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Article ; Online: Changes in use of 17-OHPC after the PROLONG trial: a physician survey.

Futterman, Itamar D / Gilroy, Laura / Zayat, Nawras / Balhotra, Kimen / Weedon, Jeremy / Minkoff, Howard

2023 Volume 51, Issue 8, Page(s) 1013–1018

Abstract: Objectives: To determine if 17α-hydroxyprogesterone caproate (17OHPC) or vaginal progesterone use for patients at risk for preterm birth has changed since the publication of the 17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG) ...

Abstract	Objectives: To determine if 17α-hydroxyprogesterone caproate (17OHPC) or vaginal progesterone use for patients at risk for preterm birth has changed since the publication of the 17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG) trial, and to assess which organizations' (Food and Drug Administration's [FDA], American College of Obstetrics and Gynecology's [ACOG] or Society of Maternal Fetal Medicine's [SMFM]) statements most influenced change. Methods: Through a vignette-based physician survey, we sought to measure (by Likert scale) how counseling tendencies regarding 17OHPC and vaginal progesterone have changed since the PROLONG trial publication. Participants were also asked which organizations' statements most influenced change. Results: With response rate of 97 % (141/145), a pre-to-post PROLONG trial comparison revealed significant changes in counseling for progesterone. Respondents were less likely to recommend 17OHPC (p<0.001) and more likely to recommend vaginal (p<0.001). The FDA statement most influenced the decision not to recommend 17OHPC for the prevention of preterm birth (r=-0.23, p=0.005). Conclusions: Providers have made significant changes in their counseling regarding progesterone use for patients at risk for preterm birth after the publication of the PRLONG trial.
Language	English
Publishing date	2023-05-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123512-6
ISSN	1619-3997 ; 0300-5577 ; 0936-174X
ISSN (online)	1619-3997
ISSN	0300-5577 ; 0936-174X
DOI	10.1515/jpm-2023-0085
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Article ; Online: The ability of a low value on an early GCT to identify women not needing repeat testing in the second trimester.

Kuyoro, Olutunmike / McLaren, Rodney A / Narayanamoorthy, Sujatha / Weedon, Jeremy / Minkoff, Howard

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2022 Volume 35, Issue 25, Page(s) 10086–10092

Abstract: Objective: To evaluate the predictive value of a low early glucose challenge test (GCT) in ruling out a subsequent diagnosis of gestational diabetes in the second trimester.: Methods: This was a retrospective cohort study of women at a single clinic ... ...

Abstract	Objective: To evaluate the predictive value of a low early glucose challenge test (GCT) in ruling out a subsequent diagnosis of gestational diabetes in the second trimester. Methods: This was a retrospective cohort study of women at a single clinic who had a normal early GCT between 2016 and 2020. Patients who did not have repeat screening in the late second trimester were excluded. Demographic data were extracted from the record. The primary outcome was a normal GCT or glucose tolerance test in the late second trimester. Logistic regression and receiver operator curves (ROC) were performed to assess the ability of the early GCT value to predict subsequent normal glucose screening. Results: Of the 532 pregnant persons with normal early GCT, 62 (11.7%) were subsequently diagnosed with gestational diabetes in the second trimester. None of the patients ( Conclusion: Early GCT value was a fair predictor for normal second trimester glucose testing for gestational diabetes. However, high-risk patients with an early GCT value of less than 80 mg/dL may be able to forego repeat second trimester screening.
MeSH term(s)	Pregnancy ; Humans ; Female ; Glucose Tolerance Test ; Pregnancy Trimester, Second ; Diabetes, Gestational/diagnosis ; Retrospective Studies ; Glucose ; Blood Glucose
Chemical Substances	Glucose (IY9XDZ35W2) ; Blood Glucose
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2022.2089553
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Zs.A 3510: Show issues

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Article ; Online: Outcomes of in-office versus operating room insertion of tympanostomy tubes in children.

Voigt, Andrew / Mooney, Sean / Minkowitz, Miriam / Weedon, Jeremy / Plum, Ann W / Rosenfeld, Richard M / Goldstein, Nira A

International journal of pediatric otorhinolaryngology

2023 Volume 175, Page(s) 111772

Abstract: Objective: Tympanostomy tube insertion in children is commonly performed under general anesthesia, but there has been increasing interest in office-based alternatives. Although initial research comparing in-office versus operating room (OR) insertion of ...

Abstract	Objective: Tympanostomy tube insertion in children is commonly performed under general anesthesia, but there has been increasing interest in office-based alternatives. Although initial research comparing in-office versus operating room (OR) insertion of tubes looks promising, there are scant data available on long-term outcomes. The objective of this study is to compare long-term outcomes of tympanostomy tubes placed in-office versus the OR, with emphasis on the duration of tube function. Methods: We reviewed electronic medical records in an academic pediatric otolaryngology practice of children under age 13 years who had tubes placed in-office or the OR between 2010 and 2021. Differences in time to unilateral and bilateral tube occlusion/extrusion were compared by Kaplan-Meier survival analysis with log rank comparison. Cox regression modeling was performed to identify predictors of tube occlusion/extrusion. Results: 817 children were included (473 office tubes, 344 OR tubes). Tube placement was equally successful for both groups (98.3% for office and 98.9% for OR). Comparison of Kaplan-Meier plots for time to unilateral and bilateral tube occlusion/extrusion by location showed no significant difference (P = .842 for unilateral and P = .714 for bilateral). However, regression analysis indicated a strong interaction of location with operator status (resident vs attending). Median time to unilateral occlusion/extrusion and bilateral occlusion/extrusion was shorter for OR residents compared to OR attendings (15.0 vs 19.5 months, P = .002, and 22.1 vs 32.0 months, P = .030, respectively). There was no difference in the time to unilateral or bilateral tube occlusion/extrusion between the office attending and OR attending groups (16.8 vs 19.5 months, P = .057 for unilateral, and 23.0 vs 32.0 months, P = .320 for bilateral). There was no significant difference between groups in the need for tube removal, repeat tubes, tube medialization, or post-extrusion tympanic membrane perforation. Conclusion: The comparable long-term outcomes found for tubes inserted in-office versus the OR, including time to occlusion/extrusion, suggest that both settings are acceptable for the procedure, with choice based primarily on parental preference, clinician experience, and shared decision making with families.
MeSH term(s)	Child ; Humans ; Infant ; Adolescent ; Otitis Media with Effusion/surgery ; Operating Rooms ; Middle Ear Ventilation/methods ; Prostheses and Implants ; Tympanic Membrane Perforation
Language	English
Publishing date	2023-10-24
Publishing country	Ireland
Document type	Review ; Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2023.111772
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Zs.A 1507: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: In reply.

Motov, Sergey / Fromm, Christian / Likourezos, Antonios / Weedon, Jeremy

Annals of emergency medicine

2018 Volume 71, Issue 2, Page(s) 267–268

Language	English
Publishing date	2018-02-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603080-4
ISSN	1097-6760 ; 0196-0644
ISSN (online)	1097-6760
ISSN	0196-0644
DOI	10.1016/j.annemergmed.2017.09.027
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Zs.A 1344: Show issues

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Article ; Online: Removal of pregnancy categories and likelihood of prescribing: a randomized trial.

Robinson, Angela / Futterman, Itamar D / Atallah, Fouad / Weedon, Jeremy / Chen, Yi-Ju Amy / Apostol, Radu / Minkoff, Howard

Journal of perinatal medicine

2022 Volume 51, Issue 4, Page(s) 546–549

Abstract: Objectives: To assess the degree to which removal of FDA' Pregnancy Categories (PC) of medications (A, B, C, and D) from labeling, affects the likelihood that providers will prescribe those medications.: Methods: Over a one-year period a convenience ... ...

Abstract	Objectives: To assess the degree to which removal of FDA' Pregnancy Categories (PC) of medications (A, B, C, and D) from labeling, affects the likelihood that providers will prescribe those medications. Methods: Over a one-year period a convenience sample of providers was recruited into a randomized, survey-based, study. Two versions of the survey were randomly distributed; version 1 presented clinical vignettes, drug information, and PC, while version 2, presented the identical information without the PC. Respondents were asked to estimate their likelihood of prescribing the drug. A mixed linear model was constructed, with likelihood of prescription as the dependent variable, treated as interval-scaled. Results: Out of 169 surveys given out, 162 (96%) were returned. Simple effects analysis showed that the presence of PC letter significantly affected the decision to prescribe category B (p<0.001) and C drugs (p=0.008) but not the A or D. Participants were significantly less likely to prescribe class B and C drugs when the letters were not available for review. These findings remained significant even when controlling for covariates (p=0.001). Conclusions: When a PC letter is absent on labeling, physicians were less likely to use category B and C drugs, the most common medications prescribed in pregnancy.
MeSH term(s)	Female ; Humans ; Pregnancy ; Surveys and Questionnaires ; Drug Prescriptions/standards
Language	English
Publishing date	2022-11-24
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	123512-6
ISSN	1619-3997 ; 0300-5577 ; 0936-174X
ISSN (online)	1619-3997
ISSN	0300-5577 ; 0936-174X
DOI	10.1515/jpm-2022-0308
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Zs.A 926: Show issues

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Article ; Online: Applying the Eosinophilic Esophagitis Endoscopic Reference Scores (EREFS) to Different Aged Children.

Ahuja, Neha / Weedon, Jeremy / Schwarz, Steven M / Sklar, Rachel / Rabinowitz, Simon S

Journal of pediatric gastroenterology and nutrition

2020 Volume 71, Issue 3, Page(s) 328–332

Abstract: Objectives: The eosinophilic esophagitis (EoE) endoscopic reference score (EREFS) was developed to analyze adults with EoE and has been successfully applied to a pediatric cohort. The present study compares EREFS in younger and older children with EoE.!# ...

Abstract	Objectives: The eosinophilic esophagitis (EoE) endoscopic reference score (EREFS) was developed to analyze adults with EoE and has been successfully applied to a pediatric cohort. The present study compares EREFS in younger and older children with EoE. Methods: The 99 patients were divided among 3 cohorts: 44 active EoE (EoE-A); 16 EoE remission (EoE-R); and 39 controls (esophageal dysfunction but <15 eos/hpf). The cohorts were then subdivided into 2 groups: younger (≤10 years) and older (>10 years) that were compared based on the composite and the individual components of their EREFS. Results: EREFS identified EoE-A in all children with an area under the receiving operating characteristics curve (AUC) of 0.85, in older children with an AUC of 0.90 and in younger children with an AUC of 0.77. Mean EREFS for ≤10 years was 1.26 ± 1.19 and 2.71 ± 1.33 for >10 years (P < 0.01). The 3 most common findings in our entire EoE-A cohort and in both ages were furrows, edema, and exudates. EREFS in patients with EoE-A had similar specificities (0.88 vs 0.89) and positive predictive values (0.89 vs 0.91) in both ages. Conclusions: The present investigation confirms the utilization of EREFS in Pediatric EoE. Furthermore, EREFS can detect EoE and document response to treatment in both younger and older children. EREFS, however, predicted EoE in the older children with a higher sensitivity (0.89 vs 0.63) and a higher negative predictive value (0.87 vs 0.59) than was seen in the younger cohort.
MeSH term(s)	Adolescent ; Adult ; Aged ; Cell Membrane ; Child ; Eosinophilic Esophagitis/diagnosis ; Esophagoscopy ; Humans ; Predictive Value of Tests ; Severity of Illness Index
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000002788
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Zs.A 1728: Show issues

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Article ; Online: Predictors of readmission for postpartum preeclampsia.

McLaren, Rodney A / Magenta, Melissa / Gilroy, Laura / Duarte, Maria Gabriela / Narayanamoorthy, Sujatha / Weedon, Jeremy / Minkoff, Howard

Hypertension in pregnancy

2021 Volume 40, Issue 3, Page(s) 254–260

Abstract: ... ...

Abstract	Objective
MeSH term(s)	Adult ; Blood Pressure/physiology ; Case-Control Studies ; Eclampsia/physiopathology ; Female ; Hospitalization ; Humans ; Hypertension/epidemiology ; Hypertension/physiopathology ; Patient Readmission/statistics & numerical data ; Postpartum Period ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Predictive Value of Tests ; Pregnancy ; Risk Factors
Language	English
Publishing date	2021-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1151886-8
ISSN	1525-6065 ; 1064-1955
ISSN (online)	1525-6065
ISSN	1064-1955
DOI	10.1080/10641955.2021.1975737
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Article ; Online: Light emitting diode-red light for reduction of post-surgical scarring: Results from a dose-ranging, split-face, randomized controlled trial.

Kurtti, Alana / Nguyen, Julie K / Weedon, Jeremy / Mamalis, Andrew / Lai, Yi / Masub, Natasha / Geisler, Amaris / Siegel, Daniel M / Jagdeo, Jared R

Journal of biophotonics

2021 Volume 14, Issue 7, Page(s) e202100073

Abstract: Scarring has significant esthetic and functional consequences for patients. A need exists for anti-scarring therapeutics. Light emitting diode-red light (LED-RL) has been shown to modulate skin fibrosis. The aim of this study is to evaluate the safety ... ...

Abstract	Scarring has significant esthetic and functional consequences for patients. A need exists for anti-scarring therapeutics. Light emitting diode-red light (LED-RL) has been shown to modulate skin fibrosis. The aim of this study is to evaluate the safety and efficacy of LED-RL to reduce post-operative scarring. Cutaneous Understanding of Red-light Efficacy on Scarring was a randomized, mock-controlled, single-blind, dose-ranging, split-face phase II clinical trial. Starting 1 week post-surgery, patients received LED-RL irradiation and temperature-controlled mock therapy to incision sites at fluences of 160, 320 or 480 J/cm
MeSH term(s)	Cicatrix/prevention & control ; Humans ; Light ; Phototherapy ; Single-Blind Method ; Skin/pathology ; Treatment Outcome
Language	English
Publishing date	2021-05-04
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.202100073
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Zs.A 6723: Show issues

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Article ; Online: Impact of Adenotonsillectomy on Homework Performance in Children With Obstructive Sleep-Disordered Breathing.

Wu, Derek / Au, Vivienne H / Yang, Billy / Horne, Sylvia J / Weedon, Jeremy / Bernstein, Michelle J / Goldstein, Nira A

The Annals of otology, rhinology, and laryngology

2021 Volume 131, Issue 11, Page(s) 1231–1240

Abstract: Objective: As a first line treatment for pediatric obstructive sleep-disordered breathing (SDB), adenotonsillectomy (AT) has been shown to confer physiologic and neurocognitive benefits to a child. However, there is a scarcity of data on how homework ... ...

Abstract	Objective: As a first line treatment for pediatric obstructive sleep-disordered breathing (SDB), adenotonsillectomy (AT) has been shown to confer physiologic and neurocognitive benefits to a child. However, there is a scarcity of data on how homework performance is affected postoperatively. Our objective was to evaluate the impact of AT on homework performance in children with SDB. Methods: Children in grades 1 to 8 undergoing AT for SDB based on clinical criteria with or without preoperative polysomnography along with a control group of children undergoing surgery unrelated to the treatment of SDB were recruited. The primary outcome of interest was the differential change in homework performance between the study group and control at follow-up as measured by the validated Homework Performance Questionnaire (HPQ-P). Adjustments were made for demographics and Pediatric Sleep Questionnaire (PSQ) scores. Results: 116 AT and 47 control subjects were recruited, and follow-up data was obtained in 99 AT and 35 control subjects. There were no significant differences between the general (total) HPQ-P scores and subscale scores between the AT and control subjects at entry and there were no significant differences in the change scores (follow-up minus initial scores) between the groups. Regression modeling also demonstrated that there were no group (AT vs control) by time interactions that predicted differential improvements in the HPQ-P ( Conclusions: Children with SDB experienced improvement in HPQ-P scores postoperatively, but the degree of change was not significant when compared to controls. Further studies incorporating additional educational metrics are encouraged to assess the true scholastic impact of AT in children with SDB.
MeSH term(s)	Adenoidectomy ; Child ; Humans ; Polysomnography ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea Syndromes/surgery ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/surgery ; Surveys and Questionnaires ; Tonsillectomy
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/00034894211062543
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Article: Cerclage Location and Gestational Age at Delivery.

Estrada, Fatima / Karakash, Scarlett / SeeToe, Terry / Weedon, Jeremy / Minkoff, Howard

AJP reports

2019 Volume 9, Issue 2, Page(s) e195–e199

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2019-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628074-7
ISSN	2157-7005 ; 2157-6998
ISSN (online)	2157-7005
ISSN	2157-6998
DOI	10.1055/s-0039-1688778
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