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  1. Article ; Online: Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis.

    Wei, Jin-Ying / Zhang, Qiang / Yao, Yue / He, Hai-Bin / Sun, Cheng-Hao / Dong, Ting-Ting / Meng, Guang-Ping / Zhang, Jie

    Epigenomics

    2022  Volume 14, Issue 16, Page(s) 931–949

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Apoptosis/genetics ; Carcinogenesis/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Membrane Proteins/genetics ; MicroRNAs/genetics ; Nuclear Proteins/genetics ; RNA, Circular/genetics ; TEA Domain Transcription Factors/genetics
    Chemical Substances DERL1 protein, human ; DNA-Binding Proteins ; MIRN873 microRNA, human ; Membrane Proteins ; MicroRNAs ; Nuclear Proteins ; RNA, Circular ; TEA Domain Transcription Factors ; TEAD1 protein, human
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2537199-X
    ISSN 1750-192X ; 1750-1911
    ISSN (online) 1750-192X
    ISSN 1750-1911
    DOI 10.2217/epi-2021-0480
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  2. Article ; Online: A Special Tinea Nigra Caused by Curvularia lunata: Case Report and Literature Review.

    Al-Odaini, Najwa / Wei, Jin-Ying / Zheng, Yan-Qing / Zheng, Dong-Yan / Khader, Jazeer A / Cao, Cun-Wei

    Mycopathologia

    2022  Volume 187, Issue 2-3, Page(s) 291–298

    Abstract: Tinea nigra is a superficial fungal infection usually caused by Hortaea werneckii (H. werneckii). We report a special case of tinea nigra in an immunocompetent child who developed a unilateral, rapidly growing pigmented lesion on her palm. Interestingly, ...

    Abstract Tinea nigra is a superficial fungal infection usually caused by Hortaea werneckii (H. werneckii). We report a special case of tinea nigra in an immunocompetent child who developed a unilateral, rapidly growing pigmented lesion on her palm. Interestingly, Curvularia lunata (C. lunata) was isolated from the lesion scrapes and was identified by both morphological features and molecular biology methods. The lesion was completely cleared by topical naftifine hydrochloride and ketoconazole cream. We present-to the best of our knowledge-the first case of tinea nigra where the causative pathogen was identified as C. lunata. We therefore provide a brief literature review of previously reported cases of tinea nigra to broaden the knowledge of the potential causative pathogens. The etiology, demography, clinical features, diagnostic methods, and treatment of the reviewed cases are summarized and analyzed.
    MeSH term(s) Child ; Curvularia ; Exophiala ; Female ; Humans ; Tinea/diagnosis ; Tinea/drug therapy ; Tinea/microbiology
    Language English
    Publishing date 2022-03-04
    Publishing country Netherlands
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 391081-7
    ISSN 1573-0832 ; 0369-299X ; 0301-486X ; 0027-5530
    ISSN (online) 1573-0832
    ISSN 0369-299X ; 0301-486X ; 0027-5530
    DOI 10.1007/s11046-022-00619-8
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  3. Article ; Online: Application of carbon nanoparticles in laparoscopic sentinel lymph node detection in patients with early-stage cervical cancer.

    Lu, Yan / Wei, Jin-Ying / Yao, De-Sheng / Pan, Zhong-Mian / Yao, Yao

    PloS one

    2017  Volume 12, Issue 9, Page(s) e0183834

    Abstract: Objective: To investigate the value of carbon nanoparticles in identifying sentinel lymph nodes in early-stage cervical cancer.: Methods: From January 2014 to January 2016, 40 patients with cervical cancer stage IA2-IIA, based on the International ... ...

    Abstract Objective: To investigate the value of carbon nanoparticles in identifying sentinel lymph nodes in early-stage cervical cancer.
    Methods: From January 2014 to January 2016, 40 patients with cervical cancer stage IA2-IIA, based on the International Federation of Gynecology and Obstetrics (FIGO) 2009 criteria, were included in this study. The normal cervix around the tumor was injected with a total of 1 mL of carbon nanoparticles (CNP)at 3 and 9 o'clock. All patients then underwent laparoscopic pelvic lymph node dissection and radical hysterectomy. The black-dyed sentinel lymph nodes were removed for routine pathological examination and immunohistochemical staining.
    Results: Among the 40 patients, 38 patients had at least one sentinel lymph node (SLN). The detection rate was 95% (38/40). One hundred seventy-three SLNs were detected with an average of 3.9 SLNs per side. 25 positive lymph nodes, which included 21 positive SLNs, were detected in 8 (20%) patients. Sentinel lymph nodes were localized in the obturator (47.97%), internal lilac (13.87%), external lilac (26.59%), parametrial (1.16%), and common iliac (8.67%) regions. The sensitivity of the SLN detection was 100% (5/5), the accuracy was 97.37% (37/38), and the negative predictive value was 100. 0% and the false negative rate was 0%.
    Conclusions: Sentinel lymph nodes can be used to accurately predict the pathological state of pelvic lymph nodes in early cervical cancer. The detection rates and accuracy of sentinel lymph node were high. Carbon nanoparticles can be used to trace the sentinel lymph node in early cervical cancer.
    MeSH term(s) Adult ; False Negative Reactions ; Female ; Humans ; Hysterectomy ; Immunohistochemistry ; Laparoscopy ; Lymph Node Excision ; Lymphatic Metastasis/pathology ; Middle Aged ; Nanotubes, Carbon/chemistry ; Neoplasm Staging ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/surgery
    Chemical Substances Nanotubes, Carbon
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0183834
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  4. Article: Calcineurin A Is Essential in the Regulation of Asexual Development, Stress Responses and Pathogenesis in

    Zheng, Yan-Qing / Pan, Kai-Su / Latgé, Jean-Paul / Andrianopoulos, Alex / Luo, Hong / Yan, Ru-Fan / Wei, Jin-Ying / Huang, Chun-Yang / Cao, Cun-Wei

    Frontiers in microbiology

    2020  Volume 10, Page(s) 3094

    Abstract: Talaromyces ... ...

    Abstract Talaromyces marneffei
    Language English
    Publishing date 2020-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2019.03094
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  5. Article ; Online: Local intra-gestational sac methotrexate injection followed by dilation and curettage in treating cesarean scar pregnancy.

    Tan, Kai-Liang / Jiang, Li / Chen, Yu-Mei / Meng, Ying / Lv, Bang-Quan / Wei, Liu-Fei / Peng, Xiao-Zhu / Ling, Yu-Ying / Lan, Jing / Wei, Jin-Ying

    Archives of gynecology and obstetrics

    2020  Volume 302, Issue 2, Page(s) 439–445

    Abstract: Purpose: To assess the safety and efficacy of local intra-gestational sac methotrexate injection followed by dilation and curettage (D&C) in treating cesarean scar pregnancies (CSP).: Method: Medical records of CSP patients treated with local intra- ... ...

    Abstract Purpose: To assess the safety and efficacy of local intra-gestational sac methotrexate injection followed by dilation and curettage (D&C) in treating cesarean scar pregnancies (CSP).
    Method: Medical records of CSP patients treated with local intra-gestational sac methotrexate injection followed by dilation and curettage were analyzed at the Maternal and Child Hospital of Guangxi Zhuang Autonomous Region, China.
    Results: Thirty-one patients were included in this study. The mean gestational age, sac diameter and thickness of the uterine scar were 49.6 ± 7.7 days, 1.8 ± 0.6 cm and 0.30 ± 0.15 cm, respectively. The median pretreatment serum β-human chorionic gonadotropin (β-HCG) level was 40,887 mIU/mL, with the 25th and 75th percentiles at 19,852 and 74,552, respectively. The median blood loss during D&C was 20 mL with the 25th and 75th percentiles at 10 mL and 50 mL. Following D&C, a Foley's balloon catheter compression was implanted in 26 (83.9%) patients due to active uterine bleeding. All patients had a β-HCG regression time of ≤ 4 weeks after D&C. While 30 patients (96.8%) had a uterine recovery time of ≤ 4 weeks, and 29 patients (93.5%) had resumption of menstruation of less than 6 weeks. Three patients (9.7%) had complications. One of them suffered from massive vaginal bleeding and underwent s blood transfusion. There were no other complications, such as pelvic infection and uterine rupture during the procedures. And no patient was converted to surgical resection or uterine artery embolization. Overall, 30 patients (96.8%) were treated successfully.
    Conclusion: Local intra-gestational sac methotrexate injection followed by D&C with the aid of a Foley's balloon catheter compression appears to be a safe and effective treatment for CSP. Further randomized controlled trials are suggested to confirm these findings.
    MeSH term(s) Adult ; Cesarean Section/adverse effects ; Cicatrix/drug therapy ; Dilatation and Curettage/methods ; Female ; Gestational Sac ; Humans ; Methotrexate/administration & dosage ; Methotrexate/therapeutic use ; Pregnancy ; Treatment Outcome
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2020-05-30
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-020-05619-x
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  6. Article: [High fat diet induced the expression of SREBP-1, TGF-beta1 and alpha-SMA in renal tubular cells and extracellular matrix accumulation in Wistar rats].

    Hao, Jun / Liu, Shu-Xia / Wei, Jin-Ying / Yao, Hong-Ye / Duan, Hui-Jun

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2010  Volume 26, Issue 3, Page(s) 307–311

    Abstract: Objective: To explore the effect of high fat diet on the expression of sterol regulatory element binding protein-1 (SREBP-1), transforming growth factor-beta1 (TGF-beta1) and alpha-smooth muscle actin (alpha-SMA) in renal tubular cells and extracellular ...

    Abstract Objective: To explore the effect of high fat diet on the expression of sterol regulatory element binding protein-1 (SREBP-1), transforming growth factor-beta1 (TGF-beta1) and alpha-smooth muscle actin (alpha-SMA) in renal tubular cells and extracellular matrix accumulation in Wistar rats.
    Methods: The Wistar rats were treated with high fat diet for 12 weeks and renal lipid deposit was detected by the method of Oil Red O staining. The immunohistochemistry and Western blot were used to investigate the expression of SREBP-1, TGF-beta1, alpha-SMA and fibronectin (FN) protein. The expression of SREBP-1 mRNA was determined with in situ hybridization. Masson staining was for the detection of extracellular matrix (ECM) accumulation.
    Results: The weight of rats raised by high fat diet increased, in company with the high serum glucose, serum triglyceride and serum insulin. The Oil Red O staining revealed that the renal proximal tubular epithelial cells showed significant lipid droplet in high fat diet rats. SREBP-1 protein and mRNA were located in the renal tubular cells and the expressions of high fat diet rats were higher than those of normal control rats. They were respectively 1.88 times and 1.85 times than those of normal control group. TGF-beta1 and alpha-SMA protein were also located in renal tubular cells and high fat diet up-regulated the expression of them. ECM accumulation was detected with Masson staining and the result showed that high fat diet treatment increased interstitial ECM product and FN protein was found high expression.
    Conclusion: High fat diet may induce lipid droplet deposit in renal tubular cells by up-regulation of the expression of SREBP-1, which causes ECM accumulation by increasing the expression of TGF-beta1 and alpha-SMA.
    MeSH term(s) Actins/metabolism ; Animals ; Diet, High-Fat ; Extracellular Matrix/metabolism ; Kidney Tubules/cytology ; Kidney Tubules/metabolism ; Male ; Rats ; Rats, Wistar ; Sterol Regulatory Element Binding Protein 1/metabolism ; Transforming Growth Factor beta1/metabolism
    Chemical Substances Actins ; Srebf1 protein, rat ; Sterol Regulatory Element Binding Protein 1 ; Transforming Growth Factor beta1 ; smooth muscle actin, rat
    Language Chinese
    Publishing date 2010-08
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1000-6834
    ISSN 1000-6834
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  7. Article: [The effect of Janus kinase 2 inhibitor AG490 on renal tubular epithelial-myofibroblast transdifferentiation induced by interleukin-1β].

    Liu, Qing-juan / Shi, Yong-hong / Liu, Shu-xia / Hao, Jun / Cao, Yan-ping / Li, Hang / Wei, Jin-ying / Duan, Hui-jun

    Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue

    2010  Volume 22, Issue 12, Page(s) 747–749

    Abstract: Objective: To investigate the effect of AG490, a Janus kinase 2 inhibitor, on epithelial-myofibroblast transdifferentiation induced by interleukin-1β (IL-1β).: Methods: Cultured human renal tubular epithelial cell line (HKCs) were divided into three ... ...

    Abstract Objective: To investigate the effect of AG490, a Janus kinase 2 inhibitor, on epithelial-myofibroblast transdifferentiation induced by interleukin-1β (IL-1β).
    Methods: Cultured human renal tubular epithelial cell line (HKCs) were divided into three groups: blank control group, IL-1β (5 ng/ml) group and AG490 group (IL-1β 5 ng/ml+AG490 10 μmol/L). The cells in all groups were collected at 24, 48, 72 hours after intervention. Immunocytochemistry and Western blotting analysis were used to determine the expressions of cytokeratin-18 (CK-18) and α-smooth muscle actin (α-SMA).
    Results: The higher expression of CK-18 (1.25±0.08) and mild expression of α-SMA (0.17±0.01) were found in blank control group. In IL-1β group, the protein level of CK-18 was gradually decreased with prolongation of stimulus (24 hours : 0.69±0.04, 48 hours: 0.52±0.03, 72 hours: 0.30±0.01), while the expression level of α-SMA was gradually increased (24 hours: 0.56±0.04, 48 hours: 1.05±0.07, 72 hours: 1.43±0.07), and the difference between blank control group and IL-1β group was statistically significant (all P<0.05). The administration of AG490 could restore the expression of CK-18 (24 hours: 1.07±0.07, 48 hours: 0.93±0.06, 72 hours: 0.83±0.06), and inhibit the expression of α-SMA induced by IL-1β (24 hours: 0.33± 0.01, 48 hours: 0.52±0.01, 72 hours: 0.61±0.04). There was significant difference between AG490 group and IL-1β group (all P<0.05). The results of immunocytochemistry and that of Western blotting were identical.
    Conclusion: IL-1β can induce the transdifferentiation of renal tubular epithelial cells, up-regulate the expression of α-SMA, induce the renal tubular epithelial cells to transform to myofibroblast, while AG490 can inhibit the effect of IL-1β.
    MeSH term(s) Actins/metabolism ; Cell Line ; Cell Transdifferentiation/drug effects ; Enzyme Inhibitors/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Humans ; Interleukin-1beta/pharmacology ; Janus Kinase 2/antagonists & inhibitors ; Keratin-18/metabolism ; Kidney Tubules/cytology ; Kidney Tubules/metabolism ; Tyrphostins/pharmacology
    Chemical Substances ACTA2 protein, human ; Actins ; Enzyme Inhibitors ; Interleukin-1beta ; Keratin-18 ; Tyrphostins ; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide ; Janus Kinase 2 (EC 2.7.10.2)
    Language Chinese
    Publishing date 2010-12
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1003-0603
    ISSN 1003-0603
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  8. Article: [Expression of cyclooxygenase-2, hMLH1 and hMSH2 proteins, and their relationship with microsatellite instability in gastric carcinoma].

    Song, Wei-qing / Han, Cai-li / Chen, Yi / Zhang, Yi-hua / Wei, Jin-ying / Liu, Yu

    Zhonghua zhong liu za zhi [Chinese journal of oncology

    2005  Volume 27, Issue 11, Page(s) 660–662

    Abstract: Objective: To investigate the expression of cyclooxygenase-2 (COX-2), human mut-l homologue 1 (hMLH1) and human mut-s homologue 2 (hMSH2) proteins in human paired gastric carcinoma (GC) and adjacent normal mucosa, and analyze their relationship with ... ...

    Abstract Objective: To investigate the expression of cyclooxygenase-2 (COX-2), human mut-l homologue 1 (hMLH1) and human mut-s homologue 2 (hMSH2) proteins in human paired gastric carcinoma (GC) and adjacent normal mucosa, and analyze their relationship with microsatellite instability (MSI).
    Methods: The protein expressions were examined by western blotting. Five MSI loci were assessed by PCR.
    Results: In 30 surgically excised GC tissues, the overexpression rate of COX-2, the low expression rate of hMLH1 and hMSH2 were 66.7%, 40% and 33.3%, respectively. Significant differences were found when compared with those of adjacent normal mucosa (P < 0.05). MSI was detected in 13 GC. The number of MSI-H (MSI-High, > or = 2 loci), MSI-L (MSI-Low, only one locus), and MSS (microsatellite stable) were 9, 4 and 17, respectively. The number of low expression rates of COX-2, hMLH1 and hMSH2 in MSI-H were 6, 8 and 5, respectively. There were significant differences compared to that of MSS (P < 0.05).
    Conclusion: The results suggest that microsatellite instability pathway is probably involved in the carcinogenesis of gastric carcinoma, which is frequently accompanied by low expression of hMLH1 and hMSH2, and may be also by low expression of COX-2.
    MeSH term(s) Adaptor Proteins, Signal Transducing/biosynthesis ; Adaptor Proteins, Signal Transducing/genetics ; Cyclooxygenase 2/biosynthesis ; Cyclooxygenase 2/genetics ; Humans ; Microsatellite Repeats/genetics ; MutL Protein Homolog 1 ; MutL Proteins ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/genetics ; Nuclear Proteins/biosynthesis ; Nuclear Proteins/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; MLH1 protein, human ; Neoplasm Proteins ; Nuclear Proteins ; PMS1 protein, human ; Cyclooxygenase 2 (EC 1.14.99.1) ; MutL Protein Homolog 1 (EC 3.6.1.3) ; MutL Proteins (EC 3.6.1.3)
    Language Chinese
    Publishing date 2005-11
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603424-x
    ISSN 0253-3766
    ISSN 0253-3766
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