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  1. Article ; Online: HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation.

    Wei, Wendi / Chen, Weida / He, Naifeng

    Journal of translational medicine

    2021  Volume 19, Issue 1, Page(s) 258

    Abstract: Background: Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this study aiming at exploring the ... ...

    Abstract Background: Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this study aiming at exploring the effect of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.
    Methods: An asthmatic rat model was induced by ovalbumin (OVA) irrigation, and determined HDAC4, KLF5, Slug, and CXCL12 expression in the lung tissues by RT-qPCR and Western blot assay. OVA was also used to induce a cell model of asthma in human BEAS-2B and HBE135-E6E7bronchial epithelial cells. The airway hyperresponsiveness (AHR), and expression of inflammatory cytokines in model mice were examined using methacholine challenge test and ELISA. The biological behaviors were measured in asthma model bronchial smooth muscle cells (BSMCs) following loss- and gain- function approaches. The interactions between HDAC4, KLF5, Slug, and CXCL12 were also detected by IP assay, dual luciferase gene reporter assay, and ChIP.
    Results: HDAC4 was upregulated in lung tissues of OVA-induced asthmatic mice, and inhibition of HDAC4 alleviated the airway inflammation and remodeling. HDAC4 increased KLF5 transcriptional activity through deacetylation; deacetylated KLF5 bound to the promoter of Slug and transcriptionally upregulated Slug expression, which in turn increased the expression of CXCL12 to promote the inflammation in bronchial epithelial cells and thus induce the proliferation and migration of BSMCs.
    Conclusion: Collectively, HDAC4 deacetylates KLF5 to upregulate Slug and CXCL12, thereby causing airway remodeling and facilitating progression of asthma.
    MeSH term(s) Airway Remodeling ; Animals ; Asthma/genetics ; Chemokines, CXC ; Disease Models, Animal ; Histone Deacetylases ; Kruppel-Like Transcription Factors/genetics ; Ligands ; Lung ; Mice ; Mice, Inbred BALB C ; Ovalbumin ; Rats ; Repressor Proteins
    Chemical Substances Chemokines, CXC ; Klf5 protein, mouse ; Kruppel-Like Transcription Factors ; Ligands ; Repressor Proteins ; Ovalbumin (9006-59-1) ; HDAC4 protein, human (EC 3.5.1.98) ; HDAC4 protein, rat (EC 3.5.1.98) ; Hdac5 protein, mouse (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2021-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-021-02812-7
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  2. Article ; Online: Influence of microplastics on the availability of antibiotics in soils.

    Ren, Suyu / Xia, Yuxiang / Jin, Xiaojie / Sun, Dan / Luo, Dan / Wei, Wendi / Yang, Qixia / Ding, Jing / Lv, Min / Chen, Lingxin

    The Science of the total environment

    2024  Volume 924, Page(s) 171514

    Abstract: Microplastics (MPs) and antibiotics, as two major types of emerging pollutants, inevitably coexist in the soil environment due to agricultural film residue, sewage irrigation and sludge application. However, the impact of MPs on antibiotic availability ... ...

    Abstract Microplastics (MPs) and antibiotics, as two major types of emerging pollutants, inevitably coexist in the soil environment due to agricultural film residue, sewage irrigation and sludge application. However, the impact of MPs on antibiotic availability in soils with varying characteristics has not been extensively studied. Therefore, in this study, an interference experiment was conducted using three types of MPs (polyethylene (PE), polyvinyl chloride (PVC) and polypropylene (PP)) in red soil, paddy soil and cinnamon soil. The available antibiotics in soils were evaluated using diffusive gradients in thin-films (DGT). Results showed that MPs had a significant impact on the amount of antibiotics adsorbed on soil solid (C
    MeSH term(s) Soil/chemistry ; Microplastics ; Plastics ; Anti-Bacterial Agents ; Soil Pollutants/analysis ; Environmental Pollutants ; Sewage
    Chemical Substances Soil ; Microplastics ; Plastics ; Anti-Bacterial Agents ; Soil Pollutants ; Environmental Pollutants ; Sewage
    Language English
    Publishing date 2024-03-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171514
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  3. Article ; Online: Network pharmacology combined with molecular docking and experimental validation to explore the potential mechanism of

    Wei, Wendi / Wu, Shaofeng / Zhou, Chenxing / Chen, Tianyou / Zhu, Jichong / Feng, Sitan / Zhan, Xinli / Liu, Chong

    Annals of medicine

    2023  Volume 55, Issue 2, Page(s) 2287193

    Abstract: Background: Cinnamomi ramulus: Methods: In this study, various public databases and online tools were employed to gather information on the compounds of : Results: The network analysis identified 2-Methoxycinnamaldehyde, cinnamaldehyde, and 2- ... ...

    Abstract Background: Cinnamomi ramulus
    Methods: In this study, various public databases and online tools were employed to gather information on the compounds of
    Results: The network analysis identified 2-Methoxycinnamaldehyde, cinnamaldehyde, and 2-Hydroxycinnamaldehyde as the major effective compounds present in
    Conclusions: This study provides insights into the effective compounds, core targets, and potential mechanisms of action of
    MeSH term(s) Humans ; Molecular Docking Simulation ; Network Pharmacology ; Matrix Metalloproteinase 9 ; Cyclooxygenase 2 ; Spondylitis, Ankylosing/drug therapy ; Toll-Like Receptor 4
    Chemical Substances Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Toll-Like Receptor 4
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2287193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 680: Show issues Location:
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  4. Article ; Online: Prediction model for spinal cord injury in spinal tuberculosis patients using multiple machine learning algorithms: a multicentric study.

    Feng, Sitan / Wang, Shujiang / Liu, Chong / Wu, Shaofeng / Zhang, Bin / Lu, Chunxian / Huang, Chengqian / Chen, Tianyou / Zhou, Chenxing / Zhu, Jichong / Chen, Jiarui / Xue, Jiang / Wei, Wendi / Zhan, Xinli

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 7691

    Abstract: Spinal cord injury (SCI) is a prevalent and serious complication among patients with spinal tuberculosis (STB) that can lead to motor and sensory impairment and potentially paraplegia. This research aims to identify factors associated with SCI in STB ... ...

    Abstract Spinal cord injury (SCI) is a prevalent and serious complication among patients with spinal tuberculosis (STB) that can lead to motor and sensory impairment and potentially paraplegia. This research aims to identify factors associated with SCI in STB patients and to develop a clinically significant predictive model. Clinical data from STB patients at a single hospital were collected and divided into training and validation sets. Univariate analysis was employed to screen clinical indicators in the training set. Multiple machine learning (ML) algorithms were utilized to establish predictive models. Model performance was evaluated and compared using receiver operating characteristic (ROC) curves, area under the curve (AUC), calibration curve analysis, decision curve analysis (DCA), and precision-recall (PR) curves. The optimal model was determined, and a prospective cohort from two other hospitals served as a testing set to assess its accuracy. Model interpretation and variable importance ranking were conducted using the DALEX R package. The model was deployed on the web by using the Shiny app. Ten clinical characteristics were utilized for the model. The random forest (RF) model emerged as the optimal choice based on the AUC, PRs, calibration curve analysis, and DCA, achieving a test set AUC of 0.816. Additionally, MONO was identified as the primary predictor of SCI in STB patients through variable importance ranking. The RF predictive model provides an efficient and swift approach for predicting SCI in STB patients.
    MeSH term(s) Humans ; Prospective Studies ; Tuberculosis, Spinal/complications ; Spinal Cord Injuries/complications ; Algorithms ; Machine Learning ; Retrospective Studies
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56711-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: To infer the probability of cervical ossification of the posterior longitudinal ligament and explore its impact on cervical surgery.

    Zhu, Jichong / Lu, Qing / Zhan, Xinli / Huang, Shengsheng / Zhou, Chenxing / Wu, Shaofeng / Chen, Tianyou / Yao, Yuanlin / Liao, Shian / Yu, Chaojie / Fan, Binguang / Yang, Zhenwei / Gu, Wenfei / Wang, Yihan / Wei, Wendi / Liu, Chong

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9816

    Abstract: The ossification of the posterior longitudinal ligament (OPLL) in the cervical spine is commonly observed in degenerative changes of the cervical spine. Early detection of cervical OPLL and prevention of postoperative complications are of utmost ... ...

    Abstract The ossification of the posterior longitudinal ligament (OPLL) in the cervical spine is commonly observed in degenerative changes of the cervical spine. Early detection of cervical OPLL and prevention of postoperative complications are of utmost importance. We gathered data from 775 patients who underwent cervical spine surgery at the First Affiliated Hospital of Guangxi Medical University, collecting a total of 84 variables. Among these patients, 144 had cervical OPLL, while 631 did not. They were randomly divided into a training cohort and a validation cohort. Multiple machine learning (ML) methods were employed to screen the variables and ultimately develop a diagnostic model. Subsequently, we compared the postoperative outcomes of patients with positive and negative cervical OPLL. Initially, we compared the advantages and disadvantages of various ML methods. Seven variables, namely Age, Gender, OPLL, AST, UA, BMI, and CHD, exhibited significant differences and were used to construct a diagnostic nomogram model. The area under the curve (AUC) values of this model in the training and validation groups were 0.76 and 0.728, respectively. Our findings revealed that 69.2% of patients who underwent cervical OPLL surgery eventually required elective anterior surgery, in contrast to 86.8% of patients who did not have cervical OPLL. Patients with cervical OPLL had significantly longer operation times and higher postoperative drainage volumes compared to those without cervical OPLL. Interestingly, preoperative cervical OPLL patients demonstrated significant increases in mean UA, age, and BMI. Furthermore, 27.1% of patients with cervical anterior longitudinal ligament ossification (OALL) also exhibited cervical OPLL, whereas this occurrence was only observed in 6.9% of patients without cervical OALL. We developed a diagnostic model for cervical OPLL using the ML method. Our findings indicate that patients with cervical OPLL are more likely to undergo posterior cervical surgery, and they exhibit elevated UA levels, higher BMI, and increased age. The prevalence of cervical anterior longitudinal ligament ossification was also significantly higher among patients with cervical OPLL.
    MeSH term(s) Humans ; Longitudinal Ligaments/surgery ; Osteogenesis ; China ; Ossification of Posterior Longitudinal Ligament/surgery ; Ossification of Posterior Longitudinal Ligament/complications ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Probability ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2023-06-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36992-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring the causal relationship between inflammatory cytokines and inflammatory arthritis: A Mendelian randomization study.

    Pan, Shixin / Wu, Shaofeng / Wei, Yating / Liu, Jingjing / Zhou, Chenxing / Chen, Tianyou / Zhu, Jichong / Tan, Weiming / Huang, Chengqian / Feng, Sitan / Zhang, Bin / Wei, Wendi / Zhan, Xinli / Liu, Chong

    Cytokine

    2023  Volume 173, Page(s) 156446

    Abstract: Objectives: Previous studies have reported an association between inflammatory cytokines and inflammatory arthritis, including Ankylosing spondylitis (AS), rheumatoid arthritis (RA), and psoriatic arthritis (PsA). This study aims to explore the causal ... ...

    Abstract Objectives: Previous studies have reported an association between inflammatory cytokines and inflammatory arthritis, including Ankylosing spondylitis (AS), rheumatoid arthritis (RA), and psoriatic arthritis (PsA). This study aims to explore the causal relationship between inflammatory cytokines and AS, RA, and PsA using Mendelian randomization (MR).
    Methods: We conducted a bidirectional two-sample MR analysis using genetic summary data from a publicly available genome-wide association study (GWAS) that included 41 genetic variations of inflammatory cytokines, as well as genetic variant data for AS, RA, and PsA from the FinnGen consortium. The main analysis method used was Inverse variance weighted (IVW) to investigate the causal relationship between exposure and outcome. Additionally, other methods such as MR Egger, weighted median (WM), simple mode, and weighted mode were employed to strengthen the final results. Sensitivity analysis was also performed to ensure the reliability of the findings.
    Results: The results showed that macrophage colony-stimulating factor (MCSF) was associated with an increased risk of AS (OR = 1.163, 95 % CI = 1.016-1.33, p = 0.028). Conversely, high levels of TRAIL and beta nerve growth factor (β-NGF) were associated with a decreased risk of AS (OR = 0.892, 95 % CI = 0.81-0.982, p = 0.002; OR = 0.829, 95 % CI = 0.696-0.988, p = 0.036). Four inflammatory cytokines were found to be associated with an increased risk of PsA: vascular endothelial growth factor (VEGF) (OR = 1.161, 95 % CI = 1.057-1.275, p = 0.002); Interleukin 12p70 (IL12p70) (OR = 1.189, 95 % CI = 1.049-1.346, p = 0.007); IL10 (OR = 1.216, 95 % CI = 1.024-1.444, p = 0.026); IL13 (OR = 1.159, 95 % CI = 1.05-1.28, p = 0.004). Interleukin 1 receptor antagonist (IL-1rα) was associated with an increased risk of seropositive RA (OR = 1.181, 95 % CI = 1.044-1.336, p = 0.008). Similarly, genetic susceptibility to inflammatory arthritis was found to be causally associated with multiple inflammatory cytokines. Lastly, the sensitivity analysis supported the robustness of these findings.
    Conclusions: This study provides additional insights into the relationship between inflammatory cytokines and inflammatory arthritis, and may offer new clues for the etiology, diagnosis, and treatment of inflammatory arthritis.
    MeSH term(s) Humans ; Cytokines/genetics ; Arthritis, Psoriatic/genetics ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Reproducibility of Results ; Vascular Endothelial Growth Factor A ; Arthritis, Rheumatoid/genetics ; Spondylitis, Ankylosing/genetics
    Chemical Substances Cytokines ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156446
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2840: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Monascustin, an Unusual γ-Lactam from Red Yeast Rice

    Wei, Wendi / Lin Sheng / Chen Minghua / Liu Tianxi / Wang Ali / Li Jinjie / Guo Qinglan / Shang Xiaoya

    Journal of natural products. 2017 Jan. 27, v. 80, no. 1

    2017  

    Abstract: Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. ...

    Abstract Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.
    Keywords Monascus purpureus ; X-ray diffraction ; amino acids ; biochemical pathways ; derivatization ; ethanol ; histone deacetylase ; red yeast rice ; rice ; spectral analysis
    Language English
    Dates of publication 2017-0127
    Size p. 201-204.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021%2Facs.jnatprod.6b00493
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Structure elucidation and NMR assignments of two unusual isomeric aromatic monacolin analogs from Monascus purpureus.

    Li, Bin / Wei, Wendi / Luan, Na / Li, Jinjie / Lao, Wenyan / Zhang, Weiku / Shang, Xiaoya

    Magnetic resonance in chemistry : MRC

    2015  Volume 53, Issue 3, Page(s) 233–236

    MeSH term(s) Circular Dichroism ; Isomerism ; Magnetic Resonance Spectroscopy/methods ; Molecular Structure ; Monascus/chemistry ; Naphthalenes/chemistry ; Spectrophotometry, Ultraviolet
    Chemical Substances Naphthalenes
    Language English
    Publishing date 2015-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1475029-6
    ISSN 1097-458X ; 0749-1581
    ISSN (online) 1097-458X
    ISSN 0749-1581
    DOI 10.1002/mrc.4162
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  9. Article ; Online: Monascustin, an Unusual γ-Lactam from Red Yeast Rice.

    Wei, Wendi / Lin, Sheng / Chen, Minghua / Liu, Tianxi / Wang, Ali / Li, Jinjie / Guo, Qinglan / Shang, Xiaoya

    Journal of natural products

    2017  Volume 80, Issue 1, Page(s) 201–204

    Abstract: Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. ... ...

    Abstract Monascustin (1), an unusual γ-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.
    MeSH term(s) Biological Products/chemistry ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/isolation & purification ; Enzyme Inhibitors/pharmacology ; Fermentation ; Histone Deacetylases/chemistry ; Histone Deacetylases/drug effects ; Lactams/chemistry ; Lactams/isolation & purification ; Lactams/pharmacology ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Monascus/chemistry
    Chemical Substances Biological Products ; Enzyme Inhibitors ; Lactams ; monascustin ; red yeast rice ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2017-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.6b00493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Four new taraxastane-type triterpenoic acids from Cirsium setosum.

    Luan, Na / Wei, Wen-Di / Wang, Ali / Wu, Xiu-Li / Qi, Yan / Li, Jin-Jie / Zheng, Jian-Quan / Shang, Xiao-Ya

    Journal of Asian natural products research

    2016  Volume 18, Issue 11, Page(s) 1015–1023

    Abstract: Four new taraxastane-type triterpenoids acids 3β,22α-dihydroxy-20-taraxasten-30-oic acid (1), 3β-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22α-hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were ... ...

    Abstract Four new taraxastane-type triterpenoids acids 3β,22α-dihydroxy-20-taraxasten-30-oic acid (1), 3β-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22α-hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments ((1)H-(1)HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9 μM.
    MeSH term(s) Cirsium/chemistry ; Drugs, Chinese Herbal/chemistry ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Triterpenes/pharmacology
    Chemical Substances Drugs, Chinese Herbal ; Triterpenes
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2016.1217519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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