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  1. Article ; Online: Complement in Acute Liver Failure: The Right Timing to Give a Sincere Compliment.

    Weber, Susanne N / Lammert, Frank

    Cellular and molecular gastroenterology and hepatology

    2021  Volume 11, Issue 5, Page(s) 1546–1547

    MeSH term(s) Humans ; Liver Failure, Acute
    Language English
    Publishing date 2021-03-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2021.02.011
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  2. Article ; Online: Altered Expression of Antimicrobial Peptides in the Upper Gastrointestinal Tract of Patients with Diabetes Mellitus.

    Linn, Oliver / Menges, Bernhard / Lammert, Frank / Weber, Susanne N / Krawczyk, Marcin

    Nutrients

    2023  Volume 15, Issue 3

    Abstract: Antimicrobial peptides (AMP) are essential components of innate immunity with a broad range of antimicrobial activities against bacteria, viruses, and fungi. The aim of this study was to investigate AMP expression in the upper gastrointestinal tract in ... ...

    Abstract Antimicrobial peptides (AMP) are essential components of innate immunity with a broad range of antimicrobial activities against bacteria, viruses, and fungi. The aim of this study was to investigate AMP expression in the upper gastrointestinal tract in normal and pathological metabolic states in humans. Furthermore, we examined the correlation between vitamin D levels and AMP expression in the same cohort. Serum concentrations of 25-hydroxyvitamin D3 were measured, and mRNA expression of β-defensins HBD-1, -2, -3, -4, α-defensins HD-5 and -6 and cathelicidin in the upper gastrointestinal tract epithelia were determined by quantitative RT-PCR in 31 individuals (10 with type 2 diabetes, 10 with insulin resistance, and 11 healthy controls). The majority of the cohort showed low vitamin D concentrations, which were negatively correlated with mRNA expression levels of HBD-3 in corpus mucosa.
    MeSH term(s) Humans ; Defensins/metabolism ; Diabetes Mellitus, Type 2/complications ; Cathelicidins ; Vitamin D ; RNA, Messenger/genetics ; RNA, Messenger/analysis
    Chemical Substances Defensins ; Cathelicidins ; Vitamin D (1406-16-2) ; RNA, Messenger
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15030754
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  3. Article ; Online: Skin advanced glycation end-products as indicators of the metabolic profile in diabetes mellitus: correlations with glycemic control, liver phenotypes and metabolic biomarkers.

    Christidis, Grigorios / Küppers, Frederic / Karatayli, Senem Ceren / Karatayli, Ersin / Weber, Susanne N / Lammert, Frank / Krawczyk, Marcin

    BMC endocrine disorders

    2024  Volume 24, Issue 1, Page(s) 31

    Abstract: Introduction: The production of advanced glycation end-products (AGEs) is a key pathomechanism related to the complications of diabetes mellitus. The measurement of HbA1c as one of the AGEs is widely used in the clinic, but also other proteins undergo ... ...

    Abstract Introduction: The production of advanced glycation end-products (AGEs) is a key pathomechanism related to the complications of diabetes mellitus. The measurement of HbA1c as one of the AGEs is widely used in the clinic, but also other proteins undergo glycation in the course of diabetes. Here, we measure skin AGEs (SAGEs) in patients with diabetes type 1 (DM1) and type 2 (DM2) and correlate them with metabolic markers as well as non-invasively measured liver fibrosis and steatosis.
    Patients and methods: In this cross-sectional study, a total of 64 patients with either DM1 or DM2 and 28 healthy controls were recruited. SAGEs were measured using autofluorescence (AGE Reader). Liver fibrosis and steatosis were quantified using transient elastography, which determines liver stiffness measurement (LSM) and controlled attenuation parameter (CAP). FGF19, FGF21 and GDF-15 were measured in blood samples using ELISA.
    Results: SAGEs were elevated in both groups of patients with diabetes as compared to healthy controls (both p < 0.001) and were higher in patients with DM2 in comparison to DM1 (p = 0.006). SAGEs correlated positively with HbA1c (r = 0.404, p < 0.001), CAP (r = 0.260, p = 0.016) and LSM (r = 0.356, p < 0.001), and negatively with insulin growth factor binding protein 3 (p < 0.001). We also detected a positive correlation between GDF15 and SAGEs (r = 0.469, p < 0.001).
    Conclusions: SAGEs are significantly elevated in patients with both DM types 1 and 2 and correlate with metabolic markers, including HbA1c and GDF15. They might also help to detect patients with advanced liver injury in the setting of diabetes.
    MeSH term(s) Humans ; Glycemic Control ; Cross-Sectional Studies ; Glycated Hemoglobin ; Maillard Reaction ; Diabetes Mellitus, Type 1 ; Fatty Liver ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/etiology ; Metabolome ; Biomarkers
    Chemical Substances Glycated Hemoglobin ; Biomarkers
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091323-0
    ISSN 1472-6823 ; 1472-6823
    ISSN (online) 1472-6823
    ISSN 1472-6823
    DOI 10.1186/s12902-024-01558-9
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  4. Article ; Online: Effects of MBOAT7 polymorphism and steatosis on liver function assessed by methacetin breath test.

    Di Ciaula, Agostino / Bonfrate, Leonilde / Shanmugam, Harshitha / Weber, Susanne N / Krawczyk, Marcin / Portincasa, Piero

    European journal of clinical investigation

    2023  Volume 53, Issue 8, Page(s) e14003

    Abstract: Background: MBOAT7 rs641738 variant is a risk factor for nonalcoholic fatty liver disease (NAFLD) and liver fibrosis, but the relationship between this polymorphism and early liver dysfunction remains uncertain.: Methods: Eighty outpatients underwent ...

    Abstract Background: MBOAT7 rs641738 variant is a risk factor for nonalcoholic fatty liver disease (NAFLD) and liver fibrosis, but the relationship between this polymorphism and early liver dysfunction remains uncertain.
    Methods: Eighty outpatients underwent blood analyses, liver imaging by ultrasound and acoustic radiation force impulse shear wave elastography and were genotyped for MBOAT7 (wild-type [WT], rs641738 heterozygous or homozygous) polymorphism using TaqMan assays.
    Results: NAFLD was confirmed in 53 patients. Portal uptake and hepatocyte microsomal metabolization of (
    Conclusions: The homozygous MBOAT7 rs641738 polymorphism per se is associated with a reduced extraction efficiency of (
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Polymorphism, Single Nucleotide ; Acyltransferases/genetics ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/complications ; Membrane Proteins/genetics
    Chemical Substances methacetin (13E468TFHP) ; Acyltransferases (EC 2.3.-) ; MBOAT7 protein, human (EC 2.3.-) ; Membrane Proteins
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14003
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    Zs.A 677: Show issues Location:
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  5. Article ; Online: ARID3A variant and the risk of primary biliary cholangitis in a Central European cohort.

    Kruk, Beata / Liebe, Roman / Weber, Susanne N / Milkiewicz, Piotr / Krawczyk, Marcin

    Journal of hepatology

    2023  Volume 80, Issue 6, Page(s) e256–e257

    MeSH term(s) Humans ; Transcription Factors/genetics ; DNA-Binding Proteins/genetics ; Female ; Male ; Liver Cirrhosis, Biliary/epidemiology ; Liver Cirrhosis, Biliary/genetics ; Liver Cirrhosis, Biliary/diagnosis ; Europe/epidemiology ; Middle Aged ; Cohort Studies ; Aged ; Risk Factors
    Language English
    Publishing date 2023-11-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2023.11.014
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  6. Article ; Conference proceedings: [No title information]

    Weber, Susanne N. / Poppenborg, Friederike / Lammert, Frank / Krawczyk, Marcin

    Zeitschrift für Gastroenterologie

    2023  Volume 61, Issue 01

    Event/congress 39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Bochum, 2023-01-27
    Language German
    Publishing date 2023-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1759914
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    Zs.A 111: Show issues Location:
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  7. Article ; Online: Effects of blocking chemokine receptor CCR1 with BX471 in two models of fibrosis prevention and rescue in mice.

    Weber, Susanne N / Nowak, Irina / Grünhage, Frank / Lammert, Frank

    Biochemistry and biophysics reports

    2021  Volume 27, Page(s) 101077

    Abstract: Background: The induction, progression and resolution of liver fibrosis are influenced by multiple chemokines. The inhibition of CCR1 signalling by a specific non-peptide inhibitor (BX471) reduces kidney fibrosis after unilateral ureteral obstruction ... ...

    Abstract Background: The induction, progression and resolution of liver fibrosis are influenced by multiple chemokines. The inhibition of CCR1 signalling by a specific non-peptide inhibitor (BX471) reduces kidney fibrosis after unilateral ureteral obstruction via suppression of leukocyte recruitment in mice. However, it remains unclear whether selective CCR1 inhibition also affects hepatic fibrogenesis. Therefore we aimed to study the effect of this intervention on liver fibrosis in prevention (CCl
    Methods: In the prevention model, hepatic fibrosis was induced by repeated injections of CCl
    Results: BX471 injections were tolerated moderately well by all mice, and all mice developed hepatic fibrosis. Significant differences were neither observed in serum aminotransferase activities after 6 weeks of treatment between the two groups in the prevention nor in the rescue model. Interestingly, hepatic collagen contents were significantly higher in mice treated with BX471 in the prevention model as compared to controls but histological stages of liver sections did not differ. Of note, we observed only moderate effects on liver fibrosis in the ABCB4 knock-out model.
    Conclusions: Our data indicate that BX471 treatment did neither affect serum and tissue markers of liver injury and fibrosis in the CCl
    Language English
    Publishing date 2021-07-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2021.101077
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  8. Article: Genetics in liver diseases: From diagnostics to precise therapy.

    Weber, Susanne N / Lammert, Frank

    Clinical liver disease

    2017  Volume 9, Issue 1, Page(s) 1–4

    Language English
    Publishing date 2017-02-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.605
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  9. Article ; Conference proceedings: [No title information]

    Hähner, Jasmina / Lambert, Irina / Weber, Susanne N. / Milkiewicz, Piotr / Stachowska, Ewa / Krawczyk, Marcin

    Zeitschrift für Gastroenterologie

    2023  Volume 61, Issue 01

    Event/congress 39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Bochum, 2023-01-27
    Language German
    Publishing date 2023-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0042-1759947
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  10. Article ; Conference proceedings: [No title information]

    Brödel, Susan / Krawczyk, Marcin / Lammert, Frank / Weber, SusanneN.

    Zeitschrift für Gastroenterologie

    2022  Volume 60, Issue 01

    Event/congress 38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber, Mannheim, 2022-01-28
    Language English
    Publishing date 2022-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0041-1740668
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
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