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  1. Article ; Online: Fitness for intensive chemotherapy: a continuing conundrum.

    Wei, Andrew H

    Blood

    2021  Volume 138, Issue 5, Page(s) 356–358

    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: BCL2 Inhibition: A New Paradigm for the Treatment of AML and Beyond.

    Wei, Andrew H / Roberts, Andrew W

    HemaSphere

    2023  Volume 7, Issue 6, Page(s) e912

    Abstract: Altering the natural history of acute myeloid leukemia (AML) in unfit and older patients has proved a highly challenging hurdle, despite several decades of concerted clinical trial effort. The arrival of venetoclax (VEN) to the clinical stage represents ... ...

    Abstract Altering the natural history of acute myeloid leukemia (AML) in unfit and older patients has proved a highly challenging hurdle, despite several decades of concerted clinical trial effort. The arrival of venetoclax (VEN) to the clinical stage represents the most important therapeutic advance to date for older patients with AML. In this review, we will explain how and why VEN works, summarize its remarkable pathway to regulatory approval, and highlight the key milestones that have been important for its successful development in AML. We also provide perspectives on some of the challenges associated with using VEN in the clinic, emerging knowledge regarding mechanisms of treatment failure, and current clinical research directions likely to shape how this drug and others in this new class of anticancer agents are used in the future.
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is BCL-xL the Achilles' heel of AEL and AMKL?

    Brown, Fiona C / Wei, Andrew H

    Blood

    2023  Volume 141, Issue 13, Page(s) 1505–1506

    MeSH term(s) Humans ; Bridged Bicyclo Compounds, Heterocyclic ; Sulfonamides ; Leukemia, Myeloid, Acute
    Chemical Substances venetoclax (N54AIC43PW) ; Bridged Bicyclo Compounds, Heterocyclic ; Sulfonamides
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022019246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enhancing our chances of picking a winner in higher-risk myelodysplastic syndromes.

    Wei, Andrew H / Seymour, John F

    British journal of haematology

    2022  Volume 198, Issue 3, Page(s) 415–418

    Abstract: Hypomethylating agents remain the current standard of care for patients with higher-risk myelodysplastic syndromes. Adès et al. report outcomes from a randomised 'pick-a-winner' study design that examined the addition of either lenalidomide, valproic ... ...

    Abstract Hypomethylating agents remain the current standard of care for patients with higher-risk myelodysplastic syndromes. Adès et al. report outcomes from a randomised 'pick-a-winner' study design that examined the addition of either lenalidomide, valproic acid or idarubicin in combination with azacitidine, compared to azacitidine alone. Commentary on: Adès et al. A randomised phase II study of azacitidine (AZA) alone or with lenalidomide (LEN), valproic acid (VPA) or idarubicin (IDA) in higher-risk MDS: GFM's 'pick a winner' trial, with the impact of somatic mutations. Br J Haematol 2022;198:535-544.
    MeSH term(s) Azacitidine/therapeutic use ; Clinical Trials, Phase II as Topic ; Humans ; Idarubicin ; Lenalidomide/therapeutic use ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/genetics ; Randomized Controlled Trials as Topic ; Valproic Acid/therapeutic use
    Chemical Substances Valproic Acid (614OI1Z5WI) ; Lenalidomide (F0P408N6V4) ; Azacitidine (M801H13NRU) ; Idarubicin (ZRP63D75JW)
    Language English
    Publishing date 2022-05-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: FLT3-ITD

    Loo, Sun / Wei, Andrew H

    Haematologica

    2022  Volume 107, Issue 4, Page(s) 783–784

    MeSH term(s) Chromosomes, Human, Pair 22/metabolism ; Core Binding Factors ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Mutation ; Trisomy/genetics ; fms-Like Tyrosine Kinase 3/genetics
    Chemical Substances Core Binding Factors ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Language English
    Publishing date 2022-04-01
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.279409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evolution of Therapy for Older Patients With Acute Myeloid Leukemia: How Should We Use Currently Available Agents?

    Kadia, Tapan M / Wei, Andrew H

    Cancer journal (Sudbury, Mass.)

    2022  Volume 28, Issue 1, Page(s) 67–72

    Abstract: Abstract: Most patients with newly diagnosed acute myeloid leukemia (AML) are 65 years or older. The treatment of AML in older patients has been characterized by distinct patient- and disease-related challenges that have impeded the meaningful progress ... ...

    Abstract Abstract: Most patients with newly diagnosed acute myeloid leukemia (AML) are 65 years or older. The treatment of AML in older patients has been characterized by distinct patient- and disease-related challenges that have impeded the meaningful progress that has been observed in younger patients with AML. Higher rates of comorbidities and frailty contribute to higher rates of treatment-related complications, whereas adverse disease features such as poor-risk genomics and secondary AML are associated with therapeutic resistance and shortened survival. Intensive chemotherapy and allogeneic stem cell transplant, although still considered standard for many newly diagnosed patients with AML, may not be appropriate for a larger subset of older patients with AML. Lower-intensity approaches such as hypomethylating agents have been widely applied for newly diagnosed older and unfit patients with AML, improving tolerability among this subset, but providing more modest response rates. Numerous analyses have attempted to tackle the utility of higher- versus lower-intensity therapy in older AML and identify the factors that can help choose the approach that best optimizes tolerability and efficacy. Recently, a greater understanding of the genomic and biologic heterogeneity of AML has led to better risk stratification and has contributed to the development of specific targeted therapies that are starting to narrow the gap between safety and efficacy. Newly approved agents, such FLT3 (FMS-like tyrosine kinase 3) inhibitors, IDH1 and IDH2 inhibitors, and the BCL2 inhibitor venetoclax, as well postremission maintenance therapy with CC-486 (oral 5-azacitidine), are being systematically incorporated into the evolving treatment of older patients with newly diagnosed AML.
    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000574
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 163: Show issues

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  7. Article ; Online: Maintenance therapy for AML: are we there yet?

    Wei, Andrew H

    Blood

    2019  Volume 133, Issue 13, Page(s) 1390–1392

    MeSH term(s) Aged ; Azacitidine ; Humans ; Leukemia, Myeloid, Acute ; Maintenance Chemotherapy
    Chemical Substances Azacitidine (M801H13NRU)
    Language English
    Publishing date 2019-03-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2019-02-897579
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  8. Article ; Online: Post-transplant maintenance therapy for MDS and AML: a bridge too far or the beginning of a new era?

    Loo, Sun / Wei, Andrew H

    Leukemia & lymphoma

    2021  Volume 62, Issue 13, Page(s) 3073–3077

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/etiology ; Leukemia, Myeloid, Acute/therapy ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/etiology
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1961243
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    Zs.A 2997: Show issues Location:
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  9. Article ; Online: Taking aim at IDH in fitter patients with AML.

    Wei, Andrew H / Daver, Naval

    Blood

    2021  Volume 137, Issue 13, Page(s) 1706–1707

    MeSH term(s) Humans ; Isocitrate Dehydrogenase/genetics ; Leukemia, Myeloid, Acute/genetics
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020009361
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  10. Article ; Online: Applying molecular measurable residual disease testing in acute myeloid leukaemia.

    Krigstein, Michael / Iland, Harry J / Wei, Andrew H

    Pathology

    2022  

    Abstract: Molecular testing in acute myeloid leukaemia (AML) has continued to dramatically advance in recent years, facilitating the ability to detect residual disease at exponentially lower levels. With the advent of the recently updated ELN consensus ... ...

    Abstract Molecular testing in acute myeloid leukaemia (AML) has continued to dramatically advance in recent years, facilitating the ability to detect residual disease at exponentially lower levels. With the advent of the recently updated ELN consensus recommendations, there is increasing complexity to ordering and interpreting measurable residual disease (MRD) assays in AML. We outline the technology itself in conjunction with the relevant testing timepoints, clinically significant thresholds and potential prognostic and therapeutic significance of MRD testing for the major molecular targets in AML. This practical overview should assist haematologists in incorporating molecular MRD assays routinely into their personalised AML clinical management.
    Language English
    Publishing date 2022-11-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2022.11.003
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