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Article ; Online: Improvements in advanced hepatocellular carcinoma to repeat implementation of primary protocol after cancer progression occurs following sequential systemic therapy and a clinical trial: A case report.

Huang, Hongwei / Wei, Qiaoqiao / Leng, Chao / Wang, Hao / Mei, Bin

2024 Volume 103, Issue 19, Page(s) e38138

Abstract: Introduction: Systemic therapy is recommended for patients with advanced hepatocellular carcinoma (aHCC). However, drug resistance occurs over time when patients receive systemic therapy, resulting in cancer progression. Due to the lack of relevant ... ...

Abstract	Introduction: Systemic therapy is recommended for patients with advanced hepatocellular carcinoma (aHCC). However, drug resistance occurs over time when patients receive systemic therapy, resulting in cancer progression. Due to the lack of relevant clinical trials, optimizing subsequent treatments after cancer progression remains elusive. Patient concerns: A 52-year-old male patient presented with epigastric discomfort and fatigue for almost 1 month with a past history of chronic hepatitis B virus infection for 30 years. Diagnosis: Based on the patient's performance status, tumor status assessed by computed tomography, liver function, he was diagnosed with HCC at BCLC stage C. Interventions and outcomes: He first received transarterial chemoembolization (TACE) combined with sintilimab and lenvatinib as first-line treatment and experienced 10-month progression-free survival. After cancer progression, the patient participated in a clinical trial of ABSK-011, a novel fibroblast growth factor receptor 4 inhibitor, with a frustrating result. Then, the patient underwent TACE and received sintilimab plus lenvatinib again. Surprisingly, the tumor had a partial response, and the patient's serum alpha-fetoprotein returned to normal. Lessons: The combined treatment of TACE plus systemic therapy might be an appropriate subsequent treatment.
MeSH term(s)	Humans ; Male ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/therapy ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Middle Aged ; Disease Progression ; Quinolines/therapeutic use ; Chemoembolization, Therapeutic/methods ; Phenylurea Compounds/therapeutic use ; Phenylurea Compounds/administration & dosage ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Chemical Substances	lenvatinib (EE083865G2) ; Quinolines ; Phenylurea Compounds ; sintilimab (8FU7FQ8UPK) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-05-10
Publishing country	United States
Document type	Journal Article ; Case Reports
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000038138
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Article ; Online: Removal of Pb from Contaminated Kaolin by Pulsed Electrochemical Treatment Coupled with a Permeable Reactive Barrier: Tuning Removal Efficiency and Energy Consumption.

Zhang, Yinyin / Zang, Libin / Zhao, Yuyan / Wei, Qiaoqiao / Han, Jiangtao

Toxics

2023 Volume 11, Issue 12

Abstract: Lead contamination in soil has emerged as a significant environmental concern. Recently, pulse electrochemical treatment (PECT) has garnered substantial attention as an effective method for mitigating lead ions in low-permeability soils. However, the ... ...

Abstract	Lead contamination in soil has emerged as a significant environmental concern. Recently, pulse electrochemical treatment (PECT) has garnered substantial attention as an effective method for mitigating lead ions in low-permeability soils. However, the impact of varying pulse time gradients, ranging from seconds to hours, under the same pulse duty cycle on lead removal efficiency (LRE) and energy consumption in PECT has not been thoroughly investigated. In this study, a novel, modified PECT method is proposed, which couples PECT with a permeable reaction barrier (PRB) and adds acetic acid to the catholyte. A comprehensive analysis of LRE and energy consumption is conducted by transforming pulse time. The results show that the LREs achieved in these experiments were as follows: PCb-3 s (89.5%), PCb-1 m (91%), PCb-30 m (92.9%), and PCb-6 h (91.9%). Importantly, these experiments resulted in significant reductions in energy consumption, with decreases of 68.5%, 64.9%, 51.8%, and 47.4% compared to constant voltage treatments, respectively. It was observed that LRE improved with an increase in both pulse duration and voltage gradient, albeit with a corresponding rise in energy consumption. The results also revealed that corn straw biochar as a PRB could enhance LRE by 6.1% while adsorbing migrating lead ions. Taken together, the present data highlights the potential of modified PECT technology for remediation of lead-contaminated soil, which provides an optimal approach to achieve high LRE while minimizing energy consumption.
Language	English
Publishing date	2023-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11120961
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Article ; Online: Does green credit promote firm environmental performance? A new perspective of economic growth target constraints.

Shao, Xuelun / Gao, Ke / Wang, Tao / Zhang, Yifan / Wei, Qiaoqiao

Environmental science and pollution research international

2023 Volume 30, Issue 50, Page(s) 108617–108634

Abstract: Green credit encompasses financial instruments and services utilized to mitigate greenhouse gas emissions and facilitate adaptation to global climate change. Establishing a long-term stable green credit institution is crucial to promoting carbon ... ...

Abstract	Green credit encompasses financial instruments and services utilized to mitigate greenhouse gas emissions and facilitate adaptation to global climate change. Establishing a long-term stable green credit institution is crucial to promoting carbon abatement goals. This study uses the difference-in-difference (DID) model to discuss the impact of green credit policy (GCP) on environmental performance based on the China industrial enterprise data. Our results show that GCP inhibits the pollution emissions and improve firm environmental performance. This improvement effect is attributed to a reduction in production scale, and financing constraints. Moreover, GCP increases the firms' exit risk from market and promotes the technological innovation of incumbent firms. Economic growth target constraints trigger a positive moderation role in the implementation of GCP. Heterogeneity results show that such improvement effect is more pronounced in state-owned firm, large-scale firms, and high R&D intensity firms. Importantly, our findings also suggest the environmental monitoring effect of green credit is dependent on the institutional quality. Only in a sound market environment can GCP effectively improve firm environmental performance. Finally, we propose to build a systematic incentives and constraints mechanism to achieve the sustainable development. The conclusions of this paper provide empirical evidence and policy implications for the implementation of GCP.
MeSH term(s)	Economic Development ; Carbon ; China ; Climate ; Climate Change ; Environmental Policy
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2023-09-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-30011-y
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Article ; Online: Assessing the performance and economic viability of solar home systems: A way forward towards clean energy exploration and consumption

Sun, Bohan / Gao, Ke / Lichuanjushi / Wei, Qiaoqiao / Wang, Hui

Renewable Energy. 2023 May, v. 208 p.409-419

2023

Abstract: Energy is an essential source of global economic expansion since it is related to fundamental generation and usage. In this context, solar home systems (SHS) are advantageous in two dimensions: reducing energy expenses and satisfying energy requirements. ...

Abstract	Energy is an essential source of global economic expansion since it is related to fundamental generation and usage. In this context, solar home systems (SHS) are advantageous in two dimensions: reducing energy expenses and satisfying energy requirements. This research intends to assess the effectiveness of implementing SHS in the economic performance of China's small and medium-sized enterprises. Moreover, we investigate the moderating impact of knowledge of SHS between the elements of a deployment of SHS and the economic performance of small and medium-sized enterprises. The data was collected from 520 respondents, and the structural equation modeling (SEM) method was employed for data analysis. The findings showed that cost-efficient energy from SHSs has a continuous and considerable relationship with the economic performance of small and medium enterprises. Likewise, knowledge of SHS moderates significantly the links between efficient energy supply via SHS, the durability of SHS, and the economic performance of small and medium-sized enterprises. Further improvement of the economic performance of small and medium-sized enterprises is required by a greater emphasis on SHS, as shown by these results, which serve as good guidance for those who design regulations.
Keywords	clean energy ; cost effectiveness ; durability ; economic performance ; economic sustainability ; energy ; equations ; renewable energy sources ; China ; Solar house system ; Durability of solar home system ; Efficient energy supply ; Cost-efficient solar home system ; Renewable energy
Language	English
Dates of publication	2023-05
Size	p. 409-419.
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2023.03.009
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Article ; Online: Environmental contamination and health risk assessment of potentially toxic trace metal elements in soils near gold mines – A global meta-analysis

Hou, Yaru / Zhao, Yuyan / Lu, Jilong / Wei, Qiaoqiao / Zang, Libin / Zhao, Xinyun

Environmental Pollution. 2023 Aug., v. 330 p.121803-

2023

Abstract: Gold mining is the most important anthropogenic source of heavy metal emissions into the environment. Researchers have been aware of the environmental impacts of gold mining activities and have conducted studies in recent years, but they have only ... ...

Abstract	Gold mining is the most important anthropogenic source of heavy metal emissions into the environment. Researchers have been aware of the environmental impacts of gold mining activities and have conducted studies in recent years, but they have only selected one gold mining site and collected soil samples in its vicinity for analysis, which does not reflect the combined impact of all gold mining activities on the concentration of potentially toxic trace elements (PTES) in nearby soils at a global scale. In this study, 77 research papers from 24 countries were collected from 2001 to 2022, and a new dataset was developed to provide a comprehensive study of the distribution characteristics, contamination characteristics, and risk assessment of 10 PTEs (As, Cd, Cr, Co, Cu, Hg, Mn, Ni, Pb, and Zn) in soils near the deposits. The results show that the average levels of all 10 elements are higher than the global background values and are at different levels of contamination, with As, Cd, and Hg at strong contamination levels and serious ecological risks. As and Hg contribute to a greater non-carcinogenic risk to both children and adults in the vicinity of the gold mine, and the carcinogenic risks of As, Cd, and Cu are beyond the acceptable range. Gold mining on a global scale has already caused serious impacts on nearby soils and should be given adequate attention. Timely heavy metal treatment and landscape restoration of extracted gold mines and environmentally friendly approaches such as bio-mining of unexplored gold mines where adequate protection is available are of great significance.
Keywords	anthropogenic activities ; carcinogenicity ; data collection ; gold ; health effects assessments ; heavy metals ; landscape restoration ; meta-analysis ; pollution ; risk ; risk assessment ; soil ; trace elements ; Potentially toxic trace elements (PTES) ; Gold mine ; Health risk
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121803
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Article ; Online: A new desorption method of polyurethane foam for the determination of gold and a comparative study on four desorption methods based on meta-analysis.

Hou, Yaru / Lu, Jilong / Li, Mao / Wei, Qiaoqiao / Fan, Yuchao / Wang, Yongzhi

RSC advances

2023 Volume 13, Issue 18, Page(s) 12355–12360

Abstract: Accurate determination of gold in geological samples is an important prerequisite and guarantee for studying geological problems. There are many methods for digestion and enrichment of gold among which polyurethane foam (PUF) enrichment after aqua regia ... ...

Abstract	Accurate determination of gold in geological samples is an important prerequisite and guarantee for studying geological problems. There are many methods for digestion and enrichment of gold among which polyurethane foam (PUF) enrichment after aqua regia digestion is the most commonly used in the experiments. A new method to help the relief of gold from the PUF was put forward in this study, and it was applied to four certified reference materials (CRMs) together with three previously used methods, and the optimal extraction and enrichment conditions were determined through experiments. The four methods were compared by meta-analysis, and the thiourea liberation method was superior to the other three methods because of its simple operation and high accuracy. Out of consideration for the incomplete adsorption of gold in the solution by only one piece of PUF, repetitive adsorption of gold with a second and a third piece of PUF in the solution was proposed in this study. Results show that the gold content obtained by secondary and tertiary adsorption accounts for 11.03% of the total content, and the highest can reach 20.74%. When the third adsorption was carried out, the gold content in several samples was below the detection limit. Therefore, repeated adsorption of gold in the solution is necessary, and three times of adsorption is necessary.
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra00118k
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Article ; Online: Organic Small-Molecule Electrodes: Emerging Organic Composite Materials in Supercapacitors for Efficient Energy Storage.

He, Yuanyuan / Wei, Qiaoqiao / An, Ning / Meng, Congcong / Hu, Zhongai

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 22

Abstract: Organic small molecules with electrochemically active and reversible redox groups are excellent candidates for energy storage systems due to their abundant natural origin and design flexibility. However, their practical application is generally limited ... ...

Abstract	Organic small molecules with electrochemically active and reversible redox groups are excellent candidates for energy storage systems due to their abundant natural origin and design flexibility. However, their practical application is generally limited by inherent electrical insulating properties and high solubility. To achieve both high energy density and power density, organic small molecules are usually immobilized on the surface of a carbon substrate with a high specific surface area and excellent electrical conductivity through non-covalent interactions or chemical bonds. The resulting composite materials are called organic small-molecule electrodes (OMEs). The redox reaction of OMEs occurs near the surface with fast kinetic and higher utilization compared to storing charge through diffusion-limited Faraday reactions. In the past decade, our research group has developed a large number of novel OMEs with different connections or molecular skeletons. This paper introduces the latest development of OMEs for efficient energy storage. Furthermore, we focus on the design motivation, structural advantages, charge storage mechanism, and various electrode parameters of OMEs. With small organic molecules as the active center, OMEs can significantly improve the energy density at low molecular weight through proton-coupled electron transfer, which is not limited by lattice size. Finally, we outline possible trends in the rational design of OMEs toward high-performance supercapacitors.
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27227692
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Article ; Online: Environmental contamination and health risk assessment of potentially toxic trace metal elements in soils near gold mines - A global meta-analysis.

Hou, Yaru / Zhao, Yuyan / Lu, Jilong / Wei, Qiaoqiao / Zang, Libin / Zhao, Xinyun

Environmental pollution (Barking, Essex : 1987)

2023 Volume 330, Page(s) 121803

Abstract	Gold mining is the most important anthropogenic source of heavy metal emissions into the environment. Researchers have been aware of the environmental impacts of gold mining activities and have conducted studies in recent years, but they have only selected one gold mining site and collected soil samples in its vicinity for analysis, which does not reflect the combined impact of all gold mining activities on the concentration of potentially toxic trace elements (PTES) in nearby soils at a global scale. In this study, 77 research papers from 24 countries were collected from 2001 to 2022, and a new dataset was developed to provide a comprehensive study of the distribution characteristics, contamination characteristics, and risk assessment of 10 PTEs (As, Cd, Cr, Co, Cu, Hg, Mn, Ni, Pb, and Zn) in soils near the deposits. The results show that the average levels of all 10 elements are higher than the global background values and are at different levels of contamination, with As, Cd, and Hg at strong contamination levels and serious ecological risks. As and Hg contribute to a greater non-carcinogenic risk to both children and adults in the vicinity of the gold mine, and the carcinogenic risks of As, Cd, and Cu are beyond the acceptable range. Gold mining on a global scale has already caused serious impacts on nearby soils and should be given adequate attention. Timely heavy metal treatment and landscape restoration of extracted gold mines and environmentally friendly approaches such as bio-mining of unexplored gold mines where adequate protection is available are of great significance.
MeSH term(s)	Adult ; Child ; Humans ; Gold/analysis ; Soil ; Cadmium/analysis ; Soil Pollutants/analysis ; Environmental Monitoring/methods ; Metals, Heavy/analysis ; Mercury/analysis ; Trace Elements/analysis ; Risk Assessment ; China
Chemical Substances	Gold (7440-57-5) ; Soil ; Cadmium (00BH33GNGH) ; Soil Pollutants ; Metals, Heavy ; Mercury (FXS1BY2PGL) ; Trace Elements
Language	English
Publishing date	2023-05-13
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121803
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Article: Geochemical study of the Ashele Copper-Zinc Deposit using portable X-ray fluorescence spectrometry based on matrix effect correction, Northwest China

Guo, Jinke / Lu, Jilong / Chen, Zesu / Zhao, Xinyun / Wei, Qiaoqiao / Fan, Yuchao / Lan, Tian

Applied geochemistry. 2022 Nov., v. 146

2022

Abstract: Because the Ashele Cu–Zn deposit is located deep below and core samples are difficult to obtain, portable X-ray fluorescence spectroscopy (pXRF), which can be used for rapid and non-destructive analysis in the field, was chosen as the testing instrument. ...

Abstract	Because the Ashele Cu–Zn deposit is located deep below and core samples are difficult to obtain, portable X-ray fluorescence spectroscopy (pXRF), which can be used for rapid and non-destructive analysis in the field, was chosen as the testing instrument. However, the testing accuracy and precision of elements are significantly affected by matrix effects. In this study, 170 samples from the deposit were measured, and the data was corrected using the matrix effect correction (MEC) method instead of the simple linear regression (SLR) method to enhance the data quality, followed by geochemical and correspondence analysis of the data. The results show that calibration data corrected by the MEC method was of greater quality than those corrected by the SLR method, particularly for elements such as Co, Cr, Mo, Sn, Ba, and W. The Ashele Cu–Zn deposit is formed in multi-phase hydrothermal superposition mineralization and is rich in Mg, Fe, and S but deficient in Al, Si, K, and Ca. The main mineralized zones are located at 400–500 m and 200–300 m. Cu, Zn, and Pb are significantly enriched in the mineralization, with the axial zoning sequence of the primary halo (Pb–Zn–Mn–As–Cu–Cd–Sn–Ba–Bi–Sb–Co–W–Mo) showing inverse zoning. The correspondence analysis results also show a clear distinction between non-metallogenesis and metallogenesis. Also, the application of pXRF based on MEC in the Ashele Cu–Zn deposit is effective and can be extended to other types of deposit studies.
Keywords	X-ray fluorescence spectroscopy ; correspondence analysis ; data quality ; geochemistry ; mineralization ; nondestructive methods ; regression analysis ; China
Language	English
Dates of publication	2022-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1499242-5
ISSN	0883-2927
ISSN	0883-2927
DOI	10.1016/j.apgeochem.2022.105461
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Article ; Online: COF-Based Electrodes with Vertically Supported Tentacle Array for Ultrahigh Stability Flexible Energy Storage.

He, Yuanyuan / An, Ning / Meng, Congcong / Xiao, Liangzhikun / Wei, Qiaoqiao / Zhou, Yi / Yang, Yuying / Li, Zhimin / Hu, Zhongai

ACS applied materials & interfaces

2022

Abstract: As an emerging porous crystal polymer, covalent organic frameworks (COFs) possess unique characteristics, such as high porosity, excellent stability, diverse topologies, designable open channels, and functional tunability. However, limited by the solid ... ...

Abstract	As an emerging porous crystal polymer, covalent organic frameworks (COFs) possess unique characteristics, such as high porosity, excellent stability, diverse topologies, designable open channels, and functional tunability. However, limited by the solid powder form, most COFs display low active site utilization and weak binding force with the current collector. In this pioneering research, we integrate redox-active COFs onto carbon fiber surfaces (AC-COFs) via strong covalent bridging. The 2,6-diaminoanthraquinone (DAAQ) pillars embedded on the carbon fiber surface are the key to precisely controlling the growth direction of COFs. The obtained tentacle-like array vertically supported on the surface of the carbon fiber can effectively induce charge transfer and prevent COFs from aggregating/collapsing. The strong covalent coupling and increase of accessible active sites contributed to the high specific capacitance of AC-COFs electrode (1034 mF cm
Language	English
Publishing date	2022-12-16
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c15092
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