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  1. Article ; Online: Sequelae and Animal Modeling of Encephalitic Alphavirus Infections.

    Reyna, Rachel A / Weaver, Scott C

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the ... ...

    Abstract Eastern (EEEV), Venezuelan (VEEV), and western equine encephalitis viruses (WEEV) are members of the genus
    MeSH term(s) Animals ; Horses ; Alphavirus ; Encephalitis ; Alphavirus Infections ; Encephalitis Virus, Western Equine ; Disease Progression ; Models, Animal
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of climate change and human activities on vector-borne diseases.

    de Souza, William M / Weaver, Scott C

    Nature reviews. Microbiology

    2024  

    Abstract: Vector-borne diseases are transmitted by haematophagous arthropods (for example, mosquitoes, ticks and sandflies) to humans and wild and domestic animals, with the largest burden on global public health disproportionately affecting people in tropical and ...

    Abstract Vector-borne diseases are transmitted by haematophagous arthropods (for example, mosquitoes, ticks and sandflies) to humans and wild and domestic animals, with the largest burden on global public health disproportionately affecting people in tropical and subtropical areas. Because vectors are ectothermic, climate and weather alterations (for example, temperature, rainfall and humidity) can affect their reproduction, survival, geographic distribution and, consequently, ability to transmit pathogens. However, the effects of climate change on vector-borne diseases can be multifaceted and complex, sometimes with ambiguous consequences. In this Review, we discuss the potential effects of climate change, weather and other anthropogenic factors, including land use, human mobility and behaviour, as possible contributors to the redistribution of vectors and spread of vector-borne diseases worldwide.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-024-01026-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5865: Show issues Location:
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  3. Article ; Online: Incrimination of mosquito vectors.

    Weaver, Scott C

    Nature microbiology

    2020  Volume 5, Issue 2, Page(s) 232–233

    MeSH term(s) Aedes/physiology ; Aedes/virology ; Animals ; Arbovirus Infections/transmission ; Arbovirus Infections/virology ; Arboviruses/physiology ; Feeding Behavior ; Humans ; Mosquito Vectors/physiology ; Mosquito Vectors/virology ; Virus Replication
    Language English
    Publishing date 2020-01-28
    Publishing country England
    Document type Journal Article
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-019-0665-5
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  4. Article ; Online: Prediction and prevention of urban arbovirus epidemics: A challenge for the global virology community.

    Weaver, Scott C

    Antiviral research

    2018  Volume 156, Page(s) 80–84

    Abstract: The recent emergence and rapid spread of Zika virus in tropical regions of the Western Hemisphere took arbovirologists and public health officials by surprise, and the earlier transfers of West Nile and chikungunya viruses from the Old to the New World ... ...

    Abstract The recent emergence and rapid spread of Zika virus in tropical regions of the Western Hemisphere took arbovirologists and public health officials by surprise, and the earlier transfers of West Nile and chikungunya viruses from the Old to the New World were also unexpected. These pandemics underscore the increasing threat of zoonotic arboviruses, especially those that are capable of entering into human-amplified, urban transmission cycles transmitted by Aedes (Stegomyia) aegypti and sometimes other Aedes (Stegomyia) spp. mosquitoes. This review serves as an introduction to a World Health Organization-sponsored conference to be held on June 18-19, 2018 in Geneva, titled "From obscurity to urban epidemics: what are the next urban arboviruses?" It is intended to set the stage and fuel discussions of future urban arbovirus threats, how we can predict these risks from known and unknown viruses, and what factors may change these risks over time.
    MeSH term(s) Animals ; Arbovirus Infections/epidemiology ; Arbovirus Infections/prevention & control ; Arbovirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Epidemics ; Global Health ; Humans ; Urban Population ; Zoonoses/epidemiology ; Zoonoses/prevention & control ; Zoonoses/transmission
    Language English
    Publishing date 2018-06-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2018.06.009
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Emergence of Epidemic Zika Virus Transmission and Congenital Zika Syndrome: Are Recently Evolved Traits to Blame?

    Weaver, Scott C

    mBio

    2017  Volume 8, Issue 1

    Abstract: The mechanisms responsible for the dramatic emergence of Zika virus (ZIKV), accompanied by congenital Zika syndrome and Guillain-Barré syndrome (GBS), remain unclear. However, two hypotheses are prominent: (i) evolution for enhanced urban transmission ... ...

    Abstract The mechanisms responsible for the dramatic emergence of Zika virus (ZIKV), accompanied by congenital Zika syndrome and Guillain-Barré syndrome (GBS), remain unclear. However, two hypotheses are prominent: (i) evolution for enhanced urban transmission via adaptation to mosquito vectors, or for enhanced human infection to increase amplification, or (ii) the stochastic introduction of ZIKV into large, naive human populations in regions with abundant Aedes aegypti populations, leading to enough rare, severe infection outcomes for their first recognition. Advances in animal models for human infection combined with improvements in serodiagnostics, better surveillance, and reverse genetic approaches should provide more conclusive evidence of whether mosquito transmission or human pathogenesis changed coincidentally with emergence in the South Pacific and the Americas. Ultimately, understanding the mechanisms of epidemic ZIKV emergence, and its associated syndromes, is critical to predict future risks as well as to target surveillance and control measures in key locations.
    MeSH term(s) Aedes/growth & development ; Aedes/virology ; Americas/epidemiology ; Animals ; Epidemics ; Guillain-Barre Syndrome/epidemiology ; Humans ; Microcephaly/epidemiology ; Pacific Islands/epidemiology ; Zika Virus/growth & development ; Zika Virus/pathogenicity ; Zika Virus Infection/complications ; Zika Virus Infection/epidemiology ; Zika Virus Infection/transmission
    Language English
    Publishing date 2017-01-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02063-16
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  6. Article ; Online: Zoonotic mosquito-borne arboviruses: Spillover, spillback, and realistic mitigation strategies.

    Campos, Rafael K / Rossi, Shannan L / Tesh, Robert B / Weaver, Scott C

    Science translational medicine

    2023  Volume 15, Issue 718, Page(s) eadj2166

    Abstract: Emerging zoonotic mosquito-borne viruses pose increasing health threats because of growing mosquito population, geographic expansions, and control challenges. We emphasize the need for global preparedness to effectively mitigate the health, societal, and ...

    Abstract Emerging zoonotic mosquito-borne viruses pose increasing health threats because of growing mosquito population, geographic expansions, and control challenges. We emphasize the need for global preparedness to effectively mitigate the health, societal, and economic impacts of spillover by these viruses through proactive measures of prediction, surveillance, prevention, and treatment.
    MeSH term(s) Animals ; Arboviruses ; Arbovirus Infections/prevention & control ; Culicidae
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.adj2166
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
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  7. Article ; Online: Impact of COVID-19 on the Vector-Borne Disease Research and Applied Public Health Workforce in the United States.

    Weldon, Caroline T / Weaver, Scott C / Jacobsen, Kathryn H

    The American journal of tropical medicine and hygiene

    2022  Volume 106, Issue 4, Page(s) 1003–1004

    Abstract: The coronavirus pandemic has imposed extraordinary demands on the public and environmental health workforce, including those who work on vector-borne disease (VBD) prevention and control. In late 2021, we surveyed more than 100 applied public health ... ...

    Abstract The coronavirus pandemic has imposed extraordinary demands on the public and environmental health workforce, including those who work on vector-borne disease (VBD) prevention and control. In late 2021, we surveyed more than 100 applied public health professionals, academic researchers, and others working on VBDs in the United States. They reported that the supply chain disruptions and limited access to facilities that impeded laboratory work in the early months of the COVID-19 pandemic in 2020 have largely resolved. However, many public health personnel across job types and career stages are still working fewer hours on VBDs than they did before the pandemic. Many reported that they expect it to take several years for VBD specialists to fully reengage with clinicians and the public, reinvigorate their partnerships and professional networks, and recover from interruptions to work productivity and professional development. Despite these challenges, most applied and academic VBD workers remain enthusiastic about their work and eager to advance this important area of infectious disease research and practice.
    Language English
    Publishing date 2022-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.21-1340
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.61: Show issues Location:
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  8. Article ; Online: Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus.

    Azar, Sasha R / Weaver, Scott C

    Journal of visualized experiments : JoVE

    2020  , Issue 159

    Abstract: The procedures presented describe a generalized methodology to infect Aedes aegypti mosquitoes with Zika virus under laboratory conditions to determine the rate of infection, disseminated infection, and potential transmission of the virus in the mosquito ...

    Abstract The procedures presented describe a generalized methodology to infect Aedes aegypti mosquitoes with Zika virus under laboratory conditions to determine the rate of infection, disseminated infection, and potential transmission of the virus in the mosquito population in question. These procedures are widely utilized with various modifications in vector competence evaluations globally. They are important in determining the potential role that a given mosquito (i.e., species, population, individual) may play in the transmission of a given agent.
    MeSH term(s) Aedes/virology ; Animals ; Mosquito Vectors ; Viral Load ; Zika Virus/isolation & purification ; Zika Virus Infection/transmission
    Language English
    Publishing date 2020-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/61112
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  9. Article: Yellow Fever: Roles of Animal Models and Arthropod Vector Studies in Understanding Epidemic Emergence.

    Shinde, Divya P / Plante, Jessica A / Plante, Kenneth S / Weaver, Scott C

    Microorganisms

    2022  Volume 10, Issue 8

    Abstract: Yellow fever virus (YFV) is a mosquito-borne flavivirus circulating throughout the tropical and sub-tropical regions of Africa and South America. It is responsible for an estimated 30,000 deaths annually, and while there is a highly successful vaccine, ... ...

    Abstract Yellow fever virus (YFV) is a mosquito-borne flavivirus circulating throughout the tropical and sub-tropical regions of Africa and South America. It is responsible for an estimated 30,000 deaths annually, and while there is a highly successful vaccine, coverage is incomplete, and there is no approved treatment for YFV infection. Despite advancements in the field, animal models for YFV infection remain scarce, and care must be taken to select an appropriate model for a given hypothesis. Small animal models require either adapted YFV strains or immunocompromised hosts. Non-human primates (NHPs) recapitulate human disease, but they require specialized facilities and training, are often in short supply and cost-prohibitive, and can present ethical concerns. The limitations in studying the mosquito vectors for YFV infection include inconsistency in the laboratory environment, the requirement for a high containment insectary, and difficulty in maintaining sylvatic mosquitoes. In this review, we discuss the roles of animal models and arthropod vector studies in understanding epidemic emergence.
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081578
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  10. Article ; Online: Vector Competence: What Has Zika Virus Taught Us?

    Azar, Sasha R / Weaver, Scott C

    Viruses

    2019  Volume 11, Issue 9

    Abstract: The unprecedented outbreak of Zika virus (ZIKV) infection in the Americas from 2015 to 2017 prompted the publication of a large body of vector competence data in a relatively short period of time. Although differences in vector competence as a result of ... ...

    Abstract The unprecedented outbreak of Zika virus (ZIKV) infection in the Americas from 2015 to 2017 prompted the publication of a large body of vector competence data in a relatively short period of time. Although differences in vector competence as a result of disparities in mosquito populations and viral strains are to be expected, the limited competence of many populations of the urban mosquito vector,
    MeSH term(s) Aedes/physiology ; Aedes/virology ; Animals ; Arboviruses/physiology ; Humans ; Mosquito Vectors/physiology ; Mosquito Vectors/virology ; Zika Virus/physiology ; Zika Virus Infection/transmission ; Zika Virus Infection/virology
    Language English
    Publishing date 2019-09-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11090867
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