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  1. Article: Trends in research on the carbon footprint of higher education: A bibliometric analysis (2010–2019)

    Li, Zhaofeng / Chen, Zheng / Yang, Ningshu / Wei, Kaiyao / Ling, Zexin / Liu, Qinqi / Chen, Guofeng / Ye, Ben Haobin

    Journal of cleaner production. 2021 Mar. 20, v. 289

    2021  

    Abstract: Reducing carbon footprints is an important part of sustainable development. Although there has been increasing research attention to this topic, little is known about the status of research on the carbon footprint of higher education (CFHE). In this ... ...

    Abstract Reducing carbon footprints is an important part of sustainable development. Although there has been increasing research attention to this topic, little is known about the status of research on the carbon footprint of higher education (CFHE). In this study we examined the status of this field by identifying the key publication outlets and the most central researchers in terms of productivity and citations, common keywords and research directions, the world regions with the most active research, and changes in these metrics over the last decade. Journal articles and conference proceedings published from 2010 to 2019 (N = 283) were identified using the Web of Science Core Collection. Bibliometric analysis showed that the University of California System was the most productive organization during this period, and the United States (USA) was the most productive region of the world. The Journal of Cleaner Production (JCLP) was the most common outlet for publication. In some cases there were strong academic-cooperation relationships, notably the research groups headed by Thomas Wiedmann and Edgar Hertwich. Cluster analysis identified six clusters of keywords: life-cycle assessment, environmental performance and carbon management, greenhouse gas emissions, design, system, and sustainability.
    Keywords administrative management ; bibliometric analysis ; carbon ; carbon footprint ; cluster analysis ; design ; environmental performance ; greenhouse gas emissions ; higher education ; life cycle assessment ; research ; researchers ; sustainable development ; California
    Language English
    Dates of publication 2021-0320
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2020.125642
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Enantioselective Approach for Expanding the Three-Dimensional Space of Tetrahydroquinoline to Develop BET Bromodomain Inhibitors.

    Lespinasse, Marie-Ange / Wei, Kaiyao / Perrin, Justine / Winkler, Matthias / Hamaidia, Sieme / Leroy, Alexis / Macek Jilkova, Zuzana / Philouze, Christian / Marche, Patrice N / Petosa, Carlo / Govin, Jérôme / Emadali, Anouk / Wong, Yung-Sing

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 64, Page(s) e202202293

    Abstract: The pharmaceutical industry has a pervasive need for chiral specific molecules with optimal affinity for their biological targets. However, the mass production of such compounds is currently limited by conventional chemical routes, that are costly and ... ...

    Abstract The pharmaceutical industry has a pervasive need for chiral specific molecules with optimal affinity for their biological targets. However, the mass production of such compounds is currently limited by conventional chemical routes, that are costly and have an environmental impact. Here, we propose an easy access to obtain new tetrahydroquinolines, a motif found in many bioactive compounds, that is rapid and cost effective. Starting from simple raw materials, the procedure uses a proline-catalyzed Mannich reaction followed by the addition of BF
    MeSH term(s) Stereoisomerism ; Quinolines ; Antineoplastic Agents ; Catalysis
    Chemical Substances 1,2,3,4-tetrahydroquinoline (CCR50N1Z9G) ; Quinolines ; Antineoplastic Agents
    Language English
    Publishing date 2022-09-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202202293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding.

    Zhou, Yingsheng / Overhulse, Justin M / Dupper, Nathan J / Guo, Yanchun / Kashemirov, Boris A / Wei, Kaiyao / Govin, Jérôme / Petosa, Carlo / McKenna, Charles E

    Journal of computational chemistry

    2022  Volume 43, Issue 32, Page(s) 2121–2130

    Abstract: Novel agents to treat invasive fungal infections are urgently needed because the small number of established targets in pathogenic fungi makes the existing drug repertoire particularly vulnerable to the emergence of resistant strains. Recently, we ... ...

    Abstract Novel agents to treat invasive fungal infections are urgently needed because the small number of established targets in pathogenic fungi makes the existing drug repertoire particularly vulnerable to the emergence of resistant strains. Recently, we reported that Candida albicans Bdf1, a bromodomain and extra-terminal domain (BET) bromodomain with paired acetyl-lysine (AcK) binding sites (BD1 and BD2) is essential for fungal cell growth and that an imidazopyridine (1) binds to BD2 with selectivity versus both BD1 and human BET bromodomains. Bromodomain binding pockets contain a conserved array of structural waters. Molecular dynamics simulations now reveal that one water molecule is less tightly bound to BD2 than to BD1, explaining the site selectivity of 1. This insight is useful in the performance of ligand docking studies to guide design of more effective Bdf1 inhibitors, as illustrated by the design of 10 new imidazopyridine BD2 ligands 1a-j, for which experimental binding and site selectivity data are presented.
    MeSH term(s) Humans ; Candida albicans/metabolism ; Ligands ; Transcription Factors/metabolism ; Binding Sites
    Chemical Substances imidazopyridine ; Ligands ; Transcription Factors
    Language English
    Publishing date 2022-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1479181-X
    ISSN 1096-987X ; 0192-8651
    ISSN (online) 1096-987X
    ISSN 0192-8651
    DOI 10.1002/jcc.26997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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