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Book ; Online ; E-Book: Aptamers selected by cell SELEX for theranostics

Tan, Weihong

2015

Author's details	Weihong Tan ... ed
Keywords	SELEX Aptamer Technique ; Aptamers, Nucleotide / genetics ; Molecular Imaging ; Nanostructures ; Nanotechnology ; Chemistry ; Oncology ; Medicine ; Biotechnology ; Nucleic acids
Subject code	660.6
Language	English
Size	XIII, 352 S. : Ill.
Publisher	Springer
Publishing place	Heidelberg u.a.
Publishing country	Germany
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT018834913
ISBN	978-3-662-46226-3 ; 978-3-662-46225-6 ; 3-662-46226-5 ; 3-662-46225-7
DOI	10.1007/978-3-662-46226-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: [Thinking on the development direction of acupuncture-moxibustion science from the study of genres of acupuncture and moxibustion].

Liu, Wei-Hong

Zhongguo zhen jiu = Chinese acupuncture & moxibustion

2021 Volume 41, Issue 9, Page(s) 951–955

Abstract: The paper introduces the general situation on academic school of acupuncture and moxibustion in ancient China, the status of the modern genres of acupuncture and moxibustion, as well as the existing problems in the relevant studies. It is pointed out ... ...

Abstract	The paper introduces the general situation on academic school of acupuncture and moxibustion in ancient China, the status of the modern genres of acupuncture and moxibustion, as well as the existing problems in the relevant studies. It is pointed out that "academic school" and "genre" should be distinguished each other in terms of modern context. The former should refer to the school of academic theory, while the latter should be the school of clinical treatment technology. It would be best to classify the modern academic school of acupuncture and moxibustion based on the therapeutic techniques with specific characteristics for the outline, focusing on the study of the academic thought of each genre. Modern genres of acupuncture and moxibustion should be more inclusive and open, "encouraging the unique academic views", rather than "restricting access to inheritance". The development of modern genres of acupuncture and moxibustion is an important driving force for the development of acupuncture-moxibustion discipline and it is ought to contribute to the reconstruction of medical theory of acupuncture and moxibustion.
MeSH term(s)	Acupuncture ; Acupuncture Therapy ; China ; Moxibustion ; Schools
Language	Chinese
Publishing date	2021-09-07
Publishing country	China
Document type	Journal Article
ISSN	0255-2930
ISSN	0255-2930
DOI	10.13703/j.0255-2930.20210420-0002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Advances in Multi-Sensor Information Fusion: Theory and Applications 2017

Jin, Xue-Bo / Sun, Shuli / Wei, Hong / Yang, Feng-Bao

2018

Abstract: The information fusion technique can integrate a large amount of data and knowledge representing the same real-world object and obtain a consistent, accurate and useful representation of that object. The data may be independent or redundant, and can be ... ...

Abstract	The information fusion technique can integrate a large amount of data and knowledge representing the same real-world object and obtain a consistent, accurate and useful representation of that object. The data may be independent or redundant, and can be obtained by different sensors at the same time or at different times. A suitable combination of investigative methods can substantially increase the profit of information in comparison with that from a single sensor.Multi-sensor information fusion has been a key issue in sensor research since the 1970s and it has been applied in many fields, such as geospatial information systems, business intelligence, oceanography, discovery science, intelligent transport systems, wireless sensor networks, etc. Recently, thanks to the vast development in sensor and computer memory technologies, more and more sensors are being used in practical systems and a large amount of measurement data are recorded and restored, which may actually be the time series big data. For example, sensors in machines and process control industries can generate a lot of data, which have real, actionable business value. The fusion of these data can greatly improve productivity through digitization.The goal of this Special Issue is to report on innovative ideas and solutions for the methods of multi-sensor information fusion in the emerging applications era, focusing on development, adoption and applications
Keywords	Electrical engineering. Electronics. Nuclear engineering
Size	1 electronic resource (VIII, 560 p.)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020098769
ISBN	9783038429333 ; 9783038429340 ; 3038429333 ; 3038429341
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Editorial for "MRI for Hepatitis B-Associated Intrahepatic Cholangiocarcinoma: A Multicenter Comparative Study".

Wei, Hong / Yoon, Jeong Hee

Journal of magnetic resonance imaging : JMRI

2023 Volume 59, Issue 3, Page(s) 1105–1106

MeSH term(s)	Humans ; Hepatitis B ; Cholangiocarcinoma ; Bile Ducts, Intrahepatic ; Bile Duct Neoplasms ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Multicenter Study ; Editorial
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28850
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Article: Modernized Machine Learning Approach to Illuminate Enzyme Immobilization for Biocatalysis.

Wei, Hong / Smith, Joseph P

ACS central science

2023 Volume 9, Issue 10, Page(s) 1913–1926

Abstract: Biocatalysis is an established technology with significant application in the pharmaceutical industry. Immobilization of enzymes offers significant benefits for commercial and practical purposes to enhance the stability and recyclability of biocatalysts. ...

Abstract	Biocatalysis is an established technology with significant application in the pharmaceutical industry. Immobilization of enzymes offers significant benefits for commercial and practical purposes to enhance the stability and recyclability of biocatalysts. Determination of the spatial and chemical distributions of immobilized enzymes on solid support materials is essential for an optimal catalytic performance. However, current analytical methodologies often fall short of rapidly identifying and characterizing immobilized enzyme systems. Herein, we present a new analytical methodology that combines non-negative matrix factorization (NMF)-an unsupervised machine learning tool-with Raman hyperspectral imaging to simultaneously resolve the spatial and spectral characteristics of all individual species involved in enzyme immobilization. Our novel approach facilitates the determination of the optimal NMF model using new data-driven, quantitative selection criteria that fully resolve all chemical species present, offering a robust methodology for analyzing immobilized enzymes. Specifically, we demonstrate the ability of NMF with Raman hyperspectral imaging to resolve the spatial and spectral profiles of an engineered pantothenate kinase immobilized on two different commercial microporous resins. Our results demonstrate that this approach can accurately identify and spatially resolve all species within this enzyme immobilization process. To the best of our knowledge, this is the
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.3c00757
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Article ; Online: Purple Urine Bag Syndrome Amelioration without Antibiotic Therapy.

Ye, Xiao-Qing / Bi, Wei-Hong / Wang, Ting

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2024 Volume 34, Issue 2, Page(s) 248

Abstract: Null. ...

Abstract	Null.
MeSH term(s)	Humans ; Urinary Tract Infections/drug therapy ; Syndrome ; Anti-Bacterial Agents/therapeutic use ; Urine
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-11
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2024.02.248
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Article ; Online: Construction of Knowledge Graph of 3D Clothing Design Resources Based on Multimodal Clustering Network

Jia Zheng / Wei Hong

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: The construction of 3D design model is a hotspot of applied research in the fields of clothing functional design system teaching and display. The simple 3D clothing visualization postprocessing lacks interactive functions, which is a hot issue that needs ...

Abstract	The construction of 3D design model is a hotspot of applied research in the fields of clothing functional design system teaching and display. The simple 3D clothing visualization postprocessing lacks interactive functions, which is a hot issue that needs to be solved urgently at present. Based on analyzing the existing clothing modeling technology, template technology, and fusion technology, and based on the multimodal clustering network theory, this paper proposes a 3D clothing design resource knowledge graph modeling method with multiple fusion of features and templates. The position of each joint point is converted into the coordinate system centered on the torso point in advance and normalized to avoid the problem that the relative position of the camera and the collector cannot be determined, and the shape of different collectors is different. The paper provides a multimodal clustering network intelligence method, illustrates the interoperability of users switching between different design networks in the seamless connection movement, and combines the hybrid intelligence algorithm with the fuzzy logic interpretation algorithm to solve the problems in the field of 3D clothing design service quality. During the simulation process, the research scheme builds a logical multimodal clustering network framework, which integrates compatibility access and global access partition fusion of style templates to achieve information extraction of clothing parts. The experimental results show that the realistic 3D clothing modeling can be achieved by layering the 3D clothing map, contour features, clothing size features, and color texture features with the modeling template. The developed ActiveX control is mounted on MSN, and the system is compatible. The performance and integration rate reached 77.1% and 89.7%, respectively, which effectively strengthened the practical role of the 3D clothing design system.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis

Zhou, Hua / Song, Wei-Hong

Biochem Genet. 2023 Feb., v. 61, no. 1 p.372-389

2023

Abstract: Atherosclerosis (AS) is the typical cardiovascular disease, which is the main underlying inducement of cardiovascular diseases. Aberrant expression of long noncoding RNA HLA complex group 11 (HCG11) was engaged with atherosclerosis. The objective of the ... ...

Abstract	Atherosclerosis (AS) is the typical cardiovascular disease, which is the main underlying inducement of cardiovascular diseases. Aberrant expression of long noncoding RNA HLA complex group 11 (HCG11) was engaged with atherosclerosis. The objective of the present research was to explore the role and the potential mechanism of HCG11 in AS. Human umbilical vein endothelial cells (HUVECs) were stimulated with oxidized low-density lipoprotein (ox-LDL) to induce the AS model in vitro. The cell viability was detected by MTT assay. Flow cytometry was performed to determine cell pyroptosis. Gene and protein levels were detected by qPCR or Western blot assay. The interaction between HCG11, miR-224-3p, and Janus kinase 1 (JAK1) was validated by dual-luciferase reporter assays. Ox-LDL treatment aggravated cell pyroptosis and inflammation in HUVECs. And the levels of HCG11 and JAK1 was enhanced in ox-LDL-induced HUVECs, while miR-224-3p expression was reduced. Additionally, knockdown of HCG11 or miR-224-3p overexpression reversed the ox-LDL-induced cell viability decline and the increase of cell pyroptosis and inflammation-related proteins, including gasdermin D N-terminal (GSDMD-N), Caspase-1, NOD-like receptor family pyrin domain-containing 3 (NLRP3), interleukin 18 (IL-18), and interleukin 1beta (IL-1β). Moreover, HCG11 could modulate the JAK1 expression via targeting miR-224-3p. The inhibitory effect of HCG11 silencing on cell pyroptosis and inflammation was reversed by miR-224-3p knockdown. Furthermore, overexpression of miR-224-3p could repress the ox-LDL-induced cell pyroptosis and inflammation via regulating JAK1 expression. Knockdown of HCG11 alleviated cell pyroptosis and inflammation induced by ox-LDL via targeting the miR-224-3p/JAK1 axis, indicating that HCG11 could be the latent target of diagnosis or treatment for AS.
Keywords	Western blotting ; atherosclerosis ; caspase-1 ; cell viability ; flow cytometry ; genes ; inflammation ; interleukin-18 ; interleukin-1beta ; low density lipoprotein ; models ; non-coding RNA ; non-specific protein-tyrosine kinase ; oxidation ; pyroptosis ; toxicity testing
Language	English
Dates of publication	2023-02
Size	p. 372-389.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-022-10261-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Sterically Hindered Diarylethenes with a Benzobis(thiadiazole) Bridge: Enantiospecific Transformation and Reversible Photosuperstructures.

Li, Mengqi / Zhu, Wei-Hong

Accounts of chemical research

2022 Volume 55, Issue 21, Page(s) 3136–3149

Abstract: ConspectusPhotochromic diarylethenes featuring reversible regulation by external light irradiation have attracted increasing attention in versatile applications such as logic gates, supramolecular systems, liquid crystals, and super-resolution imaging ... ...

Abstract	ConspectusPhotochromic diarylethenes featuring reversible regulation by external light irradiation have attracted increasing attention in versatile applications such as logic gates, supramolecular systems, liquid crystals, and super-resolution imaging because of their outstanding bistability and fatigue resistance. However, for typical diarylethene systems, there always exist three typical unsolved issues. The first is how to modulate the bistability between the open and closed forms from the viewpoint of ethene bridge aromaticity. The second is how to decrease and avoid the photoinactive parallel conformer in order to achieve a high quantum yield, since the open form possesses the photoactive antiparallel (
Language	English
Publishing date	2022-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1483291-4
ISSN	1520-4898 ; 0001-4842
ISSN (online)	1520-4898
ISSN	0001-4842
DOI	10.1021/acs.accounts.2c00419
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Article ; Online: LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis.

Zhou, Hua / Song, Wei-Hong

Biochemical genetics

2022 Volume 61, Issue 1, Page(s) 372–389

Abstract	Atherosclerosis (AS) is the typical cardiovascular disease, which is the main underlying inducement of cardiovascular diseases. Aberrant expression of long noncoding RNA HLA complex group 11 (HCG11) was engaged with atherosclerosis. The objective of the present research was to explore the role and the potential mechanism of HCG11 in AS. Human umbilical vein endothelial cells (HUVECs) were stimulated with oxidized low-density lipoprotein (ox-LDL) to induce the AS model in vitro. The cell viability was detected by MTT assay. Flow cytometry was performed to determine cell pyroptosis. Gene and protein levels were detected by qPCR or Western blot assay. The interaction between HCG11, miR-224-3p, and Janus kinase 1 (JAK1) was validated by dual-luciferase reporter assays. Ox-LDL treatment aggravated cell pyroptosis and inflammation in HUVECs. And the levels of HCG11 and JAK1 was enhanced in ox-LDL-induced HUVECs, while miR-224-3p expression was reduced. Additionally, knockdown of HCG11 or miR-224-3p overexpression reversed the ox-LDL-induced cell viability decline and the increase of cell pyroptosis and inflammation-related proteins, including gasdermin D N-terminal (GSDMD-N), Caspase-1, NOD-like receptor family pyrin domain-containing 3 (NLRP3), interleukin 18 (IL-18), and interleukin 1beta (IL-1β). Moreover, HCG11 could modulate the JAK1 expression via targeting miR-224-3p. The inhibitory effect of HCG11 silencing on cell pyroptosis and inflammation was reversed by miR-224-3p knockdown. Furthermore, overexpression of miR-224-3p could repress the ox-LDL-induced cell pyroptosis and inflammation via regulating JAK1 expression. Knockdown of HCG11 alleviated cell pyroptosis and inflammation induced by ox-LDL via targeting the miR-224-3p/JAK1 axis, indicating that HCG11 could be the latent target of diagnosis or treatment for AS.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Janus Kinase 1/genetics ; Janus Kinase 1/pharmacology ; Atherosclerosis/genetics ; Human Umbilical Vein Endothelial Cells/metabolism ; Inflammation/genetics ; Lipoproteins, LDL/pharmacology ; Apoptosis ; Cell Proliferation/physiology
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; Janus Kinase 1 (EC 2.7.10.2) ; Lipoproteins, LDL ; JAK1 protein, human (EC 2.7.10.2) ; MIRN224 microRNA, human
Language	English
Publishing date	2022-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-022-10261-0
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