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  1. Article ; Online: Management of an unusual cause of life-threatening haemoptysis: a multidisciplinary approach.

    Pramanik, Kim / Webb, Philip / Hamid, RanaShoaib

    BMJ case reports

    2021  Volume 14, Issue 5

    Abstract: We present to you a case of life-threatening haemoptysis secondary to non-cystic fibrosis bronchiectasis complicated by bronchial artery pseudoaneurysms. We discuss this patient's emergency medical management using intravenous tranexamic acid, which ... ...

    Abstract We present to you a case of life-threatening haemoptysis secondary to non-cystic fibrosis bronchiectasis complicated by bronchial artery pseudoaneurysms. We discuss this patient's emergency medical management using intravenous tranexamic acid, which resulted in successful resuscitation and eventual survival, and evaluate the need for urgent anaesthetic and interventional radiology input in such a case.
    MeSH term(s) Bronchial Arteries/diagnostic imaging ; Bronchiectasis ; Embolization, Therapeutic ; Hemoptysis/etiology ; Hemoptysis/therapy ; Humans ; Treatment Outcome
    Language English
    Publishing date 2021-05-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adenoid cystic carcinoma and chronic lymphocytic leukaemia: synchronous presentations in the lung.

    Webb, Philip S / Zhang, Yu Zhi / Burrell, Kirsten / Sinclair, Georges

    BMJ case reports

    2021  Volume 14, Issue 2

    Abstract: A 59-year-old male active smoker presented with a 6-month history of cough and breathlessness and was found to have a right upper lobe mass. Histology revealed this to be an adenoid cystic carcinoma (ACC) of the lung, while local lymph node dissection ... ...

    Abstract A 59-year-old male active smoker presented with a 6-month history of cough and breathlessness and was found to have a right upper lobe mass. Histology revealed this to be an adenoid cystic carcinoma (ACC) of the lung, while local lymph node dissection revealed a synchronous diagnosis of chronic lymphocytic leukaemia (CLL). The connection between CLL and solid organ malignancy is well documented, but the reporting of ACC in this context is novel. Mechanisms linking the two processes are revealed with the possibility of causality, and heightened vigilance for the development of primary lung tumours in CLL, and their management, is recommended.
    MeSH term(s) Carcinoma, Adenoid Cystic/diagnosis ; Carcinoma, Adenoid Cystic/surgery ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Lung ; Lung Neoplasms/diagnosis ; Lung Neoplasms/surgery ; Lymph Node Excision ; Male ; Middle Aged
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Management of non-cystic fibrosis bronchiectasis.

    Webb, Philip / King, Jenny / Baxter, Caroline / Lord, Robert W

    British journal of hospital medicine (London, England : 2005)

    2021  Volume 82, Issue 7, Page(s) 1–9

    Abstract: Bronchiectasis is a common respiratory condition, characterised by abnormal bronchial dilatation, that often leads to recurrent airway infection and inflammation. It is an increasingly recognised respiratory condition, both as a primary lung disease but ... ...

    Abstract Bronchiectasis is a common respiratory condition, characterised by abnormal bronchial dilatation, that often leads to recurrent airway infection and inflammation. It is an increasingly recognised respiratory condition, both as a primary lung disease but also co-existing with other respiratory diseases, such as chronic obstructive pulmonary disease and asthma. Diagnosis can have important treatment implications. There are shared systematic approaches to treatment, such as sputum clearance techniques, prompt treatment of exacerbations and, in certain circumstances, regular antibiotic therapy. It is vital to target antibiotic therapy appropriately, and knowledge of the patient's airway microbiology can assist with this. Certain infective and colonising organisms, such as
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bronchiectasis/diagnosis ; Bronchiectasis/etiology ; Bronchiectasis/therapy ; Humans ; Pseudomonas Infections/complications ; Pseudomonas Infections/diagnosis ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Respiratory System
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2020.0739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Online referrals improve interspecialty communication and are preferred by referring clinicians.

    Shuttleworth, Elinor / Morris, Liam / Webb, Philip

    Future healthcare journal

    2019  Volume 6, Issue Suppl 2, Page(s) 70

    Language English
    Publishing date 2019-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 3016427-8
    ISSN 2514-6653 ; 2514-6645
    ISSN (online) 2514-6653
    ISSN 2514-6645
    DOI 10.7861/futurehosp.6-2s-s70
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modified Needleman-Wunsch algorithm for clinical pathway clustering.

    Aspland, Emma / Harper, Paul R / Gartner, Daniel / Webb, Philip / Barrett-Lee, Peter

    Journal of biomedical informatics

    2021  Volume 115, Page(s) 103668

    Abstract: Clinical pathways are used to guide clinicians to provide a standardised delivery of care. Because of their standardisation, the aim of clinical pathways is to reduce variation in both care process and patient outcomes. When learning clinical pathways ... ...

    Abstract Clinical pathways are used to guide clinicians to provide a standardised delivery of care. Because of their standardisation, the aim of clinical pathways is to reduce variation in both care process and patient outcomes. When learning clinical pathways from data through data mining, it is common practice to represent each patient pathway as a string corresponding to their movements through activities. Clustering techniques are popular methods for pathway mining, and therefore this paper focuses on distance metrics applied to string data for k-medoids clustering. The two main aims are to firstly, develop a technique that seamlessly integrates expert information with data and secondly, to develop a string distance metric for the purpose of process data. The overall goal was to allow for more meaningful clustering results to be found by adding context into the string similarity calculation. Eight common distance metrics and their applicability are discussed. These distance metrics prove to give an arbitrary distance, without consideration for context, and each produce different results. As a result, this paper describes the development of a new distance metric, the modified Needleman-Wunsch algorithm, that allows for expert interaction with the calculation by assigning groupings and rankings to activities, which provide context to the strings. This algorithm has been developed in partnership with UK's National Health Service (NHS) with the focus on a lung cancer pathway, however the handling of the data and algorithm allows for application to any disease type. This method is contained within Sim.Pro.Flow, a publicly available decision support tool.
    MeSH term(s) Algorithms ; Cluster Analysis ; Critical Pathways ; Data Mining ; Humans ; State Medicine
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2057141-0
    ISSN 1532-0480 ; 1532-0464
    ISSN (online) 1532-0480
    ISSN 1532-0464
    DOI 10.1016/j.jbi.2020.103668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Problem-based review: Immune-mediated complications of 'Checkpoint Inhibitors' for the Acute Physician.

    Webb, Philip / Rice, Terry W / Cooksley, Tim

    Acute medicine

    2017  Volume 16, Issue 1, Page(s) 21–24

    Abstract: Immunotherapy with 'checkpoint-inhibitors' has significantly improved outcomes for patients with a range of malignancies. However, significant immune-mediated toxicities of these therapies are well-described. These immune-mediated toxicities can affect ... ...

    Abstract Immunotherapy with 'checkpoint-inhibitors' has significantly improved outcomes for patients with a range of malignancies. However, significant immune-mediated toxicities of these therapies are well-described. These immune-mediated toxicities can affect virtually all organ systems and are potentially fatal. The timing of onset of the adverse effects is dependent on the organ system affected and can occur after completion of the treatment. The increasing utilisation of 'checkpoint-inhibitors' means that Acute Physicians are likely to see a number of immune-mediated complications presenting to the AMU. The fundamental principles of management of immune-mediated toxicities are early recognition, supportive treatment, escalating steroid therapy (dependent on the severity of the toxicity), close liaison with Oncology and specialist organ team input. Research into the optimal strategies and pathways for the management of immune-mediated toxicity, as well as increased collaboration between Acute Physicians and Oncologists, will be necessary.
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ISSN 1747-4892
    ISSN (online) 1747-4892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prioritisation of specialist health care services; not NICE, not easy but it can be done.

    Anderson, Pippa / Webb, Philip / Groves, Sam

    Health policy (Amsterdam, Netherlands)

    2017  Volume 121, Issue 9, Page(s) 978–985

    Abstract: The challenges of delivering healthcare within budget constraints are ever present. Highly specialised technologies (HSTs) have high costs of provision inevitably contributing to NHS cost pressures. Between 2012-2015 the Welsh Health Specialised Services ...

    Abstract The challenges of delivering healthcare within budget constraints are ever present. Highly specialised technologies (HSTs) have high costs of provision inevitably contributing to NHS cost pressures. Between 2012-2015 the Welsh Health Specialised Services Committee (WHSSC) developed prioritisation methods to make recommendations for HST funding in Wales. Methods adapted as the process continued but was always evidence based and supported by a prioritisation panel of stakeholders. Methods changed from discreet choice to the Portsmouth Score Card, a simple multi-criteria decision analysis (MCDA) method. A strength of MCDA is that the impact on a decision of relevant criteria and their relative importance is explicit. This was, later, augmented by group decision support techniques. The prioritisation panel workload was on average eight HST condition treatment pairs in each l meeting, covering 133 HSTs over 3 years. Available evidence, information and value judgements were used to make decisions. The WHSSC framework identifies investment, dis-investment and recommendations transparently. The 'real-world' need for timely decisions was met, in the absence of National Institute for Health and Care Excellence (NICE) guidance on HSTs (initiated 2013, covering only drugs). In mid-2015 the prioritisation process was benchmarked against the EVIDEM framework, identifying areas of best practice and improvement: need for greater public and patient engagement. Some implementation issues for decisions based on panel recommendations remain to be resolved.
    Language English
    Publishing date 2017-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605805-x
    ISSN 1872-6054 ; 0168-8510
    ISSN (online) 1872-6054
    ISSN 0168-8510
    DOI 10.1016/j.healthpol.2017.06.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Enigma: infection or allergy? Vancomycin-induced DRESS syndrome with dialysis-dependent renal failure and cardiac arrest.

    Webb, Philip Simon / Al-Mohammad, Abdallah

    BMJ case reports

    2016  Volume 2016

    Abstract: A man aged 73 years with infective endocarditis presented with septic shock and was started on immediate antimicrobial therapy. His blood culture yielded no organism. Subsequently, he developed a severe allergic reaction to prolonged empirical vancomycin ...

    Abstract A man aged 73 years with infective endocarditis presented with septic shock and was started on immediate antimicrobial therapy. His blood culture yielded no organism. Subsequently, he developed a severe allergic reaction to prolonged empirical vancomycin therapy. This manifested as fever, widespread maculopapular rash and severe progressive acute kidney injury ultimately requiring dialysis. In the context of eosinophilia, this was determined to be drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Deciphering this complication as allergy in the context of severe infection required extreme caution due to the polarity of treatment with immunosuppression. Ultimately, this was used, with improvement of renal function, resolution of symptoms and absence of recurrence of infection. In summary, we present a case of vancomycin-related DRESS syndrome leading to dialysis-which is unique in the literature-complicating the treatment of culture-negative infective endocarditis.
    MeSH term(s) Acute Kidney Injury/chemically induced ; Acute Kidney Injury/therapy ; Aged ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Diagnosis, Differential ; Drug Hypersensitivity Syndrome/complications ; Drug Hypersensitivity Syndrome/diagnosis ; Drug Hypersensitivity Syndrome/drug therapy ; Drug Hypersensitivity Syndrome/etiology ; Glucocorticoids/therapeutic use ; Heart Arrest/chemically induced ; Heart Arrest/therapy ; Humans ; Male ; Prednisolone/therapeutic use ; Renal Dialysis ; Vancomycin/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Glucocorticoids ; Vancomycin (6Q205EH1VU) ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2016-08-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-215911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Nur 6 Tage

    Webb, Philip / Böhmert, Frank

    (Chicken-House)

    2012  

    Title translation Six days <dt.>
    Author's details Philip Webb. [Aus dem Engl. von Frank Böhmert]
    Series title Chicken-House
    Language German
    Size Online-Ressource (244 S.)
    Publisher Carlsen
    Publishing place Hamburg
    Document type Book ; Online
    ISBN 9783646922998 ; 3646922990
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Surgical and oncological score to estimate the survival benefit of resection and chemoradiotherapy in elderly (≥70 years) glioblastoma patients: A preliminary analysis.

    Zorman, Mark J / Webb, Philip / Nixon, Mickaela / Sravanam, Sanskrithi / Honeyman, Susan / Nandhabalan, Meera / Apostolopoulos, Vasileios / Stacey, Richard / Hobbs, Claire / Plaha, Puneet

    Neuro-oncology advances

    2022  Volume 4, Issue 1, Page(s) vdac007

    Abstract: Background: Elderly patients with glioblastoma are perceived to face a poor prognosis with perceptions surrounding older age and a relative lack of randomized data contributing. This study evaluated survival prognosticators in elderly glioblastoma ... ...

    Abstract Background: Elderly patients with glioblastoma are perceived to face a poor prognosis with perceptions surrounding older age and a relative lack of randomized data contributing. This study evaluated survival prognosticators in elderly glioblastoma patients to more accurately guide their treatment.
    Methods: The records of 169 elderly (≥70 years) patients with a new diagnosis of glioblastoma who had undergone neurosurgical intervention were retrospectively examined for patient sex, age, performance status, comorbidities, MGMT promoter methylation, surgical intervention, and chemoradiation regime. The adjusted survival impact of these factors was determined using Cox proportional hazards model and used to devise a two-stage scoring system to estimate patient survival at the stage of surgical (Elderly Glioblastoma Surgical Score, EGSS) and oncological management (Elderly Glioblastoma Oncological Score, EGOS).
    Results: The median overall survival (mOS) of the cohort was 28.8 weeks. Gross-total and subtotal resection were associated with improved survival compared to biopsy alone (respective mOS 65.3 and 28.1 vs 15.7 weeks,
    Conclusions: Where appropriate and safe, elderly glioblastoma patients may benefit from surgical resection and combined chemoradiotherapy with Temozolomide. The proposed EGSS and EGOS scores take into account important prognostic factors to help guide which patients should receive such treatment.
    Language English
    Publishing date 2022-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdac007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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