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  1. Article ; Online: Optimising research for neonates with encephalopathy: the role of core outcome sets.

    Devane, Declan / Ariff, Shabina / Battin, Malcolm R / Biesty, Linda / Bloomfield, Frank H / Daly, Mandy / Healy, Patricia / Haas, David M / Kirkham, Jamie J / Kibet, Vincent / Koskei, Sarah / Meher, Shireen / Molloy, Eleanor J / Niaz, Maira / Bhraonáin, Elaine Ní / Okaronon, Christabell Omukagah / Parkes, Matthew J / Tabassum, Farhana / Walker, Karen /
    Webbe, James W H / Quirke, Fiona A

    Pediatric research

    2024  Volume 95, Issue 4, Page(s) 869–870

    MeSH term(s) Infant, Newborn ; Humans ; Brain Diseases/therapy ; Hypothermia, Induced ; Outcome Assessment, Health Care ; Hypoxia-Ischemia, Brain/therapy ; Retrospective Studies
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-03006-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 373: Show issues

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  2. Article ; Online: COHESION: a core outcome set for the treatment of neonatal encephalopathy.

    Quirke, Fiona A / Ariff, Shabina / Battin, Malcolm R / Bernard, Caitlin / Biesty, Linda / Bloomfield, Frank H / Daly, Mandy / Finucane, Elaine / Healy, Patricia / Haas, David M / Kirkham, Jamie J / Kibet, Vincent / Koskei, Sarah / Meher, Shireen / Molloy, Eleanor J / Niaz, Maira / Bhraonáin, Elaine Ní / Okaronon, Christabell Omukagah / Parkes, Matthew J /
    Tabassum, Farhana / Walker, Karen / Webbe, James W H / Devane, Declan

    Pediatric research

    2023  Volume 95, Issue 4, Page(s) 922–930

    Abstract: Background: Heterogeneity in outcomes reported in trials of interventions for the treatment of neonatal encephalopathy (NE) makes evaluating the effectiveness of treatments difficult. Developing a core outcome set for NE treatment would enable ... ...

    Abstract Background: Heterogeneity in outcomes reported in trials of interventions for the treatment of neonatal encephalopathy (NE) makes evaluating the effectiveness of treatments difficult. Developing a core outcome set for NE treatment would enable researchers to measure and report the same outcomes in future trials. This would minimise waste, ensure relevant outcomes are measured and enable evidence synthesis. Therefore, we aimed to develop a core outcome set for treating NE.
    Methods: Outcomes identified from a systematic review of the literature and interviews with parents were prioritised by stakeholders (n = 99 parents/caregivers, n = 101 healthcare providers, and n = 22 researchers/ academics) in online Delphi surveys. Agreement on the outcomes was achieved at online consensus meetings attended by n = 10 parents, n = 18 healthcare providers, and n = 13 researchers/ academics.
    Results: Seven outcomes were included in the final core outcome set: survival; brain injury on imaging; neurological status at discharge; cerebral palsy; general cognitive ability; quality of life of the child, and adverse events related to treatment.
    Conclusion: We developed a core outcome set for the treatment of NE. This will allow future trials to measure and report the same outcomes and ensure results can be compared. Future work should identify how best to measure the COS.
    Impact: We have identified seven outcomes that should be measured and reported in all studies for the treatment of neonatal encephalopathy. Previously, a core outcome set for neonatal encephalopathy treatments did not exist. This will help to reduce heterogeneity in outcomes reported in clinical trials and other studies, and help researchers identify the best treatments for neonatal encephalopathy.
    MeSH term(s) Infant, Newborn ; Child ; Humans ; Quality of Life ; Research Design ; Cerebral Palsy ; Consensus ; Outcome Assessment, Health Care/methods ; Treatment Outcome
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02938-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 373: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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