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  1. Article ; Online: Lewis-acid-catalyzed phosphorylation of alcohols.

    Wang, Xiao-Hong / Liu, Xuan / Xue, Ya-Wen / Wang, Yan-Bin / Wei, Xiao-Hong / Su, Qiong

    RSC advances

    2024  Volume 14, Issue 6, Page(s) 3757–3760

    Abstract: An efficient method has been developed for reacting dialkyl H-phosphonates or diarylphosphine oxides with alcohols for constructing C-P bonds. This reaction was catalyzed by Lewis acid and involved nucleophilic substitution. A series of ... ...

    Abstract An efficient method has been developed for reacting dialkyl H-phosphonates or diarylphosphine oxides with alcohols for constructing C-P bonds. This reaction was catalyzed by Lewis acid and involved nucleophilic substitution. A series of diphenylphosphonates and diphenylphosphine oxides were obtained, from the phosphorylation of alcohols, with good-to-excellent yields.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08214h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Pharmacological research progress of five classical prescriptions in treatment of chronic heart failure].

    Chu, Xin-Yu / Wei, Xiao-Hong / Wu, Xue-Fen / Chen, Jie / Xia, Huan / Xia, Gui-Yang / Lin, Sheng / Shang, Hong-Cai

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2024  Volume 48, Issue 23, Page(s) 6324–6333

    Abstract: Chronic heart failure(CHF) is a comprehensive clinical syndrome caused by multiple factors that result in structural and/or functional abnormalities of the heart, leading to impaired ventricular contraction and/or relaxation functions. This medical ... ...

    Abstract Chronic heart failure(CHF) is a comprehensive clinical syndrome caused by multiple factors that result in structural and/or functional abnormalities of the heart, leading to impaired ventricular contraction and/or relaxation functions. This medical condition represents the final stage of various cardiovascular diseases. In the treatment of CHF, multiple clinical studies have demonstrated the benefits of using traditional Chinese medicine(TCM) to control oxidative stress, inflammation, and apoptosis, thereby delaying ventricular remodeling and reducing myocardial fibrosis. In this study, common TCM syndromes in the diagnosis and treatment of CHF in recent years were reviewed and summarized. Five common treatment methods including benefiting Qi and activating blood circulation, enhancing Qi and nourishing Yin, warming Yang for diuresis, eliminating phlegm and dampness, rescuing from collapse by restoring Yang, and corresponding classic prescriptions in prevention and treatment of CHF were concluded under the guidance of TCM syndrome differentiation thinking. Meanwhile, research progress on the modern pharmacological effects of these classic prescriptions was systematically discussed, so as to establish a unique treatment system for CHF by classic prescriptions under the guidance of TCM syndrome differentiation theory and provide innovative diagnosis and treatment strategies for clinical CHF.
    MeSH term(s) Humans ; Medicine, Chinese Traditional ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Chronic Disease ; Syndrome
    Language Chinese
    Publishing date 2024-01-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230719.201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: (±)-Yanhusuomide A, a pair of ornithine-fused benzylisoquinoline enantiomers from Corydalis yanhusuo.

    Wang, Ling-Yan / Xia, Gui-Yang / Xia, Huan / Wei, Xiao-Hong / Lin, Sheng

    Bioorganic chemistry

    2023  Volume 133, Page(s) 106407

    Abstract: Yanhusuomide A (1), a novel enantiomeric pair of ornithine-fused benzylisoquinoline, were characterized from the dried tubers of Corydalis yanhusuo, along with a biogenetically related intermediate oblongine (2). Yanhusuomide A features an ... ...

    Abstract (±)-Yanhusuomide A (1), a novel enantiomeric pair of ornithine-fused benzylisoquinoline, were characterized from the dried tubers of Corydalis yanhusuo, along with a biogenetically related intermediate oblongine (2). Yanhusuomide A features an unprecedented skeleton based on a benzylisoquinoline coupled with an ornithine derivative to form a rare 5,6-dihydro-4H-pyrido[3,4,5-de]quinazoline motif. Plausible biosynthetic pathway of 1 was proposed, and (±)-yanhusuomide A (1) presented potential inhibitory bioactivity against acetylcholinesterase (AChE) with IC
    MeSH term(s) Acetylcholinesterase ; Benzylisoquinolines/chemistry ; Corydalis/chemistry ; Molecular Docking Simulation ; Plant Tubers/chemistry
    Chemical Substances Acetylcholinesterase (EC 3.1.1.7) ; Benzylisoquinolines
    Language English
    Publishing date 2023-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Development and validation of a novel 3-gene prognostic model for pancreatic adenocarcinoma based on ferroptosis-related genes.

    Yang, Jihua / Wei, XiaoHong / Hu, Fang / Dong, Wei / Sun, Liao

    Cancer cell international

    2022  Volume 22, Issue 1, Page(s) 21

    Abstract: Background: Molecular markers play an important role in predicting clinical outcomes in pancreatic adenocarcinoma (PAAD) patients. Analysis of the ferroptosis-related genes may provide novel potential targets for the prognosis and treatment of PAAD.: ... ...

    Abstract Background: Molecular markers play an important role in predicting clinical outcomes in pancreatic adenocarcinoma (PAAD) patients. Analysis of the ferroptosis-related genes may provide novel potential targets for the prognosis and treatment of PAAD.
    Methods: RNA-sequence and clinical data of PAAD was downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) public databases. The PAAD samples were clustered by a non-negative matrix factorization (NMF) algorithm. The differentially expressed genes (DEGs) between different subtypes were used by "limma_3.42.2" package. The R software package clusterProfiler was used for functional enrichment analysis. Then, a multivariate Cox proportional and LASSO regression were used to develop a ferroptosis-related gene signature for pancreatic adenocarcinoma. A nomogram and corrected curves were constructed. Finally, the expression and function of these signature genes were explored by qRT-PCR, immunohistochemistry (IHC) and proliferation, migration and invasion assays.
    Results: The 173 samples were divided into 3 categories (C1, C2, and C3) and a 3-gene signature model (ALOX5, ALOX12, and CISD1) was constructed. The prognostic model showed good independent prognostic ability in PAAD. In the GSE62452 external validation set, the molecular model also showed good risk prediction. KM-curve analysis showed that there were significant differences between the high and low-risk groups, samples with a high-risk score had a worse prognosis. The predictive efficiency of the 3-gene signature-based nomogram was significantly better than that of traditional clinical features. For comparison with other models, that our model, with a reasonable number of genes, yields a more effective result. The results obtained with qPCR and IHC assays showed that ALOX5 was highly expressed, whether ALOX12 and CISD1 were expressed at low levels in tissue samples. Finally, function assays results suggested that ALOX5 may be an oncogene and ALOX12 and CISD1 may be tumor suppressor genes.
    Conclusions: We present a novel prognostic molecular model for PAAD based on ferroptosis-related genes, which serves as a potentially effective tool for prognostic differentiation in pancreatic cancer patients.
    Language English
    Publishing date 2022-01-15
    Publishing country England
    Document type Journal Article
    ISSN 1475-2867
    ISSN 1475-2867
    DOI 10.1186/s12935-021-02431-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Three-Component Direct Phosphorylation of Aldehydes and Alkylation of Ketones: Synthesis of γ-Ketophosphine Oxides under Acidic Conditions.

    Wang, Xiao-Hong / Xue, Ya-Wen / Bai, Chun-Yuan / Wang, Yan-Bin / Wei, Xiao-Hong / Su, Qiong

    The Journal of organic chemistry

    2023  Volume 88, Issue 23, Page(s) 16216–16228

    Abstract: An effective and economical acid-promoted three-component reaction for the construction of C-P and C-C bonds for the synthesis of γ-ketophosphine oxides with water as the only byproduct was developed. Detailed mechanistic experiments confirmed that the ... ...

    Abstract An effective and economical acid-promoted three-component reaction for the construction of C-P and C-C bonds for the synthesis of γ-ketophosphine oxides with water as the only byproduct was developed. Detailed mechanistic experiments confirmed that the reaction proceeds by phospha-aldol elimination, in which a benzylic carbocation is generated from the phosphorylation of aldehydes, which then reacts with ketone enolates under acidic conditions.
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c01674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: XinLi formula, a traditional Chinese decoction, alleviates chronic heart failure via regulating the interaction of AGTR1 and AQP1.

    Wei, Xiao-Hong / Liu, Wen-Jing / Jiang, Wei / Lan, Tao-Hua / Pan, Hai'e / Ma, Ming-Yue / You, Liang-Zhen / Shang, Hong-Cai

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2023  Volume 113, Page(s) 154722

    Abstract: Background: XinLi formula (XLF) is a traditional Chinese medicine used in clinical practice to treat chronic heart failure (CHF) in humans, with remarkable curative effect. However, the mechanism remains unknown.: Purpose: The goal of the current ... ...

    Abstract Background: XinLi formula (XLF) is a traditional Chinese medicine used in clinical practice to treat chronic heart failure (CHF) in humans, with remarkable curative effect. However, the mechanism remains unknown.
    Purpose: The goal of the current investigation was to determine how XLF affected CHF in a rat model of the condition brought on by ligation of the left anterior descending coronary artery, and to investigate the underlying mechanism.
    Study design and methods: Cardiac function was detected by echocardiography. The contents of myocardial enzymes, Ang II, ALD, TGF-β1, and inflammatory factors were measured by ELISA. Myocardial injury and myocardial fibrosis were evaluated by HE and Masson staining. Myocardial edema was assessed by cardiac mass index and transmission electron microscopy. Using Western blot and immunohistochemistry to examining the protein expression of inflammasome, TGF-β1, AGTR1, and AQP1 in the left ventricle. Furthermore, the interaction of AGTR1 and AQP1 was evaluated by co-immunoprecipitation.
    Results: XLF attenuated myocardial enzymes and myocardial injury, and improved cardiac function in rats with CHF after myocardial infarction. It also reduced Ang II and ALD levels in CHF rats, and suppressed the expression of AGTR1 and TGF-β1, finally alleviated myocardial fibrosis. By mechanism, XLF inhibited the expression of NLRP3 inflammasome proteins, reduced the plasma contents of IL-1β, IL-18, IL-6 and TNF-α. Additionally, XLF inhibited the expression of AQP1 and the interaction of AGTR1 and AQP1, alleviating myocardial edema. The common structure of the main chemical constituents of XLF were glycoside compounds with glycosyl.
    Conclusion: XLF ameliorated CHF, which was evidenced by the alleviation of myocardial fibrosis by inhibiting AGTR1/NLRP3 signal, as well as the attenuation of myocardial edema by suppressing the interaction of AGTR1 and AQP1.
    MeSH term(s) Humans ; Rats ; Animals ; Transforming Growth Factor beta1/metabolism ; Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Signal Transduction ; Drugs, Chinese Herbal/therapeutic use ; Myocardium/metabolism ; Heart Failure/metabolism ; Cardiomyopathies/metabolism ; Fibrosis ; Aquaporin 1/metabolism ; Receptor, Angiotensin, Type 1/metabolism
    Chemical Substances Transforming Growth Factor beta1 ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Drugs, Chinese Herbal ; AQP1 protein, human ; Aquaporin 1 (146410-94-8) ; AGTR1 protein, human ; Receptor, Angiotensin, Type 1 ; Aqp1 protein, rat
    Language English
    Publishing date 2023-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.154722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Research progress of natural non-alkaloids with analgesic activity].

    Wang, Ling-Yan / Xia, Huan / Xia, Gui-Yang / Wei, Xiao-Hong / Tian, Gui-Hua / Lin, Sheng

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2021  Volume 45, Issue 24, Page(s) 5840–5865

    Abstract: Pain is a complex, unpleasant feeling and emotional experience associated with actual or potential tissue damage, and manifests itself in certain autonomous psychological and behavioral responses. The commonly used opioid and non-steroidal anti- ... ...

    Abstract Pain is a complex, unpleasant feeling and emotional experience associated with actual or potential tissue damage, and manifests itself in certain autonomous psychological and behavioral responses. The commonly used opioid and non-steroidal anti-inflammatory analgesics(NSAIDs) may cause adverse reactions to the kidney, liver, cardiovascular or gastrointestinal system and cause problems of drug abuse. Therefore, it is necessary to study new analgesic drugs with less side effects and significant analgesic effects. A variety of natural products derived from terrestrial plants, microorganisms, marine organisms and fungi have been an important source of clinical medicines and provide an inexhaustible resource for the development and innovation of modern medicines. Therefore, this paper mainly reviews the natural non-alkaloids with analgesic activity in order to provide reference for the research and development of analgesic drugs derived from natural products.
    MeSH term(s) Analgesics/therapeutic use ; Analgesics, Opioid/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Biological Products/therapeutic use ; Humans ; Pain/drug therapy
    Chemical Substances Analgesics ; Analgesics, Opioid ; Anti-Inflammatory Agents, Non-Steroidal ; Biological Products
    Language Chinese
    Publishing date 2021-01-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20201104.201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Chemical constituents from ethyl acetate soluble extraction of Litsea cubeba].

    Xia, Huan / Wang, Ling-Yan / Xia, Gui-Yang / Wei, Xiao-Hong / Wang, Ya-Nan / Lin, Sheng

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2021  Volume 45, Issue 24, Page(s) 5877–5883

    Abstract: Chemical investigation on the constituents of the ethyl acetate soluble extraction of Litsea cubeba has resulted in the isolation and structure elucidation of thirty compounds, including one sesquiterpene(1), four monoterpenes(2-5), two γ-butyrolactone ... ...

    Abstract Chemical investigation on the constituents of the ethyl acetate soluble extraction of Litsea cubeba has resulted in the isolation and structure elucidation of thirty compounds, including one sesquiterpene(1), four monoterpenes(2-5), two γ-butyrolactone derivatives(6 and 7), seven tyramine derivatives(8-14), fifteen aromatic compounds(15-29), and one pyrone derivative(30) via various chromatographic techniques and spectroscopic data analysis(MS, IR, 1 D and 2 D NMR). Compounds 1-7, 13 and 14 were obtained from the genus Litsea for the first time.
    MeSH term(s) Acetates ; Litsea ; Monoterpenes ; Sesquiterpenes
    Chemical Substances Acetates ; Monoterpenes ; Sesquiterpenes ; ethyl acetate (76845O8NMZ)
    Language Chinese
    Publishing date 2021-01-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20200820.202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Poly[dimethano-lbis[μ-5-(3-pyrid-yl)tetra-zolato-κN:N]copper(II)].

    Wei, Xiao-Hong

    Acta crystallographica. Section E, Structure reports online

    2010  Volume 66, Issue Pt 5, Page(s) m551

    Abstract: In the crystal structure of the title complex, [Cu(C(6)H(4)N(5))(2)(CH(3)OH)(2)](n), the Cu(II) cation lies on an inversion center and is coordinated by four 5-(3-pyrid-yl)tetra-zolate anions and two methanol mol-ecules in an elongated distorted CuN(4)O( ... ...

    Abstract In the crystal structure of the title complex, [Cu(C(6)H(4)N(5))(2)(CH(3)OH)(2)](n), the Cu(II) cation lies on an inversion center and is coordinated by four 5-(3-pyrid-yl)tetra-zolate anions and two methanol mol-ecules in an elongated distorted CuN(4)O(2) octa-hedral geometry. Each 5-(3-pyrid-yl)tetra-zolate anion bridges two Cu(II) cations, forming a two-dimensional polymeric complex with (4,4) network topology. In the crystal structure, the two-dimensional layers are connected by inter-molecular O-H⋯N hydrogen bonding, forming a three-dimensional supra-molecular architecture.
    Language English
    Publishing date 2010-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 1600-5368 ; 1600-5368
    ISSN (online) 1600-5368
    ISSN 1600-5368
    DOI 10.1107/S1600536810013553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Progress of target determination and mechanism of bioactive components of traditional Chinese medicine].

    Wu, Xue-Fen / Wei, Xiao-Hong / Wu, Yu-Zhuo / Xia, Gui-Yang / Xia, Huan / Wang, Ling-Yan / Shang, Hong-Cai / Lin, Sheng

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2022  Volume 47, Issue 17, Page(s) 4565–4573

    Abstract: The pharmacodynamic substances of traditional Chinese medicine(TCM) are the basis for the research of TCM and the development of innovative drugs. However, the lack of clarity of targets and molecular mechanisms is the bottleneck problem that restricts ... ...

    Abstract The pharmacodynamic substances of traditional Chinese medicine(TCM) are the basis for the research of TCM and the development of innovative drugs. However, the lack of clarity of targets and molecular mechanisms is the bottleneck problem that restricts the research of pharmacodynamic substances of TCM. Bioactive components are the material basis of the efficacy of TCM, which exert activity by regulating the corresponding targets. Therefore, it is very important to identify the targets of the bioactive components to elucidate the pharmacological mechanism of TCM. Proteins are the most important drug targets, and study of the interaction between the proteins and bioactive components of TCM plays a key role in the development of pharmacological mechanism of TCM. In recent years, the main techniques for detecting the interaction between the bioactive components and proteins include surface plasmon resonance, fluorescence resonance energy transfer, bio-layer interference, molecular docking, proteome chip, target fishing, target mutant, and protein crystallization techniques, etc. This review summarized the biological target detection techniques and their applications in locating the targets of the bioactive components in TCM in the last decade, and this paper will provide useful strategies to elucidate the pharmacological mechanisms of TCM.
    MeSH term(s) Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional ; Molecular Docking Simulation ; Proteome
    Chemical Substances Drugs, Chinese Herbal ; Proteome
    Language Chinese
    Publishing date 2022-09-27
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20220330.201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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