratio [OR] = 3.15, 95% confidence interval [CI] = 1.73 to 5.75; OR = 7.64, 95% CI = 2.28 to 25.63, respectively). The exploratory secondary analysis also showed initial rhythm of VF/VT and survival with good neurologic outcome as strong predictors of obtaining consent (OR = 1.86, 95% CI = 1.17 to 2.95; OR = 4.52, 95% CI = 2.21 to 9.26, respectively).
    Conclusions: Initial arrest rhythm and survival with good neurologic outcome were highly predictive of obtaining consent in this cardiac arrest trial. This phenomenon could result in underrepresentation of outcome data in the study arm with the worse outcome and represents a significant potential confounder in studies performed under 21 § CFR 50.24. Future revisions to the exception from informed consent regulations should allow access to critical survival data recorded as part of standard documentation, regardless of patient consent status.
    MeSH term(s) Aged ; Emergency Service, Hospital/statistics & numerical data ; Female ; Health Status ; Humans ; Informed Consent/statistics & numerical data ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Out-of-Hospital Cardiac Arrest/complications ; Out-of-Hospital Cardiac Arrest/therapy ; Prospective Studies ; Research Design/statistics & numerical data ; Socioeconomic Factors ; Tachycardia, Ventricular/etiology ; Third-Party Consent/statistics & numerical data ; Ventricular Fibrillation/etiology
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.12613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Conference proceedings: Prehospital rapid-sequence intubation--what does the evidence show? Proceedings from the 2004 National Association of EMS Physicians annual meeting.

    Wang, Henry E / Davis, Daniel P / Wayne, Marvin A / Delbridge, Theodore

    Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors

    2004  Volume 8, Issue 4, Page(s) 366–377

    MeSH term(s) Emergency Medical Services ; Emergency Medical Technicians/education ; Evidence-Based Medicine ; Humans ; Intubation, Intratracheal/methods
    Language English
    Publishing date 2004-10
    Publishing country England
    Document type Congresses
    ZDB-ID 1461751-1
    ISSN 1545-0066 ; 1090-3127
    ISSN (online) 1545-0066
    ISSN 1090-3127
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  6. Article ; Online: Rationale and Strategies for Development of an Optimal Bundle of Management for Cardiac Arrest.

    Pepe, Paul E / Aufderheide, Tom P / Lamhaut, Lionel / Davis, Daniel P / Lick, Charles J / Polderman, Kees H / Scheppke, Kenneth A / Deakin, Charles D / O'Neil, Brian J / van Schuppen, Hans / Levy, Michael K / Wayne, Marvin A / Youngquist, Scott T / Moore, Johanna C / Lurie, Keith G / Bartos, Jason A / Bachista, Kerry M / Jacobs, Michael J / Rojas-Salvador, Carolina /
    Grayson, Sean T / Manning, James E / Kurz, Michael C / Debaty, Guillaume / Segal, Nicolas / Antevy, Peter M / Miramontes, David A / Cheskes, Sheldon / Holley, Joseph E / Frascone, Ralph J / Fowler, Raymond L / Yannopoulos, Demetris

    Critical care explorations

    2020  Volume 2, Issue 10, Page(s) e0214

    Abstract: Objectives: To construct a highly detailed yet practical, attainable roadmap for enhancing the likelihood of neurologically intact survival following sudden cardiac arrest.: Design setting and patients: Population-based outcomes following out-of- ... ...

    Abstract Objectives: To construct a highly detailed yet practical, attainable roadmap for enhancing the likelihood of neurologically intact survival following sudden cardiac arrest.
    Design setting and patients: Population-based outcomes following out-of-hospital cardiac arrest were collated for 10 U.S. counties in Alaska, California, Florida, Ohio, Minnesota, Utah, and Washington. The 10 identified emergency medical services systems were those that had recently reported significant improvements in neurologically intact survival after introducing a more comprehensive approach involving citizens, hospitals, and evolving strategies for incorporating technology-based, highly choreographed care and training. Detailed inventories of in-common elements were collated from the ten 9-1-1 agencies and assimilated. For reference, combined averaged outcomes for out-of-hospital cardiac arrest occurring January 1, 2017, to February 28, 2018, were compared with concurrent U.S. outcomes reported by the well-established Cardiac Arrest Registry to Enhance Survival.
    Interventions: Most commonly, interventions and components from the ten 9-1-1 systems consistently included extensive public cardiopulmonary resuscitation training, 9-1-1 system-connected smart phone applications, expedited dispatcher procedures, cardiopulmonary resuscitation quality monitoring, mechanical cardiopulmonary resuscitation, devices for enhancing negative intrathoracic pressure regulation, extracorporeal membrane oxygenation protocols, body temperature management procedures, rapid cardiac angiography, and intensive involvement of medical directors, operational and quality assurance officers, and training staff.
    Measurements and main results: Compared with Cardiac Arrest Registry to Enhance Survival (
    Conclusions: The likelihood of neurologically favorable survival following out-of-hospital cardiac arrest can improve substantially in communities that conscientiously and meticulously introduce a well-sequenced, highly choreographed, system-wide portfolio of both traditional and nonconventional approaches to training, technologies, and physiologic management. The commonalities found in the analyzed systems create a compelling case that other communities can also improve out-of-hospital cardiac arrest outcomes significantly by conscientiously exploring and adopting similar bundles of system organization and care.
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-Term Prognostic Value of Gasping During Out-of-Hospital Cardiac Arrest.

    Debaty, Guillaume / Labarere, Jose / Frascone, Ralph J / Wayne, Marvin A / Swor, Robert A / Mahoney, Brian D / Domeier, Robert M / Olinger, Michael L / O'Neil, Brian J / Yannopoulos, Demetris / Aufderheide, Tom P / Lurie, Keith G

    Journal of the American College of Cardiology

    2014  Volume 70, Issue 12, Page(s) 1467–1476

    Abstract: Background: Gasping is a natural reflex that enhances oxygenation and circulation during cardiopulmonary resuscitation (CPR).: Objectives: This study sought to assess the relationship between gasping during out-of-hospital cardiac arrest and 1-year ... ...

    Abstract Background: Gasping is a natural reflex that enhances oxygenation and circulation during cardiopulmonary resuscitation (CPR).
    Objectives: This study sought to assess the relationship between gasping during out-of-hospital cardiac arrest and 1-year survival with favorable neurological outcomes.
    Methods: The authors prospectively collected incidence of gasping on all evaluable subjects in a multicenter, randomized, controlled, National Institutes of Health-funded out-of-hospital cardiac arrest clinical trial from August 2007 to July 2009. The association between gasping and 1-year survival with favorable neurological function, defined as a Cerebral Performance Category (CPC) score ≤2 was estimated using multivariable logistic regression.
    Results: The rates of 1-year survival with a CPC score of ≤2 were 5.4% (98 of 1,827) overall, and 20% (36 of 177) and 3.7% (61 of 1,643) for individuals with and without spontaneous gasping or agonal respiration during CPR, respectively. In multivariable analysis, 1-year survival with CPC ≤2 was independently associated with younger age (odds ratio [OR] for 1 SD increment 0.57; 95% confidence interval [CI]: 0.43 to 0.76), gasping during CPR (OR: 3.94; 95% CI: 2.09 to 7.44), shockable initial recorded rhythm (OR: 16.50; 95% CI: 7.40 to 36.81), shorter CPR duration (OR: 0.31; 95% CI: 0.19 to 0.51), lower epinephrine dosage (OR: 0.47; 95% CI: 0.25 to 0.87), and pulmonary edema (OR: 3.41; 95% CI: 1.53 to 7.60). Gasping combined with a shockable initial recorded rhythm had a 57-fold higher OR (95% CI: 23.49 to 136.92) of 1-year survival with CPC ≤2 versus no gasping and no shockable rhythm.
    Conclusions: Gasping during CPR was independently associated with increased 1-year survival with CPC ≤2, regardless of the first recorded rhythm. These findings underscore the importance of not terminating resuscitation prematurely in gasping patients and the need to routinely recognize, monitor, and record data on gasping in all future cardiac arrest trials and registries.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Inhalation ; Male ; Middle Aged ; Out-of-Hospital Cardiac Arrest/complications ; Out-of-Hospital Cardiac Arrest/mortality ; Out-of-Hospital Cardiac Arrest/physiopathology ; Prognosis ; Prospective Studies ; Survival Rate ; Tachycardia, Ventricular/complications ; Time Factors ; Ventricular Fibrillation/complications ; Young Adult
    Language English
    Publishing date 2014-08-22
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2017.07.782
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  8. Article ; Online: Milestones in treatment: the tipping point and the ResQ Trial.

    Yannopoulos, Demetris / Aufderheide, Tom P / Frascone, Ralph J / Wayne, Marvin A / Mahoney, Brian D / Swor, Robert A / Domeier, Robert M / Olinger, Michael L / Holcomb, Richard G / Tupper, David E

    Lancet (London, England)

    2011  Volume 377, Issue 9783, Page(s) 2081–2; author reply 2082–3

    MeSH term(s) Cardiopulmonary Resuscitation/methods ; Humans ; Out-of-Hospital Cardiac Arrest/therapy
    Language English
    Publishing date 2011-06-18
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(11)60914-8
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  9. Article ; Online: Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trial.

    Aufderheide, Tom P / Frascone, Ralph J / Wayne, Marvin A / Mahoney, Brian D / Swor, Robert A / Domeier, Robert M / Olinger, Michael L / Holcomb, Richard G / Tupper, David E / Yannopoulos, Demetris / Lurie, Keith G

    Lancet (London, England)

    2011  Volume 377, Issue 9762, Page(s) 301–311

    Abstract: Background: Active compression-decompression cardiopulmonary resuscitation (CPR) with decreased intrathoracic pressure in the decompression phase can lead to improved haemodynamics compared with standard CPR. We aimed to assess effectiveness and safety ... ...

    Abstract Background: Active compression-decompression cardiopulmonary resuscitation (CPR) with decreased intrathoracic pressure in the decompression phase can lead to improved haemodynamics compared with standard CPR. We aimed to assess effectiveness and safety of this intervention on survival with favourable neurological function after out-of-hospital cardiac arrest.
    Methods: In our randomised trial of 46 emergency medical service agencies (serving 2·3 million people) in urban, suburban, and rural areas of the USA, we assessed outcomes for patients with out-of-hospital cardiac arrest according to Utstein guidelines. We provisionally enrolled patients to receive standard CPR or active compression-decompression CPR with augmented negative intrathoracic pressure (via an impedance-threshold device) with a computer-generated block randomisation weekly schedule in a one-to-one ratio. Adults (presumed age or age ≥18 years) who had a non-traumatic arrest of presumed cardiac cause and met initial and final selection criteria received designated CPR and were included in the final analyses. The primary endpoint was survival to hospital discharge with favourable neurological function (modified Rankin scale score of ≤3). All investigators apart from initial rescuers were masked to treatment group assignment. This trial is registered with ClinicalTrials.gov, number NCT00189423.
    Findings: 2470 provisionally enrolled patients were randomly allocated to treatment groups. 813 (68%) of 1201 patients assigned to the standard CPR group (controls) and 840 (66%) of 1269 assigned to intervention CPR received designated CPR and were included in the final analyses. 47 (6%) of 813 controls survived to hospital discharge with favourable neurological function compared with 75 (9%) of 840 patients in the intervention group (odds ratio 1·58, 95% CI 1·07-2·36; p=0·019]. 74 (9%) of 840 patients survived to 1 year in the intervention group compared with 48 (6%) of 813 controls (p=0·03), with equivalent cognitive skills, disability ratings, and emotional-psychological statuses in both groups. The overall major adverse event rate did not differ between groups, but more patients had pulmonary oedema in the intervention group (94 [11%] of 840) than did controls (62 [7%] of 813; p=0·015).
    Interpretation: On the basis of our findings showing increased effectiveness and generalisability of the study intervention, active compression-decompression CPR with augmentation of negative intrathoracic pressure should be considered as an alternative to standard CPR to increase long-term survival after cardiac arrest.
    Funding: US National Institutes of Health grant R44-HL065851-03, Advanced Circulatory Systems.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cardiopulmonary Resuscitation/instrumentation ; Cardiopulmonary Resuscitation/methods ; Cerebrovascular Circulation ; Coronary Circulation ; Emergency Medical Services ; Female ; Humans ; Male ; Middle Aged ; Neurologic Examination ; Out-of-Hospital Cardiac Arrest/mortality ; Out-of-Hospital Cardiac Arrest/therapy ; Prospective Studies ; Pulmonary Edema/epidemiology ; Tachycardia, Ventricular/mortality ; Tachycardia, Ventricular/therapy ; United States/epidemiology ; Ventricular Fibrillation/mortality ; Ventricular Fibrillation/therapy
    Language English
    Publishing date 2011-01-20
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(10)62103-4
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  10. Article: Prehospital management of acute tachyarrhythmias.

    Slovis, Corey M / Kudenchuk, Peter J / Wayne, Marvin A / Aghababian, Richard / Rivera-Rivera, Edgardo J

    Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors

    2002  Volume 7, Issue 1, Page(s) 2–12

    Abstract: Arrhythmias are commonly encountered by emergency medical services (EMS) personnel. The potential seriousness of acute symptomatic arrhythmias necessitates thorough up-to-date training of EMS personnel. The three most common acute tachyarrhythmias, not ... ...

    Abstract Arrhythmias are commonly encountered by emergency medical services (EMS) personnel. The potential seriousness of acute symptomatic arrhythmias necessitates thorough up-to-date training of EMS personnel. The three most common acute tachyarrhythmias, not linked to cardiac arrest, that are observed outside the hospital are paroxysmal supraventricular tachycardia (PSVT), atrial fibrillation with rapid ventricular response (RAF), and perfusing ventricular tachycardia (VT). Ideally, these tachyarrhythmias should be operationally defined in a manner that simplifies, particularly for EMS providers, their diagnosis and treatment. The authors recommend referring to these rhythms as regular narrow-complex tachycardia (presumed PSVT), irregularly irregular narrow-complex tachycardia (presumed RAF), or regular wide-complex tachycardia (presumed VT or aberrantly conducted PSVT). Although the value of treatments such as cardioversion is widely understood, the benefit from others, such as lidocaine, is unclear. Current preferences, recommendations, and concerns regarding the treatment of most arrhythmias outside the hospital reflect the dichotomy that sometimes exists between available evidence and actual practice.
    MeSH term(s) Acute Disease ; Adenosine/adverse effects ; Adenosine/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Cardiopulmonary Resuscitation ; Electrocardiography ; Emergency Medical Services/methods ; Humans ; Tachycardia/classification ; Tachycardia/diagnosis ; Tachycardia/drug therapy ; Valsalva Maneuver
    Chemical Substances Anti-Arrhythmia Agents ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2002-11-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1461751-1
    ISSN 1545-0066 ; 1090-3127
    ISSN (online) 1545-0066
    ISSN 1090-3127
    DOI 10.1080/10903120390937030
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