LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Weber, Jesse N"
  2. AU="Fages-Masmiquel, Ester"
  3. AU="Macias Gil, Raul"
  4. AU="Planchat, Arnaud"
  5. AU="McElrath, Erin E"
  6. AU="Koji Ueda"
  7. AU="Pillas, Diana J"
  8. AU="Thomson, Jason J"
  9. AU="Mitra, Kalyan"
  10. AU="Sanjay Desai"
  11. AU=Cox David J AU=Cox David J
  12. AU="Grebenok, Robert J."
  13. AU="Blackburne, Brittney"
  14. AU="Bortoleti, Bruna Taciane da Silva"
  15. AU="Ehrbar, Martin"
  16. AU="Lepre, Davide"
  17. AU="Olszewska, Zuzanna"
  18. AU="Vojta, Leslie"
  19. AU=Wickstrom Eric AU=Wickstrom Eric
  20. AU="Gangavarapu, Sridevi"
  21. AU="Hussein, Hazem Abdelwaheb"
  22. AU=Cai Yixin AU=Cai Yixin
  23. AU="Hüls, Anke"
  24. AU="Poondru, Srinivasu"
  25. AU="Coca, Daniel"
  26. AU="Lebeau, Paul"
  27. AU="Dehghani, Sedigheh"
  28. AU="Ishibashi, Kenji"
  29. AU="Xu, Yanhua"
  30. AU="Matera, Katarzyna"
  31. AU="Ait-Ouarab, Slimane"
  32. AU="Nicola, Coppede"
  33. AU="Dewitt, John M"
  34. AU="Sorin M. Dudea"
  35. AU="Tanusha D. Ramdin"
  36. AU="Hao, Zehui"
  37. AU="Chauhan, Aman"

Suchergebnis

Treffer 1 - 10 von insgesamt 30

Suchoptionen

  1. Artikel: A Call For More Ecologically And Evolutionarily Relevant Studies of Immune Costs.

    Sasser, Kristofer Trey / Weber, Jesse N

    Evolutionary ecology

    2022  Band 37, Heft 1, Seite(n) 203–214

    Abstract: What are the relative costs and benefits of mounting immune responses? Practitioners of ecoimmunology have grappled with this central question since the field's inception with the main tension being how to make tractable methodological choices that ... ...

    Abstract What are the relative costs and benefits of mounting immune responses? Practitioners of ecoimmunology have grappled with this central question since the field's inception with the main tension being how to make tractable methodological choices that maintain the ecological relevance of induced and measured immune costs. Here, we point out two methodological approaches that we feel are underrepresented in the field, describe risks associated with neglecting these methods, and suggest modern techniques that maximize both the diversity and ecological relevance of collected data. First, it is commonly assumed that frequently used and experimentally convenient immune stimulants will induce ecologically relevant immune responses in study organisms. This can be a dangerous assumption. Even if a stimulant's general immune response properties are well characterized, it is critical to also measure the type and scale of immune responses induced by live pathogens. Second, patterns of immune defenses evolve like other traits, thus a comparative approach is essential to understand what forces shape immune variation. Finally, we describe modern genetic and immunological approaches that will soon become essential tools for ecoimmunologists, and present case studies that exemplify the utility of our recommendations.
    Sprache Englisch
    Erscheinungsdatum 2022-10-20
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 15919-0
    ISSN 1573-8477 ; 0269-7653
    ISSN (online) 1573-8477
    ISSN 0269-7653
    DOI 10.1007/s10682-022-10213-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 2005/741: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: A call for more ecologically and evolutionarily relevant studies of immune costs

    Sasser, Kristofer T. / Weber, Jesse N.

    Evol Ecol. 2023 Feb., v. 37, no. 1 p.203-214

    2023  

    Abstract: What are the relative costs and benefits of mounting immune responses? Practitioners of ecoimmunology have grappled with this central question since the field’s inception with the main tension being how to make tractable methodological choices that ... ...

    Abstract What are the relative costs and benefits of mounting immune responses? Practitioners of ecoimmunology have grappled with this central question since the field’s inception with the main tension being how to make tractable methodological choices that maintain the ecological relevance of induced and measured immune costs. Here, we point out two methodological approaches that we feel are underrepresented in the field, describe risks associated with neglecting these methods, and suggest modern techniques that maximize both the diversity and ecological relevance of collected data. First, it is commonly assumed that frequently used and experimentally convenient immune stimulants will induce ecologically relevant immune responses in study organisms. This can be a dangerous assumption. Even if a stimulant’s general immune response properties are well characterized, it is critical to also measure the type and scale of immune responses induced by live pathogens. Second, patterns of immune defenses evolve like other traits, thus a comparative approach is essential to understand what forces shape immune variation. Finally, we describe modern genetic and immunological approaches that will soon become essential tools for ecoimmunologists, and present case studies that exemplify the utility of our recommendations.
    Schlagwörter case studies ; fields ; immune response ; pathogens ; risk ; wills
    Sprache Englisch
    Erscheinungsverlauf 2023-02
    Umfang p. 203-214.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel ; Online
    Anmerkung Review
    ZDB-ID 15919-0
    ISSN 1573-8477 ; 0269-7653
    ISSN (online) 1573-8477
    ISSN 0269-7653
    DOI 10.1007/s10682-022-10213-5
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 2005/741: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel: A spectral framework to map QTLs affecting joint differential networks of gene co-expression.

    Hu, Jiaxin / Weber, Jesse N / Fuess, Lauren E / Steinel, Natalie C / Bolnick, Daniel I / Wang, Miaoyan

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Studying the mechanisms underlying the genotype-phenotype association is crucial in genetics. Gene expression studies have deepened our understanding of the genotype → expression → phenotype mechanisms. However, traditional expression quantitative trait ... ...

    Abstract Studying the mechanisms underlying the genotype-phenotype association is crucial in genetics. Gene expression studies have deepened our understanding of the genotype → expression → phenotype mechanisms. However, traditional expression quantitative trait loci (eQTL) methods often overlook the critical role of gene co-expression networks in translating genotype into phenotype. This gap highlights the need for more powerful statistical methods to analyze genotype → network → phenotype mechanism. Here, we develop a network-based method, called snQTL, to map quantitative trait loci affecting gene co-expression networks. Our approach tests the association between genotypes and joint differential networks of gene co-expression via a tensor-based spectral statistics, thereby overcoming the ubiquitous multiple testing challenges in existing methods. We demonstrate the effectiveness of snQTL in the analysis of three-spined stickleback (
    Sprache Englisch
    Erscheinungsdatum 2024-03-30
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.03.29.587398
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Jumping gene gave fish a freshwater start.

    Weber, Jesse N / Tong, Wenfei

    Science (New York, N.Y.)

    2019  Band 364, Heft 6443, Seite(n) 831–832

    Mesh-Begriff(e) Animals ; Fishes ; Fresh Water ; Interspersed Repetitive Sequences ; Seafood
    Sprache Englisch
    Erscheinungsdatum 2019-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aax7936
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 27: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Estimating the magnitude and sensitivity of energy fluxes for stickleback hosts and

    Claar, Danielle C / Faiad, Sara M / Mastick, Natalie C / Welicky, Rachel L / Williams, Maureen A / Sasser, Kristofer T / Weber, Jesse N / Wood, Chelsea L

    Ecology and evolution

    2023  Band 13, Heft 12, Seite(n) e10755

    Abstract: Parasites are ubiquitous, yet their effects on hosts are difficult to quantify and generalize across ecosystems. One promising metric of parasitic impact uses the metabolic theory of ecology (MTE) to calculate energy flux, an estimate of energy lost to ... ...

    Abstract Parasites are ubiquitous, yet their effects on hosts are difficult to quantify and generalize across ecosystems. One promising metric of parasitic impact uses the metabolic theory of ecology (MTE) to calculate energy flux, an estimate of energy lost to parasites. We investigated the feasibility of using metabolic scaling rules to compare the energetic burden of parasitism among individuals. Specifically, we found substantial sensitivity of energy flux estimates to input parameters used in the MTE equation when using available data from a model host-parasite system (
    Sprache Englisch
    Erscheinungsdatum 2023-12-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10755
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel: Between‐population differences in constitutive and infection‐induced gene expression in threespine stickleback

    Fuess, Lauren E. / Weber, Jesse N. / den Haan, Stijn / Steinel, Natalie C. / Shim, Kum Chuan / Bolnick, Daniel I.

    Molecular ecology. 2021 Dec., v. 30, no. 24

    2021  

    Abstract: Vertebrate immunity is a complex system consisting of a mix of constitutive and inducible defences. Furthermore, host immunity is subject to selective pressure from a range of parasites and pathogens which can produce variation in these defences across ... ...

    Abstract Vertebrate immunity is a complex system consisting of a mix of constitutive and inducible defences. Furthermore, host immunity is subject to selective pressure from a range of parasites and pathogens which can produce variation in these defences across populations. As populations evolve immune responses to parasites, they may adapt via a combination of (1) constitutive differences, (2) shared inducible responses, or (3) divergent inducible responses. Here, we leverage a powerful natural host‐parasite model system (Gasterosteus aculeatus and Schistochephalus solidus) to tease apart the relative contributions of these three types of adaptations to among‐population divergence in response to parasites. Gene expression analyses revealed limited evidence of significant divergence in constitutive expression of immune defence, and strong signatures of conserved inducible responses to the parasite. Furthermore, our results highlight a handful of immune‐related genes which show divergent inducible responses which may contribute disproportionately to functional differences in infection success or failure. In addition to investigating variation in evolutionary adaptation to parasite selection, we also leverage this unique data set to improve understanding of cellular mechanisms underlying a putative resistance phenotype (fibrosis). Combined, our results provide a case study in evolutionary immunology showing that a very small number of genes may contribute to genotype differences in infection response.
    Schlagwörter Gasterosteus aculeatus ; case studies ; data collection ; evolutionary adaptation ; fibrosis ; gene expression ; genotype ; parasites ; phenotype ; vertebrates
    Sprache Englisch
    Erscheinungsverlauf 2021-12
    Umfang p. 6791-6805.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.16197
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 2005/723: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel ; Online: Interspecific variation in cooperative burrowing behavior by

    Bedford, Nicole L / Weber, Jesse N / Tong, Wenfei / Baier, Felix / Kam, Ariana / Greenberg, Rebecca A / Hoekstra, Hopi E

    Evolution letters

    2022  Band 6, Heft 4, Seite(n) 330–340

    Abstract: Animals often adjust their behavior according to social context, but the capacity for such behavioral flexibility can vary among species. Here, we test for interspecific variation in behavioral flexibility by comparing burrowing behavior across three ... ...

    Abstract Animals often adjust their behavior according to social context, but the capacity for such behavioral flexibility can vary among species. Here, we test for interspecific variation in behavioral flexibility by comparing burrowing behavior across three species of deer mice (genus
    Sprache Englisch
    Erscheinungsdatum 2022-07-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2056-3744
    ISSN (online) 2056-3744
    DOI 10.1002/evl3.293
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Immune Gene Expression Covaries with Gut Microbiome Composition in Stickleback.

    Fuess, Lauren E / den Haan, Stijn / Ling, Fei / Weber, Jesse N / Steinel, Natalie C / Bolnick, Daniel I

    mBio

    2021  Band 12, Heft 3

    Abstract: Commensal microbial communities have immense effects on their vertebrate hosts, contributing to a number of physiological functions, as well as host fitness. In particular, host immunity is strongly linked to microbiota composition through poorly ... ...

    Abstract Commensal microbial communities have immense effects on their vertebrate hosts, contributing to a number of physiological functions, as well as host fitness. In particular, host immunity is strongly linked to microbiota composition through poorly understood bi-directional links. Gene expression may be a potential mediator of these links between microbial communities and host function. However, few studies have investigated connections between microbiota composition and expression of host immune genes in complex systems. Here, we leverage a large study of laboratory-raised fish from the species
    Mesh-Begriff(e) Animals ; Bacteria/classification ; Bacteria/genetics ; Bacteria/immunology ; Gastrointestinal Microbiome ; Gene Expression ; Host Microbial Interactions/genetics ; Host Microbial Interactions/immunology ; RNA, Ribosomal, 16S/genetics ; Smegmamorpha/genetics ; Smegmamorpha/immunology ; Smegmamorpha/microbiology ; Symbiosis
    Chemische Substanzen RNA, Ribosomal, 16S
    Sprache Englisch
    Erscheinungsdatum 2021-05-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00145-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  9. Artikel ; Online: Between-population differences in constitutive and infection-induced gene expression in threespine stickleback.

    Fuess, Lauren E / Weber, Jesse N / den Haan, Stijn / Steinel, Natalie C / Shim, Kum Chuan / Bolnick, Daniel I

    Molecular ecology

    2021  Band 30, Heft 24, Seite(n) 6791–6805

    Abstract: Vertebrate immunity is a complex system consisting of a mix of constitutive and inducible defences. Furthermore, host immunity is subject to selective pressure from a range of parasites and pathogens which can produce variation in these defences across ... ...

    Abstract Vertebrate immunity is a complex system consisting of a mix of constitutive and inducible defences. Furthermore, host immunity is subject to selective pressure from a range of parasites and pathogens which can produce variation in these defences across populations. As populations evolve immune responses to parasites, they may adapt via a combination of (1) constitutive differences, (2) shared inducible responses, or (3) divergent inducible responses. Here, we leverage a powerful natural host-parasite model system (Gasterosteus aculeatus and Schistochephalus solidus) to tease apart the relative contributions of these three types of adaptations to among-population divergence in response to parasites. Gene expression analyses revealed limited evidence of significant divergence in constitutive expression of immune defence, and strong signatures of conserved inducible responses to the parasite. Furthermore, our results highlight a handful of immune-related genes which show divergent inducible responses which may contribute disproportionately to functional differences in infection success or failure. In addition to investigating variation in evolutionary adaptation to parasite selection, we also leverage this unique data set to improve understanding of cellular mechanisms underlying a putative resistance phenotype (fibrosis). Combined, our results provide a case study in evolutionary immunology showing that a very small number of genes may contribute to genotype differences in infection response.
    Mesh-Begriff(e) Animals ; Fish Diseases/genetics ; Gene Expression ; Host-Parasite Interactions/genetics ; Parasites ; Smegmamorpha/genetics
    Sprache Englisch
    Erscheinungsdatum 2021-10-18
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.16197
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 2005/723: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  10. Artikel ; Online ; Forschungsdaten: (mit Forschungsdaten) Evaluation of TagSeq, a reliable low-cost alternative for RNAseq.

    Lohman, Brian K / Weber, Jesse N / Bolnick, Daniel I

    Molecular ecology resources

    2016  Band 16, Heft 6, Seite(n) 1315–1321

    Abstract: RNAseq is a relatively new tool for ecological genetics that offers researchers insight into changes in gene expression in response to a myriad of natural or experimental conditions. However, standard RNAseq methods (e.g., Illumina ... ...

    Abstract RNAseq is a relatively new tool for ecological genetics that offers researchers insight into changes in gene expression in response to a myriad of natural or experimental conditions. However, standard RNAseq methods (e.g., Illumina TruSeq
    Mesh-Begriff(e) Computational Biology/methods ; Costs and Cost Analysis ; Gene Expression Profiling/economics ; Gene Expression Profiling/methods ; High-Throughput Nucleotide Sequencing/economics ; High-Throughput Nucleotide Sequencing/methods
    Sprache Englisch
    Erscheinungsdatum 2016-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2406833-0
    ISSN 1755-0998 ; 1755-098X ; 1755-098X
    ISSN (online) 1755-0998
    ISSN 1755-098X
    DOI 10.1111/1755-0998.12529
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang